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Researcher Information

last modified:2023/02/01

Assistant Professor SAKAMOTO, Akihiko

Laboratory Website

Faculty, Affiliation

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences
Assistant Professor

College and School Educational Field

Division of Health Sciences, Graduate School of Phamaceutical Science
Division of Pharmaceutical Sciences, Graduate School of Medical Science
School of Pharmacy, College of Medical, Pharmaceutical and Health Sciences
School of Medical and Pharmaceutical Sciences, College of Medical,Pharmaceutical and Health Sciences
School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Laboratory of Vaccinology and Applied Immunology

Academic Background

【Academic background(Doctoral/Master's Degree)】
University of Tokyo Doctor Graduate School of Pharmaceutical Sciences 201003 Completed
University of Tokyo Master Graduate School of Pharmaceutical Sciences 200703 Completed
【Academic background(Bachelor's Degree)】
University of Tokyo Faculty of Pharmaceutical Sciences 200503

Career

Kanazawa University School of Pharmacy Postdoctoral Researcher (2020/10/12-2022/09/30)
National Center for Geriatrics and Gerontology Department of Mechanism of Aging Researcher (2016/04/01-2020/10/11)
Nagoya University Graduate School of Medicine Researcher (2013/10/01-2016/03/31)
University of Tokyo Graduate School of Pharmaceutical Sciences Project Researcher (2010/04/01-2013/09/30)

Year & Month of Birth

1983/02

Academic Society

Japanese Society for Immunology

Award

Specialities

Immunology、Virology、Hematology

Speciality Keywords

Acquired immunity, Germinal center, Immunological memory, Antibody, B cell, T cell, Mouse, Virus-vectored vaccine, SARS-CoV-2

Research Themes

Development of a virus-vectored vaccine effective against SARS-CoV-2 variants

There are hopes for the development of a highly effective and durable vaccine against upcoming SARS-CoV-2 variants. Our laboratory has developed various kinds of virus-vectored vaccines against malaria, and has investigated their immunogenicity in mice. In this project, we aim to develop a novel COVID-19 vaccine that will elicit neutralizing antibodies against the recent Omicron variants in more than 90% of mice for at least half a year after homologous prime-boost immunization.

Books

Papers

  •  Adeno-associated virus-based malaria booster vaccine following attenuated replication-competent vaccinia virus LC16m8Δ priming Ammar A. Hasyim, Mitsuhiro Iyori, Tetsushi Mizuno, Yu-ichi Abe, Iroha Yamagoshi, Yenni Yusuf, Intan Syafira, Akihiko Sakamoto, Yutaro Yamamoto, Hiroaki Mizukami, Hisatoshi Shida, Shigeto Yoshida Parasitology International 92 102652 2023/02 
  •  A replication-competent smallpox vaccine LC16m8Δ-based COVID-19 vaccine Akihiko Sakamoto, Hiroaki Osawa, Hinata Hashimoto, Tetsushi Mizuno, Ammar A. Hasyim, Yu-ichi Abe, Yuto Okahashi, Ryohei Ogawa, Mitsuhiro Iyori, Hisatoshi Shida, Shigeto Yoshida Emerging Microbes & Infections 11 1 2359 2022/12 
  •  Sterile protection and transmission blockade by a multistage anti-malarial vaccine in the pre-clinical study Mitsuhiro Iyori, Andrew M. Blagborough, Tetsushi Mizuno, Yu-ichi Abe, Mio Nagaoka, Naoto Hori, Iroha Yamagoshi, Dari F. Da, William F. Gregory, Ammar A. Hasyim, Yutaro Yamamoto, Akihiko Sakamoto, Kunitaka Yoshida, Hiroaki Mizukami, Hisatoshi Shida, Shigeto Yoshida Frontiers in Immunology 13 1005476 2022/09/29 
  •  The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells Yuma Sugiyama*, Mitsuhiro Fujiwara*, Akihiko Sakamoto* (*equal contribution), Hiromichi Tsushima, Akihiko Nishikimi, Mitsuo Maruyama Immunity & Ageing 19 1 2022/01/03 
  •  Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma Shunsuke Kunou, Kazuyuki Shimada, Mika Takai, Akihiko Sakamoto, Tomohiro Aoki, Tomoya Hikita, Yusuke Kagaya, Eisuke Iwamoto, Masashi Sanada, Satoko Shimada, Fumihiko Hayakawa, Chitose Oneyama, Hitoshi Kiyoi Oncogene 40 23 3989 2021/05/16 

