Jump to contents

Researcher Information

last modified:2024/01/08

Vice President OHTAKE Shigeki

Mail Laboratory Website

Faculty, Affiliation

Administration Office
Trustee and Vice President (Liberal Arts and Science, Finance and Hospital)
Dean, Institute of Liberal Arts and Science

College and School Educational Field


Laboratory

 TEL:076-264-5083 FAX:076-234-4017

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine 198303 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 197703

Career

Kanazawa University(1983/04/01-1986/04/30)
(1986/05/01-1988/04/30)
Kanazawa University(1988/05/01-1991/06/30)
Kanazawa University(1991/07/01-1997/03/31)
Kanazawa University(1997/04/01-1998/03/31)
Kanazawa University(1998/04/01-)

Year & Month of Birth

1952/11

Academic Society


Award

Specialities

Hematology、Laboratory medicine

Speciality Keywords

Leukemia Laboratory hematology Laboratory hematology

Research Themes

Chemotherapy of hematological malignancy

Bone marrow transplantation of leukemia

Analysis of Pathophysiology of leukemia

Books

Papers

  •  CD56 expression is an independent prognostic factor for relapse in acute myeloid leukemia with t(8;21). Iriyama N,Hatta Y,Takeuchi J,Ogawa Y,Ohtake S,Sakura T,Mitani K,Ishida F,Takahashi M,Maeda T,Izumi T,Sakamaki H,Miyawaki S,Honda S,Miyazaki Y,Taki T,Taniwaki M,Naoe T Leuk Res 37 9 1021-6 2013/09
  •  Role of hematopoietic stem cell transplantation for relapsed acute promyelocytic leukemia: A retrospective analysis of JALSG-APL97. Fujita H,Asou N,Iwanaga M,Hyo R,Nomura S,Kiyoi H,Okada M,Inaguma Y,Matsuda M,Yamauchi T,Ohtake S,Izumi T,Nakaseko C,Ishigatsubo Y,Shinagawa K,Takeshita A,Miyazaki Y,Ohnishi K,Miyawaki S,Naoe T,the Japan Adult Leukemia Study Group Cancer Sci 2013/07
  •  Antithrombin deficiency in three Japanese families: One novel and two reported point mutations in the antithrombin gene. Maruyama K,Morishita E,Karato M,Kadono T,Sekiya A,Goto Y,Sato T,Nomoto H,Omi W,Tsuzura S,Imai H,Asakura H,Ohtake S,Nakao S Thromb Res 2013/06
  •  The demarcation between younger and older acute myeloid leukemia patients: A pooled analysis of 3 prospective studies. Yanada M,Ohtake S,Miyawaki S,Sakamaki H,Sakura T,Maeda T,Miyamura K,Asou N,Oh I,Miyatake J,Kanbayashi H,Takeuchi J,Takahashi M,Dobashi N,Kiyoi H,Miyazaki Y,Emi N,Kobayashi Y,Ohno R,Naoe T,for the Japan Adult Leukemia Study Group CANCER 2013/06
  •  Discontinuation of imatinib in Japanese patients with chronic myeloid leukemia. Takahashi N,Kyo T,Maeda Y,Sugihara T,Usuki K,Kawaguchi T,Usui N,Okamoto S,Ohe Y,Ohtake S,Kitamura K,Yamamoto M,Teshima H,Motoji T,Tamaki T,Sawada K,Ohyashiki K HAEMATOLOGICA 97 6 903-6

