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Researcher Information

last modified:2022/04/11

Professor SAI Yoshimichi

Mail Laboratory Website
Laboratory Website
Laboratory Website

Faculty, Affiliation

University Hospital Clinical Pharmacokinetics

College and School Educational Field

Division of Pharmaceutical Sciences, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Pharmacy, College of Medical, Pharmaceutical and Health Sciences
Department of Nursing,School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Department of Hospital Pharmacy TEL:076-265-2045 FAX:076-234-4280

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of National Science and Technology (except Gakushuin University, Konan University) 199403 Completed
Kanazawa University Master Graduate School, Division of Pharmaceutical Sciences 199103 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 1989
【Degree】
Ph.D.

Career

2014- Kanazawa University Hospital, Professor University Hospital Director of Department of Hospital Pharmacy(2014/05/01-)
2009-2014 Kanazawa University Hospital, Associate Professor University Hospital(2009/01/01-2014/04/30)
2008-2008 Faculty of Pharmacy, Keio University, Associate Professor Faculty of Pharmacy Associate Professor(2008/04/01-2008/12/31)
2004-2008 Department of Pharmacy, Kyoritsu University of Pharmacy Associate Professor Department of Pharmacy Associate Professor(2004/04/01-2008/03/31)
2000-2004 Graduate School of Natural Science and Technology, Kanazawa University, Research Associate Graduate School of Natl Sci and Technol(2000/04/01-2004/03/31)
1997-1999 School of Medicine, Tufts University Postdoctoral Fellow School of Medicine Postdoctoral Fellow(1997/09/01-1999/08/31)
1994-2000 Faculty of Pharmaceutical Sciences, Kanazawa University, Research Associate Faculty of Pharmaceutical Sciences(1994/04/01-2000/03/31)

Year & Month of Birth

1966/07

Academic Society



Japanese Society for the Study of Xenobiotics
The Academy of Pharmaceutical Science and Technology, Japan
The Academy of Pharmaceutical Science and Technology, Japan
Japanese Society of Pharmaceutical Health Care and Sciences
Japanese Society of Pharmaceutical Health Care and Sciences






International Society for the Study of Xenobiotics
The Academy of Pharmaceutical Science and Technology, Japan
The Academy of Pharmaceutical Science and Technology, Japan



Award
















Specialities

Clinical Pharmacology、Applied Pharmacology and Medical Pharmacology、Cell Biology

Speciality Keywords

Biopharmaceutics Applied Pharmacology and Medical Pharmacology Cell Biology

Research Themes

Biopharmaceutical Approach to Personalized Medicine

Books

  •  Expert's Guide 2021/03/31
  •  Expert's Guide 2020/03/30
  •  Expert's Guide 2018/03/24

Papers

  •  Three types of membranous ATPase on rat liver lysosomes Hayashi H, Arai K, Sato O, Shimaya A, Sai Y, Ohkuma S. CHEMICAL & PHARMACEUTICAL BULLETIN 40 10 2789-2786 1992/10
  •  Small GTP-binding proteins on rat liver lysosomal membranes Sai Y, Ohkuma S. CELL STRUCTURE AND FUNCTION 16 6 363-369 1992/12
  •  Inhibition of cell growth by bafilomycin A1, a selective inhibitor of vacuolar H(+)-ATPase Ohkuma S, Shimizu S, Noto M, Sai Y, Kinoshita K, Tamura H. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 29A 11 862-866 1993/11
  •  Cytosol treated with GTP gamma S disintegrates lysosomes in vitro Sai Y, Arai K, Ohkuma S.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 198 3 869-877 1994/02
  •  Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids Tamai I, Takanaga H, Maeda H, Sai Y, Ogihara T, Higashida H, Tsuji A. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 214 2 482-489 1995/09

