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Researcher Information

last modified:2024/03/29

Assistant Professor KINOSHITA Takeshi

Mail

Faculty, Affiliation

Cancer Research Institute

College and School Educational Field

Division of Medicine, Graduate School of Medical Science

Laboratory

Division of Immunology and Molecular Biology TEL:076-265-2732 FAX:076-234-4525

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine 199803 Completed
【Academic background(Bachelor's Degree)】
University of Tsukuba 198703

Career

Kanazawa University(1998/10/01-)

Year & Month of Birth

1964/04

Academic Society


Award

Specialities

Cell biology、Molecular biology

Speciality Keywords

innate-immunity,inflammation,apoptosis

Research Themes

Multiple roles for innate immunity

Books

Papers

  •  Mechanism and repertoire of ASC-mediated gene expression M Hasegawa,R Imamura,Kou Motani,T Nishiuchi,N Matsumoto,T Kinoshita,T Suda The Journal of Immunology Vol.182 No.12 7655 2009/06/15
  •  PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1 beta secretion T Kinoshita,YT Wang,M Hasegawa,R Imamura,T Suda JOURNAL OF BIOLOGICAL CHEMISTRY 280 23 21720 2005/06
  •  PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1 YT Wang,M Hasegawa,R Imamura,T Kinoshita,C Kondo,K Konaka,T Suda INTERNATIONAL IMMUNOLOGY 16 6 777 2004/06
  •  MT-MMPs and their functions: Activation of a recombinant membrane-type matrix metalloproteinase 1 (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases-2 (TIMP-2) H Sato,T Kinoshita,T Takino,K Nakayama,M Seiki TISSUE INHIBITORS OF METALLOPROTEINASES IN DEVELOPMENT AND DISEASE, PROCEEDINGS 97 2000
  •  Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1 Takeshi Kinoshita,Chiaki Kondoh,Mizuho Hasegawa,Ryu Imamura,Takashi Suda INTERNATIONAL IMMUNOLOGY 18 12 1701 2006/12

