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Researcher Information

last modified:2022/07/04

Professor INAZU Akihiro

Mail Laboratory Website
Laboratory Website

Faculty, Affiliation

Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences Clinical Laboratory Science
Professor, Graduate Course of Medical Science and Technology

College and School Educational Field

Division of Health Sciences, Graduate School of Medical Science
Division of Health Sciences,Graduate School of Medical Science
Department of Laboratory Sciences,School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Akihiro INAZU Lab

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine 1991
【Academic background(Bachelor's Degree)】
Kanazawa University 1986

Career

Kanazawa Nishi Hospital(1992/01/01-1992/03/31)
Kanazawa National Tax Bureau Medical Office(1992/04/01-1997/03/31)
Kanazawa University School of Health Sciences(1997/04/01-2005/03/31)
Kanazawa University Graduate School of Medical Science(2005/04/01-2009/03/31)

Year & Month of Birth

1962/01

Academic Society

JSCC




JSLM




ASBMB
AACC

Award

Specialities

Metabolism、Laboratory science

Speciality Keywords

Lipid Metabolism, Atherosclerosis, Clinical Chemistry

Research Themes

Function of serum high-density lipoproteins

Function of serum high-density lipoproteins

CETP inhibitor

CETP inhibitor

Molecular basis of secondary hyperlipidemia, FH-like syndrome and combined hyperlipidemia

Books

  •  Akihiro Inazu The HDL handbook 3rd Edition Academic Press, Elsevier 2017/02/22
  •  High Density Lipoproteins, Dyslipidemia and Coronary Heart Disease Springer 95-102 2010/06

Papers

  •  A teenager boy with a novel variant of Sitosterolemia presented with pancytopenia V Gok, H Tada, M E Dogan, ...., A Inazu, E Unal Clin Chim Acta 529 61-66 2022/02/12
  •  Prevalence, self-awareness, and LDL cholesterol levels among patients highly suspected as familial hypercholesterolemia in a Japanese community Hayato Tada, Junichi Shibayama, Tetsuo Nishikawa, Hirofumi Okada, Akihiro Nomura, Soichiro Usui, Kenji Sakata, Atsushi Hashiba, Akihiro Inazu, Masayuki Takamura, Masa-aki Kawashiri  Practical Laboratory Medicine 22 e038623 2020/10/19
  •  Serum sitosterol level predicting ABCG5 or ABCG8 genetic mutations  Nobuko Kojima, Hayato Tada, Soichiro Usui, Kenji Sakata, Kenshi Hayashi, Atsushi Nohara, Akihiro Inazu, Masayuki Takamura, Masa-aki Kawashiri Clin Chim Acta 507 11-16 2020
  •  Clinical whole exome sequencing in severe hypertriglyceridemia  Tada H, Nomura A, Okada H, Nakahashi T, Nozue T, Hayashi K, Nohara A, Yagi K, Inazu A, Michishita I, Mabuchi H, Yamagishi M, Kawashiri MA. Clin Chim Acta 488 31-39 2019/01
  •  HDL3 Cholesterol Levels in an Elderly Population Akihiro Inazu J Atheroscler Thromb 24 2018/01/25