show all

  •  Plasma levels of platelet-derived microparticles in patients with obstructive sleep apnea syndrome. Maruyama K,Morishita E,Sekiya A,Omote M,Kadono T,Asakura H,Hashimoto M,Kobayashi M,Nakatsumi Y,Takada S,Ohtake S J Atheroscler Thromb 19 1 98-104
  •  Significant decrease in factor VII activity by tissue thromboplastin derived from rabbit brain in a patient with congenital factor VII deficiency (FVII Padua). Sekiya A,Morishita E,Maruyama K,Asakura H,Nakao S,Ohtake S Rinsho Ketsueki 53 3 357-60
  •  Long-term outcome following imatinib therapy for chronic myelogenous leukemia, with assessment of dosage and blood levels: the JALSG CML202 study. Ohnishi K,Nakaseko C,Takeuchi J,Fujisawa S,Nagai T,Yamazaki H,Tauchi T,Imai K,Mori N,Yagasaki F,Maeda Y,Usui N,Miyazaki Y,Miyamura K,Kiyoi H,Ohtake S,Naoe T,for the Japan Adult Leukemia Study Group Cancer Sci
  •  Pre-transplant imatinib-based therapy improves the outcome of allogeneic hematopoietic stem cell transplantation for BCR-ABL-positive acute lymphoblastic leukemia.  Mizuta S, Matsuo K, Yagasaki F, Yujiri T, Hatta Y, Kimura Y, Ueda Y, Kanamori H, Usui N, Akiyama H, Miyazaki Y, Ohtake S, Atsuta Y, Sakamaki H, Kawa K, Morishima Y, Ohnishi K, Naoe T, Ohno R. LEUKEMIA 25 1 41 - 47 2011/01
  •  Analysis of bacteremia/fungemia and pneumonia accompanying acute myelogenous leukemia from 1987 to 2001 in the Japan Adult Leukemia Study Group. Yoshida M, Akiyama N, Fujita H, Miura K, Miyatake J, Handa H, Kito K, Takahashi M, Shigeno K, Kanda Y, Hatsumi N, Ohtake S, Sakamaki H, Ohnishi K, Miyawaki S, Ohno R, Naoe T. INTERNATIONAL JOURNAL OF HEMATOLOGY 93 1 66 - 73 2011/01
  •  A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT. Espinoza JL, Takami A, Onizuka M, Kawase T, Sao H, Akiyama H, Miyamura K, Okamoto S, Inoue M, Ohtake S, Fukuda T, Morishima Y, Kodera Y, Nakao S. BONE MARROW TRANSPLANTATION 2011/01
  •  Two case reports of inherited antithrombin deficiency: a novel frameshift mutation and a large deletion including all seven exons detected using two methods. Sekiya A, Morishita E, Karato M, Maruyama K, Shimogawara I, Omote M, Wakugawa Y, Shinohara M, Hayashi T, Kadohira Y, Asakura H, Nakao S, Ohtake S. INTERNATIONAL JOURNAL OF HEMATOLOGY 93 2 216 - 219 2011/02
  •  Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: the JALSG AML201 Study. Blood. 2011 Feb 24;117(8):2358-65 Ohtake S, Miyawaki S, Fujita H, Kiyoi H, Shinagawa K, Usui N, Okumura H, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R. BLOOD 117 8 2358 - 2365 2011/02
  •  A randomized comparison of 4 courses of standard-dose multiagent chemotherapy versus 3 courses of high-dose cytarabine alone in postremission therapy for acute myeloid leukemia in adults: the JALSG AML201 Study.  Miyawaki S, Ohtake S, Fujisawa S, Kiyoi H, Shinagawa K, Usui N, Sakura T, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R. BLOOD 117 8 2366 - 2372 2011/02
  •  A single-nucleotide polymorphism of the Fcγ receptor type IIIA gene in the recipient predicts transplant outcomes after HLA fully matched unrelated BMT for myeloid malignancies.  Takami A, Espinoza JL, Onizuka M, Ishiyama K, Kawase T, Kanda Y, Sao H, Akiyama H, Miyamura K, Okamoto S, Inoue M, Ohtake S, Fukuda T, Morishima Y, Kodera Y, Nakao S; Japan Marrow Donor Program. BONE MARROW TRANSPLANTATION 46 2 238 - 243 2011/02
  •  GPI-anchored protein-deficient T cells in patients with aplastic anemia and low-risk myelodysplastic syndrome: implications for the immunopathophysiology of bone marrow failure. Katagiri T, Qi Z, Ohtake S, Nakao S. EUROPEAN JOURNAL OF HAEMATOLOGY 86 3 226 - 236 2011/03
  •  BCR-ABL1 mutations in patients with imatinib-resistant Philadelphia chromosome-positive leukemia by use of the PCR-Invader assay.  Ono T, Miyawaki S, Kimura F, Kanamori H, Ohtake S, Kitamura K, Fujita H, Sugiura I, Usuki K, Emi N, Tamaki S, Aoyama Y, Kaya H, Naoe T, Tadokoro K, Yamaguchi T, Ohno R, Ohnishi K; Japan Adult Leukemia Study Group. LEUKEMIA RESEARCH 35 5 598 - 603 2011/05
