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Researcher Information

last modified:2018/04/02

Professor TAKEDA Yoshiyu


Faculty, Affiliation

University Hospital

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Cardiovascular Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences


Laboratory of Endocrine and Hypertension TEL:076-265-2252 FAX:076-234-4251

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor 1985
【Academic background(Bachelor's Degree)】
Kanazawa University 1981


Year & Month of Birth


Academic Society

Japanese Society of Hypertension

Japanese Society of Cardiovascular Endocrinology and Metabolism
Japan Hormonal Steroid Society


Japan Hormonal Steroid Society
Japan Hormonal Steroid Society
Japan Hormonal Steroid Society
Japan Hormonal Steroid Society
Japan Hormonal Steroid Society
Japan Hormonal Steroid Society


Endocrinology、Endocrinology、Cardiovascular medicine、Metabolomics

Speciality Keywords

Endocrinology, Hypertension, Diabetes mellitus

Research Themes

Endocrinological study for the mechanism of hypertension and diabetes mellitus


  •  Biochemistry and Function of Sterols CRC Press 1997/05
  •  Current Topics in STEROID RESEARCH Research Trends 1998/06


  •  A case of Cushing's syndrome due to ACTH-independent bilateral macronodular hyperplasia associated with excessive secretion of mineralocorticoids. Endocrine J. 45, 485-491, 1998 ENDOCRINE JOURNAL 45 4 485-491 1998/07
  •  Aldosterone overproduction and CYP11B2 mRNA overexpression in vessels of spontaneously hypertensive rats HORMONE RESEARCH 50 1 28-31 1998/01
  •  Angiotensin II stimulates cyclic ADP-ribose formation in neonatal rat cardiac myocytes. Biochem J 352 11 197-202 2000/11
  •  Brain nitric oxide synthase messenger RNA in central mineralocorticoid hypertension HYPERTENSION 30 4 953-956 1997/10
  •  Cardiac aldosterone production in genetically hypertensive rats HYPERTENSION 36 10 495-500 2000/10

show all

  •  Effects of chronic neutral endopeptidase inhibition in rats with cyclosporine-induced hypertension. J Hypertens 18, 927-933, J Hypertension 18 7 927-933 2000/07
  •  Effects of high sodium intake on cardiovascular aldosterone synthesis in stroke-prone spontaneously hypertensive rats. J Hyperens 19, 635-639, 2001 J Hypertension 19 7 635-639 2001/07
  •  Genetic analysis of aldosterone synthase in patients with idiopathic hyperaldosteronism. J Clin Endocrinol Metab 84 5 1633-1637 1999/05
  •  Genetic analysis of the cytochrome P-450c17a (CYP17) and aldosterone synthase (CYP11B2) in Japanese patients with 17α -hydroxylase deficiency. 54, 751-758, 2001 Clin Endocrinol 54 6 751-758 2001/06
  •  Mechanism of FK506-induced hypertension in the rat HYPERTENSION 33 1 130-136 1999/01
  •  Renal 11β-hydroxysteroid dehydrogenase in genetically salt-sensitive hypertensive rats. HYPERTENSION 32 6 1077-1082 1998/12
  •  Sodium-induced cardiac aldosterone synthesis causes cardiac hypertrophy. ENDOCRINOLOGY 141 5 1901-1904 2000/05
  •  Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus HUMAN MUTATION 19 1 23-29 2002/01
  •  Calcineurin inhibition attenuates mineralocorticoid-induced cardiac hypertrophy CIRCULATION 105 677-679 2002/12
  •  Completely skewed X-inactivation in a mentally retarded young female with pseudohypoparathyroidism type IB and juvenile renin-dependent hypertension JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 88 7 3043-3049 2003/07
  •  Pleiotropic actions of aldosterone and the effects of eplerenone, a selective mineralocroticoid receptor antagonist HYPERTENSION RESEARCH 27 781-789 2004
  •  The expression of messenger RNA for ADP-ribosyl cyclase in aldosterone-producing adenoma CLINICAL ENDOCRINOLOGY 62 504-508 2005
  •  Pathophysiological roles of adrenal renin-angiotensin system in patients with primary aldosteronism. Oda, N., Takeda, Y. et al Hypertension Research: 29 9-14 2006/01
  •  Effects of aldosterone and angiotensin II blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl salt-sensitive hypertensive rats. Zhu, A., Yoneda, T. et al American Journal of Hypertension 20; 1119-1124 2007/08
  •  Aldosterone breakthrough during angiotensin II receptor blockade in hypertensive patinents with diabetes mellitus. Yoneda, T., Takeda, Y., Usukura, M. et al American Journal of Hypertension 20  1329-1333 2007/09
  •  Effect of mineralocorticoid receptor blockade on the renal renin-angiotensin system in Dahl salt-sensitive hypertensive rats. Zhu A, Yoneda T, Demura M, Karashima S, Usukura M, Yamagishi M, Takeda Y. Journal of Hypertrension 27  800-805 2009/02
  •  Effects of a high-salt diet on adipocyte glucocorticoid receptor and 11beta-hydroxysteroid dehydrogenase 1 in salt-sensitive hypertensive rats. Usukura M, Zhu A, Yoneda T, Karashima S, Yagi K, Yamagishi M, Takeda Y. Steroids 74  978-982 2009/11
  •  Effects of eplerenone, a selective mineralocorticoid receptor antagonist, on clinical and experimental salt-sensitive hypertension. Hypertension Research 32  321-324 2009/03
  •  Protective effects of mineralocorticoid receptor blockade against neuropathy in experimental diabetic rats. Takata H, Takeda Y, Zhu A, Cheng Y, Yoneda T, Demura M, Yagi K, Karashima S, Yamagishi M. DIABETES OBESITY & METABOLISM 14 2 155 2012/04
  •  Unilateral primary aldosteronism with spontaneous remission after Long-Term spironolactone therapy. Yoneda T, Demura M, Takata H, Kometani M, Karashima S, Yamagishi M, Takeda Y. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 97 4 1109-13 2012/04
  •  Multiple noncoding exons1 of nuclear receptors NR4A family and NR5A1 in human cardiovascular and sdrenal tissues. Demura M, Wang F, Yoneda T, Takeda Y, et al. Journal of Hypertension 29 1185-1195 2011/06
  •  Clinical characteristics of primary hyperaldosteronism due to adrenal microadenoma Karashima S, Takeda Y, Yoneda T, Demura M, et al Steroids 76 1363-1366 2011/09
  •  Primary aldosteronism, diagnosis and treatment in Japan Rev Endocr Metab Disord 12 21-25 2011/03

Conference Presentations

Arts and Fieldwork


Theme to the desired joint research

○Regional differences of hypertensinogenic factors in Hokuriku area.

Grant-in-Aid for Scientific Research


Classes (Bachelors)

○Understanding Health and Illness(2017)
○Understanding Health and Illness(2017)
○Understanding Health and Illness(2016)
○Understanding Health and Illness(2016)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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