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Researcher Information

last modified:2020/01/22

Professor SHIBA Kazuhiro

Mail Laboratory Website

Faculty, Affiliation

Advanced Science Research Center  Advanced Science Research Center, Division of Tracer Kinetics

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medical Science, Graduate School of Medical Science
Division of Natural System, Graduate School of Natural Science and Technology
United Graduate School of Child Depelopment
Department of Laboratory Sciences,School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Division of Tracer Kineticster TEL:076-265-2470 FAX:076-234-4245

Academic Background

【Academic background(Bachelor's Degree)】
Kanazawa University 198003

Career

Kanazawa University Advanced Science Research Center(2014/08/01-)
Kanazawa University Advanced Science Research Center Professor(2009/04/01-)
Kanazawa University Advanced science research center associate professor(2003/04/01-2009/03/31)
Kanazawa University Radioisotope Center Assistant professor(1999/04/01-2003/03/31)
Kanazawa University(1993/04/01-1995/03/31)
Kanazawa University Radioisotope Center(1980/04/01-1999/03/31)

Year & Month of Birth

1957/01

Academic Society



Seminar of Nuclear Medicine
Japanese Society of Radiation Safety Management
Japanese Society of Radiation Safety Management
The Hokuriku journal of radioisotope research

Award

Specialities

Chemical pharmacy、Radiation science、Risk sciences of radiation and chemicals

Speciality Keywords

Brain,moleculerimaging, radioisotope, Alzheimer's Disease, Autism

Research Themes

Study on Syntheses of Radiopharmaceutical for cerebral nerve function diagnosis

Development of a high sensitive evaluation of internal radiation exposure

Books

Papers

  •  Radiotheranostics Coupled between an At-211-Labeled RGD Peptide and the Corresponding Radioiodine-Labeled RGD peptide. Kazuma Ogawa, Takuya Takeda, Kenji Mishiro, Atsushi Toyoshima, Kazuhiro Shiba, Takashi Yoshimura, Seigo Kinuya, Akira Odani. ACS Omega 4 4584-4591 2019
  •  Comparison of radioiodine- or radiobromine-labeled RGD peptides between direct and indirect labeling methods.  Kazuma Ogawa, Takuya Takeda, Masaru Yokokawa, Jing Yu, Akira Makino, Yasushi Kiyono, Kazuhiro Shiba, Seigo Kinuya, and Akira Odani. Chem Pharm Bull 66 6 651 2018/03
  •  Evaluation of Chlorella as a decorporation agent to enhance the elimination of radioactive strontium from body. Kazuma Ogawa, Tadahisa Fukuda, Jaegab Han, Yoji Kitamura, Kazuhiro Shiba, and Akira Odani PLOS ONE 2016/02/01
  •  Simultaneous acquisition of 99mTc and 123I-labeled radiotracers using a preclinical SPECT scanner with CZT detector.  Kobayashi M, Matsunari I, Nishi K, Mizutani A, Miyazaki Y, Ogai K, Sugama J, Shiba K, Kawai K, Kinuya S Ann. Nucl. Med. 2016
  •  In vivo differences between two optical isomers of radioiodinated o-iodo-trans-decalinvesamicol for use as a radioligand for the vesicular acetylcholine transporter. Izumi Uno, Takashi Kozaka, Daisuke Miwa, Yoji Kitamura, Azim Mohammad Anwar-ul, Kazuma Ogawa, Junichi Taki, Seigo Kinuya and Kazuhiro Shiba. PLOS ONE DOI:10.1371/journal.pone.01467 2016

