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Researcher Information

last modified:2022/08/08

Professor MORISHITA Eriko

Faculty, Affiliation

Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Health Sciences, Graduate School of Medical Science
Division of Health Sciences,Graduate School of Medical Science
Department of Laboratory Sciences,School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences

Laboratory

 TEL:076-265-2606 FAX:

Academic Background

【Academic background(Bachelor's Degree)】
Nippon Medical School 198603
【Degree】
Medical doctor

Career

Kanazawa University(1989/11/01-1993/03/31)
Kanazawa University(1993/04/01-1994/03/31)
Kanazawa University(1994/04/01-1997/03/31)
Kanazawa University(1997/04/01-)

Year & Month of Birth

Academic Society




Japan Atherosclerosis Society

Japan Thrombosis and Hemostasis


the Japanese Society of Hematology






Japan Thrombosis and Hemostasis
The Japanese Society of Laboratory Medicine
The Japanese Society of Clinical Hematology
Japanese Society of Laboratory Medicine
The Japanese Society on Thrombosis and Hemostasis

Award

Specialities

Hematology、Laboratory medicine

Speciality Keywords

Hematology

Research Themes

Genetic analysis and expression studiesin congenital cogulation factor deficiencies and coagulation inhibitor deficiencies

I conduct genetic analysis of individuals with congenital coagulation factor deficiencies and coagulation inhibitor deficiencies, and their families, to identify the mutation sites. I have analyzed coagulation factor deficiencies in terms of prothrombin, factors VII, X, XI, XII, and prekallikrein, as well as coagulation inhibitor deficiencies in terms of protein C, protein S(PS), antithrombin, and have continuously demonstrated new mutation sites that had not been reported internationally. Further, I generate abnormal molecules with a recombinant DNA procedure and conduct their functional analysis. PS deficiency is important also as a cause of habitual abortion, and the demand for its genetic analysis will likely increase.

Mechanism of thrombosis in arteriovascular disease

With regard to arteriosclerosis and thrombosis, I examine hyperlipidemia and thrombotic tendency with molecular markers and manifestation of monocytic coagulation−fibrinolytic factors upon lipoprotein stimulus. Recently, I have been conducting research on the effect of an antihypercholesterolemia, HMG-CoA reductase inhibitor (statin), on coagulation−fibrinolytic system as a pleiotropic effect, and have clarified that statin down-regulate monocytic tissue factors in vascular endothelial cells and the manifestation of a coagulation−fibrinolytic factor PAI-1, while down-regulate the manifestation of anticaking factor TFPI, thereby demonstrating the potential for anti-thrombogenicity effect.

Mechanism of thormbotic formation in Hemolytic Uremic Syndrome

Crosstalk betwenn inflammation and thrombosis

Disseminated Intravascular Syndrome

antiphospholipid syndrome

Mechanism of thrombosis in arteriovascular disease

Congenital thrombophilia

Antithrobotic efests of hemeoxygenase-1

Books

  •  Recent Progress in Blood Coagulation and Fibrinolysis Elsevier 1998/01
  •  Asakura H, Takahashi Y, Kubo A, Ontachi Y, Hayashi T, Omote M, Arahata M, Kadohira Y, Maekawa M, Yamazaki M, Morishita E, Takami A, Yoshida T, Miyamoto K, Nakao S Immunoglobulin preparations attenuate organ dysfunction and hemostatic abnormality by suppressing the production of cytokines in lipopolysaccharide-induced disseminated intravascular coagulation in rats 34 9 2421-5 2006/09
  •  Asakura H, Asamura R, Ontachi Y, Hayashi T, Yamazaki M, Morishita E, Miyamoto KI, Nakao S Selective inducible nitric oxide synthase inhibition attenuates organ dysfunction and elevated endothelin levels in LPS-induced DIC model rats 3 5 1050-5 2005/05
  •  Ontachi Y, Morishita E, Nakao S, etc No interplay between the pathways mediating coagulation and inflammation in tissue factor-induced disseminated intravascular coagulation in rats 34 10 2646-2650 2006/10

Papers

  •  PROTHROMBIN HIMI - A COMPOUND HETEROZYGOTE FOR 2 DYSFUNCTIONAL PROTHROMBIN MOLECULES (MET-337-]THR AND ARG-388-]HIS) E MORISHITA,M SAITO,KUMABASHIRI, I,H ASAKURA,T MATSUDA,K YAMAGUCHI BLOOD 80 9 2275 1992/11
  •  Detailed exploration of pathophysiology involving inflammatory status and bleeding symptoms between lipopolysaccharide- and tissue factor-induced disseminated intravascular coagulation in rats. Yukio Suga,Anna Kubo,Hideyuki Katsura,Yukiko Staub,Kiyomichi Tashiro,Shinya Yamada,Eriko Morishita,Hidesaku Asakura International journal of hematology 114 2 172 2021/08
  •  Blue Rubber Bleb Nevus Syndrome Complicated by Enhanced-Fibrinolytic-Type DIC: A Case Report. Shinya Yamada,Masahisa Arahata,Eriko Morishita,Hidesaku Asakura Annals of vascular diseases 14 3 252 2021/09/25
  •  Genetic analysis of a compound heterozygous patient with congenital factor X deficiency and regular replacement therapy with a prothrombin complex concentrate. Tomoki Togashi,Satomi Nagaya,Masayuki Nagasawa,Makiko Meguro-Horike,Keiji Nogami,Yuta Imai,Kana Kuzasa,Akiko Sekiya,Shin-Ichi Horike,Hidesaku Asakura,Eriko Morishita International journal of hematology 111 1 51 2020/01 
  •  Aortic Mural Thrombus Associated with Congenital Protein C Deficiency in an Elderly Patient. Kazuki Ueda,Eriko Morishita,Hironaga Shiraki,Shunzo Matsuoka,Shinsaku Imashuku Journal of atherosclerosis and thrombosis 27 1 100 2020/01/01 

