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Researcher Information

last modified:2018/04/02

Associate Professor KAWANO Mitsuhiro


Faculty, Affiliation

University Hospital

College and School Educational Field

Division of Cardiovascular Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences


Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine TEL:076-265-2253 FAX:076-234-4251

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 198703


Kanazawa Social Insurance Hospital Department of Internal Medicine(1993/04/01-2003/04/30)

Year & Month of Birth


Academic Society

Japan College of Rheumatology
Japanese Society of Sjogren's syndrome
Japanese Society of Nephrology
Japanese Society of Internal Medicine
Japanese Society for Dialysis Therapy



Collagenous pathology/Allergology

Speciality Keywords

rheumatoid arthritis, Sjogren syndrome, immunology, renal transplantation, infection

Research Themes

IgG4-related disease and tuberculosis

IgG4-related disease can be considered to be a sort of allergy disease, and tuberculosis bacteria are considered to be a triggering antigen. I examine whether Th2 and Treg are excessively stimulated when peripheral blood lymphocytes are stimulated by the tuberculosis-specific antigens ESAT-6 and CFP-10.

infectious agent associated with rheumatoid arthritis

Immunological analysis of Sjogren\'s syndrome


  •  Takao Saito, John H. Stone, Hitoshi Nakashima, Takako Saeki, Mitsuhiro Kawano IgG4-related kidney disease Springer 2016/12/28
  •  Hisanori Umehara, Kazuichi Okazaki, John H. Stone, Shigeyuki Kawa, Mitsuhiro Kawano IgG4-related disease Springer 2013/11


  •  Elevated serum levels of soluble membrane cofactor protein (CD46, MCP) in patients with systemic lupus erythematosus (SLE). CLINICAL AND EXPERIMENTAL IMMUNOLOGY 116 6 542-546 1999/06
  •  Clinical and laboratory features of anticentromere antibody positive primary Sjogren\'s syndrome. JOURNAL OF RHEUMATOLOGY 28 10 2238-2244 2001/10
  •  Diminished expression of CD59 on activated CD8+ T cells undergoing apoptosis in systemic lupus erythematosus and Sjogren\'s syndrome. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 51 3 293-299 2000/03
  •  Simultaneous clonally identical T cell expansion in tonsil and synovium in a patient with rheumatoid arthritis and chronic tonsillitis. ARTHRITIS AND RHEUMATISM 48 9 in press 2003/09
  •  IgG4-related kidney disease - an update. Kawano M, Saeki T. Curr Opin Nephrol Hypertens. 24 2 193-201 2015/03