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  •  cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter Takanaga H, Tamai I, Inaba S, Sai Y, Higashida H, Yamamoto H, Tsuji A. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 217 1 370-377 1995/12
  •  Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter Miyamoto K, Shiraga T, Morita K, Yamamoto H, Haga H, Taketani Y, Tamai I, Sai Y, Tsuji A, Takeda E. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1035 1-2 34-38 1996/02
  •  Contribution of lysosomes to the subcellular distribution of basic drugs in the rat liver Ishizaki J, Yokogawa K, Hirano M, Nakashima E, Sai Y, Ohkuma S, Ohshima T, Ichimura F. PHARMACEUTICAL RESEARCH 13 6 902-906 1996/06
  •  Sodium and chloride ion-dependent transport of beta-alanine across the blood-brain barrier Komura J, Tamai I, Senmaru M, Terasaki T, Sai Y, Tsuji A. JOURNAL OF NEUROCHEMISTRY 67 1 330-335 1996/07
  •  Immunolocalization and pharmacological relevance of oligopeptide transporter PepT1 in intestinal absorption of beta-lactam antibiotics Sai Y, Tamai I, Sumikawa H, Hayashi K, Nakanishi T, Amano O, Numata M, Iseki S, Tsuji A. FEBS LETTERS 392 1 25-29 1996/08
  •  Blood-brain-barrier transport of lipid microspheres containing clinprost, a prostaglandin I2 analogue Minagawa T, Sakanaka K, Inaba S, Sai Y, Tamai I, Suwa T, Tsuji A. JOURNAL OF PHARMACY AND PHARMACOLOGY 48 10 1016-1022 1996/10
  •  Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier Terao T, Hisanaga E, Sai Y, Tamai I, Tsuji A. JOURNAL OF PHARMACY AND PHARMACOLOGY 48 10 1083-1089 1996/10
  •  The role of vacuolar H(+)-ATPase in the control of intragranular pH and exocytosis in eosinophils Kurashima K, Numata M, Yachie A, Sai Y, Ishizaka N, Fujimura M, Matsuda T, Ohkuma S. LABORATORY INVESTIGATION 75 5 689-698 1996/11
  •  Stereoselective and carrier-mediated transport of monocarboxylic acids across Caco-2 cells Ogihara T, Tamai I, Takanaga H, Sai Y, Tsuji A. PHARMACEUTICAL RESEARCH 13 12 1828-1832 1996/12
  •  Brain-to-blood active transport of beta-alanine across the blood-brain barrier Komura J, Tamai I, Senmaru M, Terasaki T, Sai Y, Tsuji A.  FEBS LETTERS 400 1 131-135 1997/01
  •  Structure-internalization relationship for adsorptive-mediated endocytosis of basic peptides at the blood-brain barrier Tamai I, Sai Y, Kobayashi H, Kamata M, Wakamiya T, Tsuji A. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 280 1 410-415 1997/01
  •  Intestinal brush-border membrane transport of monocarboxylic acids mediated by proton-coupled transport and anion antiport mechanisms Tamai I, Takanaga H, Maeda H, Yabuuchi H, Sai Y, Suzuki Y, Tsuji A. JOURNAL OF PHARMACY AND PHARMACOLOGY 49 1 108-112 1997/01
  •  The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine. J. Pharm. Pharmacol. 49 8 796-801 1997/08
  •  Carrier-mediated transport of oligopeptides in the human fibrosarcoma cell line HT1080. Cancer Res. 57 18 4118-4122 1997/09
  •  Nonlinear intestinal absorption of 5-hydroxytryptamine receptor antagonist caused by absorptive and secretory transporters. J. Pharmacol. Exp. Ther. 283 1 108-115 1997/10
  •  Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett. 419 1 107-111 1997/12
  •  Design and synthesis of peptides passing through the blood-brain barrier. Bull. Chem. Soc. Jpn. 71 699-709 1998
  •  Possible role of anion exchanger AE2 as the intestinal monocarboxylic acid/anion antiporter. Pharm. Res. 15 3 411-416 1998/03
  •  ARF-induced lysosomal lysis in vitro. J Biochem 123 4 637-643 1998/04
  •  Disintegration of lysosomes mediated by GTPgammaS-treated cytosol: possible involvement of phospholipases. J Biochem 123 4 630-636 1998/04
  •  Intestinal absorption of fluorescence-derivatized cationic peptide 001-C8-NBD via adsorptive-mediated transcytosis. Bioorg. Med. Chem. 6 6 841-848 1998/06
  •  Adsorptive-mediated transcytosis of a synthetic basic peptide, 001-C8 in Caco-2 cells. Pharm. Res. 15 8 1305-1309 1998/08
  •  Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J. Biol. Chem. 273 32 20378-20382 1998/08
  •  Adsorptive-mediated endocytosis of a basic peptide in enterocyte-like Caco-2 cells. Am. J. Physiol. 275 3Pt1 G514-520 1998/09
  •  Hepatobiliary transport kinetics of HSR-903, a new quinolone antibacterial agent. Drug Metab. Dispos. 26 11 1113-1119 1998/11
  •  Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1. J. Pharm. Sci. 87 12 1542-1546 1998/12
  •  Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nature Genet. 21 1 91-94 1999/01
  •  Carrier-mediated lung distribution of HSR-903, a new quinolone antibacterial agent. J. Pharmacol. Exp. Ther. 289 1 79-84 1999/04
  •  Novel membrane transporter OCTN1 mediates multispecific, bidirectional and pH-dependent transport of organic cations. J. Pharmacol. Exp. Ther. 289 2 768-773 1999/05
  •  Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by monocarboxylic acid transporter MCT1. J. Pharm. Pharmcol. 51 10 1113-1121 1999/10
  •  Na+-dependent carnitine transport by OCTN2 and its pharmacological and toxicological relevance. J. Pharmacol. Exp. Ther. 291 2 778-784 1999/11
  •  Bile acid secretion and direct targeting of mdr1-green fluorescent protein from Golgi to the canalicular membrane in polarized WIF-B cells. J Cell Sci. 112 Pt 24 4535-4545 1999/12
  •  Blood-brain barrier transport of H1-antagonist ebastine and its metabolite carebastine. J. Drug Targeting 8 6 393-393 2000
  •  p-Aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1. Biochem. Biophys. Res. Commun. 270 1 254-259 2000/04
  •  Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem. Biophys. Res. Commun. 273 1 251-260 2000/06
  •  Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier. J. Pharmacol. Exp. Ther. 295 1 146-152 2000/10
  •  Molecular and functional characterization of organic cation/carnitine transporter family in mice. J. Biol. Chem. 275 51 40064-40072 2000/12