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  •  Contribution of DOCK11 to the expansion of antigen-specific populations among germinal center B cells Akihiko Sakamoto, Mitsuo Maruyama ImmunoHorizons 4 9 520 2020/09/01 
  •  Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells Akihiko Sakamoto, Shunsuke Kunou, Kazuyuki Shimada, Makoto Tsunoda, Tomohiro Aoki, Chisako Iriyama, Akihiro Tomita, Shigeo Nakamura, Fumihiko Hayakawa, Hitoshi Kiyoi Cancer Science 110 1 269 2018/11/13 
  •  Long-term intake of Lactobacillus paracasei KW3110 prevents age-related chronic inflammation and retinal cell loss in physiologically aged mice Yuji Morita, Kenta Jounai, Akihiko Sakamoto, Yasuyuki Tomita, Yoshihiko Sugihara, Hiroaki Suzuki, Konomi Ohshio, Masato Otake, Daisuke Fujiwara, Osamu Kanauchi, Mitsuo Maruyama Aging 10 10 2723 2018/10/19 
  •  Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model Guang Hua Li, Shinya Akatsuka, Shan Hwu Chew, Li Jiang, Takahiro Nishiyama, Akihiko Sakamoto, Takashi Takahashi, Mitsuru Futakuchi, Hiromu Suzuki, Kunihiko Sakumi, Yusaku Nakabeppu, Shinya Toyokuni Pathology International 67 11 564 2017/11 
  •  Involvement of Zizimin2/3 in the age-related defect of peritoneal B-1a cells as a source of anti-bacterial IgM Akihiko Sakamoto, Takenori Matsuda, Koichiro Kawaguchi, Akinori Takaoka, Mitsuo Maruyama International Immunology 29 9 431 2017/10/09 
  •  Emetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism Tomohiro Aoki, Kazuyuki Shimada, Akihiko Sakamoto, Keiki Sugimoto, Takanobu Morishita, Yuki Kojima, Satoko Shimada, Seiichi Kato, Chisako Iriyama, Shunsuke Kuno, Yasuhiko Harada, Akihiro Tomita, Fumihiko Hayakawa, Hitoshi Kiyoi Oncotarget 8 8 13085 2016/12/31 
  •  Live-cell single-molecule imaging of the cytokine receptor MPL for analysis of dynamic dimerization Akihiko Sakamoto, Takashi Tsukamoto, Yuji Furutani, Yuki Sudo, Kazuyuki Shimada, Akihiro Tomita, Hitoshi Kiyoi, Takashi Kato, Takashi Funatsu Journal of Molecular Cell Biology 8 6 553 2016/12/07 
  •  SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway Yusuke Takagi, Kazuyuki Shimada, Satoko Shimada, Akihiko Sakamoto, Tomoki Naoe, Shigeo Nakamura, Fumihiko Hayakawa, Akihiro Tomita, Hitoshi Kiyoi Cancer Science 107 9 1270 2016/09 
  •  Development and analysis of patient-derived xenograft mouse models in intravascular large B-cell lymphoma K. Shimada, S. Shimada, K. Sugimoto, M. Nakatochi, M. Suguro, A. Hirakawa, T. D. Hocking, I. Takeuchi, T. Tokunaga, Y. Takagi, A. Sakamoto, T. Aoki, T. Naoe, S. Nakamura, F. Hayakawa, M. Seto, A. Tomita, H. Kiyoi Leukemia 30 7 1568 2016/07 
  •  Fluorescence labeling of a cytokine with desthiobiotin-tagged fluorescent puromycin Akihiko Sakamoto, Mai Yamagishi, Takafumi Watanabe, Youichi Aizawa, Takashi Kato, Takashi Funatsu Journal of Bioscience and Bioengineering 105 3 238 2008/03 