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  •  Synthesis and evaluation of a new vesamicol analog o-[11C]methyl-trans-decalinvesamicol as a PET ligand for the vesicular acetylcholine transporter. Yoji Kitamura, Takashi Kozaka, Daisuke Miwa, Izumi Uno, Mohammad Anwar-ul Azim, Kazuma Ogawa, Junichi Taki, Seigo Kinuya and Kazuhiro Shiba. Ann. Nucl. Med. 2016
  •  Effect of postconditioning on dynamic expression of tenascin-C and left ventricular remodeling after myocardial ischemia and reperfusion. Taki J, Inaki A, Wakabayashi H, Matsunari I, Imada-Yoshida K, Ogawa K, Hiroe M, Shiba K, Yoshida T, Kinuya S. EJNMMI RESEARCH DOI: 10.1186/s13550-015-0100-8 2015
  •  Preparation and evaluation of an astatine-211-labeled sigma receptor ligand for alpha radionuclide therapy.  Ogawa K, Mizuno Y, Washiyama K, Shiba, K, Takahashi N, Kozaka T, Shinohara A, Odani A. Nucl. Med. Biol 42 11 875-879 2015
  •  Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease Lopatina O, Yoshihara T, Nishimura T, Zhong J, Akther S, Fakhrul AA, Liang M, Higashida C, Sumi K, Furuhara K, Inahata Y, Huang JJ, Koizumi K, Yokoyama S, Tsuji T, Petugina Y, Sumarokov A, Salmina AB, Hashida K, Kitao Y, Hori O, Asano M, Kitamura Y, Kozaka T, Shiba K, Zhong F, Xie MJ, Sato M, Ishihara K, Higashida H. Front Behav Neurosci. 8 133 2014/04
  •  The Potential of The Vesicular Acetylcholine Transporter (VAChT) Imaging Using Radiolabeled o-Bromo-trans-decalinvesamicol (OBDV) as a New PET Ligand  Mohammad Anwar-ul Azima, Takashi Kozakaa, Izumi Unoa, Daisuke Miwaa, Yoji Kitamuraa, Kazuma Ogawa, Akira Makino, Yasushi Kiyono, Kazuhiro Shiba. Synapse 68 445-453 2014/10
  •   Radiogallium Complex-Conjugated Bifunctional Peptides for Detecting Primary Cancer and Bone Metastases Simultaneously. Kazuma Ogawa, Jing Yu, Atsushi Ishizaki, Masaru Yokokawa, Masanori Kitamura, Yoji Kitamura, Kazuhiro Shiba, and Akira Odani. Bioconjugate.Chem. 26 8 1561-1570 2015
  •  Regional brain imaging of vesicular acetylcholine transporter (VAChT) using o-[125I]iodo-trans-decalinvesamicol as a new potential imaging probe.  Takashi Kozaka, Izumi Uno, Yoji Kitamura, Daisuke Miwa, Mohammad Anwar-ul Azim, Kazuma Ogawa, Kazuhiro Shiba Synapse 68 2014 2014
  •  14C-Methionine Uptake as a potential Marker of Inflammatory Processes After Myocardial Ischemia and Peperfusion. Junichi Taki, Hiroshi Wakabayashi, Anri Inaki, Kyoko Imanaka-Yoshida, Michiaki Hiroe, Kazuma Ogawa, Miyako Morooka, Kazuo Kubota, Kazuhiro Shiba, Toshimichi Yoshida and Seigo KInuya. JOURNAL OF NUCLEAR MEDICINE 54 3 431-436 2013/03
  •  Report regarding radioactivity removal from contaminated vegetables derived from the Fukushima nuclear accident.  Kazuhiro Shiba Radiation Safety Management. 12 1 31-36 2013/03
  •  Development and evaluation of a novel 99mTc-labeled annexin A5 for early detection of response to chemotherapy. Kazuma Ogawa, Katsuichi Ohtsuki, Tomomi Shibata, Miho Aoki, Morio Nakayama, Yoji Kitamura, Masahiro Ono, Masashi Ueda, Tomoki Doue, Masahisa Onoguchi, Kazuhiro Shiba, Akira Odani. PLoS One. 8 12 e81191 2013/12