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  •  Hereditary Antithrombin Deficiency Presenting with Deep Venous Thrombosis During the Second Pregnancy. Motoki Yamashita,Tomo Komaki,Kohei Tashiro,Yuki Inada,Atsushi Iwata,Masahiro Ogawa,Eriko Morishita,Shin-Ichiro Miura Internal medicine (Tokyo, Japan) 59 2 235 2020/01/15 
  •  Evaluation of Optimal Sample Processing Conditions for Accurate Measurement of Protein S Activity. Satomi Nagaya,Yuhei Araiso,Koichi Yamaguchi,Yuichiro Omote,Asaka Matsui,Hidesaku Asakura,Eriko Morishita Annals of clinical and laboratory science 51 2 206 2021/03
  •  Effect of NOS Inhibitors and Anticoagulants on Nitric Oxide Production in a Tissue-factor Induced Rat DIC Model Yukio Suga,Yoko Takahashi,Tsutomu Shimada,Shinya Yamada,Eriko Morishita,Hidesaku Asakura IN VIVO 35 4 1999 2021/07
  •  Effect on Plasma Protein S Activity in Patients Receiving the Factor Xa Inhibitors. Takako Terakami,Satomi Nagaya,Kenshi Hayashi,Hiroshi Furusho,Noboru Fujino,Takeshi Kato,Hidesaku Asakura,Eriko Morishita Journal of atherosclerosis and thrombosis 2021/07/30
  •  Clinical guidance for peripartum management of patients with hereditary thrombophilia. Takao Kobayashi,Eriko Morishita,Hiroko Tsuda,Reiko Neki,Tetsuhito Kojima,Shouichi Ohga,Masayuki Ochiai,Tomoko Adachi,Toshiyuki Miyata The journal of obstetrics and gynaecology research 47 9 3008 2021/09
  •  Recombinant human erythropoietin attenuates hepatic dysfunction by suppressing hepatocellular apoptosis in lipopolysaccharide-induced disseminated intravascular coagulation in rats. Yukio Suga,Fumio Akita,Shinya Yamada,Eriko Morishita,Hidesaku Asakura Biomedical reports 16 1 5 2022/01
  •  Recipient ADAMTS13 Single-Nucleotide Polymorphism Predicts Relapse after Unrelated Bone Marrow Transplantation for Hematologic Malignancy. Haruka Nomoto,Akiyoshi Takami,J Luis Espinoza,Makoto Onizuka,Koichi Kashiwase,Yasuo Morishima,Takahiro Fukuda,Yoshihisa Kodera,Noriko Doki,Koichi Miyamura,Takehiko Mori,Shinji Nakao,Eriko Morishita International journal of molecular sciences 20 1 2019/01/08
  •  Donor Heme Oxygenase-1 Promoter Gene Polymorphism Predicts Survival after Unrelated Bone Marrow Transplantation for High-Risk Patients. Tomohiro Horio,Eriko Morishita,Shohei Mizuno,Kaori Uchino,Ichiro Hanamura,J Luis Espinoza,Yasuo Morishima,Yoshihisa Kodera,Makoto Onizuka,Koichi Kashiwase,Takahiro Fukuda,Noriko Doki,Koichi Miyamura,Takehiko Mori,Shinji Nakao,Akiyoshi Takami Cancers 12 2 2020/02/12
  •  Recurrent Cerebral Venous Thrombosis Treated with Direct Oral Anticoagulants in a Japanese Man with Hereditary Protein C Deficiency. Kazuyuki Saito,Kazuyuki Ishii,Konosuke Furuta,Masaki Kobayashi,Yoshiaki Wada,Eriko Morishita Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 30 1 105320 2021/01
  •  Molecular genetic analysis of inherited protein C deficiency caused by the novel large deletion across two exons of PROC. Tomoki Togashi,Makiko Meguro-Horike,Satomi Nagaya,Sayaka Sugihara,Tatsuo Ichinohe,Yuhei Araiso,Koichi Yamaguchi,Kotaro Mori,Yuta Imai,Kana Kuzasa,Shin-Ichi Horike,Hidesaku Asakura,Atsushi Watanabe,Eriko Morishita Thrombosis research 188 115 2020/04
  •  Racial differences in protein S Tokushima and two protein C variants as genetic risk factors for venous thromboembolism. Hiroko Tsuda,Kenta Noguchi,Doyeun Oh,Zsuzsanna Bereczky,Lai H Lee,Dongchon Kang,Luci M S Dusse,Maria das G Carvalho,Eriko Morishita Research and practice in thrombosis and haemostasis 4 8 1295 2020/11
  •  Potential of continuous tPA infusion for multiple-organ failure from lipopolysaccharide-induced disseminated intravascular coagulation in rats. Yukio Suga,Kiyomichi Tashiro,Yukiko Staub,Shiori Komura,Shinya Yamada,Eriko Morishita,Hidesaku Asakura Thrombosis research 206 84 2021/08/19
  •  A Case of Ischemic Stroke With Congenital Protein C Deficiency and Carotid Web Successfully Treated by Anticoagulant and Carotid Stenting. Sadayoshi Watanabe,Shoji Matsumoto,Ichiro Nakahara,Akira Ishii,Taketo Hatano,Minako Mori,Eriko Morishita,Izumi Nagata Frontiers in neurology 11 99 2020 