  •  Qualitative near-infrared vascular imaging system with tuned aperture computed tomography. Matsushita T, Miyati T, Nakayama K, Hamaguchi T, Hayakawa Y, Farman AG, Ohtake S. JOURNAL OF BIOMEDICAL OPTICS 16 7 076004 2011/07
  •  Randomized trial of response-oriented individualized versus fixed-schedule induction chemotherapy with idarubicin and cytarabine in adult acute myeloid leukemia: the JALSG AML95 study. Ohtake S, Miyawaki S, Kiyoi H, Miyazaki Y, Okumura H, Matsuda S, Nagai T, Kishimoto Y, Okada M, Takahashi M, Handa H, Takeuchi J, Kageyama S, Asou N, Yagasaki F, Maeda Y, Ohnishi K, Naoe T, Ohno R. INTERNATIONAL JOURNAL OF HEMATOLOGY 91 2 276 - 283 2010/03
  •  Allogeneic stem cell transplantation versus chemotherapy as post-remission therapy for intermediate or poor risk adult acute myeloid leukemia: results of the JALSG AML97 study. Sakamaki H, Miyawaki S, Ohtake S, Emi N, Yagasaki F, Mitani K, Matsuda S, Kishimoto Y, Miyazaki Y, Asou N, Takahashi M, Ogawa Y, Honda S, Ohno R. INTERNATIONAL JOURNAL OF HEMATOLOGY 91 2 284 - 292 2010/03
  •  Phase I trial of gemtuzumab ozogamicin in intensive combination chemotherapy for relapsed or refractory adult acute myeloid leukemia (AML): Japan Adult Leukemia Study Group (JALSG)-AML206 study. Usui N, Takeshita A, Nakaseko C, Dobashi N, Fujita H, Kiyoi H, Kobayashi Y, Sakura T, Yahagi Y, Shigeno K, Ohwada C, Miyazaki Y, Ohtake S, Miyawaki S, Naoe T, Ohnishi K; Japan Adult Leukemia Study Group. Cancer Sci 102 7 1358 - 1365 2011/07
  •  The clinical characteristics of CD7+ CD56+ acute myeloid leukemias other than M0. Suzuki R, Ohtake S, Takeuchi J, Nagai M, Kodera Y, Hamaguchi M, Miyawaki S, Karasuno T, Shimodaira S, Ohno R, Nakamura S, Naoe T. INTERNATIONAL JOURNAL OF HEMATOLOGY 91 2 303 - 309 2010/03
  •  An elderly case of congenital prekallikrein deficiency Nagaya S, Morishita E, Takami A, Maruyama K, Sekiya A, Asakura H, Nakao S, Ohtake S. 46 4 348 - 351 2009/07
  •  NKG2D gene polymorphism has a significant impact on transplant outcomes after HLA-fully-matched unrelated bone marrow transplantation for standard risk hematologic malignancies. Espinoza JL, Takami A, Onizuka M, Sao H, Akiyama H, Miyamura K, Okamoto S, Inoue M, Kanda Y, Ohtake S, Fukuda T, Morishima Y, Kodera Y, Nakao S; Japan Marrow Donor Program. HAEMATOLOGICA 94 10 1412 - 1434 2009/10
  •  [Primary mucosa-associated lymphoid tissue lymphoma of the urinary bladder successfully treated by radiotherapy and rituximab]. Rinsho Ketsueki. 2008 Jan;49(1):30-4 Terasaki Y, Okumura H, Ishiura Y, Yokawa S, Kuribayashi M, Kodama K, Motoi I, Sugihara M, Saito K, Tanaka T, Yoshino T, Ohtake S, Nakao S. 49 1 30 - 34 2008/01
  •  Karyotype at diagnosis is the major prognostic factor predicting relapse-free survival for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy. Yanada M, Takeuchi J, Sugiura I, Akiyama H, Usui N, Yagasaki F, Nishii K, Ueda Y, Takeuchi M, Miyawaki S, Maruta A, Narimatsu H, Miyazaki Y, Ohtake S, Jinnai I, Matsuo K, Naoe T, Ohno R; Japan Adult Leukemia Study Group. HAEMATOLOGICA 93 2 287 - 290 2008/02
  •  Diagnosis of acute myeloid leukemia according to the WHO classification in the Japan Adult Leukemia Study Group AML-97 protocol. Wakui M, Kuriyama K, Miyazaki Y, Hata T, Taniwaki M, Ohtake S, Sakamaki H, Miyawaki S, Naoe T, Ohno R, Tomonaga M. INTERNATIONAL JOURNAL OF HEMATOLOGY 87 2 144 - 151 2008/03
  •  Living-donor lobar lung transplantation for broncho-bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: does bronchiolitis obliterans recur in transplanted lungs? Okumura H, Ohtake S, Ontachi Y, Ozaki J, Shimadoi S, Waseda Y, Kondo Y, Yamazaki H, Takami A, Yasui M, Date H, Nakao S. INTERNATIONAL JOURNAL OF HEMATOLOGY 86 4 369 - 373 2007/11
