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Researcher Information

last modified：2024/01/08

Associate Professor　OGAWA Kazuhiro

Laboratory Website

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Department of Molecular Pharmacology　TEL:076-265-2189

Academic Background

【Academic background(Doctoral/Master's Degree)】
Tohoku University　Doctor　Graduate School, Division of Medical Sciences　200103　Completed
【Academic background(Bachelor's Degree)】
Kyoto University　198503
Tohoku University　199703
【Degree】
Ph.D.

Career

Associate Professor(2005/10/01-)
Instructor　Tohoku University School of Medicine　Instructor(2002/07/01-2005/09/30)
Instructor　Hokkaido University School of Medicine　Instructor(2002/02/16-2002/06/30)

Year & Month of Birth

Academic Society






The Japanese Biochemical Society
The Japanese Pharmacological Society
The Pharmaceutical Society of Japan
The Molecular Biology Society of Japan
Japanese Society for Hygiene

Award











○Grant in aid, The Inamori Foundation(2003)
○Grant in aid, Fuji Foundation for Protein Research(2003)
○Grant in aid, Mochida Memorial Foundation for Medical and Pharmaceutical Research(2003)
○Grant in aid, Takeda Science Foundation(2002)
○Grant in Aid, Northern Advancement Center for Science and Technology(2001)
○Grant in Aid for Medical Research, Japan Foundation of Cardiovascular Research(2000)
○JSPS Research Fellow(1998)
○JSPS Research Fellow(1998)

Specialities

General pharmacology、Pathological medical chemistry、Eating habits、Medical sociology、Medical and hospital management

Speciality Keywords

heme oxygenase, hypoxia response

Research Themes

Drug discovery

Drug safety

Regulation and function of heme catabolism

Hypoxia response

Functional analysis of food chemicals

Books

  • 　Hemochromatosis factor gene in a patient with hepatoerythropoietic porphyria　7　2　476-481　1998/11

Papers

  • 　Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1.　EMBO JOURNAL　20　11　2835-2843　2001/06
  • 　Bach 1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells.　JOURNAL OF BIOLOGICAL CHEMISTRY　278　11　9125-9133　2003/03
  • 　Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines　Ding, Y., Zhang, Y. Z., Furuyama, K., Ogawa, K., Igarashi, K., Shibahara, S.　FEBS Journal　273　23　5333-5346　2006/10
  • 　Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines. A possible strategy for the maintenance of intracellular heme level.　Zhang, Y., Furuyama, K., Kaneko, K., Ding, Y., Ogawa, K., Yoshizawa, M., Kawamura, M., Takeda, K., Yoshida, T., Shibahara, S.　FEBS Journal　273　14　3136-3147　2006/06
  • 　Hypoxemia and blunted hypoxic ventilatory responses in mice lacking heme oxygenase-2　Adachi, T., Ishikawa, K., Hida, W., Matsumoto, H., Masuda, T., Date, F., Ogawa, K., Takeda, K., Furuyama, K., Zhang, Y., Kitamuro, T., Ogawa, H., Maruyama, Y., Shibahara, S　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　320　2　514-522　2004/07

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  • 　Erythropoietin regulates tumour growth of human malignancies.　CARCINOGENESIS　24　6　1021-1029　2003/06
  • 　Regulation of heme oxygenase-1 and ligand-binding transcription factors by soybean isoflavones.　Ogawa, K., Nagata, K., Suzuki, K., Konno, T., Shibahara, S., Yanagisawa, T.　7　0　125-129　2004/10
  • 　Possible implications of the induction of human heme oxygenase-1 by nitric oxide donors.　JOURNAL OF BIOCHEMISTRY　121　6　1162-1168　1997/06
  • 　An efficient method for preparing gem-dimethylcyclopropanes from gem-dibromocyclopropanes　CHEMICAL & PHARMACEUTICAL BULLETIN　3512　4977-4980　1987
  • 　Reaction of 8,8-dibromobicyclo [5.1.0] octanes with higher-order organocuprates　CHEMICAL & PHARMACEUTICAL BULLETIN　35　5　1777-1784　1987
  • 　An efficient method for preparing gem-dimethylcyclopropanes from gem-dibromocyclopropanes　CHEMICAL & PHARMACEUTICAL BULLETIN　33　8　3564-3566　1985

Conference Presentations

Others

  • 　Hypoxemia and attenuated hypoxic ventilatory responses in mice lacking heme oxygenase-2: evidence for a novel role of heme oxygenase-2 as an oxygen sensor.　Zhang, Y., Furuyama, K., Adachi, T., Ishikawa, K., Matsumoto, H., Masuda, T., Ogawa, K., Takeda, K., Yoshizawa, M., Ogawa, H., Maruyama, Y., Hida, W., Shibahara, S.　580　0　161-166　2006/05
  • 　Heme catabolic pathway as a therapeutic target.　124　5　360-362　2004/11
  • 　Trace elements in man and animals (Zinc-induced excessive glutamate release may cause accelerated senescence with deffect in learning and memory in senescence accelerated mouse)　Kluwer Academic / Plenum Publishers　2000
  • 　Heme-regulated transcription factor Bach1　48　1　1-6　2002/01
  • 　Lead, chemical porphyria, and heme as a biological mediator　196　2　53-64　2002/02

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  • 　Regulatory heme and trichloroethylene intoxication:　7　3　103-112　2002/07

Arts and Fieldwork

Patent

○Indole derivatives and medicine(publish date：1990/11/01)

Theme to the desired joint research

○Durg discovery
○Functional analysis of food chemicals

Grant-in-Aid for Scientific Research

○「ヘム代謝調節による分子レベルでの疲労制御法の開発と疲労抑制メカニズムの解明」(2013-2016)　
○「食品成分によるヘム分解系調節のメカニズム解明と機能性食品・医薬品への応用」(2009-2011)　
○「イソフラボン・ポリアミン誘導体が持つヘム分解調節作用の機能性食品・医薬品への応用」(2007-2008)　
○「ヘム鉄とイソフラボンの新しい作用メカニズムの解明による保健機能食品の開発」(2004-2005)　
○「酸素応答としてのヘム代謝調節」(1998-2000)　

Competitive research funding,Contribution

Collaborative research,Consignment study

○Infectious disease and chemotherapeutic drugs(2007-2014)

Classes (Bachelors)

○Pharmacology(2018)
○Pharmacology(2017)
○Pharmacology(2016)
○Basic and Clinical Pharmacology(2012)

Classes (Graduate Schools)

○Introduction to Basic Medical Science(2020)
○Molecular Information Pharmacology(2020)
○Introduction to Medical Science(2019)
○Molecular Information Pharmacology(2019)
○Introduction to Medical Science(2019)
○Molecular Information Pharmacology(2019)
○Molecular Information Pharmacology(2018)
○Introduction to Basic Medical Science(2018)
○Molecular Information Pharmacology(2018)
○Molecular Information Pharmacology(2017)
○Molecular Information Pharmacology(2017)
○Molecular Information Pharmacology(2017)
○Introduction to Basic Medical Science(2016)
○Molecular Information Pharmacology(2016)
○Molecular Information Pharmacology(2016)
○Molecular Information Pharmacology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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