  •  Ilio-femoral venous thrombosis with hereditary antithrombin deficiency: a case report of rare thrombotic disease and successful treatment with catheter directed thrombolysis. Hirokazu Miyashita,Kazuki Tobita,Eriko Morishita,Shigeru Saito European heart journal. Case reports 5 2 ytaa531 2021/02
  •  Comparative evaluation of reagents for measuring protein S activity: possibility of harmonization. Masahiro Ieko,Taeko Hotta,Kumiko Watanabe,Tomoko Adachi,Sawako Takeuchi,Sumiyoshi Naito,Mika Yoshida,Kazumasa Ohmura,Nobuhiko Takahashi,Eriko Morishita,Hiroko Tsuda,Dongchon Kang International journal of hematology 113 4 530 2021/04
  •  Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis. Kiyoko Kanosue,Satomi Nagaya,Eriko Morishita,Masayoshi Yamanishi,Shinsaku Imashuku TH open : companion journal to thrombosis and haemostasis 5 2 e171-e173 2021/04
  •  The Japanese Medical Science Federation COVID-19 Expert Opinion English Version. Masaomi Nangaku,Takashi Kadowaki,Hiroshi Yotsuyanagi,Norio Ohmagari,Moritoki Egi,Junichi Sasaki,Tetsuya Sakamoto,Yoshinori Hasegawa,Takashi Ogura,Shigeru Chiba,Koichi Node,Ryo Suzuki,Yasuhiro Yamaguchi,Atsuko Murashima,Norihiko Ikeda,Eriko Morishita,Kenji Yuzawa,Hiroyuki Moriuchi,Satoshi Hayakawa,Daisuke Nishi,Atsushi Irisawa,Toshiaki Miyamoto,Hidetaka Suzuki,Hirohito Sone,Yuuji Fujino JMA journal 4 2 148 2021/04/15
  •  The first reported case of acquired haemophilia A in which bleeding episodes were successfully treated via administration of a single-dose mixture of activated factor VIIa/X. Shinya Yamada,Masahisa Arahata,Eriko Morishita,Akitada Ichinose,Hidesaku Asakura Haemophilia : the official journal of the World Federation of Hemophilia 25 5 e350-e352 2019/09 
  •  直接経口抗凝固薬が血中プロテインC活性測定値に与える影響(The effect of direct oral anticoagulants on blood protein C activity) 寺上 貴子,關谷 暁子,林 研至,鈴木 健史,古荘 浩司,朝倉 英策,森下 英理子,和田 隆志 Journal of Wellness and Health Care 44 1 33 2020/08 
  •  A Case of Treatment With Dabigatran for Cerebral Venous Thrombosis Caused by Hereditary Protein C Deficiency. Taiki Fukushima,Yoshimitsu Shimomura,Satomi Nagaya,Eriko Morishita,Osamu Kawakami Cureus 13 6 e15473 2021/06
  •  Coagulation and fibrinolytic features in AL amyloidosis with abnormal bleeding and usefulness of tranexamic acid. Masahisa Arahata,Hiroyuki Takamatsu,Eriko Morishita,Yasuko Kadohira,Shinya Yamada,Akitada Ichinose,Hidesaku Asakura International journal of hematology 111 4 550 2020/04 
  •  Complete hemostasis achieved by factor XIII concentrate administration in a patient with bleeding after teeth extraction as a complication of aplastic anemia and chronic disseminated intravascular coagulation. Shinya Yamada,Hirokazu Okumura,Eriko Morishita,Hidesaku Asakura Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 31 4 274 2020/06 
  •  Portal Vein Thrombosis in a Patient with Hereditary Antithrombin Deficiency. Tamao Setaka,Katsuharu Hirano,Keiichi Moriya,Tougen Kaneko,Seie Morita,Tetsu Shinkai,Eriko Morishita,Takafumi Ichida Internal medicine (Tokyo, Japan) 58 12 1733 2019/06/15
  •  Potential therapeutics for antiphospholipid antibody associated thrombocytopenia: A systematic review and meta-analysis. Nobuya Abe,Kenji Oku,Olga Amengual,Yuichiro Fujieda,Masaru Kato,Toshiyuki Bohgaki,Shinsuke Yasuda,Rintaro Mori,Eriko Morishita,Katsue Suzuki-Inoue,Tatsuya Atsumi Modern rheumatology 30 1 116 2020/01 
  •  [COVID-19-associated coagulopathy]. Eriko Morishita [Rinsho ketsueki] The Japanese journal of clinical hematology 62 8 1236 2021 
  •  COVID-19-Related Thrombosis in Japan: Final Report of a Questionnaire-Based Survey in 2020. Hisanori Horiuchi,Eriko Morishita,Tetsumei Urano,Kenji Yokoyama Journal of atherosclerosis and thrombosis 28 4 406 2021/04/01
  •  Donor UNC-93 Homolog B1 genetic polymorphism predicts survival outcomes after unrelated bone marrow transplantation. Kaori Uchino,Lam Vu Quang,Shohei Mizuno,Tomohiro Horio,Hidesuke Yamamoto,Ichiro Hanamura,Yoshihisa Kodera,J Luis Espinoza,Makoto Onizuka,Koichi Kashiwase,Yasuo Morishima,Takahiro Fukuda,Noriko Doki,Koichi Miyamura,Takehiko Mori,Eriko Morishita,Shinji Nakao,Akiyoshi Takami Genes and immunity 22 1 35 2021/05