show all

  •  Henoch-Schönlein purpura nephritis in a patient with IgG4-related disease: A possible association. Ito K, Yamada K, Mizushima I, Aizu M, Fujii H, Mizutomi K, Matsumura M, Hayashi K, Yamagish M, Umehara H, Yamaguchi Y, Nagata M, Kawano M.  CLINICAL NEPHROLOGY 79 3 246-52 2013/03
  •  Investigations of IgG4-related disease involving the skin. Yamada K, Hamaguchi Y, Saeki T, Yagi K, Ito N, Kakuchi Y, Yamagishi M, Takehara K, Nakanuma Y, Kawano M.  Mod Rheumatol. 2012/11
  •  Etanercept-induced lupus accompanied by hemophagocytic syndrome. Araki D, Fujii H, Matsumura M, Yamagishi M, Yachie A, Kawano M.  INTERNAL MEDICINE 50 17 1843-8 2011/06
  •  A case of adult-onset Still's disease (AOSD)-like manifestations abruptly developing during confirmation of a diagnosis of metastatic papillary thyroid carcinoma. Inoue R, Kato T, Kim F, Mizushima I, Murata T, Yoshino H, Kawano M, Yamagishi M. Mod Rheumatol. 22 5 796-800 2012/09
  •  Nifedipine-induced gingival hypertrophy. Matsumura M, Suzuki Y, Yamagishi M, Kawano M.  INTERNAL MEDICINE 51 1 121 2012/09
  •  Clinical and histological changes associated with corticosteroid therapy in IgG4-related tubulointerstitial nephritis. Mizushima I, Yamada K, Fujii H, Inoue D, Umehara H, Yamagishi M, Yamaguchi Y, Nagata M, Matsumura M, Kawano M. Mod Rheumatol. 22 6 859-70 2012/11
  •  Light-microscopic characteristics of IgG4-related tubulointerstitial nephritis: distinction from non-IgG4-related tubulointerstitial nephritis.  Yoshita K, Kawano M, Mizushima I, Hara S, Ito Y, Imai N, Ueno M, Nishi S, Nomura H, Narita I, Saeki T. NEPHROLOGY DIALYSIS TRANSPLANTATION 27 7 2755-61 2012/07
  •  Characteristic tubulointerstitial nephritis in IgG4-related disease.  Yamaguchi Y, Kanetsuna Y, Honda K, Yamanaka N, Kawano M, Nagata M HUMAN PATHOLOGY 43 4 536-49 2012/04
  •  Clinical Aspects of IgG4-Related Orbital Inflammation in a Case Series of Ocular Adnexal Lymphoproliferative Disorders.  Takahira M, Ozawa Y, Kawano M, Zen Y, Hamaoka S, Yamada K, Sugiyama K. Int J Rheumatol 635473 2012/06
  •  Transient impairment of NK cell function in an infant born to a mother with adult-onset Still's disease: perinatal effect of maternal IL-18. Shimizu M, Sakakibara Y, Kawano M, Yachie A. CLINICAL IMMUNOLOGY 143 3 273-4 2012/06
  •  A case of refractory cutaneous polyarteritis nodosa in a patient with hepatitis B carrier status successfully treated with tumor necrosis factor alpha blockade.  Zoshima T, Matsumura M, Suzuki Y, Kakuchi Y, Mizushima I, Fujii H, Yamada K, Yamagishi M, Kawano M.  Mod Rheumatol. 2012/09
  •  The clinical course of patients with IgG4-related kidney disease.  Saeki T, Kawano M, Mizushima I, Yamamoto M, Wada Y, Nakashima H, Homma N, Tsubata Y, Takahashi H, Ito T, Yamazaki H, Saito T, Narita I. KIDNEY INTERNATIONAL 2013/05
  •  IgG4-related kidney disease. Saeki T, Kawano M. Kidney Int.  85 2 251-257 2014/02
  •  A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details.  Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Sumida T, Mimori T, Tanaka Y, Tsubota K, Yoshino T, Kawa S, Suzuki R, Takegami T, Tomosugi N, Kurose N, Ishigaki Y, Azumi A, Kojima M, Nakamura S, Inoue D; Research Program for Intractable Disease by Ministry of Health, Labor and Welfare (MHLW) Japan G4 team. Mod Rheumatol. 22 1 1-14 2012/02
  •  Warthin's tumor associated with IgG4-related disease.  Aga M, Kondo S, Yamada K, Sawada-Kitamura S, Yagi-Nakanishi S, Endo K, Wakisaka N, Murono S, Kawano M, Yoshizaki T.  Auris Nasus Larynx 40 5 514-7 2013/05
  •  Immunohistochemical Characteristics of IgG4-Related Tubulointerstitial Nephritis: Detailed Analysis of 20 Japanese Cases.  Kawano M, Mizushima I, Yamaguchi Y, Imai N, Nakashima H, Nishi S, Hisano S, Yamanaka N, Yamamoto M, Takahashi H, Umehara H, Saito T, Saeki T.  Int J Rheumatol 609795 2012/06
  •  Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations. Stone JH, Khosroshahi A, Deshpande V, Chan JK, Heathcote JG, Aalberse R, Azumi A, Bloch DB, Brugge WR, Carruthers MN, Cheuk W, Cornell L, Castillo CF, Ferry JA, Forcione D, Klöppel G, Hamilos DL, Kamisawa T, Kasashima S, Kawa S, Kawano M, Masaki Y, Notohara K, Okazaki K, Ryu JK, Saeki T, Sahani D, Sato Y, Smyrk T, Stone JR, Takahira M, Umehara H, Webster G, Yamamoto M, Yi E, Yoshino T, Zamboni G, Zen Y, Chari S.  ARTHRITIS AND RHEUMATISM 64 10 3061-7 2012/10
  •  Consensus statement on the pathology of IgG4-related disease.  Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, Klöppel G, Heathcote JG, Khosroshahi A, Ferry JA, Aalberse RC, Bloch DB, Brugge WR, Bateman AC, Carruthers MN, Chari ST, Cheuk W, Cornell LD, Fernandez-Del Castillo C, Forcione DG, Hamilos DL, Kamisawa T, Kasashima S, Kawa S, Kawano M, Lauwers GY, Masaki Y, Nakanuma Y, Notohara K, Okazaki K, Ryu JK, Saeki T, Sahani DV, Smyrk TC, Stone JR, Takahira M, Webster GJ, Yamamoto M, Zamboni G, Umehara H, Stone JH.  MODERN PATHOLOGY 25 9 1181-92 2012/09
