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Researcher Information

last modified:2019/03/05

Professor MIEDA Michihiro

Mail Laboratory Website

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Department of Integrative Neurophysiology

College and School Educational Field

Division of Neuroscience, Graduate School of Medical Science


Department of Integrative Neurophysiology TEL:076-265-2170 FAX:076-234-4224

Academic Background

【Academic background(Doctoral/Master's Degree)】
The University of Tokyo Doctor Biophysics and Biochemistry 199703 Completed
【Academic background(Bachelor's Degree)】
The University of Tokyo Departmant of Biophysics and Biochemistry 199203


Keio University, Medical School Department of Physiology Research associate(1997/04/01-1997/12/31)
RIKEN Brain Science institute Lab for Developmental Gene Regulation  Research Scientist(1998/01/01-2001/03/31)
University of Texas Southwestern Medical Center Department of Molecular Genetics HFSP Long-term Fellow(2001/04/01-2004/04/30)
Tokyo Medical and Dental University, Institute of Medical Research Department of Molecular Neuroscience Research Associate(2004/05/01-2007/12/31)
kanazawa University Graduate School of Medical Science Associate professor Department of Molecular Neuroscience and Integrative Physiology Associate Professor(2008/01/01-2017/01/31)
kanazawa University Graduate School of Medical Science Department of Integrative Neurophysiology Professor(2017/02/01-)

Year & Month of Birth


Academic Society



Neurophysiology/General neuroscience、General physiology

Speciality Keywords

circadian rhythm, sleep-wakefulness, feeding, brain, nervous sytem, genetically-modified mice

Research Themes

Neural mechanisms of circadian rhythms

Neural mechanisms underlying sleep/wake regulation



  •  Synchronous circadian voltage rhythms with asynchronous calcium rhythms in the suprachiasmatic nucleus. Enoki R, Oda Y, Mieda M, Ono D, Honma S, Honma KI. Proc Natl Acad Sci U S A.  in press 2017/03
  •  Fine-Tuning Circadian Rhythms: The Importance of Bmal1 Expression in the Ventral Forebrain. Mieda M, Hasegawa E, Kessaris N, Sakurai T.  Front Neurosci. 11 55 2017/02/09
  •  The intrinsic microglial clock system regulates interleukin-6 expression. Nakazato R, Hotta S, Yamada D, Kou M, Nakamura S, Takahata Y, Tei H, Numano R, Hida A, Shimba S, Mieda M, Hinoi E, Yoneda Y, Takarada T. Glia 65 1 198-208 2017/01
  •  Bone Resorption Is Regulated by Circadian Clock in Osteoblasts. Takarada T, Xu C, Ochi H, Nakazato R, Yamada D, Nakamura S, Kodama A, Shimba S, Mieda M, Fukasawa K, Ozaki K, Iezaki T, Fujikawa K, Yoneda Y, Numano R, Hida A, Tei H, Takeda S, Hinoi E. J Bone Miner Res. 2016/12/07
  •  QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior. Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T. Plos One 11 11 e0164716 2016/11/11