  •  First report of inherited protein S deficiency caused by paternal PROS1 mosaicism. Satomi Nagaya,Keiko Maruyama,Atsushi Watanabe,Makiko Meguro-Horike,Yuta Imai,Yuki Hiroshima,Shin-Ichi Horike,Koichi Kokame,Eriko Morishita Haematologica 107 1 330 2022/01/01
  •  Diagnosis and treatment of inherited thrombophilia. 森下英理子 臨床血液 58 7 866-874 2017
  •  DOAC療法が先天性血栓性素因に及ぼす影響 門平靖子, 森下英理子 血栓止血誌 29 1 20-27 2018/01
  •  周術期に留意すべき凝固異常 第1回 先天性血栓性素因~先天性プロテインC・プロテインS欠損症 森下英理子 Thrombosis Medicine 2017年12月号 2017/12
  •  動脈・静脈の疾患(上)-最近の診断・治療動向-静脈疾患の検査 森下英理子 日本臨床 75 増刊号4 196-200 2017
  •  遺伝性血栓性素因の診断と治療 森下英理子 臨床血液 58 7 866-874 2017
  •  A case of aortic aneurysm-associated DIC that responded well to a switch from warfarin to rivaroxaban. Kadohira Y, Matsuura E, Hayashi T, Morishita E, Nakao S, Asakura H. Int Med. 56 21 2913-2917 2017/11/01
  •  Fulminant bilateral cerebral infarction caused by paradoxical embolism in a patient with protein S Ala525Val substitution Yoshikawa Y, Kitayama J, Ishikawa H, Nakamura A, Taniguchi F, Morishita E, Ago T, Nakane H, Kitazono  Neurology and Clinical Neuroscience 2015/01/09
  •  Pregnancy outcomes of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab: a Japanese experience and updated review. Miyasaka N, Miura O, Kawaguchi T, Arima N, Morishita E, Usuki K, Morita Y, Nishiwaki K, Ninomiya H, Gotoh A, Imashuku S, Urabe A, Shichishima T, Nishimura J, Kanakura Y  Int J Hematol 103 6 703-712 2016
  •  Thrombosis prediction based on reference ranges of coagulation-related markers in different stages of pregnancy. Clinical and Applied   Clinical and Applied Thrombosis/Hemostasis  DOI: 10.1177. 2016
  •  Causative genetic mutations for antithrombin deficiency and their clinical background among Japanese patients Int J Hematol 2016
  •  Prophylactic administration of prothrombin complex concentrates for congenital prothrombin deficiency with a novel frameshift mutation, prothrombin saitama Seki, Masafumi; Koh, Katsuyoshi; Inoue, Takeshi; Tomita, Yuzo; Kato, Motohiro; Shimizu, Masaki; Morishita, Eriko; Hanada, Ryoji Pediatric Blood and Cancer 60 3 503-505 2013/03/01 
  •  Plasma levels of platelet-derived microparticles are increased after anaerobic exercise in healthy subjects Maruyama, Keiko; Kadono, Tadaaki; Morishita, Eriko Journal of Atherosclerosis and Thrombosis 19 6 585-587 2012/07/11 
  •  Beneficial effects of urokinase on lipopolysaccharide-induced disseminated intravascular coagulation in rats: focus on organ function and endothelin levels 93 4 724-8 2005/04
  •  Hemostatic management of surgery for imperforate anus in a patient with 13q deletion syndrome with combined deficiency of factors VII and X. Kurosawa H, Suzumura H, Okuya M, Fukushima K, Sugita K, Fujiwara T, Morishita E, Yoshioka A, Takamiya O, Arisaka O 15(1) 398-400 2009/01
  •  Changes in molecular markers of hemostatic and fibrinolytic activation under various sampling conditions using vacuum tube samples from healthy volunteers. Omote M, Asakura H, Takamichi S, Shibayama M, Yoshida T, Kadohira Y, Maekawa M, Yamazaki M, Morishita E, Nakao S, Wada T 123(2) 390-5 2008/02
  •  Expression of annexin II in human atherosclerotic abdominal aortic aneurysms. Hayashi T, Morishita E, Ohtake H, Oda Y, Ohta K, Arahata M, Kadohira Y, Maekawa M, Ontachi Y, Yamazaki M, Asakura H, Takami A, Nakao S THROMBOSIS RESEARCH 123(2)  274-80 2009/03
  •  An enhanced fibrinolysis prevents the development of multiple organ failure in DIC in spite of much activation of blood coagulation. CRITICAL CARE MEDICINE 29 6 1164-1168 2001/06
  •  Significant of decreased plasma D-Dimer levels following lipoplysaccharide-induced disseminated intravascular coagulation in rats Asakura H, Sano Y, Omote M, Yoshida T, Ontachi Y, Mizutani T, Kaneda M, Yamazaki M, Morishita E, et al INTERNATIONAL JOURNAL OF HEMATOLOGY 79 394-9 2004
  •  Effects of sarpogrelate hydrochloride in a patient with chronic graft-versus-host disease: a case report. Hayashi T, Morishita E, Ontachi Y, Yamazaki M, Asakura H, Yoshida T, Nakao S AMERICAN JOURNAL OF HEMATOLOGY 81 2 121-123 2006/02