  •  Secretory-transport of p-aminohippuric acid across intestinal epithelial cells in Caco-2 cells and isolated intestinal tissue. J. Pharm. Pharmcol. 53 1 73-81 2001/01
  •  Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol. Pharmacol. 59 2 358-366 2001/02
  •  Genetic polymorphism of drug transporters 16 2 127-133 2001/02
  •  Molecular and functional identification of large neutral amino acid transporter LAT1 and LAT2 and their pharmacological relevance at the blood-brain barrier. J. Pharm. Pharmcol. 53 4 497-503 2001/04
  •  Active intestinal secretion of new quinolone antimicrobials and the partial contribution of P-glycoprotein. J. Pharm. Pharmcol. 53 5 699-709 2001/05
  •  Na+-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney. Biochim. Biophys. Acta, 1512 2 273-284 2001/06
  •  Functional characterization of human organic anion transporting polypeptide OATP-B in comparison with liver-specific OATP-C. Pharm. Res. 18 9 1262-1269 2001/09
  •  Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier. J. Neurochem 79 5 959-969 2001/12
  •  Analysis of the mechanisms of the drug-drug interaction from a view of pharmacogenomics 60 1 74-80 2002/01
  •  Involment of multidrug resistance-associated protein 2 in intestinal secretion of grepafloxacin in rats. Antimicrob. Agents Chemother. 46 2 344-349 2002/02
  •  Evaluation of blood-brain barrier transporters by co-culture of brain capillary endothelial cells with astrocytes. Drug Metabol Pharmacokinet 17 1 34-41 2002/03
  •  Inhibitory effect of supramolecular polyrotaxane-dipeptide conjugates on digested peptide uptake via intestinal human peptide transporter Bioconjug Chem 13 3 582-587 2002/05
  •  Enhanced delivery of drugs to the liver by adenovirus-mediated heterologous expression of the human oligopeptide transporter PEPT1 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 301 3 812-819 2002/06
  •  Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4 GENE 293 1-2 67-75 2002/06
  •  Genetic Polymorphisms of Human Organic Anion Transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): Allele Frequencies in the Japanese Population and Functional... JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 302 2 804-813 2002/08
  •  The Mechanism by which cAMP Activates Phosphoinositide 3-Kinase and Increases Bile Acid Secretion in WIF-B9 Cells AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 283 C1655-1666 2002/08
  •  Studies on functional sites of organic cation/carnitine transporter OCTN2 (SLC22A5) using a Ser467Cys mutant protein JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 302 3 1286-1294 2002/09
  •  PepT1 mRNA expression is induced by stavation and its level correlates with absorptive transport of cefadroxil longitudinally in the rat intestine PHARMACEUTICAL RESEARCH 19 10 1415-1421 2002/10
  •  Delivery of Peptide Drugs to the Brain by Adenovirus-mediated heterologous expression of human oligopeptide transporter at the blood-brain barrier JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 305 1 40-47 2003/04
  •  Expression and functional characterization of the adhesion molecule spermatogenic immunoglobulin superfamily in the mouse testis BIOLOGY OF REPRODUCTION 68 5 1755-1763 2003/05
  •  Active drug delivery by heterologous expression of membrane transporters 123 6 413-422 2003/06
  •  Experimental demonstration of the unstirred water layer effect on drug transport in Caco-2 cells JOURNAL OF PHARMACEUTICAL SCIENCES 92 7 1502-1508 2003/07
  •  Contribution of organic anion transporting polypeptide analogue [D-Ala2, D-Leu5]-enkephalin Nozawa T, Tamai I, Sai Y, Nezu J, Tsuji A J Pharm Pharmacol 55 7 1013-1020 2003/07
  •  Influence of drugs and nutrients on transporter gene expression levels in Caco-2 and LS180 intestinal epithelial cell lines Li Q, Sai Y, Kato Y, Tamai I, Tsuji A Pharm Res 20 8 1119-1124 2003/08
  •  Acetyl-l-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2 Inano A, Sai Y, Nikaido H, Hashimoto N, Asano M, Tsuji A Biopharm Drug Dispos 24 8 357-365 2003/11
  •  Involvement of multiple transport systems in the disposition of an active metabolite of a prodrug-type new quinolone antibiotic, Prulifloxacin Yagi Y, Shibutani S, Hodoshima N, Ishiwata K, Okudaira N, Li Q, Sai Y, Kato Y, Tsuji A Drug Metab Pharmacokinet 18 6 381-389 2003/12
  •  Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations Tamai I, Nakanishi T, Kobayashi D, China K, Kosugi Y, Nezu J, Sai Y, Tsuji A Mol Pharm 1 1 57-66 2004/01
  •  The genetic polymorphism of drug transporters: Functional analysis approaches Ishikawa T, Tsuji A, Inui K, Sai Y, Anzai N, Wada M, Endou H, Sumino Y Pharmacogenomics 5 1 67-99 2004/01
  •  Transporter-mediated renal handling of nafamostat mesilate Li Q, Sai Y, Kato Y, Muraoka H, Tamai I, Tsuji A J Pharm Sci 93 2 262-272 2004/02
  •  Functional regions of organic cation/carnitine transporter OCTN2 (SLC22A5): Roles in carintine recognistion Inano A, Sai Y, Kato Y, Tamai I, Ishiguro M, Tsuji A. Drug Metab Pharmacokinet 19 3 180-189 2004/06
  •  Transporter-mediated drug discovery:-Recent progress and experimental approaches- Sai Y, Tsuji A DRUG DISCOVERY TODAY 9 16 712-719 2004/08
  •  Screening of the interaction between xenobiotic transporters and PDZ proteins Kato Y, Yoshida K, Watanabe C, Sai Y, Tsuji A Pharm Res 21 10 1886-1894 2004/10
  •  Characterization of renal excretion mechanism for a novel diuretic, M71500, in rats Nishimura T, Kato Y, Sai Y, Ogihara T, Tsuji A J Pharm Sci 93 10 2558-2566 2004/10
  •  Functional characterization of human organic cation transporter OCTN1: single nucleotide polymorphisms in the Japanese population Kawasaki Y, Kato Y, Sai Y, Tsuji A J Pharm Sci 93 12 2920-2926 2004/12
  •  PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2 Kato Y, Sai Y, Yoshida K, Watanabe C, Hirata T, Tsuji A MOLECULAR PHARMACOLOGY 67 3 734-743 2005/03