Conference Presentations

  • Improved immunogenicity of the recombinant vaccinia virus by targeting the immunomodulatory A46R gene locus (conference:51st Annual Meeting of the Japanese Society for Immunology)(2022/12/09)
  • Deduced function of DOCK11 in B cells in secondary immune responses with protein antigens (conference:51st Annual Meeting of the Japanese Society for Immunology)(2022/12/07)
  • Development of a COVID-19 vaccine using a highly attenuated replication-competent vaccinia virus vector (conference:26th Annual Meeting of the Japanese Society for Vaccinology)(2022/11/26)
  • An LC16m8Δ-vectored COVID-19 vaccine effectively elicits neutralizing antibodies and cellular immune responses in a mouse model (conference:69th Annual Meeting of the Japanese Society for Virology)(2022/11/14)
  • A Novel Malaria Multistage Vaccine Based on Vaccinia virus-Prime/AAV5-Boost Elicits Sterile Protection and Transmission Blocking Efficacy (conference:ASTMH 2022 Annual Meeting)(2022/11/01)

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  • Optimization of Plasmodium falciparum multistage vaccine based on the heterologous viral-vectored platform in a murine model (conference:ASTMH 2022 Annual Meeting)(2022/11/01)
  • Pre-erythrocytic and transmission-blocking multi-stage malaria vaccine strategy shows a strong synergic effect to control malaria disease (conference:ASTMH 2022 Annual Meeting)(2022/10/31)
  • Plasmodium vivax multistage vaccine based on the heterologous viral-vectored platform achieves sterile protection and transmission blocking (conference:ASTMH 2022 Annual Meeting)(2022/10/31)
  • Availability of the highly attenuated replication-competent vaccinia virus strain LC16m8Δ as a COVID-19 vaccine platform (conference:16th Vaccine Congress)(2022/09/12)
  • A novel COVID-19 vaccine based on a Made-in-Japan live attenuated virus induces neutralizing antibodies against S-pseudotyped virus in a murine model (conference:68th Annual Meeting of the Japanese Society for Virology)(2021/11/16)
  • Exosomal miRNA from cancer-associated fibroblast confers pyrimidine analogue resistance in lymphoma (conference:83rd Annual Meeting of the Japanese Society of Hematology)(2021/09/24)
  • Contribution of DOCK11 to defective humoral immunity in aged mice (conference:43rd Annual Meeting of the Japan Society for Biomedical Gerontology)(2020/05/27)
  • Contribution of DOCK11 to the expansion of antigen-specific B-cell populations (conference:48th Annual Meeting of the Japanese Society for Immunology)(2019/12/12)
  • Contribution of DOCK11 to the expansion of antigen-specific B-cell populations (conference:42nd Annual Meeting of the Molecular Biology Society of Japan)(2019/12/06)
  • Inflammation and trophic control on immunosenescence (conference:42nd Annual Meeting of the Molecular Biology Society of Japan)(2019/12/04)
  • Resistance of pyrimidine analogs in primary lymphoma cells is induced by exosomes from cancer associated fibroblasts (conference:78th Annual Meeting of the Japanese Cancer Association)(2019/09/26)
  • Involvement of DOCK11 in B-cell immune responses (conference:42nd Annual Meeting of the Japan Society for Biomedical Gerontology)(2019/06/08)
  • Immunosenescence: the forefront of infection and trophic control (conference:139th Annual Meeting of the Pharmaceutical Society of Japan)(2019/03/21)
  • Involvement of DOCK11 in B-cell responses against T cell-independent type 2 antigens (conference:45th Annual Meeting of the Japanese Society for Immunology)(2018/12/10)
  • Exosomes derived from cancer associated fibroblasts elicit survival and drug resistance of primary lymphoma cells (conference:60th ASH Annual Meeting)(2018/11/29)
  • Exosomes secreted from CAFs elicits gemcitabine resistance through anti-apoptotic mechanism (conference:80th Annual Meeting of the Japanese Society of Hematology)(2018/10/12)
  • Significance of exosomes secreted from cancer-associated fibroblasts in lymphoma microenvironment (conference:77th Annual Meeting of the Japanese Cancer Association)(2018/09/28)