  •  Effects of combined therapy of danaparoid sodium and tranexamic acid on chronic disseminated intravascular coagulation associated with abdominal aortic aneurysm Ontachi Y, Asakura H, Morishita E, et al Circulation Journal 69 9 1150-1153 2005/09
  •  A case of factor X (FX) deficiency due to novel mutation V196M, FX Hofu. 1) Shinohara K, Adachi M, Matsui K, Matsuda K, Nagaya S, Morishita E INTERNATIONAL JOURNAL OF HEMATOLOGY 87 3 256-259 2008/03
  •  Increased macrophage colony-stimulating factor levels in patients with Graves' disease. Morishita E, Sekiya A, Hayashi T, Kadohira Y, Maekawa M, Yamazaki M, Asakura H, Nakao S, Ohtake S INTERNATIONAL JOURNAL OF HEMATOLOGY 88(3)  272-7 2008/03
  •  One missence mutation in the factor X gene causing factor X deficiency (factor X Kanazawa) INTERNATIONAL JOURNAL OF HEMATOLOGY 73 3 390-392 2001/04
  •  Marked difference in pathophysiology between tissue factor-and lipopolysaccharide-induced disseminated intravascular coagulation models in rats. CRITICAL CARE MEDICINE 30 1 161-164 2002/11
  •  Beneficial effect of the active form of vitamin D3 against LPS-induced DIC but not against tissue-factor-induced DIC in rat models. THROMBOSIS AND HAEMOSTASIS 85 287-290 2001/02
  •  Depressed plasma activity of antithrombin or protein C is not due to consumption coagulopathy in septic patients with DIC. EUROPEAN JOURNAL OF HAEMATOLOGY 67 170-175 2001/06
  •  Atorvastatin reduces plasma levels of factor VII activity and factor VII antigen in patients with hyperlipidemia 9 1 72-78 2002/01
  •  Depressed plasma activity of plasminogen or a2-plasmin inhibitor is not due to consumption coagulopathy in septic patients with DIC. Blood Coagulation and Fibrinolysis 12 4 275-281 2001/06
  •  All-trans retinoic acid is partially effective against lipopolysaccharide-induced but not against tissue-factor-induced DIC in rat models. BLOOD COAGULATION & FIBRINOLYSIS 12 4 301-306 2001/06
  •  Beneficial effect of low-molecular-weight heparin against lipopolysaccharide-induced disseminated intravascular coagulation in rats is abolished by coadministrastion of tranexamic acid Asakura H, Sano Y, Yoshida T, Omote M, Ontachi Y, Mizutani T, Yamazaki M, Morishita E, et al INTENSIVE CARE MEDICINE 30 1950-1955 2004
  •  Prothrombin fragment1+2 mesures treatment effect in patients with antiphospholipid syndrome. 91 3 121-128 1998/08
  •  Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency. OSTEOPOROSIS INTERNATIONAL 12 996-1000 2001/12
  •  Role of fibrinolysis in tissue-factor-induced disseminated intravascular coagulation in rats - an effect of tranexamic acid Asakura H, Sano Y, Yamazaki M, Morishita E, et al HAEMATOLOGICA 89 6 757-8 2004/06
  •  Treatment of DIC with all-trans retinoic acid in an endotoxin-induced rat. SEMINARS IN THROMBOSIS AND HEMOSTASIS 24 3 227-231 1998/12
  •  Short-term effects of fluvastatin, a HMG-CoA reductase inhibitor, on coagulation and the fibrinolytic system in patientswith hypercholesterolemia. INTERNATIONAL JOURNAL OF HEMATOLOGY 69 4 274-276 1999/06
  •  Elevated plasma levels of free-form of TFPI in hypercholesterolemic patients. ATHEROSCLEROSIS 154 1 203-212 2001/01
  •  Prednisolone inhibits endotoxin-induced disseminated intravascular coagulation and improves mortality in rats: importance of inflammatory cytokine suppression. BLOOD COAGULATION & FIBRINOLYSIS 10 6 321-330 1999/09
  •  Increased plasma levels of free tissue factor pathway inhibitor in patients with Graves' disease. Thromb Haemost 79 5 919-923 1998/05
  •  An idiopathic skin eruption resembling a butterfly rash in a septic patient with disseminated intravascular coagulation following bone marrow transplantation Ontachi Y, Asakura H, Funada H, Takami A, Saito M, Morishita E, etal BLOOD COAGULATION & FIBRINOLYSIS 15 3 255-259 2004/03
  •  Antithrombotic role of nitric oxide in rats under physiological conditions Asakura H, Okudaira M, Ontachi Y, Mizutani T, Omote M, Yoshida T, Kaneda M, Yamazaki M, Morishita E, et al THROMBOSIS AND HAEMOSTASIS 91 71-5 2004
  •  Elevated levels of free tissue factor pathway inhibitor antigen in cases of disseminated intravascular coagulation caused by various underlying diseases. BLOOD COAGULATION & FIBRINOLYSIS 12 1 1-8 2001/01