  •  Biochemical and molecular pharmacological aspects of transporters as determinants of drug disposition Yoshimichi Sai Drug Metab Pharmacokinet 20 2 91-99 2005/04
  •  Platelet-derived dgrowth factor-BB (PDGF-BB) induces differentiation of bone marrow endothelial progenitor cell-derived cell line TR-BME2 into mural cells, and changes the phenotype Miyata T, Iizasa H, Sai Y, Fujii J, Terasaki T, Nakashima E J Cell Physiol 204 3 948-955 2005/04
  •  Multidrug resistance associated protein 1 (MRP1) functions as an efflux pump of xenobiotics in the skin Li Q, Kato Y, Sai Y, Tsuji A Pharm Res 22 6 842-846 2005/06
  •  Prediction of theophylline clearance in CCl4-treated rats using in vivo CYP1A2 and CYP3A2 contents assessed with the PKCYP test Kose N, Yamamoto K, Sai Y, Isawa M, Suwa T, Nakashima E Drug Metab Pharmacokinet 20 3 168-176 2005/06
  •  Na+/H+ Exchanger 3 affects transport property of H+/oligopeptide transporter 1 Watanabe C, Kato Y, Ito S, Kubo Y, Sai Y, Tsuji A Drug Metab Pharmacokinet 20 6 443-451 2005/12
  •  Characterization of the transdermal transport of flurbiprofen and indomethacin Li Q, Tsuji H, Kato Y, Sai Y, Kubo Y, Tsuji A J Control Release 110 3 542-556 2006/02
  •  Carrier-mediated hepatic uptake of a novel non-renal excretion type uric acid generation inhibitor, Y-700 Sai Y, Kato Y, Nakamura K, Kato S, Nishimura T, Kubo Y, Tamai I, Yang S, Hu Z, Yamada I, Tsuji A J Pharm Sci 95 2 336-347 2006/02
  •  International comparison of educational systems for OTC drugs in pharmacy schools Tsukiji M, Isawa M, Kose N, Rigod JF, Sai Y, Nakashima E Jpn J Drug Inform 8 1 6-12 2006/05
  •  Involvement of organic anion transporting polypeptide OATP-B (OATP2B1) in apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells Sai Y, Kaneko Y, Ito S, Kato Y, Tamai I, Artursson P, Tsuji A DRUG METABOLISM AND DISPOSITION 34 8 1423-1431 2006/08
  •  Organic cation/carnitine transporter octn2 (slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse Kato Y, Sugiura M, Sugiura T, Wakayama T, Kubo Y, Kobayashi D, Sai Y, Tamai I, Iseki S, Tsuji A MOLECULAR PHARMACOLOGY 70 3 829-837 2006/09
  •  Characterization of the uptake mechanism for a novel loop diuretic, M17055, in Caco-2 cells: involvement of organic anion transporting polypeptide (OATP)-B Nishimura T, Kubo Y, Kato Y, Sai Y, Ogihara T, Tsuji A PHARMACEUTICAL RESEARCH 24 1 90-99 2007/01
  •  Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells Wakayama T, Sai Y, Ito A, Kato Y, Murakami Y, Nakashima E, Tsuji A, Kitamura Y, Iseki S BIOLOGY OF REPRODUCTION 76 1081-1090 2007/02
  •  Hepatocyte growth factor and c-Met expression in pericytes: implications for atherosclerotic plaque development Liu Y, Wilkinson F, Kirton J, Jeziorska M, Iizasa H, Sai Y, Nakashima E, Heagerty A, Canfield A, Alexander M JOURNAL OF PATHOLOGY 212 1 12-19 2007/04
  •  Altered Expression of basement membrane-related molecules in rat brain pericyte, endothelial, and astrocyte cell lines after transforming growth factor-beta1 treatment Kose N, Asashima T, Muta M, Iizasa H, Sai Y, Terasaki T, Nakashima E Drug Metab Pharmacokinet 22 4 255-266 2007/04
  •  Transport of carinitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa Kobayashi D, Tamai I, Sai Y, Yoshida K, Wakayama T, Kido Y, Nezu J, Iseki S, Tsuji A REPRODUCTION 134 5 651-658 2007/11
  •  Study of e-learning for OTC medications as an educational tool for pharmacy students Tsukiji M, Isawa M, Kose N, Rigod J-F, Sai Y, Nakashima E Jpn J Drug Inform 9 3 198-204 2007/12
  •  Potential of various drugs to inhibit nucleoside uptake in rat syncytiotrophoblast cell line, TR-TBT 18d-1 Chishu T, Sai Y, Nishimura T, Sato K, Kose N, Nakashima E PLACENTA 29 5 461-467 2008/05
  •  Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of (beta)-lactam antibiotics Kato Y, Takahara S, Kato S, Kubo Y, Sai Y, Tamai I, Yabuuchi H, Tsuji A DRUG METABOLISM AND DISPOSITION 36 6 1088-1096 2008/06
  •  Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carnitine to the heart Iwata D, Kato Y, Wakayama T, Sai Y, Kubo Y, Iseki S, Tsuji A Drug Metab Pharmacokinet 23 3 207-215 2008/06
  •  Characterization of the mechanism of Zidovudine uptake by rat conditionally immortalized syncytiotrophoblast cell line TR-TBT. Sai Y, Nishimura T, Shimpo S, Chishu T, Sato K, Kose N, Terasaki T, Mukai C, Miyakoshi N, Kang YS, Nakashima E. PHARMACEUTICAL RESEARCH 25 7 1647-1653 2008/07
  •  Enhancement of zidovudine uptake by dehydroepiandrosterone sulfate in rat syncytiotrophoblast cell line TR-TBT 18d-1. Nishimura T, Seki Y, Sato K, Chishu T, Kose N, Terasaki T, Kang YS, Sai Y, Nakashima E. DRUG METABOLISM AND DISPOSITION 36 10 2080-2085 2008/10
  •  Influx mechanism of 2’, 3’-dideoxyinosine (ddI) and uridine at the blood-placenta barrier. Sato K, Sai Y, Nishimura T, Chishu T, Kose N, Nakashima E. PLACENTA 30 3 263-269 2009/03
  •  Expression, localization and binding activity of the ezrin/radixin/moesin proteins in the mouse testis Wakayama T, Nakata H, Kurobo M, Sai Y, Iseki S J Histochem Cytochem 57 4 351-362 2009/04
  •  Effect of low-dose paclitaxel and docetaxel on endothelial progenitor cell Muta M, Yanagawa T, Sai Y, Saji S, Suzuki E, Aruga T, Kuroi K, Matsumoto G, Toi M, Nakashima E Oncology 77 3-4 182-191 2009/09
  •  Surfactants influence the distribution of taxanes in peritoneal dissemination tumor-bearing rats. Kamijo Y, Ito C, Nomura M, Sai Y, Miyamoto KI Cancer Lett 287 2 182-186 2010/01
  •  Differential expression of ezrin and CLP36 in the two layers of syncytiotrophoblast in rats. Higuchi K,Iizasa H,Sai Y,Horieya S,Lee KE,Wada M,Deguchi M,Nishimura T,Wakayama T,Tamura A,Tsukita S,Kose N,Kang YS,Nakashima E Biol Pharm Bull 33 8 1400-6 2010/08
  •  Proton-coupled erythromycin antiport at rat blood-placenta barrier. Sai Y,Nishimura T,Ochi K,Tanaka N,Takagi A,Tomi M,Kose N,Kobayashi Y,Miyakoshi N,Kitagaki S,Mukai C,Nakashima E Drug Metab Dispos 38 9 1576-81 2010/09
