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Researcher Information

last modified：2026/02/18

Professor　SUZUKI, Takeshi

Mail Laboratory Website

Faculty, Affiliation

Cancer Research Institute

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Natural Sciences, Graduate School of Natural Science and Technology
Division of Transdisciplinary Sciences,Graduate School of Frontier Science Initiative
Division of Medicine, Graduate School of Medical Science
Division of Natural System, Graduate School of Natural Science and Technology
Course in Biosystems, School of Biological Science and Technology, College of Science and Engineering

Laboratory

Division of Functional Genomics　TEL:076-265-2734　FAX:076-234-4502

Academic Background

【Academic background(Doctoral/Master's Degree)】
The University of Tokyo　Doctor　Graduate School, Division of Science　199403　Completed
【Academic background(Bachelor's Degree)】
The University of Tokyo　198903
【Degree】
Ph. D.

Career

Research Associate(1994/04/01-1999/05/31)
Research Fellow　Research Fellow(1999/06/01-2003/03/31)
Associate Professor(2003/04/01-2007/03/31)

Year & Month of Birth

1966/11

Academic Society

Japanese Cancer Association
The Molecular Biology Society of Japan

Award

Specialities

Molecular biology、Cell biology、General medical chemistry、Virology

Speciality Keywords

Tumor virus, Oncogene, Genome informatics

Research Themes

Identification of novel cancer genes using retroviral insertional mutagenesis

Books

Papers

  • 　Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice　Suzuki T, Minehata K, Akagi K, Jenkins NA, Copeland NG　EMBO JOURNAL　25　14　3411-3421　2006/07
  • 　meis1 regulates the development of endothelial cells in zebrafish　Ken-ichi Minehata, Atsuo Kawahara, Takeshi Suzuki　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　374　4　647-652　2008/10
  • 　Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene　Akihiko Ishimura, Minoru Terashima, Hiroshi Kimura, Keiko Akagi, Yutaka Suzuki, Sumio Sugano, Takeshi Suzuki　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　389　366-371　2009/11
  • 　The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase　Minoru Terashima, Akihiko Ishimura, Masakazu Yoshida, Yutaka Suzuki, Sumio Sugano, Takeshi Suzuki　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　399　238-244　2010/08
  • 　PLU1 histone demethylase decreases the expression of KAT5 and enhances the invasive activity of the cells　Masakazu Yoshida, Akihiko Ishimura, Minoru Terashima, Zanabazar Enkhbaatar, Naohito Nozaki, Kenji Satou, Takeshi Suzuki　BIOCHEMICAL JOURNAL　437　555-564　2011/08