Conference Presentations

  • Impact of direct oral anticoagulants on Protein S total activity assay -New method to test protein S-(conference:International Society on Thrombosis and Haemostasis 2019)(2019/07/19)
  • A Case of Venous Thromboembolism Caused by Protein C deficiency due to a Novel Genetic Mutation(2022/03/11)
  • COVID-19-associated coagulopathy(conference:Cardiovascular and Metabolic Week 2020)
  • Molecular basis and thrombotic manifestations of antithrombin deficiency in Japanese patients(conference:Scientific and Standardization Committee Symposium, International Society on Thrombosis and Haemostasis)
  • 当研究室における先天性アンチトロンビン欠乏症の遺伝子解析および臨床背景(Genetic analysis and clinical background of antithrombin deficiency analyzed in our laboratory)(conference:臨床血液)(2018/09)

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  • COVID-19-Related Thrombosis in Japan: Results of a Questionnaire-based Survey in 2020(conference:International Society on Thrombosis and Haemostasis 2021)(2021/07/17)
  • 後天性第V因子インヒビターの診断に有用なマーカー(Useful markers for diagnosing acquired factor V inhibitors: perspectives from the literature)(conference:臨床血液)(2018/09)
  • DICを伴う血管奇形による小腸出血にアピキサバンとトロンビン液内服の併用が著効した1例(Effect of combining apixaban and oral thrombin for enterorrhagia due to DIC and venous malformations)(conference:臨床血液)(2018/09)
  • Adeno-associated virus vector-mediated gene therapy for congenital protein C deficiency in mice(conference:第83回日本血液学会学術集会)(2021/09/23)
  • COVID-19-associated coagulopahty(conference:The 19th International Symposium on Atherosclerosis)(2021/10/25)
  • Updates on using recombinant thrombomodulin for disseminated intravascular coagulation. SSC Session (Plasma coagulation inhibitor)(conference:International Society on Thrombosis and Haemostasis 2021)(2021/07/17)
  • COVID-19-associated coagulopahty(2021/03/13)
  • 十全大補湯によるNK細胞機能増強効果の検討(conference:第57回日本臨床検査医学会東海・北陸支部総会、第336回日本臨床化学会東海・北陸支部例会)(2018/03/11)
  • ヘパリンからDOACへの変更に伴い治療効果が著変下血管腫に伴う慢性DICの一例(conference:第18回TTMフォーラム)(2018/03/03)
  • 直接経口抗凝固薬が血中アンチトロンビン、プロテインC、プロテインS活性測定値に与える影響(conference:第79回日本血液学会学術集会)(2017/10/20)
  • 十全大補湯によるNK細胞機能増強効果の検討(conference:第42回北陸臨床病理集談会)(2017/09/02)
  • ヒト iPS 細胞由来造血幹細胞を用いた6pLOH マウスモデルの作製(conference:第42回北陸臨床病理集談会)(2017/09/02)
  • 先天性プロテインC欠損症の遺伝子解析および異常プロテインC蛋白(K437E)の機能解析(conference:第42回北陸臨床病理集談会)(2017/09/02)
  • EliAによる自動分析装置を用いた抗リン脂質抗体価測定の有用性(conference:第18回日本検査血液学会学術集会)(2017/07/22)
  • 当院で経験した第V因子インヒビター4例の特徴.(conference:第39回日本血栓止血学会学術集会)(2017/06/08)
  • Possible therapeutics for antiphospholipid antibody related thrombocytopenia:A systemic review and meta-analysis(conference:The American College of Rheumatology/Association of Rheumatology Health Professionals 2017 annual meeting.)(2017/11/03)
  • 先天性血友病の診断と治療(conference:中外製薬研修会)(2018/03/14)
  • 静脈血栓塞栓症の成因と治療―悪性腫瘍を中心にー(conference:Cancer VTE Seminar in Yokohama)(2018/03/01)
  • 静脈血栓塞栓症の成因と治療(conference:第五回抗凝固療法セミナー)(2018/02/26)
  • 基礎から学ぶ播種性血管内凝固症候群(DIC)(conference:血液・凝固セミナー)(2018/02/20)
  • 遺伝性血栓性素因と検査(conference:石川県医師会臨床検査制度管理調査合同報告会)(2018/02/11)
