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Researcher Information

last modified:2019/03/01

Professor SUDA Takashi

Mail Laboratory Website

Faculty, Affiliation

Cancer Research Institute

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science

Graduate School of Phamacy
Division of Natural System, Graduate School of Natural Science and Technology


Division of Immunology and Molecular Biology

Academic Background

【Academic background(Doctoral/Master's Degree)】
Osaka University Doctor 1988 Completed
Osaka University Master 1984 Completed
【Academic background(Bachelor's Degree)】
Saitama University 1982


Kanazawa University Cancer Research Institute Professor(1998/04/01-)
Osaka Bioscience Institute Department of Molecular Biology(1995/11/01-1998/03/31)
Osaka Bioscience Institute Department of Molecular Biology(1992/04/01-1995/10/31)

Year & Month of Birth

Academic Society

Japanese Society for Immunology

The Japanese Society of Cell Death Research
The American Association of Immunologist



Experimental Pathology、Immunology、Pathological medical chemistry

Speciality Keywords

Immunology, Apoptosis, Fas ligand, Inflammation, Cancer

Research Themes

Study on the Apoptosis of Cancer Cells.

Study on Immune Regulation by Fas Ligand

Study on the molecular mechanisms of cell death and inflammation


  •  Apoptosis 2001/06


  •  Molecular cloning and expression of the Fas ligand: a novel member of the tumor necrosis factor family Suda T, Nagata S, et al. CELL 75 6 1169-1178 1993/12
  •  Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand Takahashi T, Suda T, et al. CELL 76 6 969-976 1994/03
  •  Lethal effect of the anti-Fas antibody in mice Ogasawara J, Suda T, et al NATURE 364 6440 806-809 1993/08
  •  Fas ligand in human serum. Tanaka M, Suda T et al. NATURE MEDICINE 2 3 317-322 1996/03
  •  Essential roles of the Fas ligand in the development of hepatitis. Kondo T, Suda T, et al. NATURE MEDICINE 3 4 409-413 1997/04