show all

  • 　High-throughput retroviral tagging for identification of genes involved in initiation and progression of mouse splenic marginal zone lymphomas.　Shin MS, Fredrickson TN, Hartley JW, Suzuki T, Akagi K, Morse HC　CANCER RESEARCH　64　13　4419-27　2004/07
  • 　Early B-cell factor-associated zinc-finger gene is a frequent target of retroviral integration in murine B-cell lymphomas.　Warming S, Suzuki T, Yamaguchi TP, Jenkins NA, Copeland NG　ONCOGENE　23　15　2727-31　2004/04
  • 　RTCGD: retroviral tagged cancer gene database.　Akagi K, Suzuki T, Stephens RM, Jenkins NA, Copeland NG　NUCLEIC ACIDS RESEARCH　32　D　523-7　2004/01
  • 　Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma.　Kelly J, Spolski R, Kovanen P, Suzuki T, Bollenbacher J, Pise-Masison C, Radonovich M, Lee S, Jenkins NA, Copeland NG, Morse HC, Leonard W　JOURNAL OF EXPERIMENTAL MEDICINE　198　1　79-89　2003/07
  • 　Transactivation of the Fucosyltransferase VII gene by human T-cell leukemia virus type I Tax through a variant cAMP-responsive element.　Hiraiwa N, Yabuta T, Yoritomi K, Hiraiwa M, Tanaka Y, Suzuki T, Yoshida M, Kannagi R　BLOOD　101　9　3615-21　2003/05
  • 　Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related kruppel-like zinc finger protein.　Warming S, Liu P, Suzuki T, Akagi K, Lindtner S, Pavlakis G, Jenkins NA, Copeland NG　BLOOD　101　5　1934-40　2003/03
  • 　Genome-based identification of cancer genes by proviral tagging in mouse retrovirus induced T-cell lymphoma.　Kim R, Trubetskoy A, Suzuki T, Jenkins NA, Copeland NG, Lenz J　JOURNAL OF VIROLOGY　77　3　2056-62　2003/02
  • 　Common sites of retroviral integration in mouse hematopoietic tumors identified by high-throughput, single nucleotide polymorphism-based, mapping and bacterial artificial chromosome hybridization.　Shen H, Suzuki T, Munroe DJ, Stewart C, Rasmussen L, Gilbert DJ, Jenkins NA, Copeland NG　JOURNAL OF VIROLOGY　77　2　1584-8　2003/01
  • 　HTLV-I ENCODED TAX IN ASSOCIATION WITH NF-KAPPA-B PRECURSOR P105 ENHANCES NUCLEAR-LOCALIZATION OF NF-KAPPA-B P50 AND P65 IN TRANSFECTED CELLS　M WATANABE,MA MURAMATSU,H HIRAI,T SUZUKI,J FUJISAWA,M YOSHIDA,KI ARAI,N ARAI　ONCOGENE　8　11　2949　1993/11
  • 　THE TRANSACTIVATOR TAX OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-1 (HTLV-1) INTERACTS WITH CAMP-RESPONSIVE ELEMENT (CRE) BINDING AND CRE MODULATOR PROTEINS THAT BIND TO THE 21-BASE-PAIR ENHANCER OF HTLV-1　T SUZUKI,JI FUJISAWA,M TOITA,M YOSHIDA　PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　90　2　610　1993/01
  • 　ISOLATION AND CHARACTERIZATION OF FRA-2, AN ADDITIONAL MEMBER OF THE FOS GENE FAMILY　H NISHINA,H SATO,T SUZUKI,M SATO,H IBA　PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　87　9　3619　1990/05
  • 　HIGH-LEVEL EXPRESSION OF HUMAN C-JUN GENE CAUSES CELLULAR-TRANSFORMATION OF CHICKEN-EMBRYO FIBROBLASTS　T SUZUKI,Y HASHIMOTO,H OKUNO,H SATO,H NISHINA,H IBA　JAPANESE JOURNAL OF CANCER RESEARCH　82　1　58　1991/01
  • 　INHIBITION OF JUN TRANSFORMATION BY A MUTATED FOS GENE - DESIGN OF AN ANTIONCOGENE　H OKUNO,T SUZUKI,T YOSHIDA,Y HASHIMOTO,T CURRAN,H IBA　ONCOGENE　6　9　1491　1991/09
  • 　DIFFERENCE IN TRANSCRIPTIONAL REGULATORY FUNCTION BETWEEN C-FOS AND FRA-2　T SUZUKI,H OKUNO,T YOSHIDA,T ENDO,H NISHINA,H IBA　NUCLEIC ACIDS RESEARCH　19　20　5537　1991/10