  •  Development and evaluation of a radiobromine-labeled sigma ligand for tumor imaging.   Kazuma Ogawa, Hiroya Kanbara, Yasushi Kiyono, Yoji Kitamura, Tatsuto Kiwada, Takashi Kozaka, Masanori Kitamura, Tetsuya Mori, Kazuhiro Shiba, Akira Odani. NUCLEAR MEDICINE AND BIOLOGY 40 4 445-450 2013/05
  •  Development of novel radiogallium-labeled bone imaging agents using oligo-aspartic acid peptides as carriers Ogawa K, Ishizuka A, Takai K, Kitamura Y, Kiwada T, Shiba K, Odani A. PLoS One. 8 12 e84335 2013/12
  •  Decontamination of radioactivity from contaminated vegetables derived from the Fukushima nuclear accident. Kazuhiro Shiba, Yoji Kitamura, Takashi Kozaka, Izumi Uno, Kikuo Shimizu, Kazuyoshi Masumoto, Masahiro Hirota, Shogo Higaki, Hirokazu Miyoshi, Takuya Saze, Minoru Sakama, Makoto Yanaga Radiation Measurement 55 26-29 2013
  •  Characteristics of radioactive contamination of vegetables derived from the Fukushima nuclear accident. Kazuhiro Shiba, Yoji Kitamura, Takashi Kozaka, Izumi Uno, Kikuo Shimizu, Masahiro Hirota, Shogo Higaki, Kazuyoshi Masumoto. Radiation Safety Management. 11 1 23-26 2012/12
  •   Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT) Takashi Kozaka, Izumi Uno, Yoji Kitamura, Daisuke Miwa, Kazuma Ogawa, Kazuhiro Shiba. BIOORGANIC & MEDICINAL CHEMISTRY 20 16 4936-4941 2012/08
  •  Endogenous Secretory Receptor for Advanced Glycation End-products Inhibits Amyloid-β1-42 Uptake into Mouse Brain. Sugihara T, Munesue S, Yamamoto Y, Sakurai S, Akhter N, Kitamura Y, Shiba K, Watanabe T, Yonekura H, Hayashi Y, Hamada J, Yamamoto H. Journal of Alzheimers Disease, 28 3 709-720 2012/01
  •  Chemical removal of radionuclides in contaminated spinach derived from the Fukushima nuclear accident.  Kazuhiro Shiba, Yoji Kitamura, Takashi Kozaka, Izumi Uno, Hirokazu Miyoshi, Makoto Yanaga, Radiation Safety Management 11 1 19-22 2012/12
  •  Preparation and evaluation of a radiogallium complex-conjugated bisphosphonate as a bone scintigraphy agent. Ogawa K., Takai K., Kanbara H., Kiwada T., Kitamura Y., Shiba K, Odani A NUCLEAR MEDICINE AND BIOLOGY 38 5 631-636 2011/05
  •  Development and evaluation of a novel radioiodinated vesamicol analog as a sigma receptor imaging agent. Kazuma Ogawa, Hiroya Kanbara, Kazuhiro Shiba, Yoji Kitamura, Takashi Kozaka, Tatsuto Kiwada and Akira Odani. EJNMMI Research 54 2 1-10 2012/12
  •  Dynamic Expression of Tenascin-C After Myocardial Ischemia and Rperfusion: Assessment by 125I-Anti-Tenascin-C Antibody Imaging. Taki J, Inaki A, Wakabayashi H, Imanaka-Yoshida K, Ogawa K, Hiroe M, Shiba K et al. JOURNAL OF NUCLEAR MEDICINE 51  1116-1122 2010/08
