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Researcher Information

last modified:2020/04/10

Associate Professor FUJINO Noboru


Faculty, Affiliation

College and School Educational Field

Division of Health Sciences, Graduate School of Phamaceutical Science
Division of Neuroscience, Graduate School of Medical Science
Department of Nursing,School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences


 TEL:076-265-2254 FAX:076-234-4251

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa university Doctor Graduate School, Division of Medical Sciences 199903 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 199303


Kanazawa University(2004/04/01-)
Harvard Medical School Department of Genetics Associate(2000/10-2003/03)

Year & Month of Birth


Academic Society

The Japanese Heart Failure Society
Japanese College of Cardiology
Japanese Circulation Society (JCS)


○Fukuda Foundation for Medical Technology(2005)


hypertrophic cardiomyopathy dilated cardiomyopathy phospholamban、Cardiovascular medicine

Speciality Keywords

hypertrophic cardiomyopathy, dilated cardiomyopathy, genetic diagnosis

Research Themes

Genetic Diagnosis of Hypertrophic Cardiomyopathy



  •  Exercise-induced ST-segment depression and systolic dysfunction in patients with nonobstructive hypertrophic cardiomyopathy AMERICAN HEART JOURNAL 140 1 52-60 2000/07
  •  Clinical features of hypertrophic cardiomyopathy caused by a Lys183 deletion mutation in the cardiac troponin I gene CIRCULATION 102 6 663-669 2000/08
  •  Acute increases in plasma oxidized low-density lipoprotein immediately after percutaneous transluminal coronary angioplasty AMERICAN JOURNAL OF CARDIOLOGY 87 1 102-103 2001/01
  •  Cardiac troponin T Arg92Trp mutation and progression from hypertrophic to dilated cardiomyopathy CLINICAL CARDIOLOGY 24 5 397-402 2001/05
  •  A novel mutation Lys273Glu in the cardiac troponin T gene shows high degree of penetrance and transition from hypertrophic to dilated cardiomyopathy AMERICAN JOURNAL OF CARDIOLOGY 89 1 29-33 2002/01