  •  Increased macrophage colony-stimulating factor levels in patients with Graves' disease.  Morishita E, Sekiya A, Hayashi T, Kadohira Y, Maekawa M, Yamazaki M, Asakura H, Nakao S, Ohtake S. INTERNATIONAL JOURNAL OF HEMATOLOGY 88 3 272 277 2008/10
  •  Prospective monitoring of BCR-ABL1 transcript levels in patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia undergoing imatinib-combined chemotherapy. Yanada M, Sugiura I, Takeuchi J, Akiyama H, Maruta A, Ueda Y, Usui N, Yagasaki F, Yujiri T, Takeuchi M, Nishii K, Kimura Y, Miyawaki S, Narimatsu H, Miyazaki Y, Ohtake S, Jinnai I, Matsuo K, Naoe T, Ohno R; Japan Adult Leukemia Study Group. BRITISH JOURNAL OF HAEMATOLOGY 143 4 503 - 510 2008/11
  •  Multicenter prospective study of interferon alpha versus allogeneic stem cell transplantation for patients with new diagnoses of chronic myelogenous leukemia. INTERNATIONAL JOURNAL OF HEMATOLOGY 26 2 276-280 2004/08
  •  Cytogenetic heterogeneity of acute myeloid leukaemia (AML) with trilineage dysplasia: Japan Adult Leukaemia Study Group-AML 92 study BRITISH JOURNAL OF HAEMATOLOGY 120 1 56-62 2003/01
  •  Accelerated telomere length shortening in granulocytes. A diagnostic marker for myeloproliferative diseases EXPERIMENTAL HEMATOLOGY 30 12 1399-1404 2002/12
  •  Induction therapy by frequent administration of doxorubicin with four other drugs, followed by intensive consolidation and maintenance therapy for adult ALL LEUKEMIA 16 7 1259-1266 2002/07
  •  Multicenter prospective study of interferon-alpha versus bone marrow transplantation for newly diagnosed patients with chronic myelogenous leukemia: a preliminary analysis Cancer Chemother Pharmacol 48 1 59-64 2001/08
  •  Analysis of prognostic factors in newly diagnosed patients with acute promyelocytic leukemia: the APL92 study of the Japan Adult Leukemia Study Group (JALSG). Cancer Chemother Pharmacol 48 1 65-71 2001/08
  •  Brain natriuretic peptide is a predictor of anthracycline-induced cardiotoxicity Acta Haematol 104 4 158-163 2001/03
  •  Trisomy 14 with thrombocytosis and monocytosis Acta Haematol 103 4 206-209 2000/08
  •  CD8-depleted donor leukocyte transfusions for cytomegalovirus antigenemia in patient with acute lymphoblastic leukemia treated with allogeneic CD34(+) cell transplantation Am J Hematol 65 4 278-280 2000/12
  •  No beneficial effect from addition of etoposide to daunorubicin, cytarabin, and 6-mercaptopurine in individualized induction therapy of acute myeloid leukemia: the JALSG-AML92 study International J Hematol 70 2 97-104 1999/08
  •  Clinical Analysis and TPO Levels in Three Patients With Refractory Thrombocytopenia Am J Hematol 62 1 103-105 1999/01
  •  Anti-Fas IgM monoclonal antibody enhances apoptosis induced by low-dose cytosine arabinoside Anticancer Res 19 1 197-204 1999/01
  •  A long term follow-up of a randomized trial comparing interferon-alpha with busulfan for chronic myelogenous leukemia. The Kouseisho Leukemia Study Group Leukemia Res 22 9 779-786 1998/09
  •  Acute Hepatitis A Virus Infection-Associated Hemophagocytic Syndrome Am J Gastroenterology 93 7 1187-1188 1998/07
  •  Primary Prostatic Lymphoma of Mucosa-Associated Lymphoid Tissue INTERNAL MEDICINE 37 7 628-630 1998/07
  •  Lack of prognostic significance of CD34 expression in adult AML when FAB M0 and M3 are excluded Am J Hematol 57 3 265-266 1998/03
  •  Analysis of prognostic factors in newly diagnosed acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy. J Clin Oncol 16 1 78-85 1998/01
  •  Thyroid Tumor as Initial Presentation of Hodgkin\'s Disease: A Case Report Including an Immuno- phenotypic Characterization Acta Haematol 98 4 214-216 1997/10
  •  Prognostic significance of immunoglobulin heavy chain gene rearrangement in patients with acute myelogenous leukemia LEUKEMIA 11 6 803-806 1997/06
  •  Treatment of acute myeloid leukemia and myelodysplastic syndrome with orally administered cytarabine ocfosfate and granulocyte colony-stimulating factor Int J Hematol 65 3 263-268 1997/04