  •  Roles of TauT and system A in cytoprotection of rat syncytiotrophoblast cell line exposed to hypertonic stress. Nishimura T,Sai Y,Fujii J,Muta M,Iizasa H,Tomi M,Deureh M,Kose N,Nakashima E PLACENTA 31 11 1003-9 2010/11
  •  Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity. Katsuda H,Yamashita M,Katsura H,Yu J,Waki Y,Nagata N,Sai Y,Miyamoto K Biol Pharm Bull 33 11 1867-71 2010/11
  •  Preventive effects of Salacia reticulata on non-alcoholic fatty liver disease (NAFLD)/ non-alcoholic steatohepatitis (NASH) in monosodium glutamate treated mice. 101. Watanabe M, Shimada T, Iiduka S, Iida N, Kojima K, Ishizaki J, Sai Y, Miyamoto KI, Aburada M J Trad Med 28 2 73-82 2011/05
  •  Salacia reticulata inhibits differentiation of 3T3-L1 adipocytes. Shimada T,Nagai E,Harasawa Y,Watanabe M,Negishi K,Akase T,Sai Y,Miyamoto K,Aburada M J Ethnopharmacol 136 1 67-74 2011/06
  •  Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis. Kurayama R,Ito N,Nishibori Y,Fukuhara D,Akimoto Y,Higashihara E,Ishigaki Y,Sai Y,Miyamoto K,Endou H,Kanai Y,Yan K LABORATORY INVESTIGATION 91 7 992-1006 2011/07
  •  mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome. Ito N,Nishibori Y,Ito Y,Takagi H,Akimoto Y,Kudo A,Asanuma K,Sai Y,Miyamoto KI,Takenaka H,Yan K LABORATORY INVESTIGATION 91 11 1584-1595 2011/08
  •  6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs. Lee NY,Sai Y,Nakashima E,Ohtsuki S,Kang YS JOURNAL OF PHARMACEUTICAL SCIENCES 100 9 3773-82 2011/09
  •  A randomized, quadruple crossover single-blind study on immediate action of chewed and unchewed low-dose acetylsalicylic acid tablets in healthy volunteers. Sai Y,Kusaka A,Imanishi K,Matsumoto M,Takahashi R,Sugimoto N,Sugama J,Anada T,Asakura H,Miyamoto K JOURNAL OF PHARMACEUTICAL SCIENCES 100 9 3884-91 2011/09
  •  Enhancement of zidovudine transfer to molt-4 cells, a human t-cell model, by dehydroepiandrosterone sulfate. Nishimura T,Tanaka J,Tomi M,Seki Y,Kose N,Sai Y,Nakashima E J Pharm Sci 100 9 3959-67 2011/09
  •  Preventive effect of geniposide on metabolic disease status in spontaneously obese type 2 diabetic mice and free fatty acid-treated HepG2 cells. Kojima K,Shimada T,Nagareda Y,Watanabe M,Ishizaki J,Sai Y,Miyamoto K,Aburada M Biol Pharm Bull 34 10 1613-8 2011/10
  •  [Investigation for relation of gustatory and olfactory impairment in patients receiving cancer chemotherapy] Suga Y,Kitade H,Kawagishi A,Takeda K,Haruki K,Ishizaki J,Sai Y,Kasahara K,Arai K,Miyamoto K Gan To Kagaku Ryoho 38 13 2617-21 2011/12
  •  Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation. Kimura K,Yamada T,Matsumoto M,Kido Y,Hosooka T,Asahara S,Matsuda T,Ota T,Watanabe H,Sai Y,Miyamoto K,Kaneko S,Kasuga M,Inoue H DIABETES 61 1 61-73 2012/01
  •  Flavangenol (pine bark extract) and its major component procyanidin B1 enhance fatty acid oxidation in fat-loaded models. Shimada T,Tokuhara D,Tsubata M,Kamiya T,Kamiya-Sameshima M,Nagamine R,Takagaki K,Sai Y,Miyamoto K,Aburada M EUROPEAN JOURNAL OF PHARMACOLOGY 677 1-3 147-53 2012/02
  •  Evaluation of safety in clinical use of generic paclitaxel [NK] for injection. Tsukiyama I,Hotta K,Takeuchi M,Onishi M,Toyama Y,Saito H,Sai Y,Miyamoto K,Hasegawa T Jpn J Cancer Chemother 39 4 613-7 2012/04
  •  Elimination of teicoplanin by adsorption to the filter membrane during haemodiafiltration: screening experiments for linezolid, teicoplanin and vancomycin followed by in vitro haemodiafiltration models for teicoplanin. Shiraishi Y,Okajima M,Sai Y,Miyamoto K,Inaba H Anaesth Intensive Care 40 3 442-9 2012/05
  •  Disposition kinetics of taxanes in peritoneal dissemination. Miyamoto K,Shimada T,Sawamoto K,Sai Y,Yonemura Y Gastroenterol Res Pract 2012 963403 2012/05
  •  CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. Kitade H,Sawamoto K,Nagashimada M,Inoue H,Yamamoto Y,Sai Y,Takamura T,Yamamoto H,Miyamoto K,Ginsberg HN,Mukaida N,Kaneko S,Ota T DIABETES 61 7 1680-90 2012/07
  •  Change in pharmacokinetics of mycophenolic acid as a function of age in rats and effect of coadministered amoxicillin/clavulanate. Ishizaki J,Tsuda T,Suga Y,Ito S,Arai K,Sai Y,Miyamoto K Biol Pharm Bull 35 7 1009-13 2012/07
  •  Pharmacist-based Donepezil Outpatient Consultation Service to improve medication persistence. Watanabe N,Yamamura K,Suzuki Y,Umegaki H,Shigeno K,Matsushita R,Sai Y,Miyamoto K,Yamada K Patient Prefer Adherence 6 605-611 2012/08
  •  Puerariae flos alleviates metabolic diseases in Western diet-loaded, spontaneously obese type 2 diabetic model mice Kubo K, Shimada T, Onishi R, Tsubata M, Kamiya T, Nagamine R, Iizuka S, Sai Y, Amagaya S, Aburada M, Miyamoto KI J Nat Med 66 4 622-630 2012/10
  •  Pharmacokinetic analysis for proper use of drugs in obese, enteral nutrition and other patients 121 4 167-171 2012/12
  •  Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy. Kitano A,Shimasaki T,Chikano Y,Nakada M,Hirose M,Higashi T,Ishigaki Y,Endo Y,Takino T,Sato H,Sai Y,Miyamoto K,Motoo Y,Kawakami K,Minamoto T PLoS One 8 2 e55289 2013/02
  •  Influence of long-term enteral nutrition on pharmacokinetics of digoxin in rats. Higashi K,Tanaka C,Imanishi K,Sawamoto K,Horikawa T,Ohkawa H,Matsushita R,Sai Y,Miyamoto K Drug Metab Pharmacokinet 28 1 44-52 2013/02
  •  Integrin α3 is overexpressed in glioma stem-like cells and promotes invasion. Nakada M,Nambu E,Furuyama N,Yoshida Y,Takino T,Hayashi Y,Sato H,Sai Y,Tsuji T,Miyamoto KI,Hirao A,Hamada JI BRITISH JOURNAL OF CANCER 108 12 2516-24 2013/06
  •  Mechanism of nucleoside uptake in rat placenta and induction of placental CNT2 in experimental diabetes. Nishimura T,Chishu T,Tomi M,Nakamura R,Sato K,Kose N,Sai Y,Nakashima E Drug Metab Pharmacokinet 27 4 439-46 2013/08
  •  Evaluation of rat in vivo fetal-to-maternal transfer clearances of various xenobiotics by umbilical perfusion. Nishimura T,Takanohashi T,Tomi M,Horikoshi M,Higuchi K,Sai Y,Nakashima E JOURNAL OF PHARMACEUTICAL SCIENCES 102 9 3356-63 2013/09