show all

  •  Assessment of QT intervals and prevalence of short QT syndrome in Japan Funada A, Hayashi K, Ino H, Fujino N, et al. Clin Cardiol 31 6  270-274 2008/06
  •  Takotsubo cardiomyopathy with marked ST-segment elevation and electrical alternans complicated with hyperglycemic hyperosmolar state. Oe K, Mori K, Otsuji M, Konno T, Fujino N, Yamagishi M Int Heart J 49 5 629-635 2008/09
  •  Impact of QT variables on clinical outcome of genotyped hypertrophic cardiomyopathy. Ann Noninvasive Electrocardiol 14 1 65-71 2009/01
  •  Long QT syndrome and associated gene mutation carriers in Japanese children: results from ECG screening examinations. CLINICAL SCIENCE 117 12 415-424 2009/09
  •  Impact of anti-apoptotic and anti-oxidative effects of bone marrow mesenchymal stem cells with transient overexpression of heme oxygenase-1 on myocardial ischemia. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 298 5 H1320-1329 2010/05
  •  Heterogeneity of clinical manifestation of hypertrophic cardiomyopathy caused by deletion of lysine 183 in cardiac troponin I gene. Int Heart J 51 3 214-217 2010/05
  •  Impact of renin-angiotensin system polymorphisms on development of systolic dysfunction in hypertrophic cardiomyopathy. Evidence from a study of genotyped patients. Funada A, Konno T, Fujino N, Muramoto A, Hayashi K, Tsubokawa T, Sakata K, Kawashiri MA, Takeda Y, Ino H, Yamagishi M.  Circ J. 74 12 2674-2680 2010/11
  •  A KCR1 variant implicated in susceptibility to the long QT syndrome. Hayashi K, Fujino N, Higashida H, Yamagishi M, ほか13名 JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 50 1 50-57 2011/01
  •  A case of cibenzoline toxicosis resulted in cardiopulmonary arrest - Showing remarkable left ventricular dyssynchrony 43 1 87-92 2011/01
  •  Multiple noncoding exons 1 of nuclear receptors NR4A family (nerve growth factor-induced clone B, Nur-related factor 1 and neuron-derived orphan receptor 1) and NR5A1 (steroidogenic factor 1) in human cardiovascular and adrenal tissues. Demura M, Fujino N, Yamagishi M, Takeda Y, ほか17名 JOURNAL OF HYPERTENSION 29 6 1185-1195 2011/06
  •  Current Perspectives of Genetic Cardiovascular Disease 6 2 105-114 2011/06
  •  Efficacy and safety of coadministration of rosuvastatin, ezetimibe, and colestimide in heterozygous familial hypercholesterolemia Kawashiri MA, Fujino N, Yamagishi Mほか10名 AMERICAN JOURNAL OF CARDIOLOGY 109 3 364-369 2012/02
  •  A novel mutation in the transmembrane nonpore region of the KCNH2 gene causes severe clinical manifestations of long QT syndrome Liu L, Hayashi K, Fujino N, Higashida H, Yamagishi M, ほか10名 Heart Rhythm 10 1 61-67 2013/01
  •  Impact of systolic dysfunction in genotyped hypertrophic cardiomyopathy Fujino N, Yamagishi M, ほか8名 CLINICAL CARDIOLOGY 36 3 160-165 2013/03
  •  Current perspectives in genetic cardiovascular disorders: from basic to clinical aspects Kawashiri MA, Fujino N, Yamagishi M, ほか3名 HEART AND VESSELS online online online 2013/08
  •  Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy. Results From Multicenter Registration in Japan. Fujita, Takashi; Fujino, Noboru; Anan, Ryuichiro; Tei, Chuwa; Kubo, Toru; Doi, Yoshinori; Kinugawa, Shintaro; Tsutsui, Hiroyuki; Kobayashi, Shigeki; Yano, Masafumi; Asakura, Masanori; Kitakaze, Masafumi; Komuro, Issei; Konno, Tetsuo; Hayashi, Kenshi; Kawashiri, Masaaki; Ino, Hidekazu; Yamagishi, Masakazu JACC: Heart Failure 1 6 459-466 2013/12/01 
  •  Left ventricular apical aneurysm and systolic dysfunction in hypertrophic cardiomyopathy Fujino, Noboru; Konno, Tetsuo; Yamagishi, Masakazu; Hayashi, Kenshi Journal of Cardiology 2014/05/27 
  •  Compound heterozygosity deteriorates phenotypes of hypertrophic cardiomyopathy with founder MYBPC3 mutation: Evidence from patients and zebrafish models Hodatsu, Akihiko; Konno, Tetsuo; Hayashi, Kenshi; Funada, Akira; Fujita, Takashi; Nagata, Yoji; Fujino, Noboru; Kawashiri, Masaaki; Yamagishi, Masakazu American Journal of Physiology - Heart and Circulatory Physiology 307 11 H1594-H1604 2014/01/01 
  •  Fragmented QRS Predicts Heart Failure Progression in Patients With Hypertrophic Cardiomyopathy Nomura, Akihiro;Konno, Tetsuo;Fujita, Takashi;Tanaka, Yoshihiro;Nagata, Yoji;Tsuda, Toyonobu;Hodatsu, Akihiko;Sakata, Kenji;Nakamura, Hiroyuki;Kawashiri, Masa-Aki;Fujino, Noboru;Yamagishi, Masakazu;Hayashi, Kenshi CIRCULATION JOURNAL 79 1 136-143 2015/01/01 
  •  Right ventricular hypertrophy is associated with cardiovascular events in hypertrophic cardiomyopathy: evidence from study with magnetic resonance imaging. Nagata Y, Konno T, Fujino N, Hodatsu A, Nomura A, Hayashi K, Nakamura H, Kawashiri MA, Yamagishi M. Can J Cardiol 31 6 702-708 2015/01/24
  •  Whole exome sequencing combined with integrated variant annotation prediction identifies asymptomatic Tangier disease with compound heterozygous mutations in ABCA1 gene. Tada H, Kawashiri MA, Nohara A, Saito R, Tanaka Y, Nomura A, Konno T, Sakata K, Fujino N, Takamura T, Inazu A, Mabuchi H, Yamagishi M, Hayashi K. Atherosclerosis 240 2 324-329 2015/04/07
