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Researcher Information

last modified:2020/04/09

Associate Professor USUI Soichiro


Faculty, Affiliation

University Hospital

College and School Educational Field


Department of Disease Control and Homeostasis TEL:076-265-2238 FAX:076-234-4248

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medical Sciences 200409 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 199703


Post Doc UMDNJ Post Doc(2005/04/01-2008/03/31)
Assistant professor Department of Cardiology University Hosp assistant professor(2008/10/01-2009/03/31)
Clinical fellow Department of Cardiology University Hosp(2008/04/01-2008/09/30)
Assistant professor Department of Cardiology University Hosp assistant professor(2009/04/01-)

Year & Month of Birth


Academic Society

Japan Circulation Society
Japanese Collage of Cardiology
Japanease Society of Internal Medicine
American Heart Association
Japanese Association of Cardiac Rehabilitation
Japanese Vascular Biology and Medicine Organization
Japanese Society for Regenerative Medicine


Japanese Society for Regenerative Medicine
○Melvin L. Marcus Young Investigation Awards(2007/11/05)
○Japan Heart Foundation/Novartis Grant for Research Award on Molecular and Cellular Cardiol(2010/04/01)
○AHA Basic Cardiovascular Sciences New Investigator Travel Award(2007/07/31)


Cardiovascular medicine

Speciality Keywords

Caldiology, heart failure, Cardiac remodeling

Research Themes

Study of adipose-derived regenerative cells for ischemic heart failure

Impact of Liver Dysfunction during Cardiac Remodeling

The role of MAFbx in cardiac remodeling


  •  Current Therapy in Cardiovascular Diseases 2020/01/30


  •  Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB CIRCULATION RESEARCH 109 2 287 2011/07
  •  Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Odashima M, Usui S, Takagi H, Hong C, Liu J, Yokota M, Sadoshima J CIRCULATION RESEARCH 100 9 1344-1352 2007/05
  •  Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart PLOS one 8 1 51632 2013/01
  •  Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice HYPERTENSION RESEARCH 35 3 287 2012/03
  •  Global changes in gene expression during cardiac hypertrophy: a new direction of cardiac signaling research. Usui S, Yeh I, Tian B, Sadoshima J. 41 2 219-222 2006/08