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  •  Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand Miwa K, Suda T, et al. NATURE MEDICINE 4 11 1287-1292 1998/11
  •  Purification and characterization of the Fas-ligand that induces apoptosis Suda T, Nagata S JOURNAL OF EXPERIMENTAL MEDICINE 179 3 873-879 1994/03
  •  Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing Suda T, Nagata S, et al. JOURNAL OF EXPERIMENTAL MEDICINE 186 12 2045-2050 1997/12
  •  Prevention of Hepatocellular Carcinoma Development Associated with Chronic Hepatitis by Anti-Fas Ligand Antibody Therapy Nakamoto Y, Suda T et al. JOURNAL OF EXPERIMENTAL MEDICINE 196 8 1105-1111 2002/10
  •  Caspase-1 induces apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC)-mediated necrosis independently of its catalytic activity Kou Motani, Hiroko Kushiyama, Ryu Imamura, Takeshi Kinoshita, Takumi Nishiuchi, and Takashi Suda JOURNAL OF BIOLOGICAL CHEMISTRY in press 2011/08
  •  Characterization of Innate and Adaptive Immune Responses in PYNOD-deficient mice 1. Nakajima S, Imamura R, Yoshino M, Sakurai M, Tsuchiya K, Sugihara K, Asano M, and Suda T ImmunoHorizons 2 4 129-141 2018/04/01
  •  Involvement of p38MAPK in Impaired Neutrophil Bactericidal Activity of Hemodialysis Patients 2. Kamikawa Y, Sakai N, Miyake T, Sagara A, Shinozaki Y, Kitajima S, Toyama T, Hara A, Iwata Y, Shimizu M, Furuichi K, Imamura R, Suda T, Kaneko S, Wada T. Ther Apher Dial 22 4 345–354 2018/01/10
  •  Vitamin B6 Prevents IL-1β Protein Production by Inhibiting NLRP3 Inflammasome Activation Peipei Zhang, Kohsuke Tsuchiya, Takeshi Kinoshita, Hiroko Kushiyama, Sofya Suidasari, Mizuki Hatakeyama, Hisanori Imura, Norihisa Kato and Takashi Suda Journal of Biological Chemistry 291 47 24517- 24527 2016/11/18
  •  NLRP3 mediates NF-κB activation and cytokine induction in microbially induced and sterile inflammation Takeshi Kinoshita, Ryu Imamura, Hiroko Kushiyama, and Takashi Suda PLoS One 10 e0119179 2015/03/11
  •  Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages INTERNATIONAL IMMUNOLOGY 25 6 363-372 2013/06
  •  Roles of the PI3K/Akt pathway and autophagy in TLR3 signaling-induced apoptosis and growth arrest of human prostate cancer cells. CANCER IMMUNOLOGY IMMUNOTHERAPY 61 5 667-676 2012/05
  •  Inflammasome and cell death 30 4 566-570 2012/03
  •  Fas Ligand Has a Greater Impact than TNF-α on Apoptosis and Inflammation in Ischemic Acute Kidney Injury Nephron Extra 2 1 27-38 2012/01
  •  Activation of ASC induces apoptosis or necrosis depending on the cell type and causes tumor eradication Kou Motani, Kouji Kawase, Ryu Imamura, Takeshi Kinoshita, Hiroko Kushiyama and Takashi Suda Cancer Science 101 8 1822-1827 2010/08
  •  Anti-inflammatory activity of PYNOD and its mechanism in humans and mice JOURNAL OF IMMUNOLOGY 184 10 2010/05
  •  Mechanism and repertoire of ASC-mediated gene expression JOURNAL OF IMMUNOLOGY 182 12 7655-7662 2009/06
  •  ASC at the crossroad of cell death and inflammation Experimental Medicine 2008/12
  •  Expression of NLRP7 (PYPAF3, NALP7)Protein in Endometrial Cancer Tissues Ohno S, Kinoshita T, Ohno Y, Minamoto T, Suzuki N, Inoue M ANTICANCER RESEARCH 28 4C  2493-2497 2008/07
  •  NLR family: cytoplasmic pathogen sensors 15 5 39-45 2007/08
  •  Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production Matsumoto N, Imamura R, Suda T EUROPEAN JOURNAL OF BIOCHEMISTRY 274 9 2376-2384 2007/05
  •  Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells Fujisawa A, Suda T, et al. BLOOD 109 7 2903-2911 2007/04
  •  Mechanism of ASC-mediated apoptosis: Bid-dependent apoptosis in type II cells Hasegawa M, Suda T, et al. ONCOGENE 26 12 1748-1756 2007/03
  •  IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis BCG infection Umemura M, Suda T, et al. JOURNAL OF IMMUNOLOGY 178 6 3786-3796 2007/03
  •  Fas-associated Factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1 Kinoshita T, Suda T, et al. INTERNATIONAL IMMUNOLOGY 18 12 1701-1706 2006/12
  •  General nature of the STAT3-activated anti-inflammatory response El Kasmi K C, Suda T, et al. JOURNAL OF IMMUNOLOGY 177 11 7880-7888 2006/12
  •  Fas ligand induces cell-autonomous IL-23 production indendritic cells, a mechanism for Fas ligand-induced IL-17 production Kidoya H, Suda T, et al. JOURNAL OF IMMUNOLOGY 175 12 8024-8031 2005/12
  •  Apaf-1 like proteins at a crossroads of apoptosis and inflammation 24 9 929-933 2005/08
  •  PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1b secretion. Kinoshita T, Suda T, et al JOURNAL OF BIOLOGICAL CHEMISTRY 280 23 21720-21725 2005/06
  •  ASC-mediated NF-kB activation leading to IL-8 production requires caspase-8 and is inhibited by CLARP. Hasegawa M, Suda, T et al JOURNAL OF BIOLOGICAL CHEMISTRY 280 15 15122-15130 2005/04
  •  Physiological and pathological roles of apoptosis 63 S4 395-400 2005/04
  •  Fas ligand induces cell-autonomous NF-kB activation and IL-8 production by a mechanism distinct from that of TNF-a. Imamura R, Suda T, et al JOURNAL OF BIOLOGICAL CHEMISTRY 279 45 46415-46423 2004/11
  •  Involvement of IL-17 in Fas ligand-induced inflammation Umemura M, Suda T, et al INTERNATIONAL IMMUNOLOGY 16 8 1099-1108 2004/08
  •  Fas ligand and inflammation and carcinogenesis 22 11 190-195 2004/07
  •  PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1. Wang Y, Suda T, et al INTERNATIONAL IMMUNOLOGY 16 6 777-786 2004/06
  •  Different procarcinogenic potentials of lymphocyte subsets in a transgenic mouse model of chronic hepatitis B Nakamoto Y, Suda T, et al CANCER RESEARCH 64 9 3326-3333 2004/05
  •  Pathogen-associated molecular patterns sensitize macrophages to Fas ligand-induced apoptosis and IL-1beta release Fukui M, Suda T, et al JOURNAL OF IMMUNOLOGY 171 4 1868-1874 2003/08
  •  Genomic structure and inducible expression of the IL-22 receptor α chain in mice Tachiiri A, Suda T, et al GENES AND IMMUNITY 4 2 153-159 2003/03
  •  Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice Shimizu H, Suda T, et al GASTROENTEROLOGY 123 4 1265-1277 2002/10
  •  Prevention and induction of autoimmune exocrinopathy is dependent on pathogenic autoantigen cleavage in murine Sjogren's syndrome Saegusa K. Suda T, et al JOURNAL OF IMMUNOLOGY 169 2 1050-1057 2002/07
  •  Requirement of Fas expression in B cells for tolerance induction Fukuyama H, Suda T, et al EUROPEAN JOURNAL OF IMMUNOLOGY 32 1 223-230 2002/01
  •  In vitro prevention of cell-mediated xeno-graft rejection via the Fas/FasL-pathway in CrmA-transducted porcine kidney cells. Fujino M, Suda T, et al XENOTRANSPLANTATION 8 2 115-124 2001/05
  •  The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity Shudo K, Suda T, et al EUROPEAN JOURNAL OF IMMUNOLOGY 31 8 2504-2511 2001/08
  •  Possible Role of Organ-Specific Autoantigen for Fas Ligand-Mediated Activation-Induced Cell Death in Murine Sjogren's Syndrome Ishimaru N, Suda T et al JOURNAL OF IMMUNOLOGY 167 10 6031-6037 2001/11
  •  The apoptosis is kin to the inflammation Experimental Medicine 19 13 198-205 2001/08
  •  Transgenic expression of Fas in T cells blocks lymphoproliferation but not autoimmune disease in MRL-lpr mice J Immunol 160 8 3805-3811 1998/04