  •  Estrogen receptor α induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells. Oda K,Nishimura T,Higuchi K,Ishido N,Ochi K,Iizasa H,Sai Y,Tomi M,Nakashima E JOURNAL OF PHARMACEUTICAL SCIENCES 102 9 3364-72 2013/09
  •  Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin. Nakamichi N,Shima H,Asano S,Ishimoto T,Sugiura T,Matsubara K,Kusuhara H,Sugiyama Y,Sai Y,Miyamoto K,Tsuji A,Kato Y JOURNAL OF PHARMACEUTICAL SCIENCES 102 9 3407-17 2013/09
  •  Hepatic arterial infusion chemotherapy with gemcitabine and 5‑fluorouracil or oral S‑1 improves the prognosis of patients with postoperative liver metastases from pancreatic cancer Hidehiro Tajima, Hirohisa Kitagawa, Tomoya Tsukada, Koichi Okamoto, Shin‑Ichi Nakanuma, Seisho Sakai, Isamu Makino, Hiroyuki Furukawa, Hironori Hayashi, Katsunobu Oyama, Masafumi Inokuchi, Hisatoshi Nakagawara, Tomoharu Miyashita, Hiroshi Itoh, Hideto Fujita, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Takashi Fujimura, Tetsuo Ohta, Wataru Koda, Tetsuya Minami, Yasuji Ryu, Junichiro Sanada, Toshifumi Gabata, Osamu Matsui, Yoshimichi Sai Mol Clin Oncol 1 5 869-874 2013/09
  •  Ligand-dependent EphB1 signaling suppresses glioma invasion and correlates with patient survival. Teng L, Nakada M, Furuyama N, Sabit H, Furuta T, Hayashi Y, Takino T, Dong Y, Sato H, Sai Y, Miyamoto KI, Berens ME, Zhao SG, Hamada JI. Neuro Oncol 2013/11
  •  Hepatic arterial infusion chemotherapy with gemcitabine for patients with postoperative liver metastases from pancreatic cancer Tajima H, Kitagawa H, Shoji M, Okamoto K, Nakanuma S, Sakai S, Kinoshita J, Makino I, Hayashi H, Nakamura K, Oyama K, Nakagawara H, Miyashita T, Takamura H, Ohta T, Minami T, Koda W, Sanada J, Gabata T, Sai Y. 40 12 1668-1671 2013/11
  •  Enantioselective disposition of clenbuterol in rats. Hirosawa I, Ishikawa M, Ogino M, Ito H, Hirano T, Yamada H, Asahi M, Kotaki H, Sai Y, Miyamoto KI. Biopharm Drug Dispos 35 4 207-217 2014/04
  •  Basic fibroblast growth factor is essential to maintain endothelial progenitor cell phenotype in TR-BME2 cells Sai Y, Nishimura T, Muta M, Iizasa H, Miyata T, Nakashima E. Biol Pharm Bull 37 4 688-693 2014/04
  •  System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts. Nishimura T, Yagi R, Usuda M, Oda K, Yamazaki M, Suda S, Okazaki F, Sai Y, Higuchi K, Maruyama T, Tomi M, Nakashima E. Biochim Biophys Acta (Biomembrane) 1838 5 1306-1312 2014/05
  •  Mechanisms of lower maintenance dose of tacrolimus in obese patients. Sawamoto K, Huong TT, Sugimoto N, Mizutani Y, Sai Y, Miyamoto KI. Drug Metab Phrmacokinet 29 4 341-347 2014/08
  •  Fetal growth retardation and lack of hypotaurine in ezrin knockout mice. Nishimura T, Higuchi K, Sai Y, Sugita Y, Yoshida Y, Tomi M, Wada M, Wakayama T, Tamura A, Tsukita S, Soga T, Nakashima E. PLoS ONE 21 9 e105423 2014/08
  •  Pharmacokinetics of docetaxel during hyperthermic intraperitoneal chemotherapy for peritoneal metastasis Yonemura Y, Canbay E, Sako S, Ishibashi H, Hirano M, Mizumoto A, Takeshita K, Takao N, Ichinose M, Liu Y, Li Y, Ikeda S, Noguchi A, Sai Y. Jpn J Cancer Chemother 41 12 2496-2499 2014/11
  •  Long-term follow-up of post hematopoietic stem cell transplantation for Hurler syndrome: clinical, biochemical, and pathological improvements Yasuda E, Mackenzie W, Ruhnke K, Shimada T, Mason RW, Zustin J, Martin PL, Thacker M, Orii T, Sai Y, Tomatsu S. Mol Genet Metab Rep 2 65-76 2015/03/02
  •  Saturable hepatic extraction of gemcitabine involves biphasic uptake mediated by nucleoside transporters equilibrative nucleoside transporter 1 and 2. Shimada T, Nakanishi T, Tajima H, Yamazaki M, Yokono R, Takabayashi M, Shimada T, Sawamoto K, Miyamoto K, Kitagawa H, Ohta T, Tamai I, Sai Y. J Pharm Sci 104 9 3162-3169 2015/06/02
  •  Effect of switching basal insulin regimen to degludec on quality of life in Japanese patients with type 1 and type 2 diabetes mellitus Okada Mo, Okada Ma, Nishigami J, Yamaaki N, Furukawa K, Ohyama K, Shimada T, Sai Y. J Pharm Health Care Sci 1 26 2015/09/30
  •  PK/PD analysis of biapenem in patients undergoing continuous hemodiafiltration Akashita G, Hosaka Y, Noda T, Isoda K, Shimada T, Sawamoto K, Miyamoto K, Taniguchi T, Sai Y. J Pharm Health Care Sci 1 31 2015/11/14
  •  Oxytocin for male subjects with autism spectrum disorder and comorbid intellectual disabilities: A randomized pilot study  Toshio Munesue, Hiroyuki Nakamura, Mitsuru Kikuchi, Yui Miura, Noriyuki Takeuchi, Tokie Anme, Eiji Nanba, Kaori Adachi, Kiyotaka Tsubouchi, Yoshimichi Sai, Kenichi Miyamoto, Shinichi Horike, Shigeru Yokoyama, Hideo Nakatani, Hirotaka Kosaka, Yoshio Minabe, Haruhiro Higashida Frontiers Psyc 7 2 2016/01/21
  •  Co-administration of dexamethasone increases severity and accelerates onset day of neutropenia in bladder cancer patients on methotrexate, vinblastine, adriamycin and cisplatin chemotherapy: a retrospective cohort study Shingo Itai, Yukio Suga, Yusuke Hara, Kouji Izumi, Yuji Maeda, Yasuhide Kitagawa, Junko Ishizaki, Tsutomu Shimada, Atsushi Mizokami and Yoshimichi Sai J Pharm Health Care Sci  3 3 1-6 2017/01/11
  •  Drug interaction between methotrexate and salazosulfapyridine in Japanese patients with rheumatoid arthritis  Morihiro Okada, Hiroshi Fujii, Yukio Suga, Satoshi Morito, Masae Okada, Jun Nishigami, Mitsuhiro Kawano, Tsutomu Shimada, Yoshimichi Sai J Pharm Health Care Sci 3 7 1-7 2017/01/19
  •  Multiple Oral Dosing Pharmacokinetics of Standardized Extract of Centella asiatica ECa 233 and Its Inductive Effect on Efflux Transporters in Rat Tosapol Anukunwithaya, Mayuree H. Tantisira, Tsutomu Shimada, Yoshimichi Sai, Phisit Khemawoot Planta Medica International Open 4 e66-e73 2017/10/11