show all

  •  S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. Takuwa N,Ohkura S,Takashima S,Ohtani K,Okamoto Y,Tanaka T,Hirano K,Usui S,Wang F,Du W,Yoshioka K,Banno Y,Sasaki M,Ichi I,Okamura M,Sugimoto N,Mizugishi K,Nakanuma Y,Ishii I,Takamura M,Kaneko S,Kojo S,Satouchi K,Mitumori K,Chun J,Takuwa Y Cardiovasc Res 85 3 484-93 2010/02
  •  Altered hepatic gene expression profiles associated with myocardial ischemia. Ootsuji H,Honda M,Kaneko S,Usui S,Okajima M,Okada H,Sakai Y,Takamura T,Horimoto K,Takamura M Circ Cardiovasc Genet 3 1 68-77 2010/02
  •  Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. JOURNAL OF BIOLOGICAL CHEMISTRY 279 13 12300-12311 2004/03
  •  Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells. Ryu Y,Takuwa N,Sugimoto N,Sakurada S,Usui S,Okamoto H,Matsui O,Takuwa Y Circ Res 90 3 325-32 2002/02
  •  Muscle-specific RING finger 1 negatively regulates pathological cardiac hypertrophy through downregulation of calcineurin A Maejima, Yasuhiro; Usui, Soichiro; Zhai, Peiyong; Takamura, Masayuki; Kaneko, Shuichi; Zablocki, Daniela K.; Yokota, Mitsuhiro; Isobe, Mitsuaki; Sadoshima, Junichi Circulation: Heart Failure 7 3 479-490 2014/01/01 
  •  Rho-kinase activation in leukocytes plays a pivotal role in myocardial ischemia/reperfusion injury Kitano, Katsunori; Usui, Soichiro; Ootsuji, Hiroshi; Takashima, Shinichiro; Kobayashi, Daisuke; Murai, Hisayoshi; Furusho, Hiroshi; Nomura, Ayano; Kaneko, Shuichi; Takamura, Masayuki PLoS ONE 9 3 2014/03/17 
  •  Diabetes impairs the angiogenic capacity of human adipose-derived stem cells by reducing the CD271+ subpopulation in adipose tissue. Inoue O, Usui S, Takashima SI, Nomura A, Yamaguchi K, Takeda Y, Goten C, Hamaoka T, Ootsuji H, Murai H, Kaneko S, Takamura M. Biochem Biophys Res Commun. 517 2 369 2019/07/27
  •  Sphigosine-1-phosphate receptor 1 promotes neointimal hyperplasia in a mouse model of carotid artery injury. Kitano T, Usui S, Takashima SI, Inoue O, Goten C, Nomura A, Yoshioka K, Okajima M, Kaneko S, Takuwa Y, Takamura M. Biochem Biophys Res Commun. 511 3 179 2019/03/26
  •  Endogenous muscle atrophy F-box is involved in the development of cardiac rupture after myocardial infarction. Usui S, Chikata A, Takatori O, Takashima SI, Inoue O, Kato T, Murai H, Furusho H, Nomura A, Zablocki D, Kaneko S, Sadoshima J, Takamura M. J Mol Cell Cardiol. 126 1 1 2019/01
  •  Endogenous Selenoprotein P, a Liver-Derived Secretory Protein, Mediates Myocardial Ischemia/Reperfusion Injury in Mice Chadani H, Usui S, Inoue O, Kusayama T, Takashima SI, Kato T, Murai H, Furusho H, Nomura A, Misu H, Takamura T, Kaneko S, Takamura M. Int J Mol Sci. 19 3 E878 2018
  •  Long-Term Administration of Eicosapentaenoic Acid Improves Post-Myocardial Infarction Cardiac Remodeling in Mice by Regulating Macrophage Polarization. Takamura M, Kurokawa K, Ootsuji H, Inoue O, Okada H, Nomura A, Kaneko S, Usui S. J Am Heart Assoc 6 2 2017
  •  The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells. Nasti A, Sakai Y, Seki A, Buffa GB, Komura T, Mochida H, Yamato M, Yoshida K, Ho TTB, Takamura M, Usui S, Wada T, Honda M, Kaneko S Eur J Immunol. 47 12 2163 2017
  •  Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6. Ohkura SI, Usui S, Takashima SI, Takuwa N, Yoshioka K, Okamoto Y, Inagaki Y, Sugimoto N, Kitano T, Takamura M, Wada T, Kaneko S, Takuwa Y. PLoS One.  2017/08/03
  •  Altered gene expression in T-cell receptor signalling in peripheral blood leucocytes in acute coronary syndrome predicts secondary coronary events. Takashima S, Usui S, Kurokawa K, Kitano T, Kato T, Murai H, Furusho H, Oda H, Maruyama M, Nagata Y, Usuda K, Kubota K, Takeshita Y, Sakai Y, Honda M, Kaneko S, Takamura M. Open Heart. 2016
  •  Adipose-derived regenerative cells exert beneficial effects on systemic responses following myocardial ischemia/reperfusion. Takamura M, Usui S, Inoue O, Ootsuji H, Takashima SI, Nomura A, Kato T, Murai H, Furusho H, Sakai Y, Kaneko S. Cardiol J. 2016
  •  Sodium 4-Phenylbutyrate Attenuates Myocardial Reperfusion Injury by Reducing the Unfolded Protein Response. Takatori O, Usui S, Okajima M, Kaneko S, Ootsuji H, Takashima SI, Kobayashi D, Murai H, Furusho H, Takamura M. J Cardiovasc Pharmacol Ther.  2016

Conference Presentations

Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Classes (Bachelors)

Classes (Graduate Schools)

○Disease Control and Homeotasis(2017)
○Disease Control and Homeotasis(2017)
○Disease Control and Homeotasis(2017)
○Disease Control and Homeotasis(2017)
○Disease Control and Homeotasis(2016)
○Disease Control and Homeotasis(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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