  • 　TRANSCRIPTIONAL ACTIVATOR TAX OF HTLV-1 BINDS TO THE NF-KAPPA-B PRECURSOR P105　H HIRAI,J FUJISAWA,T SUZUKI,K UEDA,M MURAMATSU,A TSUBOI,N ARAI,M YOSHIDA　ONCOGENE　7　9　1737　1992/09
  • 　ANALYSIS OF FRA-2 GENE-EXPRESSION　T YOSHIDA,T SUZUKI,H SATO,H NISHINA,H IBA　NUCLEIC ACIDS RESEARCH　21　11　2715　1993/06
  • 　A TRANSACTIVATOR TAX OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-1 BINDS TO NF-KAPPA-B P50 AND SERUM RESPONSE FACTOR (SRF) AND ASSOCIATES WITH ENHANCER DNAS OF THE NF-KAPPA-B SITE AND CARG BOX　T SUZUKI,H HIRAI,J FUJISAWA,T FUJITA,M YOSHIDA　ONCOGENE　8　9　2391　1993/09
  • 　[Mechanism of transcriptional activation by HTLV-1 Tax].　Fujisawa J,Hirai H,Suzuki T,Yoshida M　Human cell　6　4　266　1993/12
  • 　KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family.　Zanabazar Enkhbaatar,Minoru Terashima,Dulamsuren Oktyabri,Shoichiro Tange,Akihiko Ishimura,Seiji Yano,Takeshi Suzuki　Cell cycle (Georgetown, Tex.)　12　13　2100　2013/07/01
  • 　Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Kruppel-like zinc finger protein　S Warming,P Liu,T Suzuki,K Akagi,S Lindtner,GN Pavlakis,NA Jenkins,NG Copeland　BLOOD　101　5　1934　2003/03
  • 　JMJD5, a Jumonji C (JmjC) Domain-containing Protein, Negatively Regulates Osteoclastogenesis by Facilitating NFATc1 Protein Degradation　Min-Young Youn,Atsushi Yokoyama,Sally Fujiyama-Nakamura,Fumiaki Ohtake,Ken-ichi Minehata,Hisataka Yasuda,Takeshi Suzuki,Shigeaki Kato,Yuuki Imai　JOURNAL OF BIOLOGICAL CHEMISTRY　287　16　12994　2012/04
  • 　Roles of histone methyl-modifying enzymes in development and progression of cancer　Takeshi Suzuki,Minoru Terashima,Shoichiro Tange,Akihiko Ishimura　Cancer Science　104　7　795　2013/07
  • 　PLU1 histone demethylase decreases the expression of KAT5 and enhances the invasive activity of the cells　Masakazu Yoshida,Akihiko Ishimura,Minoru Terashima,Zanabazar Enkhbaatar,Naohito Nozaki,Kenji Satou,Takeshi Suzuki　BIOCHEMICAL JOURNAL　437　3　555　2011/08
  • 　The tumor suppressor Rb and its related Rb12 genes are regulated by Utx histone demethylase　Minoru Terashima,Akihiko Ishimura,Masakazu Yoshida,Yutaka Suzuki,Sumio Sugano,Takeshi Suzuki　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　399　2　238　2010/08
  • 　meis1 regulates the development of endothelial cells in zebrafish　Ken-ichi Minehata,Atsuo Kawahara,Takeshi Suzuki　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　374　4　647　2008/10
  • 　Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice　Takeshi Suzuki,Ken-ichi Minehata,Keiko Akagi,Nancy A. Jenkins,Neal G. Copeland　EMBO JOURNAL　25　14　3422　2006/07
  • 　Early B-cell factor-associated zinc-finger gene is a frequent target of retroviral integration in murine B-cell lymphomas　S Warming,T Suzuki,TP Yamaguchi,NA Jenkins,NG Copeland　ONCOGENE　23　15　2727　2004/04
  • 　RTCGD: retroviral tagged cancer gene database　K Akagi,T Suzuki,RM Stephens,NA Jenkins,NG Copeland　NUCLEIC ACIDS RESEARCH　32　Database issue　D523　2004/01
  • 　Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma　JA Kelly,R Spolski,PE Kovanen,T Suzuki,J Bollenbacher,CA Pise-Masison,MF Radonovich,S Lee,NA Jenkins,NG Copeland,HC Morse,WJ Leonard　JOURNAL OF EXPERIMENTAL MEDICINE　198　1　79　2003/07
