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Researcher Information

last modified:2019/02/15

Associate Professor HINOI Eiichi

Mail Laboratory Website

Faculty, Affiliation

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field


Department of Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Kanazawa University TEL:076-234-4472 FAX:076-234-4472

Academic Background

【Academic background(Doctoral/Master's Degree)】
Setsunan University Master 200004 Completed
Kanazawa University Doctor 200303 Completed
【Academic background(Bachelor's Degree)】
Setsunan University 199806


2003-2004 Assistant Professor Kanazawa University(2003/04/01-2004/03/31)
2004-2006 Assistant Professor Kanazawa University(2004/04/01-2006/03/31)
2006 Post-Doc Baylor College of Medicine(2006/04/01-2006/06/30)
2006-2009 Post-Doc Columbia University(2006/07/01-2009/04/30)
2009- Associate Professor Kanazawa University(2009/05/01-)

Year & Month of Birth


Academic Society


○Gakujutu shourei(2010/12/06)
○Gakujutu shourei(2010/12/06)


transmitter bone glutamate、cell biology

Speciality Keywords

metabolic bone disease, osteoblast, osteoclast

Research Themes

Exhaustive search and functional analysis of bone-derived secreted molecules.

Research for elucidation of regulatory mechanisms of osteoblasts function by Clock genes.



  •  Regulation of osteoclastogenesis by osteocytes through growth differentiation factor-15 Hinoi, Eiichi Yakugaku Zasshi 134 12 1259-1263 2014/01/01 
  •  Toward a new era of pharmacological therapeutics Ikegaya, Yuji; Hinoi, Eiichi Yakugaku Zasshi 133 12 1335-1336 2013/01/01 
  •  The transcription factor ATF4 regulates glucose metabolism through its expression in osteoblasts. JOURNAL OF CLINICAL INVESTIGATION 119 2807-2817 2009/09
  •  An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. Ann NY Acad Sci 1173 E20-30 2009/09
  •  Interference by adrenaline with chondrogenic differentiation through suppression of gene transactivation mediated by Sox9 family members. BONE 45 568-578 2009/09

show all

  •  Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes. JOURNAL OF CELLULAR PHYSIOLOGY 220 756-764 2009/09
  •  Predominant promotion by tacrolimus of chondrogenic differentiation to proliferating chondrocytes. J Pharmacol Sci 109 413-423 2009/03
  •  The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. JOURNAL OF CELL BIOLOGY 183 7 1235-1242 2008/12
  •  Theanine, an ingredient of green tea, inhibits [3H]glutamine transport in neurons and astroglia in rat brain. JOURNAL OF NEUROSCIENCE RESEARCH 86 1846-1856 2008/06
  •  Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME 105 5266-5270 2008/04
  •  Serine racemase suppresses chondrogenic differentiation in cartilage in a Sox9-dependent manner. JOURNAL OF CELLULAR PHYSIOLOGY 215 320-328 2008/03
  •  Osteoblast protects osteoclast devoid of sodium-dependent vitamin C transporters from oxidative cytotoxicity of ascorbic acid. EUROPEAN JOURNAL OF PHARMACOLOGY 575 1-11 2007/12
  •  Suppression by glutamate of proliferative activity through glutathione depletion mediated by cystine/glutamate antiporter in mesenchymal C3H10T1/2 stem cells. JOURNAL OF CELLULAR PHYSIOLOGY 213 721-729 2007/12
  •  Glutamate is a determinant of cellular proliferation through modulation of nuclear factor E2 p45-related factor-2 expression in osteoblastic MC3T3-E1cells. JOURNAL OF CELLULAR PHYSIOLOGY 213 105-114 2007/10
  •  Endocrine Regulation of energy metabolism by the skeleton. CELL 130 456-469 2007/08
  •  Glutamate suppresses osteoclastogenesis through the cystine/glutamate antiporter. Am J Pathol 170 1277-1290 2007/04
  •  Oral administration of phenolic antidiarrheic ingredients prevents ovariectomy-induced bone loss. BIOCHEMICAL PHARMACOLOGY 73 385-393 2007/02
  •  Nuclear factor E2 p45-related factor 2 negatively regulates chondrogenesis. BONE 40 337-344 2007/02
  •  Possible expression of a particular EUROPEAN JOURNAL OF PHARMACOLOGY 550 24-32 2006/11
  •  Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. GENES & DEVELOPMENT 20 21 2937-2942 2006/11
  •  Cytoprotection by pyruvate through an anti-oxidative mechanism in cultured rat calvarial osteoblasts. HISTOLOGY AND HISTOPATHOLOGY 21 969-977 2006/09
  •  A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. MOLECULAR PHARMACOLOGY 70 925-935 2006/09
  •  Glutamate inhibits chondral mineralization through apoptotic cell death mediated by retrograde operation of the cystine/glutamate antiporter. JOURNAL OF BIOLOGICAL CHEMISTRY 281 24553-24565 2006/08
  •  Upregulation of per mRNA expression by PTH through a PKA-CREB-dependent mechanism in chondrocytes. JOURNAL OF BIOLOGICAL CHEMISTRY 281 23632-23642 2006/08
  •  Nrf2 negatively regulates osteoblast differentiation via interfering with Runx2 dependent transcriptional activation. JOURNAL OF BIOLOGICAL CHEMISTRY 281 18015-18024 2006/06

Conference Presentations

Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Classes (Bachelors)

○Pharmacology 1(2017)
○Pharmaceutical Chemistry(2017)
○Experiments in Biology 2(2017)
○Experiments in Fundamental Chemistry(2017)
○Pharmacology 2(2017)
○Basic Physiology(2017)
○Experiments in Fundamental Chemistry(2016)
○Experiments in Biology 2(2016)
○Pharmacology 1(2016)
○Pharmacology 2(2016)

Classes (Graduate Schools)

○Integral Pharmacology(2017)
○Advanced Course of Pharmacological Studies for Drug Development(2017)
○Molecular Pharmacology(2017)
○Experimental Techniques in Precision Medicine Research(2017)
○Bone Biology(2017)
○Bone Biology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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