  •  Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation. Hayashi K, Konno T, Tada H, Tani S, Liu L, Fujino N, Nohara A, Hodatsu A, Tsuda T, Tanaka Y, Kawashiri MA, Ino H, Makita N, Yamagishi M. Circ Arrhythm Electrophysiol 8 5 1095-1104 2015/06/30
  •  Increased extent of myocardial fibrosis in genotyped hypertrophic cardiomyopathy with ventricular tachyarrhythmias. Fujita T, Konno T, Yokawa J, Masuta E, Nagata Y, Fujino N, Funada A, Hodatsu A, Kawashiri MA, Yamagishi M, Hayashi K. J Cardiol 66 1 63-68 2015/07/01
  •  Electrocardiographic QRS Fragmentation as a Marker for Myocardial Fibrosis in Hypertrophic Cardiomyopathy. Konno T, Hayashi K, Fujino N, Oka R, Nomura A, Nagata Y, Hodatsu A, Sakata K, Furusho H, Takamura M, Nakamura H, Kawashiri MA, Yamagishi M. J Cardiovasc Electrophysiol 26 10 1081-1087 2015/08/11
  •  Whole exome sequencing combined with integrated variant annotation prediction identifies a causative myosin essential light chain variant in hypertrophic cardiomyopathy. Nomura A, Tada H, Teramoto R, Konno T, Hodatsu A, Won HH, Kathiresan S, Ino H, Fujino N, Yamagishi M, Hayashi K. J Cardiol 67 2 133-139 2016/02/01
  •  Usefulness of Electrocardiographic Voltage to Determine Myocardial Fibrosis in Hypertrophic Cardiomyopathy. Konno T, Nagata Y, Teramoto R, Fujino N, Nomura A, Tada H, Sakata K, Furusho H, Takamura M, Nakamura H, Kawashiri MA, Yamagishi M, Hayashi K. Am J Cardiol 117 3 443-449 2016/02/01
  •  The cohort study of the cardiomyopathy with gene mutations Heart View 20 2 76-81 2016/02/01
  •  Hypokalemia and the Disappearance of Giant Negative T Waves. Konno T, Hayashi K, Fujino N, Yamagishi M. Intern Med 55 5 545-546 2016/03/01
  •  Overview of the 81st Annual Scientific Meeting of the Japanese Circulation Society - Cardiovascular Medicine for the Next Generation. Fujino N, Yoshimuta T, Ichida F, Kinugawa K, Usuda K, Kitayama M, Ino H, Kawashiri MA, Tada H, Mizuno S, Hayashi K, Takemura H, Yamagishi M; all the members of the Japanese Circulation Society in Hokuriku District. Circ J.  81 9 1261-1267 2017/08/25
  •  Characteristics of induced pluripotent stem cells from clinically divergent female monozygotic twins with Danon disease. Yoshida S, Nakanishi C, Okada H, Mori M, Yokawa J, Yoshimuta T, Ohta K, Konno T, Fujino N, Kawashiri MA, Yachie A, Yamagishi M, Hayashi K. J Mol Cell Cardiol.  114 234-242 2018/01/01
  •  Late Gadolinium Enhancement for Prediction of Mutation-Positive Hypertrophic Cardiomyopathy on the Basis of Panel-Wide Sequencing. Teramoto R, Fujino N, Konno T, Nomura A, Nagata Y, Tsuda T, Tada H, Sakata K, Yamagishi M, Hayashi K, Kawashiri MA. Circ J.  2018/02/03
  •  Impact of B-Type Natriuretic Peptide Level on Risk Stratification of Thromboembolism and Death in Patients With Nonvalvular Atrial Fibrillation - The Hokuriku-Plus AF Registry. Hayashi K, Tsuda T, Nomura A, Fujino N, Nohara A, Sakata K, Konno T, Nakanishi C, Tada H, Nagata Y, Teramoto R, Tanaka Y, Kawashiri MA, Yamagishi M; Hokuriku-Plus AF Registry Investigators. Circ J.  2018/03/01
  •  Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases Hayashi K, Fujino N, et al.  Cardiovasc Res 2020/01/24
  •  Impact of renal function on mid-term outcomes in heart failure patients treated with tolvaptan. Fujioka K, Mizuno S, Ichise T, Matsui T, Hirase H, Yamaguchi M, Aoyama T, Yamagishi M, Fujino N, Kawashiri MA, Hayashi K Ther Adv Cardiovasc Dis 13 1-9 2019/01/01
  •  Impact of cardiac myosin light chain kinase gene mutation on development of dilated cardiomyopathy. Hodatsu A, Fujino N, Uyama Y, Tsukamoto O, Imai-Okazaki A, Yamazaki S, Seguchi O, Konno T, Hayashi K, Kawashiri MA, Asano Y, Kitakaze M, Takashima S, Yamagishi M. ESC Heart Fail 2019/01/28
  •  Effect of hypertrophic cardiomyopathy on the prediction of thromboembolism in patients with nonvalvular atrial fibrillation. Tsuda T, Hayashi K, Fujino N, Konno T, Tada H, Nomura A, Tanaka Y, Sakata K, Furusho H, Takamura M, Kawashiri MA, Yamagishi M; Hokuriku-Plus AF Registry Investigators Heart Rhythm 2018/11/29
  •  Limited effects of long-term enzyme replacement therapy on the cardiac conduction system in Fabry disease. Kaneda T, Takeda M, Suematsu T, Yamamoto R, Takata M, Higashikata T, Ino H, Tsujibata A, Hayashi K, Fujino N, Kawashiri MA J Cardiol Cases 17 5 178-181 2018/02/09
  •  Phenotype and Prognosis of the Lamin A/C Gene (LMNA) Mutation Carriers in Japan. Fujino N, Hayashi K, Sakata K, Nomura A, Kawashiri MA. Circ J 82 11 2699-2700 2018/10/25
  •  Functional analysis of KCNH2 gene mutations of type 2 long QT syndrome in larval zebrafish using microscopy and electrocardiography. Tanaka Y, Hayashi K, Fujino N, Konno T, Tada H, Nakanishi C, Hodatsu A, Tsuda T, Nagata Y, Teramoto R, Yoshida S, Nomura A, Kawashiri MA, Yamagishi M Heart Vessels 34 1 159-166 2019/01/01