  •  Usefulness of competitive inhibitors of protein binding for improving the pharmacokinetics of 186Re-MAG3-conjugated bisphosphonate (186Re-MAG3-HBP), an agent for treatment of painful bone metastases Ogawa K, Mukai T, K. Shiba K et al EUROPEAN JOURNAL OF NUCLEAR MEDICINE 36 115-121 2009/01
  •  Development of 90Y-DOTA conjugated bisphosphonate for treatment of painful bone metastases. Ogawa K, Kawashima H, Shiba K etc. NUCLEAR MEDICINE AND BIOLOGY 36  129-135 2009/02
  •  Development of 90Y-DOTA conjugated bisphosphonate for treatment of painful bone metastases Ogawa K, Kawashima H, Shiba K,et al. NUCLEAR MEDICINE AND BIOLOGY 29 434-440 2009/02
  •  Preparation and evaluation of 186/188Re-labeled antibody (A7) for radioimmunotherapy with rhenium(I) tricarbonyl core as a chelate site. Ogawa K, Kawashima H, Kinuya S, Shiba K, et al ANNALS OF NUCLEAR MEDICINE 23  843-848 2009/11
  •  Evaluation of radioiodinated vesamicol analogs for sigma receptor imaging in tumor and radionuclide receptor therapy. Ogawa K, Shiba K et al 100  2118-2192 2009/07
  •  Therapeutic effects for the palliation of metastatic bone pain of a rhenium-186 complex-conjugated bisphosphonate in an animal model. Ogawa K, Mukai T, Shiba K, et al JOURNAL OF NUCLEAR MEDICINE 48 1 122-127 2007
  •  Changes of Tc-99m Sestanibi uptake in P-glycoprotein expressing Leukaemia Cells Treated in vivo with Antisense Oligodeoxynucleotide Complementary to mdr1 mRNA. Kinuya S, Bai J, Yokoyama K, Shiba K, et. al. 5 2 115-118 2006/04
  •  Binding with Serum Components Favorably Affects Cellular Uptake of 111In-Oligonucleotide in a Leukemia Cell Line. Bai, J., Kinuya, S., Shiba, K et al 21 1 36-40 2006
  •  99mTc-sestamibi to monitor treatment with antisense oligodeoxynucleotide complementary to MRP mRNA in human breast cancer cells. S Kinuya, J Bai, K Shiba,et al. ANNALS OF NUCLEAR MEDICINE 20 1 29-34 2006/04
  •  Analysis of molecular mechanisms of IgA nephropathy in 1,4- galactosyltransferase-I-deficient mice. Nishie T, Renhua, Ogawa K, Shiba K et al NEPHROLOGY 11 S3 A68 2006
  •  Anti-angiogenic therapy and chemotherapy affect 99mTc-sestamibi and 99mTc-HL91 accumulation differentially in tumour xenografts. Kinuya S, Yokoyama K, Fukuoka M, Shiba K et.al NUCLEAR MEDICINE COMMUNICATIONS 21 1067-1073 2005
  •  Hypoxia as a factor for 67Ga accumulation in tumorur cells Kinuya S, Feng X, Yokoyama K, Shiba K et.al NUCLEAR MEDICINE COMMUNICATIONS 25 49-53 2004/01
  •  A Change of in Vivo Characteristics Depending on Specific Activity of Radioiodinated (+)-2-[4-(4-iodophenyl) piperidino] cyclohexanol [(+)-pIV] as a Ligand for Sigma Receptor Imaging. Akhter N, Shiba K, Ogawa K, Tsuji S, et al. NUCLEAR MEDICINE AND BIOLOGY 35 1 29-34 2008
  •  In vivo Characterization of Radioiodinated (+)-2-[4-(4-iodophenyl) piperidino] cyclohexanol [(+)-pIV] as a potential sigma-1 receptor imaging agent. Akhter N, Shiba K, Ogawa K, Kinuya S et al NUCLEAR MEDICINE AND BIOLOGY 34 6 697-702 2007
  •  Self-radiolysis of tritiated thymidine. Radioisotopes. Shiba K, Mori H 46 622-626 1997