  • 静脈血栓塞栓症の成因と治療,骨髄腫治療のトータルマネジメント~VTEとSREへの対応~(2018/02/01)
  • 静脈血栓塞栓症の成因と治療(conference:緩和ケアカンファレンス)(2018/01/25)
  • 知っておきたい静脈血栓塞栓症の傾向と対策(conference:血栓塞栓症を考える会)(2017/04/06)
  • 静脈血栓塞栓症の病態・診断・治療~悪性腫瘍および先天性血栓性素因を中心に~(conference:iMET in KOBE)(2017/06/22)
  • APTT延長を認めたらどんな病態を考えますか?(conference:45nd SEKISUI Coagulation Seminar in Ariake)(2017/07/01)
  • 静脈血栓塞栓症の病態・診断・治療~悪性腫瘍および先天性血栓性素因を中心に~(conference:東葛HEART研究会)(2017/11/14)
  • 悪性腫瘍に関連する血栓症(conference:第17回群馬血栓止血研究会)(2017/11/16)
  • 静脈血栓塞栓症の病態・診断・治療~悪性腫瘍および先天性血栓性素因を中心に~(conference:VTE BOARD FORUM 2017)(2017/12/04)
  • 播種性血管内凝固症候群(DIC)と輸血(conference:愛知県臨床検査技師輸血研究班講演会)(2017/12/09)
  • 先天性血栓性素因の病態と解釈~臨床検査技師の視点から~(conference:第18回日本検査血液学会学術集会)(2017/07/22)
  • 先天性第X因子欠乏症5症例のphenotypeおよびgenotype(conference:第12回日本血栓止血学会学術標準化委員会(SSC))(2018/02/10)
  • 部会活動の紹介ならびに指定難病「特発性血栓症」の診断に際しての問題点(conference:第12回日本血栓止血学会学術標準化委員会(SSC))(2018/02/10)
  • 血液の難病に挑む~出血と血栓に関連する血液難病について~(conference:厚生労働科学研究費補助金難治性疾患政策研究事業 血液凝固異常症等に関する研究班)(2018/02/03)
  • Development of ELISA system for detection of Protein S K196E mutation, a genetic risk factor for venous thromboembolism.(conference:ISTH)(2015/06/20)
  • Thrombomodulin has a significant impact on transplant outcomes after HLA-fully-matched unrelated bone marrow transplantation for standard risk hematologic malignancies(conference:56th American Society of Hematoogy Annual Meeting)(2014/12/05)
  • An uncommon case of deep venous thrombosis and pulmonary thromboembolism in a juvenile with compound heterozygous congenital protein S deficiency(conference:XXVI World Congress of the International Union of Angiology)(2014/08/10)
  • A genetic variant in the CD53 intron functiononally predicts transplant outcomes after HLA-matched unrelated bone marrow transplantation(conference:第18回欧州血液学会(EHA))(2013/06/13)
  • Management of pregnancy in paroxysmal nocturnal hemoglobinuria(conference:55rd ASH Annual Meeting)(2013/12/07)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「血液凝固異常症等に関する調査研究班」(2020-2022) 
○「遺伝性血栓症の病因(オミックス解析)と病態の解明」(2022-2024) 
○「ヘムオキシゲナーゼー1が造血幹細胞移植後治療成績におよぼす効果と新規治療戦略」(2018-2020) 
○「身近に感じる血液のしくみを一緒に体験してみよう」(2018-2018) 
○「血液凝固異常症等に関する調査研究班」(2017-2019) 
○「ヘムオキシゲナ-ゼ-1と同種造血幹細胞移植後転帰の関連性および新規治療戦略」(2015-2018) 
○「抗リン脂質抗体関連血小板減少症の病態解明と治療指針の構築に関する研究」(2015-2016) 
○「生体侵襲時におけるヘムオキシゲナーゼ1を介する血栓形成制御機構の解明」(2006-2008) 
○「身近に感じる血液のしくみを一緒に体験してみよう」(2015-) 
○「身近に感じる血液のしくみを一緒に体験してみよう」(2014-) 
○「ヘムオキシゲナーゼー1が造血幹細胞移植治療成績におよぼす改善効果の解明と新規治療戦略」(2015-) 
○「ヘムオキシゲナーゼー1が造血幹細胞移植後治療成績におよぼす効果と新規治療戦略」(2015-2017) 
○「血液凝固異常症等に関する調査研究班」(主任研究者 村田満)」(2014-2016) 
○「「生体侵襲時におけるヘムオキシゲナーゼ1と同種造血幹細胞移植後転帰の関連性および新規治療戦略」」
○「ヘムオキシゲナ-ゼ-1と同種造血幹細胞移植後転帰の関連性および新規治療戦略」(2012-2014)
○「ヘムオキシゲナ-ゼ-1と同種造血幹細胞移植後転帰の関連性および新規治療戦略」(2012-2014) 
○「ヒムオキシゲナーゼ-1(HO-1)が凝固・線容系因子の発現調節に果たす役割の解明」(2007-2009) 
○「生体侵襲時におけるヘムオキシゲナーゼ-1を介する血栓形成制御機構の解明」(2009-2011) 
○「生体侵襲時におけるヘムオキシゲナーゼ1を介する血栓形成制御機構の解明」(2007-) 
○「白血病における白血球インテグリンMac-1を介する線容機序」(2001-) 
○「白血病における白血病インテグリンMac-1を介する線溶機序」(2000-) 
○「インテグリンMac-1を介する白血病細胞表面の凝固開始機構」(1998-) 
○「インテグリンMac-1を介する白血病細胞表面の凝固開始機構」(1997-) 

