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Researcher Information

last modified:2017/05/23

Assistant Professor MUNESUE Seiichi

Mail

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Cardiovascular Medicine, Graduate School of Medical Science
Division of Cardiovascular Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

 TEL:076-265-2181 FAX:076-234-4217

Academic Background

【Degree】
biotechnology

Career

Postdoctoral fellow Facul.of engineering, Kyoto Sangyo Univ Postdoctoral fellow(2002/04-2005/03)
assistant professor Facl. of engineering, Kyoto Sangyo Univ. assistant professor(2005/04-2007/03)
assistant professor Dept. of Molecular Vascular Biology(2007/04-)

Year & Month of Birth

1971/08

Academic Society

Award

Specialities

General medical chemistry

Speciality Keywords

biochemistry, molecular biology, diabetes

Research Themes

Analysis of the mechanism of diabetes complecation development

Books

  •  Munesue, S., Yoshitomi, Y., Kusano, Y., Koyama, Y., Nishiyama, A., Nakanishi, H., Miyazaki, K., Ishimaru, T., Miyaura, S., Okayama, M. and Oguri, K. A novel function of syndecan-2, suppression of MMP-2 activation, which causes suppression of metastasis. 282  28164-28174 2007

Papers

  •  Low-molecular weight heparin suppresses RAGE-mediated expression of the malignant phenotype in human fibrosarcoma cells. Cancer science 104 6 740-749 2013/06
  •  Endogenous secretory receptor for advanced glycation end-products inhibits amyloid-beta1-42 uptake into mouse brain.  J Alzheimer’s Dis 28 3 409-420 2012/11
  •  Induction of receptor for advanced glycation end-products by insufficient leptin action triggers pancreatic β-cell failure in type 2 diabetes. Genes to Cells 2013/01
  •  Septic shock is associated with receptor for advanced glycation endproducts (RAGE) ligation of LPS. JOURNAL OF IMMUNOLOGY 186 5 3248-3257 2011/01
  •  Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications. Exp Diabetes Res 2012/11

show all

  •  Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy.  Abouzed TK, Munesue S, Harashima A, Masuo Y, Kato Y, Khailo K, Yamamoto H, Yamamoto Y. J Diabetes Res. 1786789 2016
  •  Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination. Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T. Gastric Cancer 19  1052-1065 2016
  •  Maltitol endows foods with lower 3-deoxyglucosone content and less RAGE agonism as a sweetener against sucrose. Kuretani A, Kawamura R, Munesue S, Yamamoto Y, Honda J, Yamamoto H.  Glycative Stress Res, 1 25-31
  •  cAMP ameliorates inflammation by modulation of macrophage receptor for advanced glycation end-products. Motoyoshi S, Yamamoto Y, Munesue S, Igawa H, Harashima A, Saito H, Han D, Watanabe T, Sato H, Yamamoto H. Biochem J 463 75-82  2014
  •  Low molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression of malignant phenotype in human fibrosarcoma cells Takeuchi, Akihiko; Yamamoto, Yasuhiko; Munesue, Seiichi; Harashima, Ai; Watanabe, Takuo; Yonekura, Hideto; Yamamoto, Hiroshi; Tsuchiya, Hiroyuki Cancer Science 104 6 740-749 2013/06/01 
  •  Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury Sakai, Seisho; Tajima, Hidehiro; Miyashita, Tomoharu; Nakanuma, Shinichi Ichi; Makino, Isamu; Hayashi, Hironori; Nakagawara, Hisatoshi; Kitagawa, Hirohisa; Fushida, Sachio; Fujimura, Takashi; Saito, Hidehito; Munesue, Seiichi; Yamamoto, Yasuhiko; Ohta, Tetsuo Digestive Diseases and Sciences 59 4 787-794 2014/01/01 
  •  Low-molecular weight fractions of Japanese soy sauce act as a RAGE antagonist via inhibition of RAGE trafficking to lipid rafts Munesue, Seiichi; Yamamoto, Yasuhiko; Urushihara, Ryouta; Inomata, Kouhei; Saito, Hidehito; Motoyoshi, So; Watanabe, Takuo; Yonekura, Hideto; Yamamoto, Hiroshi Food and Function 4 12 1835-1842 2013/12/01 
  •  Validated liquid culture monitoring system for lifespan extension of Caenorhabditis elegans through genetic and dietary manipulations Win, Myat Thu Thu; Yamamoto, Yasuhiko; Munesue, Seiichi; Han, Dong; Harada, Shinichi; Yamamoto, Hiroshi Aging and Disease 4 4 178-185 2013/01/01 
  •  Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 and an independent mechanism Toda, Masaaki; D'Alessandro-Gabazza, Corina Nayade; Takagi, Takehiro; Chelakkot-Govindalayathila, Ayshwarya Lakshmi; Taguchi, Osamu; Roeen, Ziaurahman; Munesue, Seiichi; Yamamoto, Yasuhiko; Yamamoto, Hiroshi; Gabazza, Esteban Cesar; Morser, John Allergology International 63 1 57-66 2014/03/17 
  •  Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic β-cell failure in type 2 diabetes Han, Dong; Yamamoto, Yasuhiko; Munesue, Seiichi; Motoyoshi, So; Saito, Hidehito; Win, Myat Thu Thu; Watanabe, Takuo; Tsuneyama, Koichi; Yamamoto, Hiroshi Genes to Cells 18 4 302-314 2013/04/01 

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「食品に含まれるRAGEシグナル阻害成分の同定と阻害機構の解明」(2014-2016)

Classes (Bachelors)

○Biochemistry2(2017)

Classes (Graduate Schools)

○Molecular Biology of the Cardiovascular System(2017)
○Molecular Biology of the Cardiovascular System(2017)
○Molecular Biology of the Cardiovascular System(2016)
○Molecular Biology of the Cardiovascular System(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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