  •  Rapid Reduction of sigma-1 Receptor Binding and 18F-FDG Uptake in Rat Gliomas After In vivo Treatment with Doxorubicine. Waarde AV, Shiba K, Jong JR, Ishiwata K et al JOURNAL OF NUCLEAR MEDICINE 48 8 1320-1326 2007
  •  Intraperitoneal radioimmunotherapy to treat the early phase of peritoneal dissemination of human colon cancer cells in a murine model. Kinuya S, Yokoyama K, Fukuoka M, Shiba K, et al NUCLEAR MEDICINE COMMUNICATIONS 28 2 129-133 2007
  •  Evaluation of (+)-p-[11C]methylvesamicol for mapping sigma1 receptors : a comparison with [11C]SA4503. K. Ishiwata, K. Kawamura, K. Yajima, QingGeLeTu, H. Mori and K. Shiba. NUCLEAR MEDICINE AND BIOLOGY 33 543-548 2006
  •  Synthesis and evaluation of fluorine-18-labeled SA4503 as a selective sigma1 receptor ligand for positron emission tomography. Kawamura K, Tsukada H, Shiba K, Tsuji C et al. NUCLEAR MEDICINE AND BIOLOGY 34 5 571-577 2007
  •  Synthesis and binding affinities of methylvesamicol analogs for the acetylcholine transporter and sigma receptor. K. Shiba, K. Ogawa, K.Ishiwata, K. Yajima and H. Mori. BIOORGANIC & MEDICINAL CHEMISTRY 14 2620-2626 2006/04
  •  A simple and rapid radiochemical choline acetyltransferase (ChAT) assay screening test. Shiba K, Ogawa K, KinuyaK, Yajima K and Mori H. JOURNAL OF NEUROSCIENCE METHODS 157 98-102 2006
  •  In vitro detection of mdri1 mRNA in murine leukemia cells with 111In-labeled oligonucleotide. J. Bai, K. Yokoyama, K. Shiba et al EUROPEAN JOURNAL OF NUCLEAR MEDICINE 31 11 1523-1529 2004/11
  •  Synthesis and evaluation of vesamicol analog (-)-o-[11C]methylvesamicol as a PET ligand for vesicular acetylcholine transporter. K. Kawamura, K. Shiba, H. Tsukada, S. Nishiyama, H. Mori and K. Ishiwata. ANNALS OF NUCLEAR MEDICINE 20 6 417-424 2006/07
  •  Locoreginal radioimmunotherapy with 186Re-labeled monoclonal antibody in treating small peritoneal carcinomatosis of colon cancer in mice in comparison with 131I-counterpart. Kinuya S, Yokoyama K, Mori H, Shiba K et al. CANCER LETTERS 219 41-48 2005
  •  In vitro characterization of radioiodinated (+)-2-[4-(4-iodophenyl) piperidino]cyclohexanol [(+)-pIV] as a sigma-1 receptor ligand. Shiba, K., Ogawa, K., Mori, H BIOORGANIC & MEDICINAL CHEMISTRY 13 4 1095-1099 2005/02
  •  Improved survival of mice bearing liver metastases of colon cancer cells treated with a combination of radioimmunotherapy and antiangiogenic therapy S. Kinuya, K. Yokoyama, K. Koshida, H. Mori, K. Shiba et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE MOLECULAR IMAGING 31 7 981-985 2004/07
  •  Limitations of 99mTc tetrofosmin in assessing reversal effects of verapamil on the function of multi-drug resistance associated protein 1. S. Kinuya, X-F Li, H. Mori, K. Shiba, et al. NUCLEAR MEDICINE COMMUNICATIONS 25 6 585-589 2004