  •  Cutoff Values of Serum IgG4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease. Masaki Y, Kurose N, Yamamoto M, Takahashi H, Saeki T, Azumi A, Nakada S, Matsui S, Origuchi T, Nishiyama S, Yamada K, Kawano M, Hirabayashi A, Fujikawa K, Sugiura T, Horikoshi M, Umeda N, Minato H, Nakamura T, Iwao H, Nakajima A, Miki M, Sakai T, Sawaki T, Kawanami T, Fujita Y, Tanaka M, Fukushima T, Eguchi K, Sugai S, Umehara H. Int J Rheumatol 580814 2012/06
  •  Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011.  Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Yoshino T, Nakamura S, Kawa S, Hamano H, Kamisawa T, Shimosegawa T, Shimatsu A, Nakamura S, Ito T, Notohara K, Sumida T, Tanaka Y, Mimori T, Chiba T, Mishima M, Hibi T, Tsubouchi H, Inui K, Ohara H. Mod Rheumatol. 22 1 21-30 2012/02
  •  Ablation of the Ccr2 gene exacerbates polyarthritis in interleukin-1 receptor antagonist–deficient mice.  Fujii H, Baba T, Ishida Y, Kondo T, Yamagishi M, Kawano M, Mukaida N.  ARTHRITIS AND RHEUMATISM 63 1 96-106 2011/01
  •   Sudden death of a young male with previously undiagnosed autosomal dominant polycystic kidney disease (ADPKD).  Zuka M, Onoe T, Kawano M, Yamagishi M, Ohshima T. Leg Med (Tokyo) 13 1 35-38 2011/01
  •  IgG4-related tubulointerstitial nephritis and hepatic inflammatory pseudotumor without hypocomplementemia. Kim F, Yamada K, Inoue D, Nakajima K, Mizushima I, Kakuchi Y, Fujii H, Narumi K, Matsumura M, Umehara H, Yamagishi M, Kawano M. INTERNAL MEDICINE 50 11 1239-44 2011/06
  •  A case of sarcoidosis developing as sarcoid myopathy concomitant with systemic sclerosis and review of the literature. Ogane K, Kato T, Mizushima I, Kawano M, Yamagishi M. Mod Rheumatol. 22 1 142-6 2012/02
  •  Proposal for a new clinical entity, IgG4-positive multi-organ lymphoproliferative syndrome: Analysis of 64 cases of IgG4-related disorders. Masaki Y, Dong L, Kurose N, Kitagawa K, Morikawa Y, Yamamoto M, Takahashi H, Shinomura Y, Imai K, Saeki T, Azumi A, Nakada S, Sugiyama E, Matsui S, Origuchi T, Nishiyama S, Nishimori I, Nojima T, Yamada K, Kawano M, Zen Y, Kaneko M, Miyazaki K, Tsubota K, Eguchi K, Tomoda K, Sawaki T, Kawanami T, Tanaka M, Fukushima T, Sugai S, Umehara H.  ANNALS OF THE RHEUMATIC DISEASES 68 8 1310-5 2009/08
  •  Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis. Saeki T, Nishi S, Imai N, Ito T, Yamazaki H, Kawano M, Yamamoto M, Takahashi H, Matsui S, Nakada S, Origuchi T, Hirabayashi A, Homma N, Tsubata Y, Takata T, Wada Y, Saito A, Fukase S, Ishioka K, Kana Miyazaki, Masaki Y, Umehara H, Sugai S and Narita I.  KIDNEY INTERNATIONAL 2010/11
  •  Apparent diffusion coefficient map based on diffusion-weighted magnetic resonance imaging is useful in diagnosing the brainstem variant of reversible posterior leukoencephalopathy syndrome with uremia. Katano K, Kakuchi Y, Nakashima A, Nakahama K, Kawano M. Clin Exp Nephrol 14 5 479-82 2010/10
  •  A case of IgG4-related chronic sclerosing sialadenitis and dacryoadenitis associated with tuberculosis. Kawano M, Yamada K, Kakuchi Y, Ito K, Hamano R, Fujii H, Inoue R, Matsumura M, Takahira M, Zen Y, Yachie A, Nakashima A, Yamagishi M.  Mod Rheumatol 19 1 87-90 2009/01
  •  Efficacy of diffusion-weighted magnetic resonance imaging in detecting infected cysts in a case of polycystic kidney disease. Katano K, Kakuchi Y, nakashima A, Takahashi S, Kawano M.  Clin Nephrol. 75 Suppl 1 24-6 2011/02
  •  Treatment of IgG4-related disease.  Kawano M, Yamada K. Curr Immunol Rev 7 246-251 2011/05
  •  A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7. Miyagi K, Kiyonaka S, Yamada K, Miki T, Mori E, Kato K, Numata T, Sawaguchi Y, Numaga T, Kimura T, Kanai Y, Kawano M, Wakamori M, Nomura H, Koni I, Yamagishi M, Mori Y JOURNAL OF BIOCHEMISTRY 284 49 34400-12 2009/12
  •  IgG4-related Skin Lesions in a Patient with IgG4-related Chronic Sclerosing Dacryoadenitis and Sialoadenitis. Kakuchi Y, Yamada K, Suzuki Y, Ito N, Yagi K, Matsumura M, Yamagishi M, Umehara H, Zen Y, Hasegawa M, Takehara K, Kawano M. INTERNAL MEDICINE 50 14 1465-9 2011/07

Conference Presentations

Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Classes (Bachelors)

○Immunology & Allergic Disorders(2017)
○Immunology & Allergic Disorders(2016)
○Kidney, Urogenital Organ & Male Genital Organ(2016)

Classes (Graduate Schools)

○Introduction to Medicine(2017)
○Internal Medicine(2017)
○Internal Medicine(2017)
○Internal Medicine(2016)
○Internal Medicine(2016)
○Introduction to Medicine(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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