  •  Contribution of equilibrative nucleoside transporters 1 and 2 to gemcitabine uptake in pancreatic cancer cells. Hioki M, Shimada T, Yuan T, Nakanishi T, Tajima H, Yamazaki M, Yokono R, Takabayashi M, Sawamoto K, Akashita G, Miyamoto KI, Ohta T, Tamai I, Shimada T, Sai Y. Biopharm Drug Dispos 39 256-264 2018/04/22
  •  Incidence and risk factors of cholinergic syndromes induced by FOLFILINOX in advanced pancreatic adenocarcinoma Tomoyo Ito, Junya Nakade, Tsutomu Shimada Yoshimichi Sai Japanese Journal of Pharmaceutcal Healthcare and Sciences 44 8 403-409 2018/08
  •  Risk factors for oxaliplatin-induced vascular pain in patients with colorectal cancer and comparison of the efficacy of preventive methods. Yukio Suga, Nana Ikeda, Manami Maeda, Angelina Yukiko Staub, Tsutomu Shimada, Miwa Yonezawa, Hironori Kitade, Hideyuki Katsura, Morihiro Okada, Junko Ishizaki, Yoshimichi Sai and Ryo Matsushita J Pharm Health Care Sci 4 18 1-7 2018/08/07
  •  Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies. Satsuki Hashimoto, Kyoko Honda, Kouhei Fujita, Yuka Miyachi, Kazuya Isoda1, Ko Misaka, Yukio Suga, Satoshi Kato, Hiroyuki Tsuchiya, Yukio Kato, Masaki Okajima, Takumi Taniguchi, Tsutomu Shimada, Yoshimichi Sai J Pharm Health Care Sci 4 27 1-9 2018/11/12
  •  Multiday corticosteroids in cancer chemotherapy delay the diagnosis of and antimicrobial administration for febrile neutropenia: a double-center retrospective study. Hiroki Uda, Yukio Suga, Eriko Toriba, Angelina Yukiko Staub, Tsutomu Shimada, Yoshimichi Sai, Masami Kawahara, Ryo Matsushita J Pharm Health Care Sci 5 3 1-8 2019/02/04
  •  Risk Factors for Peripheral Neuropathy Induced by Albumin-bound Paclitaxel Plus Gemcitabine Therapy in Pancreatic Cancer Patients N Yamamoto, Y Hori, R Takahiro, Y Suga, T Shimada, Y Sai Japanese Journal of Pharmaceutical Health Care and Sciences 45 3 127-134 2019/03
  •  Palonosetron on Days 1 and 5 Versus Granisetron Daily (Days 1-5) in Germ Cell Tumour Therapy. Shimura Y, Izumi K, Itai S, Iwamoto H, Yaegashi H, Suga Y, Shimada T, Mizokami A, Sai Y. In Vivo 33 2 643-647 2019/04
  •  Incidence and risk factors of neonatal hypoglycemia after ritodrine therapy in premature labor: a retrospective cohort study. Shoko Shimokawa*, Akiko Sakata*, Yukio Suga, Kazuya Isoda, Shingo Itai, Katsuhiko Nagase, Tsutomu Shimada, Yoshimichi Sai J Pharm Health Care Sci 5 7 1-7 2019/04/16
  •  Improvement of informed consent document management in clinical trials using an electronic medical record system. Takahiro Kawakami, Katsuhiko Nagase, Yuko Yokoi, Yoshimichi Sai, Toshinori Murayama Jpn J Clin Pharmacol Ther 50 3 81-86 2019/05
  •  Detailed assessment and risk factor analysis of corticosteroid-induced psychiatric disorders in pediatric, adolescent, and young adult patients undergoing induction or consolidation therapy for hematologic malignancy. Yukiko Staub, Yukio Suga, Yasuhiro Ikawa, Kiyotaka Tsubouchi, Mikie Hashimoto, Atsufumi Kawagishi, Tsutomu Shimada, Yoshimichi Sai, Katsuji Nishimura, Ryo Matsushita. J Oncol Pharm Pract 1-11 2019/10/21
  •  A previously unknown drug-drug interaction is suspected in delayed elimination of plasma methotrexate in high-dose methotrexate therapy. Ishizaki J, Nakano C, Kitagawa K, Suga Y, Sai Y Ann Pharmacother 54 1 29-35 2020/01
  •  Examination of Aggregate Formation upon Simultaneous Dissolution of Methacrylic Acid Copolymer LD Enteric Coating Agent, Pharmaceutical Additives, and Zwitterionic Ingredients. Nakagawa Y, Suzuki T, Suga Y, Shimada T, Sai Y. Biol Pharm Bull 43 4 682-687 2020/04
  •  Initial serum C-reactive protein level as a predictor of increasing serum vancomycin concentration during treatment Kazuya Isoda, Junya Nakade; Yukio Suga; Tsutomu Shimada; Yoshimichi Sai, Suga Y, Shimada T, Sai Y. TDM 43 5 652-656 2021/10
  •  Association of a continuous continence self-management program with independence in voiding behavior among stroke patients: a retrospective cohort study Miho Shogenji, Mikako Yoshida, Koyomi Sumiya, Tsutomu Shimada, Yasunori Ikenaga, Yoru Ogawa, Kohei Hirako, Yoshimichi Sai Neurourol Urodyn 41 4 2022/03/30
  •  Limited impact of murine placental MDR1 on fetal exposure of certain drugs explained by bypass transfer between adjacent syncytiotrophoblast layers. Arimi Fujita, Saki Noguchi, Rika Hamada, Satoko Inoue, Tsutomu Shimada, Satomi Katakura, Tetsuo Maruyama, Yoshimichi Sai, Tomohiro Nishimura, Masatoshi Tomi. Pharm Res 2022/01/03
  •  Risk factors for interstitial lung disease induced by gemcitabine plus albumin-bound paclitaxel therapy in pancreatic ductal adenocarcinoma patients Rikako Ueda, Naho Yamamoto, Yuki Hori, Kouji Yoshida, Koushiro Ohtsubo, Takeshi Terashima, Tsutomu Shimada, Yoshimichi Sai. J Pharm Health Care Sci 8 1 1-8 2022/02/02
  •  Oxytocin-Trust Link in Oxytocin-Sensitive Participants and Those without Autistic Traits  Yusuke Kinari, Hirofumi Kurokawa, Hiroko Okudaira, Kiyotaka Tsubouchi, Yoshimichi Sai, Mitsuru Kikuchi, Haruhiro Higashida, Fumio Ohtake Frontiers in Neuroscience 15 659737 1-13 2021/05/25
  •  Administration of erlotinib in apple juice overcomes decreased absorption in a rat model of gastric acid suppression Shimada T, Okano M, Yamada M, Ogawa Y, Ueda A, Nagase K, Sai Y. Drug Metab Pharmacokinet 35 6 534-538 2020/12
  •  Risk Factors for Delayed Elimination of Methotrexate in Children, Adolescents and Young Adults With Osteosarcoma Misaka KO, Suga Y, Staub Y, Tsubata A, Shimada T, Sai Y, Matsushita R. In Vivo 34 6 3459-3465 2020/11
  •  Comparison of Tolerability Between 2-Weekly and 3-Weekly Docetaxel Regimen in Castration-resistant Prostate Cancer Shimura Y, Suga Y, Itai S, Iwamoto H, Takezawa Y, Yaegashi H, Izumi K, Shimada T, Sai Y, Matsushita R, Mizokami A. Anticancer Res 40 8 4291-4297 2020/08
  •  Competitiveness and individual characteristics: a double-blind placebo-controlled study using oxytocin. Kurokawa H, Kinari Y, Okudaira H, Tsubouchi K, Sai Y, Kikuchi M, Higashida H, Ohtake F. Sci Rep 10 1 11526 2020/07/13