show all

  •  NLRP3 Mediates NF-kappa B Activation and Cytokine Induction in Microbially Induced and Sterile Inflammation Takeshi Kinoshita,Ryu Imamura,Hiroko Kushiyama,Takashi Suda PLOS ONE 10 3 e0119179 2015/03
  •  ASC-mediated NF-kappa B activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP M Hasegawa,R Imamura,T Kinoshita,N Matsumoto,J Masumoto,N Inohara,T Suda JOURNAL OF BIOLOGICAL CHEMISTRY 280 15 15122 2005/04
  •  Expression of NLRP7 (PYPAF3, NALP7) protein in endometrial cancer tissues Satoshi Ohno,Takeshi Kinoshita,Yumiko Ohno,Toshinari Minamoto,Nobutaka Suzuki,Masaki Inoue,Takashi Suda ANTICANCER RESEARCH 28 4C 2493 2008/07
  •  Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity. Motani K,Kushiyama H,Imamura R,Kinoshita T,Nishiuchi T,Suda T The Journal of biological chemistry 286 39 33963 2011/09
  •  Activation of ASC induces apoptosis or necrosis depending on the cell type and causes tumor eradication MOTANI Kou,KAWASE Kouji,IMAMURA Ryu,KINOSHITA Takeshi,KUSHIYAMA Hiroko,SUDA Takashi Cancer Science 101 8 1822 2010 
  •  Mechanism and Repertoire of ASC-Mediated Gene Expression Mizuho Hasegawa,Ryu Imamura,Kou Motani,Takumi Nishiuchi,Norihiko Matsumoto,Takeshi Kinoshita,Takashi Suda JOURNAL OF IMMUNOLOGY 182 12 7655 2009/06
  •  Mechanism of ASC-mediated apoptosis: Bid-dependent apoptosis in type II cells M. Hasegawa,K. Kawase,N. Inohara,R. Imamura,W. -C Yeh,T. Kinoshita,T. Suda ONCOGENE 26 12 1748 2007/03
  •  Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily - A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors T Uekita,Gotoh, I,T Kinoshita,Y Itoh,H Sato,T Shiomi,Y Okada,M Seiki JOURNAL OF BIOLOGICAL CHEMISTRY 279 13 12734 2004/03
  •  Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2. Sato H,Kinoshita T,Takino T,Nakayama K,Seiki M FEBS Letters 393 1 101 1996/09
  •  Processing of a precursor of 72-kilodalton type IV collagenase/gelatinase A by a recombinant membrane-type 1 matrix metalloproteinase. Kinoshita T,Sato H,Takino T,Itoh M,Akizawa T,Seiki M Cancer Research 56 11 2535 1996/06
  •  Cell surface binding and activation of gelatinase A induced by expression of membrane-type-1-matrix metalloproteinase (MT1-MMP). Sato H,Takino T,Kinoshita T,Imai K,Okada Y,Stetler Stevenson WG,Seiki M FEBS Letters 385 3 238 1996/05
  •  Anti-Inflammatory Activity of PYNOD and Its Mechanism in Humans and Mice Ryu Imamura,Yetao Wang,Takeshi Kinoshita,Misao Suzuki,Tetsuo Noda,Junji Sagara,Shun'ichiro Taniguchi,Hiroshi Okamoto,Takashi Suda JOURNAL OF IMMUNOLOGY 184 10 5874 2010/05
  •  Caspase-1 induces apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC)-mediated necrosis independently of its catalytic activity Kou Motani,H Kushiyama,R Imamura,T Kinoshita,T Nishiuchi,T Suda The Journal of Biological Chemistry Vol.286 33963 2011/08/08
  •  Fas ligand induces cell-autonomous NF-kappa B activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha R Imamura,K Konaka,N Matsumoto,M Hasegawa,M Fukui,N Mukaida,T Kinoshita,T Suda JOURNAL OF BIOLOGICAL CHEMISTRY 279 45 46415 2004/11
  •  Mechanism of ASC-mediated apoptosis: Bid-dependent apoptosis in type II cells M. Hasegawa,K. Kawase,N. Inohara,R. Imamura,W. -C Yeh,T. Kinoshita,T. Suda ONCOGENE 26 12 1748 2007/03
  •  Vitamin B6 Prevents IL-1 beta Protein Production by Inhibiting NLRP3 Inflammasome Activation Peipei Zhang,Kohsuke Tsuchiya,Takeshi Kinoshita,Hiroko Kushiyama,Sofya Suidasari,Mizuki Hatakeyama,Hisanori Imura,Norihisa Kato,Takashi Suda JOURNAL OF BIOLOGICAL CHEMISTRY 291 47 24517 2016/11
  •  Caspase-1 initiates apoptosis in the absence of gasdermin D. Tsuchiya K,Nakajima S,Hosojima S,Thi Nguyen D,Hattori T,Manh Le T,Hori O,Mahib MR,Yamaguchi Y,Miura M,Kinoshita T,Kushiyama H,Sakurai M,Shiroishi T,Suda T Nature communications 10 1 2091 2019/05 
  •  Caspase‐7 mediates caspase‐1‐induced apoptosis independently of Bid Mamunur Rashid Mahib,Shoko Hosojima,Hiroko Kushiyama,Takeshi Kinoshita,Toshihiko Shiroishi,Takashi Suda,Kohsuke Tsuchiya Microbiology and Immunology 64 2 143 2020/02 
  •  Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes Kohsuke Tsuchiya,Shoko Hosojima,Hideki Hara,Hiroko Kushiyama,Mamunur Rashid Mahib,Takeshi Kinoshita,Takashi Suda Cell Reports 34 12 2021/03/23
  •  TIMP-2 promotes activation of progelatinase a by membrane-type 1 matrix metalloproteinase immobilized on agarose beads T Kinoshita,H Sato,Akiko,Okada,E Ohuchi,K Imai,Y Okada,M Seiki JOURNAL OF BIOLOGICAL CHEMISTRY 273 26 16098 1998/06

Conference Presentations

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「アポトーシス促進因子Bidの制御機構」(2001-) 
○「新規Bid結合因子によるアポトーシス制御機構の解明」(2003-) 
○「新規BH3ファミリー結合因子の機能解析」(2003-) 
○「TNFレセプターファミリーDR6のシグナル伝達機構解明」(2002-) 
○「抗炎症因子NLRP7の発現制御と新機能:細胞増殖、分化、運動、腫瘍化への関与」(2008-)
○「自然免疫制御因子PYPAF2, PYPAF3の細胞生存、増殖への関与」(2007-) 
○「Fas-associated factor 1はマクロファージ抗炎症因子か?」(2006-) 
○「単球系細胞における炎症反応のフィードバック制御機構」(2005-) 
○「BH3ファミリーの細胞内局在を制御する新規因子」(2005-) 
○「NF-kB活性化を介した自然免疫制御因子群NLRファミリーの新機能」(2009-) 
○「自然免疫制御因子NLRPファミリーを介したがん細胞サイトカイン産生制御機構の解明」(2010-) 
○「自然免疫ストレスセンサーNLRP3の新機能とその分子機構解明」(2011-2013) 

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

○Body Defense Mechanisms(2017)
○Body Defense Mechanisms(2017)
○Body Defense Mechanisms(2016)
○Seminar on Tumor Biology(2016)
○Body Defense Mechanisms(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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