Conference Presentations

  • Pyroptosis enhances killing of Listeria monocytogenes by ampicillin in vivo.(conference:The 47th Annual Meeting of the Japanese Society for Immunology)(2018/12/10)
  • Caspase-1 initiates apoptosis in the absence of gasdermin D(conference:The 27th Annual Meeting of the Japanese Society for Cell Death Research)(2018/07/27)
  • Caspase-1-induced pyroptosis potentiates anti-tumor immunity(conference:Australia-Japan Meeting on Cell Death)(2018/05/22)
  • Switches between apoptosis and pyroptosis in macrophages and cancer cells(conference:Australia-Japan Meeting on Cell Death)(2018/05/22)
  • Analysis of immune responses in PYNOD deficient mice(2016/12/07)

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  • Analysis of the steady-state transport of skin self-antigens in Pynod-Ccr7-double knockout mice(conference:The 24th International Symposium on Molecular Cell Biology of Macrophages)(2016/06/04)

Arts and Fieldwork


Theme to the desired joint research

○Study on the NLR family

Grant-in-Aid for Scientific Research

○「Fas/Fasリガンドシステムの生理的、病理的意義の解析 」(1995-1996) 
○「アポトーシスを誘導する細胞表面抗原:Fasのリガンド遺伝子のクローニング 」(1993-1994) 

Classes (Bachelors)

Classes (Graduate Schools)

○Molecular Oncology(2018)
○Biology of Cancer 2A(2018)
○Biology of Cancer 2B(2018)
○Biology of Cancer 2B(2017)
○Cancer molecular pathology 2(2017)
○Body Defense Mechanisms(2017)
○Body Defense Mechanisms(2017)
○Cancer molecular pathology 2(2017)
○Cancer molecular pathology 2(2017)
○Biology of Cancer 2A(2017)
○Cancer molecular pathology 2(2017)
○Molecular Oncology(2017)
○Body Defense Mechanisms(2017)
○Medical Sciences(2016)
○Body Defense Mechanisms(2016)
○Body Defense Mechanisms(2016)
○Body Defense Mechanisms(2016)
○Biology of Cancer 2B(2016)
○Biology of Cancer 2A(2016)
○Cancer molecular pathology 2(2016)
○Molecular Oncology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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