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Researcher Information

last modified:2019/02/15

Assistant Professor KINOSHITA Takeshi

Mail

Faculty, Affiliation

Cancer Research Institute

College and School Educational Field

Division of Cancer Medicine, Graduate School of Medical Science

Laboratory

Division of Immunology and Molecular Biology TEL:076-265-2732 FAX:076-234-4525

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor 199803 Completed
【Academic background(Bachelor's Degree)】
University of Tsukuba 198703

Career

Kanazawa University(1998/10/01-)

Year & Month of Birth

1964/04

Academic Society


Award

Specialities

Cell biology、Molecular biology

Speciality Keywords

apoptosis, inflammation, innate-immunity

Research Themes

Multiple roles for innate immunity

Books

Papers

  •  TIMP-2 Promotes Activation of Progelatinase A by Membrane-Type 1 Matrix Metalloproteinase Immobilized on Agarose Beads JOURNAL OF BIOLOGICAL CHEMISTRY 273 26 16098-16103 1998/06
  •  Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors JOURNAL OF BIOLOGICAL CHEMISTRY 279 13 12734-43 2004/03
  •  PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1 INTERNATIONAL IMMUNOLOGY 16 6 777-86 2004/04
  •  Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha JOURNAL OF BIOLOGICAL CHEMISTRY 279 45 46415-46423 2004
  •  ASC-mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP JOURNAL OF BIOLOGICAL CHEMISTRY 280 15 15122-15130 2005

show all

  •  PYPAF3, a PYRIN-containing APAF-1-like Protein, Is a Feedback Regulator of Caspase-1-dependent Interleukin-1{beta} Secretion JOURNAL OF BIOLOGICAL CHEMISTRY 280 23 21720-21725 2005/06
  •  Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1 Kinoshita T, Kondoh C, Hasegawa M, Imamura R, Suda T Kinoshita T, Kondoh C, Hasegawa M, Imamura R, Suda T 18 12 1701 2006/12
  •  Mechanism of ASC-mediated apoptosis: bid-dependent apoptosis in type II cells Hasegawa M, Kawase K, Inohara N, Imamura R, Yeh WC, Kinoshita T, Suda T ONCOGENE 26 12 1748 2007/03
  •  Expression of NLRP7 (PYPAF3, NALP7) Protein in Endometrial Cancer Tissues. 28  2493-2498 2008
  •  Mechanism and repertoire of ASC-mediated gene expression. Hasegawa M, Imamura R, Motani K, Nishiuchi T, Matsumoto N, Kinoshita T, Suda T. JOURNAL OF IMMUNOLOGY 182 12 7655 2009/06
  •  Anti-inflammatory activity of PYNOD and its mechanism in humans and mice Imamura R, Wang Y, Kinoshita T, Suzuki M, Noda T, Sagara J, Taniguchi S, Okamoto H, Suda T JOURNAL OF IMMUNOLOGY 184 5874 2010/05
  •  Caspase-1 induces apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC)-mediated necrosis independently of its catalytic activity Motani K, Kushiyama H, Imamura R, Kinoshita T, Nishiuchi T, Suda T JOURNAL OF BIOLOGICAL CHEMISTRY 2011/08
  •  NLRP3 Mediates NF-kappaB Activation and Cytokine Induction in Microbially Induced and Sterile Inflammation Kinoshita T., Imamura R., Kushiyama H., Suda T. PLoS One 10 3 e0119179 2015/03 
  •  Vitamin B6 prevents IL-1β production by inhibiting NLRP3 inflammasome activation Zhang P., Tsuchiya K., Kinoshita T., Kushiyama H., Suidasari S., Hatakeyama M., Imura H., Kato N., and Suda T. J. Biol. Chem. 291 47 24517-24527 2016

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「アポトーシス促進因子Bidの制御機構」(2001-) 
○「新規Bid結合因子によるアポトーシス制御機構の解明」(2003-) 
○「新規BH3ファミリー結合因子の機能解析」(2003-) 
○「TNFレセプターファミリーDR6のシグナル伝達機構解明」(2002-) 
○「抗炎症因子NLRP7の発現制御と新機能:細胞増殖、分化、運動、腫瘍化への関与」(2008-)
○「自然免疫制御因子PYPAF2, PYPAF3の細胞生存、増殖への関与」(2007-) 
○「Fas-associated factor 1はマクロファージ抗炎症因子か?」(2006-) 
○「単球系細胞における炎症反応のフィードバック制御機構」(2005-) 
○「BH3ファミリーの細胞内局在を制御する新規因子」(2005-) 
○「NF-kB活性化を介した自然免疫制御因子群NLRファミリーの新機能」(2009-) 
○「自然免疫制御因子NLRPファミリーを介したがん細胞サイトカイン産生制御機構の解明」(2010-) 
○「自然免疫ストレスセンサーNLRP3の新機能とその分子機構解明」(2011-2013) 

Classes (Bachelors)

Classes (Graduate Schools)

○Body Defense Mechanisms(2017)
○Body Defense Mechanisms(2017)
○Body Defense Mechanisms(2016)
○Seminar on Tumor Biology(2016)
○Body Defense Mechanisms(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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