  • 　Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element　N Hiraiwa,T Yabuta,K Yoritomi,M Hiraiwa,Y Tanaka,T Suzuki,M Yoshida,R Kannagi　BLOOD　101　9　3615　2003/05
  • 　Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphornas　R Kim,A Trubetskoy,T Suzuki,NA Jenkins,NG Copeland,J Lenz　JOURNAL OF VIROLOGY　77　3　2056　2003/02
  • 　New genes involved in cancer identified by retroviral tagging　T Suzuki,HF Shen,K Akagi,HC Morse,JD Malley,DQ Naiman,NA Jenkins,NG Copeland　NATURE GENETICS　32　1　166　2002/09
  • 　HTLV type I tax oncoprotein binds to DNA topoisomerase I and inhibits its catalytic activity　M Yoshida,T Suzuki　AIDS RESEARCH AND HUMAN RETROVIRUSES　16　16　1639　2000/11
  • 　HTLV-1 tax oncoprotein binds to DNA topoisomerase I and inhibits its catalytic activity　T Suzuki,M Uchida-Toita,T Andoh,M Yoshida　VIROLOGY　270　2　291　2000/05
  • 　Tax oncoprotein of HTLV-1 binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control　T Suzuki,Y Ohsugi,M Uchida-Toita,T Akiyama,M Yoshida　ONCOGENE　18　44　5967　1999/10
  • 　Down-regulation of the INK4 family of cyclin-dependent kinase inhibitors by tax protein of HTLV-1 through two distinct mechanisms　T Suzuki,T Narita,M Uchida-Toita,M Yoshida　VIROLOGY　259　2　384　1999/07
  • 　Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site　T Suzuki,M Uchida-Toita,M Yoshida　ONCOGENE　18　28　4137　1999/07
  • 　Trans-activator Tax of human T-cell leukemia virus type 1 enhances mutation frequency of the cellular genome　H Miyake,T Suzuki,H Hirai,M Yoshida　VIROLOGY　253　2　155　1999/01
  • 　HTLV-1 tax protein interacts with cyclin-dependent kinase inhibitor p16lnk4a and counteracts its inhibitory activity to CDK4　Takeshi Suzuki　Leukemia　11　3　14　1997
  • 　[Interaction of HTLV-1 Tax with cellular factors].　Suzuki T,Yoshida M　Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　41　8 Suppl　1249　1996/06
  • 　TAX PROTEIN OF HTLV-1 DESTABILIZES THE COMPLEXES OF NF-KAPPA-B AND I-KAPPA-B-ALPHA AND INDUCES NUCLEAR TRANSLOCATION OF NF-KAPPA-B FOR TRANSCRIPTIONAL ACTIVATION　T SUZUKI,H HIRAI,T MURAKAMI,M YOSHIDA　ONCOGENE　10　6　1199　1995/03
  • 　HTLV-1 ONCOPROTEIN TAX AND CELLULAR TRANSCRIPTION FACTORS　M YOSHIDA,T SUZUKI,J FUJISAWA,H HIRAI　TRANSACTING FUNCTIONS OF HUMAN RETROVIRUSES　193　79　1995
  • 　TAX PROTEIN OF HTLV-1 INTERACTS WITH THE REL HOMOLOGY DOMAIN OF NF-KAPPA-B P65 AND C-REL PROTEINS BOUND TO THE NF-KAPPA-B BINDING-SITE AND ACTIVATES TRANSCRIPTION　T SUZUKI,H HIRAI,M YOSHIDA　ONCOGENE　9　11　3099　1994/11
  • 　HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16(INK4A) and counteracts its inhibitory activity towards CDK4　T Suzuki,S Kitao,H Matsushime,M Yoshida　EMBO JOURNAL　15　7　1607　1996/04
  • 　HTLV-1 TAX ENHANCES NF-KAPPA-B2 EXPRESSION AND BINDS TO THE PRODUCTS P52 AND P100, BUT DOES NOT SUPPRESS THE INHIBITORY FUNCTION OF P100　T MURAKAMI,H HIRAI,T SUZUKI,JI FUJISAWA,M YOSHIDA　VIROLOGY　206　2　1066　1995/02
  • 　Common sites of retroviral integration in mouse hematopoietic tumors identified by high-throughput, single nucleotide polymorphism-based mapping and bacterial artificial chromosome hybridization　HF Shen,T Suzuki,DJ Munroe,C Stewart,L Rasmussen,DJ Gilbert,NA Jenkins,NG Copeland　JOURNAL OF VIROLOGY　77　2　1584　2003/01