  •  Reduction of 99mTc-sestamibi and 99mTc-tetrofosmin uptake in MRP-expressing breast cancer cells under hypoxic conditions is independent of MRP function. S. Kinuya, X-F Li, K. Yokoyama, K. Shiba,et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE MOLECULAR IMAGING 30 11 1529-1531 2003/11
  •  Evaluation of Radioiodinated (-)-o-iodovesamicol as a radiotracer for mapping the vesicular acetylcholine transporter. Kazuhiro Shiba et al. ANNALS OF NUCLEAR MEDICINE 17 6 451-456 2003/07
  •  Local delivery of 131I-MIBG to treat peritoneal neuroblastoma. S. Kinuya, X-F Li, K. Yokoyama, K. Shiba et al EUROPEAN JOURNAL OF NUCLEAR MEDICINE MOLECULAR IMAGING 30 9 1246-1250 2003/09
  •  Benefits of combined radioimmunotherapy and anti-angiogenic therapy in a liver metastasis model of human colon cancer cells. 54. X-F Li, S. Kinuya, K. Yokoyama, K. Shiba et al EUROPEAN JOURNAL OF NUCLEAR MEDICINE 29 12 1669-1674 2002/12
  •  Feasibility of 186Re-radioimmunotherapy for treatment in an adjuvant setting of colon cancer. S. Kinuya, K. Yokoyama, K. Shiba et al JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 129 392-396 2003/09
  •  The potentialof radioiodinated (-)-m-iodovesamicol for diagnosing cholinergic deficit dementia K. Shiba, H. Mori, E. Ikeda et al. NUCLEAR MEDICINE AND BIOLOGY 28 261-264 2001
  •  Intraperitoneal radioimmunotherapy in treateing peritoneal carcinomatosis of colon cancer in mice compared with systemic radioimmunotherary. S. Kinuya, X-F Li, K.Yokoyama, K. Shiba et al. 94 7 650-654 2003/07
  •  Retrograde transport of nerve growth factor from olfactory bulb to olfactory epithelium T. Miwa, N. Uramoto, T. Ishimaru, M. Furukawa, K. Shiba et al. NEUROREPORT 9 153-155 1998
  •  Reduction of vesicular acetylcholine transporter in B-amyloid protein infused rats with memory impairment E. Ikeda, K. Shiba, H. Mori, A. Ichikawa, H. Sumiya, I. Kuji and N. Tonami NUCLEAR MEDICINE COMMUNICATIONS 21 933-937 2000
  •  Radioiodinated (-)-2-[4-(3-iodophenyl)piperidino]cyclohexanol: A Potential Radioligand for Mapping Presynaptic Cholinergic Neurons. K. Shiba, H. Mori, H. Matsuda, A. Ichikawa and N. Tonami. NUCLEAR MEDICINE COMMUNICATIONS 17 485-492 1996
  •  Effect of vagal autotransplantation on quantitative [3H]-vesamicol binding image in rats with unilateral lesions of nucleus basalis magnocellularis E. Ikeda, A. Ichikawa, H. Mori, K. Shiba, H. Sumiya and N. Tonami NEUROSCIENCE LETTERS 300 33-36 2001
  •  Discrepancy between blood flow and muscariic receptor distribution in rat brain middle cerebral artery occlusion. I. Kuji, H. Matsuda, H. Sumiya, J. Taki, S. Tsuji, K. Kinuya, A. Ichikawa, K. Shiba, H. Mori, N. Tonami EUROPEAN JOURNAL OF NUCLEAR MEDICINE 24 665-669 1997
  •  Characterization of radioiodinated (-)-ortho-iodovesamicol binding in rat brain preparations K. Shiba, H. Mori, N. Tonami. LIFE SCIENCES 65 2002
  •  Characterization of Radioiodinated (-)-m-iodovesamicol in rat cerebral membranes. K. Shiba, H. Mori, A. Ichikawa and N. Tonami. LIFE SCIENCES 59 13 1039-1045 1996

