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Researcher Information

last modified:2020/01/22

Assistant Professor KOZAKA, Takashi

Laboratory Website
Laboratory Website

Faculty, Affiliation

Advanced Science Research Center Division of Tracer Kinetics

College and School Educational Field


Laboratory

Division of Tracer Kinetics

Academic Background

【Degree】
Ph.D.

Career

Year & Month of Birth

Academic Society

Society of Nuclear Medicine and Molecular Imaging
Japanese Society of Radiation Safety Management
The Japanese Society of Nuclear Medicine
Japan Radioisotope Association
Japanese Society for Molecular Imaging
The Pharmaceutical Society of Japan

Award

Specialities

Speciality Keywords

Organic synthetic chemistry, Radiopharmaceutical chemistry, Molecular imaging

Research Themes

Books

Papers

  •  Evaluation of Ga-DOTA-(D-Asp)n as bone imaging agents: D-aspartic acid peptides as carriers to bone Kazuma Ogawa, Atsushi Ishizaki, Kenichiro Takai, Yoji Kitamura, Akira Makino, Takashi Kozaka, Yasushi Kiyono, Kazuhiro Shiba & Akira Odani. Scientific Reports 7 1 1-11 2017/10
  •  Development of a novel radiobromine-labeled sigma-1 receptor imaging probe Kazuma Ogawa, Ryohei Masuda, Yoshiaki Mizuno, Akira Makino, Takashi Kozaka, Yoji Kitamura, Yasushi Kiyono, Kazuhiro Shiba, Akira Odani Nuclear Medicine and Biology 61 28-35 2018/06
  •  In Vivo Differences between Two Optical Isomers of Radioiodinated o-iodo-trans-decalinvesamicol for Use as a Radioligand for the Vesicular Acetylcholine Transporter Izumi Uno, Takashi Kozaka, Daisuke Miwa, Yoji Kitamura, Mohammad Anwar-ul Azim, Kazuma Ogawa, Junichi Taki, Seigo Kinuya, Kazuhiro Shiba PLOS ONE 11 1 p.e0146719 (1-14) 2016/01
  •  Synthesis and evaluation of a new vesamicol analog o-[11C]methyl-trans-decalinvesamicol as a PET ligand for the vesicular acetylcholine transporter Yoji Kitamura, Takashi Kozaka, Daisuke Miwa, Izumi Uno, Mohammad Anwar-ul Azim, Kazuma Ogawa, Junichi Taki, Seigo Kinuya, Kazuhiro Shiba Annals of Nuclear Medicine 30 2 122-129 2016/02
  •  Preparation and evaluation of an astatine-​211-​labeled sigma receptor ligand for alpha radionuclide therapy Kazuma Ogawa, Yoshiaki Mizuno, Kohshin Washiyama, Kazuhiro Shiba, Naruto Takahashi, Takashi Kozaka, Shigeki Watanabe, Atsushi Shinohara, Akira Odani Nuclear medicine and biology 42 11 875-879 2015/07

