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Researcher Information

last modified:2019/02/15

Associate Professor SAKAI Yoshio


Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences School of Medicine, College of Medical,Pharmaceutical and Health

College and School Educational Field

Division of Cardiovascular Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences


 TEL:076-265-2235 FAX:076-234-4250

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor 200010 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 199403


Year & Month of Birth


Academic Society




Speciality Keywords

liver diseases

Research Themes

Immune function in gastrointestinal disease

Gene therapy for cancer

Regenerative Medicine



  •  Early Role of CD4+ Th1 Cells and Antibodies in HER-2 Adenovirus Vaccine Protection against Autochthonous Mammary Carcinomas. JOURNAL OF IMMUNOLOGY 174 7 4228-36 2005/04
  •  Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance. BLOOD 105 2 721-74 2005/01
  •  Vaccination by Genetically Modified Dendritic Cells Expressing a Truncated neu Oncogene Prevents Development of Breast Cancer in Transgenic Mice. CANCER RESEARCH 64 21 8022-8 2004/11
  •  Enhanced Anti-tumor Effects of Herpes Simplex Virus Thymidine Kinase / Ganciclovir System by Codelivering Monocyte Chemoattractant Protein-1 in Hepatocellular Carcinoma. CANCER GENE THERAPY 8 10 695-704 2001/10
  •  Gene therapy for hepatocellular carcinoma using two recombinant adenovirus vectors with a-fetoprotein promoter and Cre/loxP system. JOURNAL OF VIROLOGICAL METHODS 92 1 5-17 2001/01