  • 　TAX PROTEIN OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I BINDS TO THE ANKYRIN MOTIFS OF INHIBITORY FACTOR KAPPA-B AND INDUCES NUCLEAR TRANSLOCATION OF TRANSCRIPTION FACTOR NF-KAPPA-B PROTEINS FOR TRANSCRIPTIONAL ACTIVATION　H HIRAI,T SUZUKI,J FUJISAWA,J INOUE,M YOSHIDA　PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　91　9　3584　1994/04
  • 　Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene　Akihiko Ishimura,Minoru Terashima,Hiroshi Kimura,Keiko Akagi,Yutaka Suzuki,Sumio Sugano,Takeshi Suzuki　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　389　2　366　2009/11
  • 　Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression　Akihiko Ishimura,Ken-ichi Minehata,Minoru Terashima,Gen Kondoh,Takahiko Hara,Takeshi Suzuki　DEVELOPMENT　139　4　749　2012/02
  • 　ASH2L, a COMPASS core subunit, is involved in the cell invasion and migration of triple-negative breast cancer cells through the epigenetic control of histone H3 lysine 4 methylation.　Gerelsuren Batbayar,Akihiko Ishimura,Hanbing Lyu,Sasithorn Wanna-Udom,Makiko Meguro-Horike,Minoru Terashima,Shin-Ichi Horike,Takahisa Takino,Takeshi Suzuki　Biochemical and biophysical research communications　669　19　2023/08/20
  • 　KDM2B is involved in the epigenetic regulation of TGF-β-induced epithelial–mesenchymal transition in lung and pancreatic cancer cell lines　Sasithorn Wanna-Udom,Minoru Terashima,Kusuma Suphakhong,Akihiko Ishimura,Takahisa Takino,Takeshi Suzuki　Journal of Biological Chemistry　296　100213　2021/01　
  • 　A novel celecoxib analog UTX-121 inhibits HT1080 cell invasion by modulating membrane-type 1 matrix metalloproteinase.　Hirari Yamahana,Takahisa Takino,Yoshio Endo,Hisatsugu Yamada,Takeshi Suzuki,Yoshihiro Uto　Biochemical and biophysical research communications　521　1　137　2020/01/01
  • 　Epithelial-to-Mesenchymal Transition Is a Mechanism of ALK Inhibitor Resistance in Lung Cancer Independent of ALK Mutation Status.　Fukuda K,Takeuchi S,Arai S,Katayama R,Nanjo S,Tanimoto A,Nishiyama A,Nakagawa T,Taniguchi H,Suzuki T,Yamada T,Nishihara H,Ninomiya H,Ishikawa Y,Baba S,Takeuchi K,Horiike A,Yanagitani N,Nishio M,Yano S　Cancer Res　79　7　1658　2019/04
  • 　MEG8 long noncoding RNA contributes to epigenetic progression of the epithelial-mesenchymal transition of lung and pancreatic cancer cells.　Terashima M,Ishimura A,Wanna-Udom S,Suzuki T　The Journal of biological chemistry　293　47　18016　2018/09
  • 　Epigenetic regulation of epithelial-mesenchymal transition by KDM6A histone demethylase in lung cancer cells　Minoru Terashima,Akihiko Ishimura,Sasithorn Wanna-udom,Takeshi Suzuki　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　490　4　1407　2017/09
  • 　Corrigendum to “TGF-β1 facilitates MT1-MMP-mediated proMMP-9 activation and invasion in oral squamous cell carcinoma cells” [BBREP_101072] (Biochemistry and Biophysics Reports (2021) 27, (S2405580821001667), (10.1016/j.bbrep.2021.101072))　Hirari Yamahana,Minoru Terashima,Risa Takatsuka,Chikako Asada,Takeshi Suzuki,Yoshihiro Uto,Takahisa Takino　Biochemistry and Biophysics Reports　2021