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  •  Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease Olga Lopatina, Toru Yoshihara, Tomoko Nishimura, Jing Zhong, Shirin Akther, Azam A. K. M. Fakhrul, Mingkun Liang, Chiharu Higashida, Kohei Sumi, Kazumi Furuhara, Yuki Inahata, Jian-Jung Huang, Keita Koizumi, Shigeru Yokoyama, Takahiro Tsuji, Yulia Petugina, Andrei Sumarokov, Alla B. Salmina, Koji Hashida, Yasuko Kitao, Osamu Hori, Masahide Asano, Yoji Kitamura, Takashi Kozaka, Kazuhiro Shiba, Fangfang Zhong, Min-Jue Xie, Makoto Sato, Katsuhiko Ishihara and Haruhiro Higashida Frontiers in Behavioral Neuroscience 8 133 1-18 2014/04
  •  The potential of o-​bromo-​trans-​decalinvesamicol as a new PET ligand for vesicular acetylcholine transporter imaging Azim Mohammad Anwar-ul, Kozaka Takashi, Uno Izumi, Miwa Daisuke, Kitamura Yoji, Ogawa Kazuma, Makino Akira, Kiyono Yasushi, Shiba Kazuhiro Synapse 68 10 445-453 2014/07
  •  Regional brain imaging of vesicular acetylcholine transporter using o-[125 I]iodo-trans-decalinvesamicol as a new potential imaging probe. Kozaka T,Uno I,Kitamura Y,Miwa D,Anwar-Ul Azim M,Ogawa K,Shiba K SYNAPSE 68 3 107-13 2014/03
  •  Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents Takashi Kozaka, Kyoko Nakagawa-Goto, Qian Shi, Chin-Yu Lai, Ernest Hamel, Kenneth F. Bastow, Arnold Brossi and Kuo-Hsiung Lee BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20 14 4091-4094 2010/05
  •  Stereoselective total syntheses of three Lycopodium alkaloids, (-)-magellanine, (+)-magellaninone, and (+)-paniculatine, based on two Pauson-Khand reactions. Kozaka T,Miyakoshi N,Mukai C JOURNAL OF ORGANIC CHEMISTRY 72 26 10147-54 2007/11
  •  Decontamination of radioactivity from contaminated vegetables derived from The Fukushima nuclear accident. Shiba K., Kitamura Y., Kozaka T., Uno I., Shimizu K., Masumoto K., Hirota M., Higaki S., Miyoshi H., Saze T., Sakama M., Yanaga M. RADIATION MEASUREMENTS 55 1 26-29 2013/08
  •  Development and evaluation of a radiobromine-labeled sigma ligand for tumor imaging. Ogawa K,Kanbara H,Kiyono Y,Kitamura Y,Kiwada T,Kozaka T,Kitamura M,Mori T,Shiba K,Odani A NUCLEAR MEDICINE AND BIOLOGY 40 4 445-50 2013/05
  •  Antitumor Agents. 284. New Desmosdumotin B Analogues with Bicyclic B-Ring as Cytotoxic and Antitubulin Agents Kyoko Nakagawa-Goto, Pei-Chi Wu, Chin-Yu Lai, Ernest Hamel, Hao Zhu, Liying Zhang, Takashi Kozaka, Emika Ohkoshi, Masuo Goto, Kenneth F. Bastow, and Kuo-Hsiung Lee JOURNAL OF MEDICINAL CHEMISTRY 54 5 1244-1255 2011/02
  •  Characteristics of radioactive contamination of vegetables derived from the Fukushima nuclear accident Radiation Safety Management 11 1 19-22 2012/07
  •  Chemical removal of radionuclides in contaminated spinach derived from the Fukushima nuclear accident Radiation Safety Management 11 1 23-26 2012/07
  •  Development and evaluation of a novel radioiodinated vesamicol analog as a sigma receptor imaging agent. Ogawa K,Kanbara H,Shiba K,Kitamura Y,Kozaka T,Kiwada T,Odani A EJNMMI Research 2 1 54 2012/09
  •  Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT). Kozaka T,Uno I,Kitamura Y,Miwa D,Ogawa K,Shiba K Bioorg Med Chem 20 16 4936-41 2012/08

Conference Presentations

  • Usefulness of radioiodinated 2-[4-(2-iodophenyl)piperidino]cyclopentanol(OI5V) for early diagnosing neurodegenerative disorder caused by stress.(conference:12th World Congress of the World Federation of Nuclear Medicine and Biology)(2018/04/21)
  • Study on the Application of ATR for the Measurement of Infrared Absorption Spectrum of Food Adductives Identification Tests(conference:139th Annual Meeting of the Pharmaceutical Society of Japan)(2019/03/23)
  • Changes in cholinergic nervous system (VAChT) in stress-bearing mice(conference:139th Annual Meeting of the Pharmaceutical Society of Japan)(2019/03/21)
  • Measurement of σ-1 receptor density in the duplication 15q mouse model by [125I]OI5V (conference:139th Annual Meeting of the Pharmaceutical Society of Japan)(2019/03/23)
  • Involvement of P-glycoprotein on brain migration of VAChT imaging agent (OIDV)(conference:139th Annual Meeting of the Pharmaceutical Society of Japan)(2019/03/23)