show all

  •  The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells. Nasti A, Sakai Y, Seki A, Buffa GB, Komura T, Mochida H, Yamato M, Yoshida K, Ho TTB, Takamura M, Usui S, Wada T, Honda M, Kaneko S. Eur J Immunol 47 12 2163 2017
  •  Localizatoin of Xenobiotic Transporter OCTN1/SLC22A4 in Hepatic Stellate Cells and Its Protective Role in Liver Fibrosis. Tang Y, Masuo Y, Sakai Y, Wakayama T, Sugiura T, Harada R, Futatsugi A, Komura T, Nakamichi N, Sekiguchi H, Sutoh K, Usumi K, Iseki S, Kaneko S, Kato Y. J Pharm Sci 105 5 1779-89 2016
  •  Prediction formula for interrupter respiratory resistance in healthy Japanese adults. Nakade Y, Fujimura M, Ohkura N, Okuizumi Y, Nakata M, Nanbu Y, Oe H, Horita H, Sakai Y, Wada T.  臨床病理 60 8 725-733 2012
  •  Adipose-derived regenerative cells exert beneficial effects on systemic responses following myocardial ischemia/reperfusion. Takamura M, Usui S, Inoue O, Ootsuji H, Takashima SI, Nomura A, Kato T, Murai H, Furusho H, Sakai Y, Kaneko S. Cardiol J 23 6 685-693 2016
  •  Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model.  Takegoshi K, Honda M, Okada H, Takabatake R, Matsuzawa-Nagata N, Campbell JS, Nishikawa M, Shimakami T, Shirasaki T, Sakai Y, Yamashita T, Takamura T, Tanaka T, Kaneko S.  Oncotarget.  2017
  •  Phase I clinical study of liver regenerative therapy for cirrhosis by intrahepatic arterial infusion of freshly isolated autologous adipose tissue-derived stromal/stem (regenerative) cell. Regenerative Therapy Yoshio Sakai, Masayuki Takamura, Akihiro Seki, Hajime Sunagozaka, 3, Takeshi Terashima, Takuya Komura, Masatoshi Yamato, Masaki Miyazawa, Kazunori Kawaguchi, Alessandro Nasti, Hatsune Mochida, Soichiro Usui, Nobuhisa Otani, Takahiro Ochiya, Takashi Wada, Masao Honda, Shuichi Kaneko. Regenerative Therapy 52-64 2017
  •  Response to chemotherapy improves hepatic reserve for patients with hepatocellular carcinoma and Child-Pugh B cirrhosis. Terashima T, Yamashita T, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S Cancer Sci. 107 9 1263-9 2016/09
  •  Jagged1 DNA Copy Number Variation Is Associated with Poor Outcomein Liver Cancer.  Kawaguchi K, Honda M, Yamashita T, Okada H, Shirasaki T, Nishikawa M, Nio K, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S. Am J Pathol. 186 8 2055-67 2016
  •  Nodular lesions and mesangiolysis in diabetic nephropathy. Wada T, Shimizu M, Yokoyama H, Iwata Y, Sakai Y, Kaneko S, Furuichi K.  Clin Exp Nephrol. 17 1 3-9 2013
  •  肝癌幹細胞の生物学的特徴と幹細胞標的新規治療法開発の可能性 酒井佳夫、山下太郎、金子周一 肝胆膵 65 1 63-71 2012
  •  Association of changes in the gene expression profile of blood cells with the local tumor inflammatory response in a murine tumor model. Sakai Y, Tatsumi I, Higashimoto M, Seki A, Nasti A, Yoshida K, Kawaguchi K, Wada T, Honda M, Komura T, Kaneko S. Biochem Biophys Res Commun 428 1 36-43 2012
  •  Association of interleukin-28B genotype and hepatocellular carcinoma recurrence in patients with chronic hepatitis C. Hodo Y, Honda M, Tanaka A, Nomura Y, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Sakai A, Sasaki M, Nakanuma Y, Moriyama M, Kaneko S.  Clin Cancer Res. 19 7 1827-37 2013
  •  MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells. Shirasaki T, Honda M, Shimakami T, Horii R, Yamashita T, Sakai Y, Sakai A, Okada H, Watanabe R, Murakami S, Yi M, Lemon SM, Kaneko S. J Virol 87 9 5270-86 2013
  •  Gene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling.  Ueda T, Honda M, Horimoto K, Aburatani S, Saito S, Yamashita T, Sakai Y, Nakamura M, Takatori H, Sunagozaka H, Kaneko S. Genomics.  101 4 238-48 2013
  •  CCL2/CCR2 augments the production of transforming growth factor-beta1, type 1 collagen and CCL2 by human CD45-/collagen 1-positive cells under high glucose concentrations. Hara A, Sakai N, Furuichi K, Sakai Y, Takeya M, Bucala R, Mukaida N, Takuwa Y, Matsushima K, Kaneko S, Wada T. Clin Exp Nephrol 17 793-804 2013
  •  Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma. Honda M, Yamashita T, Yamashita T, Arai K, Sakai Y, Sakai A, Nakamura M, Mizukoshi E, Kaneko S. BMC Cancer. 15 13 191 2013
  •  ER stress induced impaired TLR signaling and macrophage differentiation of human monocytes. Komura T, Sakai Y, Honda M, Takamura T, Wada T, Kaneko S. Cell Immunol. 282 1 44-52 2013
  •  Adipose tissue derived stromal stem cell therapy in murine ConA-derived hepatitis is dependent on myeloid-lineage and CD4+ T-cell suppression Higashimoto M, Sakai Y, Takamura M, Usui S, Nasti A, Yoshida K, Seki A, Komura T, Honda M, Wada T, Furuichi K, Ochiya T, Kaneko S.  Eur J Immunol.  43 11 2956-68 2013
  •  Hepatitis B Virus (HBV) Core-Related Antigen During Nucleos(t)ide Analog Therapy Is Related to Intra-hepatic HBV Replication and Development of Hepatocellular Carcinoma. Honda M, Shirasaki T, Terashima T, Kawaguchi K, Nakamura M, Oishi N, Wang X, Shimakami T, Okada H, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S. J Infect Dis 213 7 1096-106 2016
  •  Reversibility of the Pulmonary Function Based on the Partial Flow-volume Curve Predicts the Efficacy of Bronchodilator Therapy for Treating Chronic Cough. Nakade Y, Fujimura M, Ohkura N, Nakata M, Nanbu Y, Oe H, Horita H, Sakai Y, Wada T. Intern Med. 52 18 2017-23 2013
  •  食道静脈瘤に対する内視鏡的硬化療法後に第Ⅴ因子欠損症を来した1例 山田和俊、北村和哉、丹尾幸樹、島上哲朗、荒井邦明、柿木嘉平太、山下太郎、酒井佳夫、水腰英四郎、金子周一. gastoenterological endoscopy 56 3 451-456 2014
  •  Efficacy of Continuous Plasma Diafiltraion Therapy in critical Patients with Acute Liver Failure Komura T, Taniguchi T, Sakai Y, Yamashita T, Mizukoshi E, Noda T, Okajima M, Kaneko S  J Gastroenterol Hepatol. 29 4 782-6 2014