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Laboratory Hematology(2020)
○Hematology(2020)
○Immunology(2020)
○Laboratory Medicine of Blood Transfusion(2020)
○Pathophysiology 1(2020)
○Practice in Laboratory Hematology(2020)
○Human Physiology(2020)
○Public Health(2020)
○Human Physiology(2020)
○Clinial Practice of Hematology and Blood Transfusion(2020)
○Customized Research Project(2020)
○Hematology(2019)
○Laboratory Medicine of Blood Transfusion(2019)
○Public Health(2019)
○Clinial Practice of Hematology and Blood Transfusion(2019)
○Laboratory Hematology(2019)
○Practice in Laboratory Hematology(2019)
○Pathophysiology 1(2019)
○Research Project(2019)
○Immunology(2019)
○Customized Research Project(2019)
○Clinial Practice of Hematology and Blood Transfusion(2019)
○Medical English(2017)
○Presentation and Debate (Freshman Seminar II)(2017)
○Presentation and Debate (Freshman Seminar II)(2017)
○Immunology(2017)
○Laboratory Medicine of Blood Transfusion(2017)
○Freshman Seminar I(2017)
○Introduction to Region-studies(2017)
○Practice in Laboratory Hematology(2017)
○Laboratory Hematology(2017)
○Lecture and Practice of Hematology(2017)
○Pathophysiology 1(2017)
○Immunology(2016)
○Clinial Practice of Hematology and Blood Transfusion(2016)

Classes (Graduate Schools)

○Laboratory Oncology: Seminar(2020)
○Laboratory Oncology: Lecture(2020)
○Advanced Laboratory Oncology: Research(2020)
○Clinical Immunohematology: Lecture(2020)
○Laboratory Oncology: Research(2020)
○Clinical Immunohematology: Seminar(2020)
○An Introduction to Medical Laboratory Sciences:Lec(2020)
○Advanced Laboratory Oncology: Research(2019)
○An Introduction to Medical Laboratory Sciences:Lec(2019)
○Laboratory Oncology: Lecture(2019)
○Clinical Immunohematology: Seminar(2019)
○Laboratory Oncology: Seminar(2019)
○Clinical Immunohematology: Lecture(2019)
○Laboratory Oncology: Research(2019)
○Research Design in Health Science 2: Lecture(2019)
○Advanced Laboratory Oncology: Research(2019)
○Laboratory Oncology: Seminar(2019)
○Laboratory Oncology: Lecture(2019)
○Laboratory Oncology: Research(2019)
○Clinical Immunohematology: Seminar(2019)
○Clinical Immunohematology: Lecture(2019)
○An Introduction to Medical Laboratory Sciences:Lec(2019)
○Fostering the independence of researchers(2018)
○Advanced Laboratory Oncology: Research(2017)
○Advanced Laboratory Oncology: Research(2017)
○Laboratory Oncology: Seminar(2017)
○Laboratory Oncology: Seminar(2017)
○Clinical Immunohematology: Seminar(2017)
○Clinical Immunohematology: Seminar(2017)
○Laboratory Oncology: Research(2017)
○Laboratory Oncology: Research(2017)
○Laboratory Oncology: Research(2017)
○An Introduction to Medical Laboratory Sciences:Lec(2017)
○Laboratory Oncology: Seminar(2017)
○Clinical Immunohematology: Seminar(2017)
○Laboratory Oncology: Lecture(2017)
○Fostering the independence of researchers(2017)
○Advanced Laboratory Oncology: Research(2017)
○Clinical Immunohematology: Lecture(2017)
○Laboratory Oncology: Research(2016)
○An Introduction to Medical Laboratory Sciences:Lec(2016)
○Laboratory Oncology: Seminar(2016)
○Clinical Immunohematology: Seminar(2016)
○Advanced Laboratory Oncology: Research(2016)
○Research Design in Health Science: Lecture(2016)
○Laboratory Oncology: Lecture(2016)
○Clinical Immunohematology: Lecture(2016)
○Advanced Laboratory Oncology: Research(2012)
○Clinical Immunohematology: Lecture(2012)
○Laboratory Oncology: Lecture(2012)
○Laboratory Oncology: Research(2012)
○Laboratory Oncology: Seminar(2012)
○Clinical Immunohematology: Seminar(2012)
○An Introduction to Medical Laboratory Sciences:Lec(2012)
○Advanced Laboratory Oncology: Research(2011)
○Advanced Laboratory Oncology: Research(2010)
○Laboratory Oncology: Seminar(2010)
○Laboratory Oncology: Lecture(2010)
○Laboratory Oncology: Seminar(2009)
○Laboratory Oncology: Lecture(2009)
○Advanced Laboratory Oncology: Research(2009)
○Advanced Laboratory Oncology: Research(2008)

International Project

International Students

Lecture themes

Others (Social Activities)

○石川県医師会(2018-2018)

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