show all

  •  Manipulating the Cellular Circadian Period of Arginine Vasopressin Neurons Alters the Behavioral Circadian Period. Mieda M, Okamoto H, Sakurai T. Current Biology 26 18 2535-42 2016/09/26
  •  Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior rhythm. Mieda M, Ono D, Hasegawa E, Okamoto H, Honma K, Honma S, Sakurai T Neuron 85 5 1103-16 2015/03/04
  •  Orexin neurons suppress narcolepsy via 2 distinct efferent pathways Hasegawa, Emi; Yanagisawa, Masashi; Sakurai, Takeshi; Mieda, Michihiro Journal of Clinical Investigation 124 2 604-616 2014/02/03 
  •  Differential roles of orexin receptors in the regulation of sleep/wakefulness Mieda, Michihiro; Tsujino, Natsuko; Sakurai, Takeshi Frontiers in Endocrinology 4 MAY 2013/09/20 
  •  Orexin (Hypocretin) receptor agonists and antagonists for treatment of sleep disorders: Rationale for development and current status Mieda, Michihiro; Sakurai, Takeshi CNS Drugs 27 2 83-90 2013/05/06 
  •  Differential roles of orexin receptors in the regulation of sleep/wakefulness. Mieda M,Tsujino N,Sakurai T Front Endocrinol (Lausanne) 4 57 2013/05
  •  Neurotensin Co-Expressed in Orexin-Producing Neurons in the Lateral Hypothalamus Plays an Important Role in Regulation of Sleep/Wakefulness States Furutani, Naoki; Hondo, Mari; Kageyama, Haruaki; Tsujino, Natsuko; Mieda, Michihiro; Yanagisawa, Masashi; Shioda, Seiji; Sakurai, Takeshi PLoS ONE 8 4 2013/04/19 
  •  Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness States. Furutani N,Hondo M,Kageyama H,Tsujino N,Mieda M,Yanagisawa M,Shioda S,Sakurai T PLoS One 8 4 e62391 2013/04
  •  Orexin Receptor-1 in the Locus Coeruleus Plays an Important Role in Cue-Dependent Fear Memory Consolidation Soya, Shingo;Shoji, Hirotaka;Hasegawa, Emi;Hondo, Mari;Miyakawa, Tsuyoshi;Yanagisawa, Masashi;Mieda, Michihiro;Sakurai, Takeshi JOURNAL OF NEUROSCIENCE 33 36 14549-+ 2013 
  •  GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons. 20. Saito YC, Tsujino N, Hasegawa E, Akashi K, Abe M, Mieda M, Sakimura K, Sakurai T Frontiers in Neural Circuits 7 192 2013
  •  Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status. Mieda M,Sakurai T CNS DRUGS 27 2 83-90 2013/02
  •  Clock genes influence gene expression in growth plate and endochondral ossification in mice. Takarada T,Kodama A,Hotta S,Mieda M,Shimba S,Hinoi E,Yoneda Y J Biol Chem 287 43 36081-95 2012/10
  •  Overview of orexin/hypocretin system. Mieda M,Sakurai T Prog Brain Res 198 5-14 2012/10
  •  Bmal1 in the nervous system is essential for normal adaptation of circadian locomotor activity and food intake to periodic feeding. Mieda M,Sakurai T J Neurosci 31 43 15391-6 2011/10
  •  Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal. Sakurai T,Mieda M Trends Pharmacol Sci 32 8 451-62 2011/08
  •  Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice. Sasaki K,Suzuki M,Mieda M,Tsujino N,Roth B,Sakurai T PLoS One 6 5 e20360 2011/05
  •  Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep. Mieda M,Hasegawa E,Kisanuki YY,Sinton CM,Yanagisawa M,Sakurai T J Neurosci 31 17 6518-26 2011/04
  •  Pharmacogenetic Modulation of Orexin Neurons Alters Sleep/Wakefulness States in Mice Sasaki, Koh;Suzuki, Mika;Mieda, Michihiro;Tsujino, Natsuko;Roth, Bryan;Sakurai, Takeshi PLOS ONE 6 5 0-0 2011
  •  Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory. Nagata-Kuroiwa R,Furutani N,Hara J,Hondo M,Ishii M,Abe T,Mieda M,Tsujino N,Motoike T,Yanagawa Y,Kuwaki T,Yamamoto M,Yanagisawa M,Sakurai T PLoS One 6 2 e16972 2011/02
  •  The orexin system: roles in sleep/wake regulation. Sakurai T,Mieda M,Tsujino N Ann N Y Acad Sci 1200 149-61 2010/07
  •  Integrative physiology of orexins and orexin receptors. Mieda M,Sakurai T CNS Neurol Disord Drug Targets 8 4 281-95 2009/08
  •  R-spondin3 is required for mouse placental development. Aoki M, Mieda M, Ikeda T, Hamada Y, Nakamura H, Okamoto H. DEVELOPMENTAL BIOLOGY 301  218-226 2007
  •  Central control of bone remodeling by neuromedin U. Sato S, Hanada R, Kimura A, Abe T, Matsumoto T, Iwasaki M, Inose H, Ida T, Mieda M, Takeuchi Y, Fukumoto S, Fujita T, Kato S, Kangawa K, Kojima M, Shinomiya K, Takeda S. NATURE MEDICINE 13  1234-40 2007
  •  The dorsomedial hypothalamic nucleus as a food-entrainable circadian pacemaker. Mieda M, Williams SC, Richardson JA, Tanaka K, Yanagisawa M. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME 103  12150-12155 2006
  •  Indispensability of the glutamate transporters GLAST and GLT1 to brain development. Matsugami TR, Tanemura K, Mieda M, Nakatomi R, Yamada K, Kondo T, Ogawa M, Obata K, Watanabe M, Hashikawa T, Tanaka K. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME 103  12161-12166 2006
  •  Orexin peptides prevent cataplexy and improve wakefulness in orexin neuron-ablated model of narcolepsy in mice. Mieda M, Willie JT, Hara J, Sinton CM, Sakurai T, Yanagisawa M. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME 101  4649-4654 2004
  •  Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness. Mieda M, Williams SC, Sinton CM, Richardson J, Sakurai T, Yanagisawa M. JOURNAL OF NEUROSCIENCE 24  10493-10501 2004
  •  Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami K, Sugiyama F, Goto K, Yanagisawa M, Sakurai T NEURON 38  701-713 2003
  •  Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. Georgescu D, Zachariou V, Barrot M, Mieda M, Willie JT, Eisch AJ, Yanagisawa M, Nestler EJ, DiLeone RJ. JOURNAL OF NEUROSCIENCE 23  3106-3111 2003
  •  The network mechanism of the central circadian pacemaker of the SCN: Do AVP neurons play a more critical role than expected?  Michihiro Mieda Frontiers in Neuroscience 13 139 2019/02/25
  •  Time restriction of food intake during scircadian cycle is a possible regulator of reproductive function in post-adolescent female rats Tomoko Fujiwara, Rieko Nakata, Masanori Ono, Michihiro Mieda, Hitoshi Ando, Takiko Daikoku, Hiroshi Fujiwara Current Developments in Nutrition Epub ahead of print 2018/11/26
  •  Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice. Zhang T, Yanagida J, Kamii H, Wada S, Domoto M, Sasase H, Deyama S, Takarada T, Hinoi E, Sakimura K, Yamanaka A, Maejima T, Mieda M, Sakurai T, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K. Addict Biol.  Epub ahead of print 2019/02/07
  •  Sexually Dimorphic Vasopressin Cells Modulate Social Investigation and Communication in Sex-Specific Ways. Rigney N, Whylings J, Mieda M, de Vries G, Petrulis A. eNeuro 6 1 ENEURO.0415-18.2019 2019/01/28
  •  Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons. Saito YC, Maejima T, Nishitani M, Hasegawa E, Yanagawa Y, Mieda M, Sakurai T. J Neurosci. 38 28 6366-6378 2018/07/11
  •  Disruption of Bmal1 Impairs Blood-Brain Barrier Integrity via Pericyte Dysfunction. Nakazato R, Kawabe K, Yamada D, Ikeno S, Mieda M, Shimba S, Hinoi E, Yoneda Y, Takarada T. J Neurosci. 37 42 10052 2017/10/18
  •  Astrocytes Regulate Daily Rhythms in the Suprachiasmatic Nucleus and Behavior. Tso CF, Simon T, Greenlaw AC, Puri T, Mieda M, Herzog ED. Current Biology 27 7 1055 2017/04/03
  •  The roles of orexins in sleep/wake regulation. Mieda M. Neurosci Res 118 56 2017/05/16
  •  Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity.  Hasegawa E, Maejima T, Yoshida T, Masseck OA, Herlitze S, Yoshioka M, Sakurai T, Mieda M. Proc Natl Acad Sci U S A 114 17 E3526 2017/04/25