  • Contribution of Zizimin2/3 to the age-related defect in B-1a cells as a source of anti-pneumococcal immunoglobulin M (conference:41st Annual Meeting of Japan Society for Biomedical Gerontology)(2018/06/02)
  • Zizimin2-deficient mice showing defective production of natural antibacterial immunoglobulin M and interruption in B-cell development (conference:19th Germinal Centre Conference)(2017/09/14)
  • A novel food constituent potentially mitigates inflammation in physiologically aged mice (conference:IAGG 2017 World Congress)(2017/07/24)
  • Involvement of Zizimin2 in the defective antibody production by aged peritoneal B-1a B cells (conference:40th Annual Meeting of the Japan Society for Biomedical Gerontology)(2017/06/16)
  • Effects of food constituents on immunosenescence in physiological aged mice (conference:40th Annual Meeting of the Japan Society for Biomedical Gerontology)(2017/06/16)
  • Concomitant deletion of Zizimin2 and 3 for mimicking impaired protective immunity against pneumococcal infection in aged mice (conference:ASAR Symposium 2017)(2017/03/02)
  • Concomitant deletion of Zizimin2/3 for mimicking impaired protective immunity in aged mice (conference:45th Annual Meeting of the Japanese Society for Immunology)(2016/12/05)
  • The murine immunosenescence-associated gene Zizimin2 promoter region and its transcriptional regulation with aging (conference:45th Annual Meeting of the Japanese Society for Immunology)(2016/12/06)
  • Emetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism (conference:58th ASH Annual Meeting)(2016/12/04)
  • Discovering the novel drug targeting tumor-microenvironment for intractable lymphoma (conference:78th Annual Meeting of the Japanese Society of Hematology)(2016/10/15)
  • Inhibition of glycolytic metabolism as a potential therapeutic target for MYC/BCL2 positive DLBCL (conference:75th Annual Meeting of the Japanese Cancer Association)(2016/10/07)
  • Lymph node-associated stromal fibroblasts support B-cell lymphoma cells via the PI3K pathway (conference:77th Annual Meeting of the Japanese Society of Hematology)(2015/10/18)
  • SPIB expression is a novel poor prognostic factor in DLBCL (conference:77th Annual Meeting of the Japanese Society of Hematology)(2015/10/17)
  • Lymph node-associated stromal fibroblasts as a potential source of humoral factors to support B-cell lymphoma cells (conference:74th Annual Meeting of the Japanese Cancer Association)(2015/10/08)
  • Lymph node-associated stromal fibroblasts as a potential source of humoral factors to support B-cell lymphoma cells via the phosphatidylinositol 3-kinase pathway (conference:ISEH 44th Annual Scientific Meeting)(2015/09/17)
  • Dynamic dimerization of the myeloproliferative neoplasm-relevant MPL mutant revealed by single-molecule imaging (conference:73rd Annual Meeting of the Japanese Cancer Association)(2014/09/25)
  • Super-resolution imaging of mRNA nano-structure in stress granule (conference:8th Asian Biophysics Association Symposium)(2013/05)
  • 3D-super-resolution microscopy reveals mRNA nano-structure in stress granule (conference:Biophysical Society 57th Annual Meeting)(2013/02)
  • Positive feedback control of thrombopoietin signaling by the monomer-dimer equilibrium of the thrombopoietin receptor revealed by single-molecule fluorescence imaging (conference:2012 Gordon Research Conference on Single Molecule Approaches to Biology)(2012/07)
  • Super-resolution imaging of intracellular mRNAs in stress granule (conference:Biophysical Society 56th Annual Meeting)(2012/02)
  • Super-resolution imaging of intracellular mRNAs in stress granule (conference:JST-BBSRC Joint Symposium)(2012/01)
  • Single-molecule imaging of dynamics of thrombopoietin receptors on the plasma membrane (conference:Seoul Nanohealth 2011)(2011/11)
  • Thrombopoietin and c-Mpl in Xenopus laevis (conference:NTU-WASEDA U Joint Symposium)(2008/03)
  • In vitro translation of thrombopoietin labeled with fluorescent puromycin at the C-terminus (conference:20th IUBMB and 11th FAOBMB Congress)(2006/06)