Conference Presentations

Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Classes (Bachelors)

○Introduction to Infection Control(2017)
○Practice of Wellness Promotion(2017)
○Practice of Wellness Promotion(2017)
○Basic Physiology(2017)
○Chronic and Hospice Care Nursing : Clinical Practice(2017)
○Adult Nursing: Skills Laboratory(2017)
○Health Assessment: Skills Laboratory(2017)
○Lecture on Internal Medicine and Surgery(2017)
○English for Nursing Students(2017)
○Introduction to Information Technology(2017)
○Geriatric Medicine(2017)
○Lecture on Psychiatry and Rehabilitation and Geriatrics(2017)
○English for Nursing Students(2016)
○Lecture on Psychiatry and Rehabilitation and Geriatrics(2016)
○Introduction to Infection Control(2016)
○Chronic and Hospice Care Nursing : Clinical Practice(2016)
○Geriatric Medicine(2016)
○Introduction to Information Technology(2016)
○Adult Nursing: Skills Laboratory(2016)
○Basic Physiology(2016)
○Health Assessment: Skills Laboratory(2016)
○Lecture on Internal Medicine and Surgery(2016)

Classes (Graduate Schools)

○Chronic/Terminal Care Nursing Technology: Seminar(2017)
○Internal Medicine(2017)
○Chronic Care/Wound Management: Seminar(2017)
○Internal Medicine(2017)
○Chronic Care/Wound Management: Lecture(2017)
○Chronic/Terminal Care Nursing Technology: Lecture(2017)
○Introduction to Medicine(2017)
○Human Anatomy and Physiology: Lecture(2017)
○Research Design in Nursing 1: Lecture(2017)
○Chronic/Terminal Care Nursing Technology: Seminar(2016)
○Human Anatomy and Physiology: Lecture(2016)
○Chronic/Terminal Care Nursing Technology: Lecture(2016)
○Introduction to Medicine(2016)
○Chronic Care/Wound Management: Seminar(2016)
○Chronic Care/Wound Management: Lecture(2016)
○Internal Medicine(2016)
○Internal Medicine(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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