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Researcher Information

last modified:2019/12/08

Associate Professor OSHIMA Hiroko

Mail Laboratory Website

Faculty, Affiliation

Cancer Research Institute

College and School Educational Field

Graduate School of Phamacy

Laboratory

Division of genetics TEL:076-265-2724 FAX:076-234-4519

Academic Background

【Academic background(Bachelor's Degree)】
Kumamoto University 199203

Career

1992-1997 Banyu Tsukuba Research Institute
1997-2000 Merck Research Laboratory
2001-2005 Kyoto University

Year & Month of Birth

1969/09

Academic Society

Award

Specialities

Experimental pathology

Speciality Keywords

Research Themes

Inflammatory responses in gastrointestinal tumorigenesis

Inflammatory responses in gastrointestinal tumorigenesis Inflammation and related induction of PGE2 pathway play an important role in gastrointestinal tumorigenesis. Gastritis in mice by transgenic expression of COX-2 and mPGES-1 or infection with Helicobacter causes SPEM development, which may contribute to gastric tumorigenesis.

Generation of inflammation-associated gastric cancer mouse model

Generation of inflammation-associated gastric cancer mouse model Activation of Wnt signaling and suppression of BMP pathway are both thought to cause gastric tumorigenesis. However, mouse model with Wnt activation or BMP suppression in the stomach did not develop tumors. Importantly, induction of gastritis by PGE2 induction in these model mice results in development of adenocarcinoma and hamartoma, respectively. These results indicate importance of inflammatory responses for gastric tumorigenesis.

Books

Papers

  •  Activation of epidermal growth factor receptor signaling by the prostaglandin E2 receptor EP4 pathway during gastric tumorigenesis.  Oshima H, Popivanova BK, Oguma K, Kong D, Ishikawa T, and Oshima M.  Cancer Science 2011/04
  •  Platelet 12-lipoxigenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency. Piao Y, Du Y, Oshima H, Jin J, Nomura M, Yoshimoto T, Oshima M 2008
  •  Activated macrophages promote Wnt signaling through tumor necrosis factor-alpha in gastric tumor cell. Oguma K, Oshima H, Aoki M, Uchio R, Naka K, Nakamura S, Hirao A, Saya H, Taketo MM, Oshima M 2008
  •  Induction and downregulation of Sox17 and its possible roles during the course of gastrointestinal tumorigenesis Du YC, Oshima H, Oguma K, Kitamura T, Itadani H, Fujimura T, Piao YS, Yoshimoto T, Minamoto T, Taketo MM, Oshima M. GASTROENTEROLOGY 2009/09
  •  Induction of prostaglandin E2 pathway promotes gastric hamartoma development with suppression of bone morphogenetic protein signaling Oshima H, Itadani H, Kotani H, Taketo MM, Oshima M. CANCER RESEARCH 69 7 2729-2733 2009/04

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  •  Wnt activation and PGE2 induction. Oshima H, and Oshima M PATHOLOGY INTERNATIONAL 2010/09
  •  Prostaglandin E2 signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors Oshima H, Hioki K, Popivanova BK, Oguma K, van Rooijen N, and Oshima M GASTROENTEROLOGY 2011/01
  •  ProstaglandinE2, Wnt, and BMP in gastric tumor mouse models Hiroko Oshima. Keisuke Oguma, Yu-Chen Du and Masanobu Oshima Cancer Science 2009/10
  •  Inteatinal cancer progression by mutant p53 though the acquisition of invasiveness associated with complex glandular formation. Nakayama M, Sakai E, Echizen K, Yamada Y, Oshima H, Han TS, Ohki R, Fujii S, Ochiai A, Robine S, Voon DC, Tanaka T, Taketo MM, Oshima M. Oncogene 36 42 5885-5896 2017/10/19

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「上皮細胞腫瘍化と炎症反応の相互作用による消化管発癌機序」(2011-2014) 
○「SOX17の発現変化によるWnt活性制御が消化管腫瘍悪性化に及ぼす影響」(2010-2011) 
○「消化器腫瘍発生におけるCXCL14および組織マクロファージの役割」(2007-) 
○「炎症反応に起因した胃粘膜上皮細胞の腫瘍性増殖機序の研究」(2005-)

Classes (Bachelors)

Classes (Graduate Schools)

○Molecular Genetics of Tumor Biology(2017)
○Molecular Genetics of Tumor Biology(2017)
○Seminar on Tumor Biology(2016)
○Molecular Genetics of Tumor Biology(2016)
○Molecular Genetics of Tumor Biology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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