Conference Presentations

  • Recent Review of Cardiotoxicity of Target Therapies and Anticancer Drugs(conference:The 81st Annual Scientific Meeting of the Japanese Circulation Society 2017)(2017/03/18)
  • (2017.6.9、) (2017/06/09)
  • A longitudinal survey on urinary independence and prescription trends in post-stroke patients(conference:ACCP 2022, The 21st Asian Conference on Clinical Pharmacy)(2022/02/11)
  • Long-term administration of Elental® affects the pharmacokinetic parameters of oral tacrolimus in rats(conference:ACCP 2022, The 21st Asian Conference on Clinical Pharmacy)(2022/02/11)
  • Effect of soluble dietary fiber on decreased digoxin blood concentration in patients with long term semi-digested nutrition(2017/11/29)

show all

  • Pharmacokinetic analysis of intravenous administrerd fentanyl in adjuvant induced arthritis rat(2017/11/29)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

○Development of Drug Screening Format for Transporters
○Active Delivery of Drugs by in vivo Heterologous Expression of Transporters
○Development of Transporter-Aided Artificial Organs

Grant-in-Aid for Scientific Research

○「共焦点レーザー顕微鏡を用いたペプチドの細胞内動態解析と脳実質細胞標的化への応用」(1995-1995) 
○「外来性遺伝子発現系を用いた小腸上皮薬物担体輸送機構の解明」(1995-1995) 
○「ダイナミックインターフェースとしての血液脳関門機能と薬物脳移行相関」(1995-1996) 
○「小腸オリゴペプチド輸送体の組織及び細胞内分布の免疫化学的解析と薬物輸送特性」(1996-1996) 
○「モノカルボン酸系の組織特異的機能発現とドラックデリバリーへの応用」(1996-1996) 
○「小腸モノカルボン酸輸送体の組織及び細胞内分布の免疫化学的解析と薬物輸送の分子機構」(1997-1998) 
○「血液脳関門トランスポーターの分子機構と薬物の脳移行制御」(1997-1998) 
○「トランスポーター発現アデノウイルスベクターを用いたペプチド様抗がん剤の脳腫瘍送達」(2000-2000) 
○「ペプチドトランスポーターを利用した腫瘍特異的抗がん剤デリバリー」(2000-2001) 
○「ペプチド輸送系の組織特異的発現と分子認識多様性を利用した腫瘍選択的薬物デリバリー」(2000-2001) 
○「血液脳関門の機能的実態解明に基づいた薬物中枢移行性評価法の確立」(2000-2001) 
○「薬物トランスポーター群の分子認識・輸送の多様性に基づいた臓器移行性の制御」(2000-2002) 
○「BBB指向性トランスポーター発現アデノウイルスベクターを用いた抗がん剤脳腫瘍送達」(2001-2001) 
○「薬物トランスポーター群のMultispecificity発現機構に関する研究」(2001-2002) 
○「アンチセンス発現アデノウイルスを用いたトランスポーターの薬物体内動態制御機能評価」(2002-2003) 
○「薬物輸送トランスポーターの迅速同定システムの構築とその寄与の推定」(2004-2005) 
○「脳血管内皮細胞、周皮細胞、星状細胞が関わる血液能関門における基底膜維持機構の解明」(2004-2005) 
○「トランスポーター活性アレイを用いた胎盤関門異物認識の全容解明」(2006-2007) 
○「胎盤関門のダイナミクスを制御するトランスポーター-エズリン複合体」(2008-2010) 
○「副作用マネジメントと毒性回避のための臨床薬物動態研究」(2011-2014) 
○「腹膜偽粘液腫の本邦における発生頻度・病態の解明・治療法の開発」(2013-2013) 
○「肥満時の薬物動態変動による医薬品副作用の回避戦略」(2015-2018) 
○「careとcureを融合した看護薬剤学モデルの開発」(2017-2021) 
○「加齢による薬物体内動態の個人間変動予測の新機軸」(2019-2022) 

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Seminar in Pharmacy 3(2021)
○Seminar in Pharmacy 2(2021)
○Graduation Research in Pharmacy 3(2021)
○Graduation Research in Pharmacy 2(2021)
○Clinical Pharmacology(2021)
○Clinical Pharmacy Practice(2021)
○Pharmacy Practice 3(2021)
○Pharmacy Practice 2(2021)
○Pharmacy Practice 1(2021)
○Safety Management for Drug Therapy(2021)
○Basic and Clinical Pharmacology(2021)
○Seminar in Pharmacy 3(2020)
○Seminar in Pharmacy 2(2020)
○Graduation Research in Pharmacy 3(2020)
○Graduation Research in Pharmacy 2(2020)
○Pharmacy Practice 4(2020)
○Pharmacy Practice 3(2020)
○Pharmacy Practice 1(2020)
○Clinical Pharmacy Practice(2020)
○Clinical Pharmacology(2020)
○Pharmacy Practice 2(2020)
○Safety Management for Drug Therapy(2020)
○Basic and Clinical Pharmacology(2020)
○Clinical Pharmacology(2019)
○Clinical Pharmacy Practice(2019)
○Hospital Pharmacy Practice 1(2019)
○Pharmacy Practice 2(2019)
○Safety Management for Drug Therapy(2019)
○Basic and Clinical Pharmacology(2019)
○Basic and Clinical Pharmacology(2017)
○Hospital Pharmacy Practice 2(2017)
○Community Pharmacy(2017)
○Hospital Pharmacy Practice 1(2017)
○Pharmacology(BSL)(2017)
○Safety Management for Drug Therapy(2017)
○Safety Management for Drug Therapy(2016)
○Basic and Clinical Pharmacology(2016)
○Pharmacology(BSL)(2016)
○Hospital Pharmacy Practice 1(2016)
○Hospital Pharmacy Practice 2(2016)
○Management of Community Pharmacy(2016)

Classes (Graduate Schools)

○Medicinal Informatics(2021)
○Basic Training on Medical Researches(2021)
○Molecular Mechanisms of Drug Response(2021)
○Medicinal Informatics(2021)
○Medicinal Informatics(2020)
○Medicinal Informatics(2020)
○Medicinal Informatics(2020)
○Intensive Lectures on Medical Researches(2020)
○Basic Training on Medical Researches(2020)
○Medicinal Informatics(2019)
○Medicinal Informatics(2019)
○Hospital Pharmacy Practice 1(2017)
○Molecular Mechanisms of Drug Response(2017)
○Medicinal Informatics(2017)
○Medicinal Informatics(2017)
○Medicinal Informatics(2017)
○Molecular Mechanisms of Drug Response(2016)
○Medicinal Informatics(2016)
○Medicinal Informatics(2016)
○Medicinal Informatics(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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