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Researcher Information

last modified:2022/05/30

Associate Professor OGAWA Kazuhiro

Laboratory Website

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences


Department of Molecular Pharmacology TEL:076-265-2189

Academic Background

【Academic background(Doctoral/Master's Degree)】
Tohoku University Doctor Graduate School, Division of Medical Sciences 200103 Completed
【Academic background(Bachelor's Degree)】
Kyoto University 198503
Tohoku University 199703


Associate Professor(2005/10/01-)
Instructor Tohoku University School of Medicine Instructor(2002/07/01-2005/09/30)
Instructor Hokkaido University School of Medicine Instructor(2002/02/16-2002/06/30)

Year & Month of Birth

Academic Society

The Japanese Biochemical Society
The Japanese Pharmacological Society
The Pharmaceutical Society of Japan
The Molecular Biology Society of Japan
Japanese Society for Hygiene


○Grant in aid, The Inamori Foundation(2003)
○Grant in aid, Fuji Foundation for Protein Research(2003)
○Grant in aid, Mochida Memorial Foundation for Medical and Pharmaceutical Research(2003)
○Grant in aid, Takeda Science Foundation(2002)
○Grant in Aid, Northern Advancement Center for Science and Technology(2001)
○Grant in Aid for Medical Research, Japan Foundation of Cardiovascular Research(2000)
○JSPS Research Fellow(1998)
○JSPS Research Fellow(1998)


General pharmacology、Pathological medical chemistry、Eating habits、Medical sociology、Medical and hospital management

Speciality Keywords

heme oxygenase, hypoxia response

Research Themes

Drug discovery

Drug safety

Regulation and function of heme catabolism

Hypoxia response

Functional analysis of food chemicals


  •  Hemochromatosis factor gene in a patient with hepatoerythropoietic porphyria 7 2 476-481 1998/11


  •  Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1. EMBO JOURNAL 20 11 2835-2843 2001/06
  •  Bach 1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells. JOURNAL OF BIOLOGICAL CHEMISTRY 278 11 9125-9133 2003/03
  •  Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines Ding, Y., Zhang, Y. Z., Furuyama, K., Ogawa, K., Igarashi, K., Shibahara, S. FEBS Journal 273 23 5333-5346 2006/10
  •  Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines. A possible strategy for the maintenance of intracellular heme level. Zhang, Y., Furuyama, K., Kaneko, K., Ding, Y., Ogawa, K., Yoshizawa, M., Kawamura, M., Takeda, K., Yoshida, T., Shibahara, S. FEBS Journal 273 14 3136-3147 2006/06
  •  Hypoxemia and blunted hypoxic ventilatory responses in mice lacking heme oxygenase-2 Adachi, T., Ishikawa, K., Hida, W., Matsumoto, H., Masuda, T., Date, F., Ogawa, K., Takeda, K., Furuyama, K., Zhang, Y., Kitamuro, T., Ogawa, H., Maruyama, Y., Shibahara, S BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 320 2 514-522 2004/07

show all

  •  Erythropoietin regulates tumour growth of human malignancies. CARCINOGENESIS 24 6 1021-1029 2003/06
  •  Regulation of heme oxygenase-1 and ligand-binding transcription factors by soybean isoflavones. Ogawa, K., Nagata, K., Suzuki, K., Konno, T., Shibahara, S., Yanagisawa, T. 7 0 125-129 2004/10
  •  Possible implications of the induction of human heme oxygenase-1 by nitric oxide donors. JOURNAL OF BIOCHEMISTRY 121 6 1162-1168 1997/06
  •  An efficient method for preparing gem-dimethylcyclopropanes from gem-dibromocyclopropanes CHEMICAL & PHARMACEUTICAL BULLETIN 3512 4977-4980 1987
  •  Reaction of 8,8-dibromobicyclo [5.1.0] octanes with higher-order organocuprates CHEMICAL & PHARMACEUTICAL BULLETIN 35 5 1777-1784 1987
  •  An efficient method for preparing gem-dimethylcyclopropanes from gem-dibromocyclopropanes CHEMICAL & PHARMACEUTICAL BULLETIN 33 8 3564-3566 1985

Conference Presentations


  •  Hypoxemia and attenuated hypoxic ventilatory responses in mice lacking heme oxygenase-2: evidence for a novel role of heme oxygenase-2 as an oxygen sensor. Zhang, Y., Furuyama, K., Adachi, T., Ishikawa, K., Matsumoto, H., Masuda, T., Ogawa, K., Takeda, K., Yoshizawa, M., Ogawa, H., Maruyama, Y., Hida, W., Shibahara, S. 580 0 161-166 2006/05
  •  Heme catabolic pathway as a therapeutic target. 124 5 360-362 2004/11
  •  Trace elements in man and animals (Zinc-induced excessive glutamate release may cause accelerated senescence with deffect in learning and memory in senescence accelerated mouse) Kluwer Academic / Plenum Publishers 2000
  •  Heme-regulated transcription factor Bach1 48 1 1-6 2002/01
  •  Lead, chemical porphyria, and heme as a biological mediator 196 2 53-64 2002/02

show all

  •  Regulatory heme and trichloroethylene intoxication: 7 3 103-112 2002/07

Arts and Fieldwork


○Indole derivatives and medicine(publish date:1990/11/01)

Theme to the desired joint research

○Durg discovery
○Functional analysis of food chemicals

Grant-in-Aid for Scientific Research


Competitive research funding,Contribution

Collaborative research,Consignment study

○Infectious disease and chemotherapeutic drugs(2007-2014)

Classes (Bachelors)

○Basic and Clinical Pharmacology(2012)

Classes (Graduate Schools)

○Introduction to Basic Medical Science(2020)
○Molecular Information Pharmacology(2020)
○Introduction to Medical Science(2019)
○Molecular Information Pharmacology(2019)
○Introduction to Medical Science(2019)
○Molecular Information Pharmacology(2019)
○Molecular Information Pharmacology(2018)
○Introduction to Basic Medical Science(2018)
○Molecular Information Pharmacology(2018)
○Molecular Information Pharmacology(2017)
○Molecular Information Pharmacology(2017)
○Molecular Information Pharmacology(2017)
○Introduction to Basic Medical Science(2016)
○Molecular Information Pharmacology(2016)
○Molecular Information Pharmacology(2016)
○Molecular Information Pharmacology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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