Conference Presentations

  • Neural mechanisms underlying the central circadian pacemaker of the SCN (2018/07/28)
  • Genetic dissection of neural mechanisms underlying the central circadian pacemaker (conference:Sapporo Symposium on Biological Rhythm in 2018)(2018/07/14)
  • Critical roles of AVP neurons in the central circadian clock of the SCN(2018/03/30)
  • Neural mechanisms underlying the sleep-wake regulation by orexins(conference:ConBio2017)(2017/12/07)
  • AVP neurons play a critical role in the circadian pacemaking of SCN(2017/03)

show all

  • AVP neurons play a critical role in the circadian pacemaking of the SCN. (conference:Sapporo Symposium on Biological Rhythm)(2016/11)
  • Roles of monoamine neurons in sleep-wake regulation by orexin.(conference:The 29th Conference of the International Society for Chronobiology)(2016/10)

Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Classes (Bachelors)

○Basic Health Science(2017)
○Functions of the Body & Their Integration(2017)
○Practical Medical Research(2017)
○Freshman Seminar I(2017)
○Basic Physiology(2017)
○Freshman Seminar I(2016)
○Basic Health Science(2016)

Classes (Graduate Schools)

○The Function of the Human Body(2017)
○Molecular Neuroscience and Intergrative Physiology(2017)
○Molecular Neuroscience and Integrative Physiology(2017)
○Molecular Neuroscience and Integrative Physiology(2017)
○Frontier Life Science(2016)
○Molecular Neuroscience and Intergrative Physiology(2016)
○Molecular Neuroscience and Integrative Physiology(2016)
○The Function of the Human Body(2016)
○Molecular Neuroscience and Integrative Physiology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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