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  • Development of a imaging probe for diagnosing stress-related neurodegenerative disorder(conference:The 58th Annual Scientific Meeting of the Japanese Society of Nuclear Medicine)(2018/11/16)
  • Development of radioiodinated sigma-1 receptor ligands(conference:138th Annual Meeting of the Pharmaceutical Society of Japan)(2018/03/27)
  • Study on the Application of ATR for the Measurement of Infrared Absorption Spectrum of Food Adductives Identification Tests(conference:138th Annual Meeting of the Pharmaceutical Society of Japan)(2018/03/26)
  • The development of a novel σ-1 receptor imaging agent for SPECT(2017/05/26)
  • Characteristics of 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) as a new sigma-1 receptor imaging agent(conference:2017 SNMMI 64th annual meeting)(2017/06/13)
  • Study on the Application of ATR for the Measurement of Infrared Absorption Spectrum of Food Adductives Identification Tests(conference:137th Annual Meeting of the Pharmaceutical Society of Japan)(2017/03/26)
  • The structure-activity relationship between structure of vesamicol analogs and affinity of VAChT and sigma receptors.(conference:137th Annual Meeting of the Pharmaceutical Society of Japan)(2017/03/26)
  • The possibility of vesamicol analog with 5-membered ring as a sigma-1 receptor imaging probe(conference:137th Annual Meeting of the Pharmaceutical Society of Japan)(2017/03/26)
  • Changes of the dopamine nerve system by stress in the model mouse for 15q duplication.(conference:137th Annual Meeting of the Pharmaceutical Society of Japan)(2017/03/25)
  • Development and evaluation of a radiobromine labeled sigma ligand for tumor imaging(conference:EANM'11 Annual Congress of the European Association of Nuclear Medicine)(2011/10/17)
  • The radioactivity removal of contaminated vegetables caused by the Fukushima nuclear accident(conference:The 7th International Workshop on Ionizing Radiation Monitoring)(2011/12/04)
  • Difference of biodistribution of (+)-[125I]-pIV by rodent species and contribution of the metabolite to long-term accumulation in tumor(2011/03/30)
  • Developement of o-iodo-trans-decalinvesamicol (OIDV) as a potential VAChT imaging prove(2011/03/30)
  • Study on the Measurement of Infrared Absorption Spectrum of a Food Additive Neotame(2011/03/30)
  • Brain uptake of Oxytocin, potential therapeutic agent for autism(2011/03/30)
  • Study on the brain uptake and metabolism of Oxytocin, a possible pharmaceutical for autism.(2012/03/29)
  • Removal of radioactivity in the contaminated vegetables caused by the Fukushima nuclear accident(2012/03/29)
  • The development of VAChT-imaging probes for early diagnosis of Alzheimer's disease(2012/03/30)
  • Study on the Application of ATR for the Measurement of Infrared Absorption Spectrum of a Food Additive(2012/03/31)
  • Study on a radiomeal-octabromoporphyrin complex as a tumor imaging agent.(2012/05/31)
  • Development of a radiobromine-labeled compound as a sigma receptor ligand for tumor imaging(conference:2016 SNMMI 63th annual meeting)(2016/06/13)
  • In vitro Evaluation of meta-bromo benzovesamicol (MBBzV) as a Potential Vesicular Acetylcholine Transporter (VAChT) Imaging Probe(2016/05/05)
  • Regional brain distribution of the dopamine nerve system of CD157/BST1 knockout mouse(2016/03/29)
  • The possibility of the sigma receptor as the target of the early imaging of the stress disorder(2016/03/28)
  • The development study on new sigma-2 receptor selective ligands based on vesamicol(2016/03/28)
  • Study of radiomeal-octabromoporphyrin complex as a tumor diagnostic agent(2014/06/14)
  • Introduction of radiobromine labeled decalinvesamicol analogue as a new and promising PET vesicular acetylcholine transporter (VAChT) imaging probe(conference:2014 SNMMI 61th annual meeting)(2014/06/08)
  • A new and promising VAChT imaging probe for PET: Radiobromine labeled analogue of decalinvesamicol(2014/03/28)
  • ヨードベンゼンからの18F化法(2014/02/08)
  • Evaluation of radiolabeled o-bromo-trans-decalinvesamicol (OBDV) as a PET ligand for the vesicular acetylcholine transporter (VAChT)(conference:International Workshop for Molecular Functional Imaging -Brain and Gynecologic Oncology-)(2014/03/03)
  • In vivo evaluation of radiobromine-labeled o-bromo-trans-decalinvesamicol (OBDV) as a potential VAChT imaging probe(2013/12/14)
  • In vivo evaluation of radiomeal-octabromoporphyrin complex as a tumor imaging agent」(2013/06/28)
  • In vivo evaluation of radioiodinated o-iodo-trans-decalinvesamicol(OIDV) as a vesicular acetylcholine transporter (VAChT) imaging agent.(conference:2013 SNMMI 60th annual meeting)(2013/06/10)
  • The development of potential vesicular acetylcholine transporter (VAChT) PET imaging probes(conference:2013 SNMMI 60th annual meeting)(2013/06/10)

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「アルツハイマー病の早期診断用シナプス前コリン作動性神経分子イメージング剤の開発」(2014-2017) 
○「固形腫瘍の早期発見・増殖能診断を目的としたσ-2受容体イメージング剤の開発研究」(2014-2016) 
○「脳内σ—1受容体イメージングによる老化及びストレス性疾患の客観的評価に関する研究」(2011-2013) 
○「アルツハイマー病の早期診断を目的としたコリントランスポーターイメージング剤の開発」(2011-2013) 

Classes (Bachelors)

○Radioisotope in In-Vitro and In-Vivo Techniques(2017)
○Radiation Measurement Experiment 2(2017)
○Radiochemistry Experiment(2017)
○Radiochemistry Experiment(2016)
○Radioisotope in In-Vitro and In-Vivo Techniques(2016)
○Radiation Measurement Experiment 2(2016)

Classes (Graduate Schools)

○Seminar on Advanced Medical Science(2017)
○Introduction to Basic Medical Science(2016)
○Seminar on Advanced Medical Science(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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