  •  Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin 28B genotypes Honda M, Shirasaki T, Shimakami T, Sakai A, Horii R, Arai K, Yamashita T, Sakai Y, Yamashita T, Okada H, Murai K, Nakamura M, Mizukoshi E, Kaneko S. Hepatology 59 3 828-38 2014
  •  Impact of kidney function and urinary protein excretion on pulmonary function in Japanese patients with chronic kidney disease. Nakade Y, Toyama T, Furuichi K, Kitajima S, Ohkura N, Sagara A, Shinozaki Y, Hara A, Kitagawa K, Shimizu M, Iwata Y, Oe H, Nagahara M, Horita H, Sakai Y, Kaneko S, Wada T. Clin Exp Nephrol 18 5 763-9 2014
  •  Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice. Okada H, Honda M, Campbell JS, Takegoshi K, Sakai Y, Yamashita T, Shirasaki T, Takabatake R, Nakamura M, Tanaka T, Kaneko S  2015 Sep;106(9):1143-52. doi: 10.1111/cas.12730. Epub 2015 Sep 1. 106 9 1143-52 2015
  •  Post-progression survival and progression-free survival in patients with advanced hepatocellular carcinoma treated by sorafenib Terashima T, Yamashita T, Takata N, Nakagawa H, Toyama T, Arai K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S Hepatol Res 46 7 650-6 2016
  •  Inflammatory features of pancreatic cancer highlighted by monocytes/macrophages and CD4+ T cells with clinical impact Komura T, Sakai Y, Harada K, Kawaguchi K, Takabatake H, Kitagawa H, Wada T, Honda M, Ohta T, Nakanuma Y, Kaneko S Cancer Sci. 106 6 672-686 2015
  •  Enhanced and specific gene expression via tissue-specific production of Cre recombinase using adenovirus vector. Biochem Biophys Res Commun 244 2 455-462 1998/03
  •  Enhanced antitumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant protein-1 against hepatocellular carcinoma. CANCER GENE THERAPY 10 4 260-269 2003/04
  •  Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent. J Natl Cancer Inst. 96 9 703-708 2004/05
  •  Monocyte Chemoattractant protein-1 gene delivery enhances antitumor effects of herpes simplex virus thymidine kinase/ganciclovir system in a model of colon cancer.  CANCER GENE THERAPY 13 4 357-66 2005/04
  •  Virological effects and safety of combined double filtration plasmapheresis (DFPP) and interferon therapy in patients with chornic hepatitis C: preliminary study. HEPATOLOGY RESEARCH 36 167-175
  •  Combined therapy of transcatheter hepatic arterial embolization with intratumoral dendritic cell infusion for hepatocellular carcinoma: clinical safety. Clin Exp Immunol 147 296-305
  •  Prolonged, NK Cell-Mediated Antitumor Effects of Suicide Gene Therapy Combined with Monocyte Chemoattractant Protein-1 against Hepatocellular Carcinoma. JOURNAL OF IMMUNOLOGY 178 574-583
  •  Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C virus and its susceptibility to interferon. FEBS LETTERS 581 10 1983-1987 2007/04
  •  Reactive peripheral blood plasmacytosis in a patient with acute hepatitis a. INTERNATIONAL JOURNAL OF HEMATOLOGY 85 3 191-194 2007/04
  •  Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes. Biochem Biophys Res Commun 85 3 191-194 2007/09
  •  Therapy of advanced established murine breast cancer with a recombinant adenoviral ErbB-2/neu vaccine. CANCER RESEARCH 68 6 1979-1987 2008/03
  •  Optimal amount of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy against hepatocellular carcinoma by M1 macrophage activation.  cancer science 99 2075-2082
  •  Common Transcriptional Signature of Tumor-infiltrating Mononuclear Inflammatory Cells and Peripheral Blood Mononuclear Cells in Hepatocellular Carcinoma Patients. CANCER RESEARCH 68 10267-10279
  •  Two cases of a nonfunctioning pancreatic endocrine tumor found on a medical checkup.  Nippon Shokakibyo Gakkai Zasshi 106 560-568
  •  Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. HEPATOLOGY 49 1098-1112
  •  CD14+monocytes are vulnerable and functionally impaired under ER stress in patients with type 2 diabetes. DIABETES 59 3 634-643 2010/03
  •  Altered hepatic gene expression profiles associated with myocardial ischemia.  Circ Cardiovasc Genet 3 1 68-77 2010/02
  •  Interleukin-15 and its Receptor Augment Dendritic Cell Vaccination Against the neu Oncogene Through the Induction of neu Antibodies Partially Independent of CD4 Help. CANCER RESEARCH 70 3 1072-81 2010/02
  •  Differential Gene Expression Profiling in Blood from Patients with Digestive System Cancers.  Biochem Biophys Res Commun 400 1 7-15 2010/09
  •  La protein required for internal ribosome entry site-directed translation is a potential therapeutic target for hepatitis C virus replication. JOURNAL OF INFECTIOUS DISEASES 202 1 75-85 2010/07
  •  Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C.  GASTROENTEROLOGY 139 2 499-509 2010/08
  •  Differential interferon signaling in liver lobule and portal area cells under treatment for chronic hepatitis C. JOURNAL OF HEPATOLOGY 53 5 817 2010/11
  •  Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma. INTERNATIONAL JOURNAL OF CANCER 129 7 1576-1585 2011/10
  •  Involvement of bone-marrow-derived cells in kidney fibrosis. Clin Exp Nephrol 15 1 8-13 2011/02
  •  Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C. GASTROENTEROLOGY 141 1 128-140 2011/07
  •  Prevention of intrahepatic metastasis of liver cancer by suicide gene therapy and chemokine ligand 2/monocyte chemoattractant protein-1 delivery in mice. JOURNAL OF GENE MEDICINE 12 12 1002-1013 2010/12
  •  Comparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma. HEPATOLOGY 53 4 1206-1216 2011/04
  •  Frequency of CD45RO+ subset in CD4+CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma. CANCER LETTERS 307 2 165-7-173 2011/08
  •  Clinical evaluation of rapid identification of bacteria from positive-testing blood culture bottles by internal transcribed spacer PCR 59 5 439-445 2011/05