Others

  •  Immunosenescence: the forefront of infection and trophic control Mitsuo Maruyama, Akihiko Sakamoto, Yuji Morita, Akinori Takaoka Yakugaku Zasshi 140 3 391 2020/03
  •  Emetine Elicits Apoptosis of Intractable B-Cell Lymphoma Cells with MYC Rearrangement through Inhibition of Glycolytic Metabolism Tomohiro Aoki, Kazuyuki Shimada, Akihiko Sakamoto, Keiki Sugimoto, Takanobu Morishita, Yuki Kojima, Satoko Shimada, Seiichi Kato, Chisako Iriyama, Shunsuke Kuno, Yasuhiko Harada, Shigeo Nakamura, Akihiro Tomita, Fumihiko Hayakawa, Hitoshi Kiyoi Blood 128 22 3019 2016/12 
  •  Lymph node-associated stromal fibroblasts as a potential source of humoral factors to support B-cell lymphoma cells via the phosphatidylinositol 3-kinase pathway Akihiko Sakamoto, Kazuyuki Shimada, Miyuki Katayama, Fumihiko Hayakawa, Akihiro Tomita, Hitoshi Kiyoi Experimental Hematology 43 9 S93 2015/09 
  •  Super-Resolution Fluorescence Imaging Reveals Nanoscale Organization of Stress Granule Ko Sugawara, Kohki Okabe, Akihiko Sakamoto, Takashi Funatsu Biophysical Journal 106 2 397A 2014/01
  •  3D-Super-Resolution Microscopy Reveals MRNA Nano-Structure in Stress Granule Ko Sugawara, Kohki Okabe, Akihiko Sakamoto, Takashi Funatsu Biophysical Journal 104 2 667A 2013/01

show all

  •  Single molecule dynamics of the thrombopoietin receptor on the plasma membrane Akihiko Sakamoto, Takashi Kato, Takashi Funatsu Seikagaku 83 10 912 2011/10

Arts and Fieldwork

Patent

○ Stromal cells derived from lymph nodes of patients with blood related diseases (publish date:2017/01/19)(No:特許2019-6578621)

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○ Grant-in-Aid for Challenging Research (Exploratory)「Versatile next-generation vaccine platform -Application for COVID-19-」(2022-2024) 
○ Grant-in-Aid for Scientific Research (C)「Development of novel heterologous virus-vectored vaccines for COVID-19」(2021-2023) 
○ Practical Research for Innovative Cancer Control「Comparative analysis of malignant lymphoma cells and its microenvironment cells to develop novel treatment targeting microenvironmental support mechanism」(2014-2015) 

Competitive research funding,Contribution

○ Investigation of the roles of Zizimin2 in mouse B cells for preventing the elderly from infectious diseases  Research Funding for Longevity Sciences National Center for Geriatrics and Gerontology (2018-2019)

Collaborative research,Consignment study

Classes (Bachelors)

○ Host Defense (2022)
○ Experiments in Biology 1 (2022)
○ Laboratory Rotation 1 (2022)
○ Early Laboratory Rotation 1 (2022)
○ Early Laboratory Rotation 2 (2022)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

○ Kanazawa University (20221107-20221118) Workplace vaccination

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