Conference Presentations

Others

  •  Chronic myelogenous leukemia with p190BCR-ABL expression: the missing link with monocytosis 41 12 1092-1093 2002/12
  •  Therapeutic strategy for adult acute myelogenous leukemia 202 1 11-16 2002/07
  •  Improvement of the results of chemotherapy for acute myeloid leukemia and clinical trials in Japan. 41 1 1-9 2004/01

Arts and Fieldwork

Patent

Theme to the desired joint research

○Research on Therapy of Leukemia
○Development of Web Application for Clinical Research

Grant-in-Aid for Scientific Research

○「白血病細胞におけるIineage crossoverの臨床的意義」(1999-1999) 
○「白血病細胞におけるlineage crossoverの臨床的意義」(2000-2000) 
○「白血病細胞におけるIineage crossoverの臨床的意義」(2001-2001) 
○「血漿中の腫瘍由来核酸を用いた腫瘍マーカー検査法の確立」(2002-2002) 
○「血漿中の腫瘍由来核酸を用いた腫瘍マーカー検査法の確立」(2003-2003) 
○「難治性白血病に対する標準的治療法の確立に関する研究(臨床研究チームの整備)」(2003-2003) 
○「難治性白血病に対する標準的治療法の確立に関する研究」(2008-2010) 
○「難治性白血病に対する標準的治療法の確立に関する研究 」(2005-2007) 

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Hematology(2017)
○Introduction to Practical Medicine(2017)
○Practice of Wellness Promotion(2017)
○Practice of Wellness Promotion(2017)
○Practice of Wellness Promotion(2017)
○Practice of Wellness Promotion(2016)
○Practice of Wellness Promotion(2016)
○Practice of Wellness Promotion(2016)
○Practice of Wellness Promotion(2016)
○Practice of Wellness Promotion(2016)
○Practice of Wellness Promotion(2016)
○Laboratory Hematology(2016)
○Introduction to Medical Science(2016)
○Laboratory Course in Clinical Cytology(2016)
○Hematology(2016)
○Practice in Laboratory Hematology(2016)
○Pathophysiology 1(2016)
○Introduction to Practical Medicine(2016)
○Practice of Wellness Promotion(2016)
○Practice of Wellness Promotion(2016)
○Practice of Wellness Promotion(2016)
○Practice of Wellness Promotion(2016)
○Practice of Wellness Promotion(2016)
○Practice of Wellness Promotion(2016)
○Practice of Wellness Promotion(2016)
○Practice of Wellness Promotion(2016)

Classes (Graduate Schools)

○Advanced Laboratory Oncology: Research(2016)
○Laboratory Oncology: Research(2016)
○Clinical Immunohematology: Lecture(2016)
○Clinical Immunohematology: Seminar(2016)
○An Introduction to Medical Laboratory Sciences:Lec(2016)
○Laboratory Oncology: Seminar(2016)
○Laboratory Oncology: Lecture(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

To Page Top