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Researcher Information

last modified:2018/04/27

Professor WONG, Richard W.

Laboratory Website

Faculty, Affiliation

WPI Nano Life Science Institute

College and School Educational Field


Laboratory

Academic Background

【Degree】
Doctor of Medicine

Career

Associate Prof. FSO, Kanazawa University(2008/04-2012/03)
金沢大学 理工学域自然システム学類 Professor(2012/04-2018/03)
DIvision Head and Professor, MCB division, Bio-AFM center(2015/04-2018/03)
Institute for Frontier Science Initiative  Unit leader and Professor(2015/04-)
WPI-NanoLSI(2017/10-)

Year & Month of Birth

Academic Society

The American Society for Cell Biology
The Royal Society of Medicine, United Kingdom
Protein Science Society of Japan
The Japanese Association of Anatomists (JAA)
JSCB

Award

Specialities

Speciality Keywords

nucleoporin, NPC, Cell cycle, mitotic spindles, kinesin, nuclear pore, SRM, HS-AFM

Research Themes

Nucleoporins structures and functions

We study RNA and protein transport through Nuclear Pore Complex (NPC) (also termed nucleoporins or nups) to ER . Many developmental defects and tumors are directly associated with alterations in nucleo-cytoplasmic transport, and my lab is interested in understanding how the NPC mediates transport and in gaining a better understanding of the molecular mechanisms of these defects. Meanwhile, we are also investigating the association of NPC proteins with the mitotic spindle during cell division.

Books

Papers

  •  Colorectal cancer cells require glycogen synthase kinase-3β for sustaining mitosis via translocated promoter region (TPR)-dynein interaction Dewi FRP, Domoto T, Hazawa M, Kobayashi A, Douwaki T, Minamoto T and Wong RW (Correspondence)  Oncotarget 9 13337-13352. 2018/01/30
  •  Rock-dependent phosphorylation of NUP62 regulates p63 nuclear transport and cell fate of squamous cell carcinoma Hazawa M, Lin D, Kobayashi A, Jiang YY, Dewi FRP, Mohamed MS, Hartono H, Nakada S, Meguro-Horike M, Horike S, Koeffler H and Wong RW EMBO rep 19 1 73-88 2018/01/15
  •  High-Speed Atomic Force Microscopy Reveals Loss of Nuclear Pore Resilience as a Dying Code in Colorectal Cancer Cells. Mohamed MS, Kobayashi A, Taoka A, Watanabe-Nakayama T, Kikuchi Y, Hazawa M, Minamoto T, Fukumori Y, Kodera N, Uchihashi T, Ando T, Wong RW 11 6 5567-5578 2017/06/17
  •  ZNF750 is a lineage-specific tumor suppressor in squamous cell carcinoma.  Hazawa M, Lin D, Handral H, Xu L, Chen Y, Jiang YY, Thippeswamy A, Ding LW, Meng X, Sharma A, Samuel S, Movahednia M, Wong RW, Yang H, Tong C, and Koeffler H Oncogene   doi: 10.1038/onc.2016.377. 36(16): 2243-2254. 2017/04/20

Conference Presentations

  • Identifying nanoscopic spider cobweb features of native nuclear pores in cancer cells. (conference:International Symposium on Atomic Force Microscopy at Solid-Liquid Interfaces)(2017/11/08)
  • ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport in squamous cell carcinoma(conference:The 2017 ASCB | EMBO Meeting)(2017/12/04)
  • Loss of Nuclear Pore Selective Barrier Revealed by High-Speed Atomic Force Microscopy in Colorectal Cancer Cells (2017/09/20)

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

Classes (Bachelors)

○Research Seminar in Biology (2)(2017)
○Research Work in Biology(2)(2017)
○Physiology 2(2017)
○Recombinant Dna Technology Lab(2017)
○Research Work in Biology(1)(2017)
○Research Seminar in Biology (1)(2017)
○Research Work in Biology(1)(2016)
○Research Seminar in Biology (1)(2016)
○Research Seminar in Biology (2)(2016)
○Recombinant Dna Technology Lab(2016)
○Recombinant Dna Technology Lab(2016)
○Physiology 2(2016)
○Research Work in Biology(2)(2016)

Classes (Graduate Schools)

○Molecular and Cellular Biology(2017)
○Integrated Systems Biology A(2017)
○Molecular and Cellular Biology(2017)
○Molecular and Cellular Biology(2017)
○Molecular and Cellular Biology(2017)
○Integrated Systems Biology B(2017)
○Integrated Systems Biology B(2016)
○Integrated Systems Biology A(2016)
○Molecular and Cellular Biology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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