Conference Presentations

  • Potentials of Adipose Tissue-derived Mesenchymal Stem Cell Therapy for Liver Disease(conference:Nagoya Shinshu Forum 2012)
  • Features of immunomodulatory and therapeutic effects of mesenchymal stromal/stem cells on non-alcoholic steatohepatitis murine model in early and cirrhotic phases(conference:The 64th Annual Meeting of the American Association for the Study of Liver Diseases)(2013/11)
  • Genes Expression of Whole Blood Cells Reflect the Distinct Pathophysiological Features of Type C Cirrhosis and Hepatocellular Carcinoma Patients(conference:AASLD)(2011)

Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「骨髄および脂肪由来細胞を用いた次世代型肝臓再生・修復(抗線維化) 療法の開発研究 」(2009-2011) 

Classes (Bachelors)

○Infectious Diseases(2017)
○Extended Bsl(2017)
○Laboratory Medicine(BSL)(2017)
○Clinical Chemistry(2017)
○Laboratory Medicine(CE)(2017)
○Laboratory Medicine(BSL)(2016)
○Extended Bsl(2016)
○Laboratory Medicine(CE)(2016)
○Clinical Chemistry(2016)
○Infectious Diseases(2016)

Classes (Graduate Schools)

○Introduction to Medicine(2017)
○Clinical Chemistry and Laboratory Medicine(2017)
○Clinical Chemistry and Laboratory Medicine(2017)
○Clinical Chemistry and Laboratory Medicine(2016)
○Clinical Chemistry and Laboratory Medicine(2016)
○Introduction to Medicine(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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