Conference Presentations

  • Development of a radiobromine-labeled compound as a sigma receptor ligand for tumor imaging. (conference:2016SNMMI 63th annual meeting,)(2016/06/11)
  • Dose it reflect inflammatory change or angiogenesis or both? (conference:2016SNMMI 63th annual meeting, )(2016/06/11)
  • In vitro evaluation meta-bromo benzovesamicol as PET VAChT imaging Probe(conference:The 2nd Asian Nuclear Medicine Academic Forum 2016,(ANMAF 2016))(2016/05/05)
  • Imaging of angiogenesis using I-125 labeled arginine-glycine-asparate targeting alpha(v)beta(3) integrin after myocardial ischemia and reperfusion.(conference:2015SNMMI 62th annual meeting)(2015/06/06)
  • Study of radiomeal-octabromoporphyrin complex as a tumor diagnostic agent(2014/06/14)

show all

  • Postconditioningfacilitate myocardial inflammatory resolution after severe ischemia and reperfusion: Assessment by C-14 methionine autoradiography. (conference:2014 SNMMI 61th annual meeting.)(2014/06/07)
  • Introduction of radiobromine labeled decalinvesamicol analogue as a new and promising PET vesicular acetylcholine transporter (VAChT) imaging probe(conference:2014 SNMMI 61th annual meeting.)(2014/06/07)
  • [77Br]OBDV revealed the potentiality of [76Br]OBDV as a new VAChT PET imaging probe for the early diagnosis of AD(2014/03/27)
  • Evaluation of radiolabeled o-bromo-decalinvesamicol (OBDV) as a PET ligand for the Vesicular Acetylcholine Transporter (VAChT).(conference:International Workshop on Molecular Functional Imaging for Brain and Gynecologic Oncology)
  • In vivo evaluation of radiobromine-labeled o-bromo-trans-decalinvesamicol (OBDV) as a potential VAChT imaging probe(2013/12/14)
  • Development of ultra-high-resolution pinhole collimator for small animal SPECT with CZT detector.(conference:2013 SNMMI 60th annual meeting.)(2013/06/08)
  • Correlation between Tc-99m-Annexin-V and left vebtricular remodeling in rats with ischemia and reperfusion.(conference:2013 SNMMI 60th annual meeting.)(2013/06/08)
  • The development of potential vesicular acetylcholine transporter (VAChT) PET imaging probes. (conference:2013 SNMMI 60th annual meeting.)(2013/06/08)
  • In vivo evaluation of radioiodinated o-iodo-trans-decalinvesamicol(OIDV) as a vesicular acetylcholine transporter (VAChT) imaging agent.(conference:2013 SNMMI 60th annual meeting.)(2013/06/08)
  • Syntheses and in vitro evaluation of OBBV as a potential σ-1 recyntheses eptor imaging probe. (2013/05/30)

Arts and Fieldwork

Patent

Theme to the desired joint research

○Development of ChAT mapping agent for Alzheimer\'s disease early diagnosis

Grant-in-Aid for Scientific Research

○「アルツハイマー病の早期診断を目的としたコリントランスポーターイメージング剤の開発」(2011-2013) 
○「虚血心筋障害、リモデリングにおける心筋間質の病態変化とその画像化に関する研究」(2011-2013) 
○「虚血心筋障害、リモデリングにおける心筋間質の病態変化とその画像化に関する研究」(2008-2010) 
○「アルツハイマー病の早期診断用シナプス前コリン作動性神経分子イメージング剤の開発」(2007-2010) 
○「認知症及びストレス性精神疾患の進行・治療指針予測を可能にするイメージング剤の開発(」(2007-2009) 
○「新規トランスポーターマッピング剤による「アルツハイマー病の早期診断」に関する研究」(2005-2006) 
○「アルツハイマー病の早期診断を目的とした放射性神経機能診断薬の開発」(2002-2004) 
○「アルツハイマー病の客観的診断を目的としたトランスポーターマッピング剤の開発」(1999-2001) 
○「アルツハイマー性痴呆の診断を目的とした放射性ヨウ素標識ベサミコールの開発研究」(1997-1998) 

Classes (Bachelors)

○Radioisotope in In-Vitro and In-Vivo Techniques(2017)
○Radiation Measurement Experiment 2(2017)
○Radiochemistry Experiment(2017)
○Radioisotope in In-Vitro and In-Vivo Techniques(2016)
○Radiation Measurement Experiment 2(2016)
○Radiochemistry Experiment(2016)

Classes (Graduate Schools)

○Exploring and preventive diagnostics(2017)
○Seminar on Animal Experimentation(2017)
○Cognitive Neuroscience of Emotion and Behavior(2016)
○Training Program on Cognitive and Behavioral Neurobiology(2016)
○Introduction to Basic Medical Science(2016)
○Seminar on Animal Experimentation(2016)
○Exploring and preventive diagnostics(2016)
○Seminar on Advanced Medical Science(2016)
○Seminar on Advanced Medical Science(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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