show all

  •  Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease.  Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, McCarthy S, Emdin CA, Klarin D, Natarajan P, Zekavat SM, Gupta N, Peloso GM, Borecki IB, Teslovich TM, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartze DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Juang JJ, Hsiung CA, Lin SY, Wang JS, Tada H, Kawashiri MA, Inazu A, Yamagishi M, Katsuya T, Nakashima E, Nakatochi M, Yamamoto K, Yokota M, Momozawa Y, Rotter JI, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer CJ, Abecasis GR, Saleheen D, Kubo M, Kato N, Ida Chen YD, Dewey FE, Kathiresan S. Circ Res 121 1 81-88 2017/06/23
  •  Anti-atherogenicity of HDL and the assay for HDL function Akihiro Inazu, Yutaka Takino 45 18-24 2016/01
  •  Novel mutations of cholesteryl ester transfer protein (CETP) gene in Japanese hyperalphalipoproteinemic subjects Ohtani, Rumiko; Inazu, Akihiro; Noji, Yoshihiro; Wakasugi, Takanobu; Miwa, Kenji; Tada, Hayato; Kawashiri, Masaaki; Noguchi, Tohru; Nohara, Atsushi; Kobayashi, Junji; Koizumi, Junji; Yamagishi, Masakazu; Mabuchi, Hiroshi Clinica Chimica Acta 413 42130 537-543 2012/03/22 
  •  Cholesterol efflux from J774 macrophages and Fu5AH hepatoma cells to serum is preserved in CETP deficient patients Clinica Chimica Acta 402 1-2 19-24 2009/04
  •  Decreased post-prandial triglyceride response and diminished remnant lipoprotein formation in cholesteryl ester transfer protein (CETP) deficiency. Inazu A et al. ATHEROSCLEROSIS 196  953-957 2008/02
  •  Cholesteryl ester transfer protein inhibitor (JTT-705) and the development of atherosclerosis in rabbits with severe hypercholesterolemia Zhiping Huang, Akihiro Inazu, Atsushi Nohara, Toshinori Higashikata, Hiroshi Mabuchi Clinical Science 103 587-594 2002
  •  Cholesteryl ester transfer protein and atherosclerosis. CURRENT OPINION IN LIPIDOLOGY 11 4 389-396 2000/08
  •  A low prevalence of coronary heart disease in subjects with increased high-density lipoprotein cholesterol levels including those with plasma cholesteryl ester transfer protein deficiency. Prev Med 27 5 659-667 1998/09
  •  Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of HDL cholesterol JOURNAL OF CLINICAL INVESTIGATION 94 5 1872-1882 1994/11
  •  Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation NEW ENGLAND JOURNAL OF MEDICINE 323 18 1234-1238 1990/11
  •  Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins.  Brown ML, Inazu A, Hesler CB, Agellon LB, Mann C, Whitlock ME, Marcel YL, Milne RW, Koizumi J, Mabuchi H, Takeda R, Tall AR. Nature 342 6248 448-51 1989/11/23

Conference Presentations

  • Etiology of hyperalphalipoproteinemia and CETP inhibitors(2020/10/30)
  • Hyperalphalipoproteinemia and HDL function test(2019/09/27)
  • Lp(a) molecular weight (MW) determination and relationship between Lp(a) MW and repeated number of kringle 4-2 of apo(a) gene(2016/03/19)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

○HDL function assay development
○Lipid lowering agent, HDL modulating agent Pharmacogenetics
○Gene and environment interaction in human cardiovascular disease

Grant-in-Aid for Scientific Research

○「複合型高脂血症発症に関与する肝性リパーゼ活性・内因性リパーゼインヒビターの役割」(2020-2023) 
○「PHRを活用することによる個人の行動変容に関する研究 オンライン特定保健指導・オンライン診療におけるPHR活用による行動変容に関する研究 」(2020-2021) 
○「コレステリルエステル転送蛋白欠損におけるリン脂質代謝異常と抗糖尿病性」(2012-2014) 
○「アンジオポエチン様蛋白異常による高高比重リポ蛋白血症の抗動脈硬化性」(2009-2011) 

Competitive research funding,Contribution

Collaborative research,Consignment study

○Pleiotropic effects of statin(2001-2003)

Classes (Bachelors)

○Clinical Chemistry(2021)
○Environmental Hygiene-Laboratory and Field Work(2021)
○Metabolism of Drugs and Xenobiotics(2021)
○Human Physiology(2021)
○Basic Health Science 1(2021)
○Basic Health Science 2(2021)
○Clinical Chemistry(2021)
○Clinical Chemistry Laboratory(2021)
○Pathophysiology 2(2021)
○Clinial Practice of Clinical Chemistry(2021)

Classes (Graduate Schools)

○Biological Information Analysis: Seminar(2021)
○Biological Information Analysis: Lecture(2021)
○Molecular Biology for Laboratory Medicine:Research(2021)
○Research Design in Health Science(Clinical): Lecture(2021)

International Project

International Students

Lecture themes

Others (Social Activities)

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