  • 　Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells.　Masaharu Hazawa,Dini Kurnia Ikliptikawati,Yuki Iwashima,De-Chen Lin,Yuan Jiang,Yujia Qiu,Kei Makiyama,Koki Matsumoto,Akiko Kobayashi,Goro Nishide,Lim Keesiang,Hironori Yoshino,Toshinari Minamoto,Takeshi Suzuki,Isao Kobayashi,Makiko Meguro-Horike,Yan-Yi Jiang,Takumi Nishiuchi,Hiroki Konno,H Phillip Koeffler,Kazuyoshi Hosomichi,Atsushi Tajima,Shin-Ichi Horike,Richard W Wong　Cell Chem Biol.　31　4　792　2024/04
  • 　Critical role of glioma-associated oncogene homolog 1 in maintaining invasive and mesenchymal-like properties of melanoma cells.　I Ketut Gunarta,Rong Li,Ryota Nakazato,Ryusuke Suzuki,Jambaldorj Boldbaatar,Takeshi Suzuki,Katsuji Yoshioka　Cancer Science　108　8　1602　2017/08
  • 　Isolation of Highly Migratory and Invasive Cells in Three-Dimensional Gels.　Takahisa Takino,Takeshi Suzuki,Motoharu Seiki　Current protocols in cell biology　86　1　e103　2020/03
  • 　Subtype-selective induction of apoptosis in translocation-related sarcoma cells induced by PUMA and BIM upon treatment with pan-PI3K inhibitors.　Sho Isoyama,Naomi Tamaki,Yutaka Noguchi,Mutsumi Okamura,Yuki Yoshimatsu,Tadashi Kondo,Takeshi Suzuki,Shin-Ichi Yaguchi,Shingo Dan　Cell Death Dis.　14　2　169　2023/02
  • 　KDM8 epigenetically controls cardiac metabolism to prevent initiation of dilated cardiomyopathy.　Abdalla Ahmed,Jibran Nehal Syed,Lijun Chi,Yaxu Wang,Carmina Perez-Romero,Dorothy Lee,Etri Kocaqi,Amalia Caballero,Jielin Yang,Quetzalcoatl Escalante-Covarrubias,Akihiko Ishimura,Takeshi Suzuki,Lorena Aguilar-Arnal,Gerard Bryan Gonzales,Kyoung-Han Kim,Paul Delgado-Olguín　Nature Cardiovascular Research　2　174　2023/02
  • 　JARID2 Is Involved in Transforming Growth Factor-Beta-Induced Epithelial-Mesenchymal Transition of Lung and Colon Cancer Cell Lines　Shoichiro Tange,Dulamsuren Oktyabri,Minoru Terashima,Akihiko Ishimura,Takeshi Suzuki　PLOS ONE　9　12　e115684　2014/12
  • 　P28-11 The CRISPR-Cas13a gene-editing system underlies a potential therapeutic strategy for EML4-ALK-positive lung cancer cells　Saifullah Saifullah,Matomo Sakari,Takeshi Suzuki,Seiji Yano,Toshifumi Tsukahara　Annals of Oncology　32　S347　2021/07
  • 　MEG3 Long Noncoding RNA Contributes to the Epigenetic Regulation of Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines　Minoru Terashima,Shoichiro Tange,Akihiko Ishimura,Takeshi Suzuki　JOURNAL OF BIOLOGICAL CHEMISTRY　292　1　82　2017/01
  • 　DOT1L histone methyltransferase regulates the expression of BCAT1 and is involved in sphere formation and cell migration of breast cancer cell lines　Dulamsuren Oktyabri,Akihiko Ishimura,Shoichiro Tange,Minoru Terashima,Takeshi Suzuki　BIOCHIMIE　123　20　2016/04
  • 　Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis　Akihiko Ishimura,Minoru Terashima,Shoichiro Tange,Takeshi Suzuki　CELL AND TISSUE RESEARCH　363　3　723　2016/03
  • 　EED regulates epithelial-mesenchymal transition of cancer cells induced by TGF-beta　Dulamsuren Oktyabri,Shoichiro Tange,Minoru Terashima,Akihiko Ishimura,Takeshi Suzuki　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　453　1　124　2014/10
  • 　The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB.　Sasithorn Wanna-Udom,Minoru Terashima,Hanbing Lyu,Akihiko Ishimura,Takahisa Takino,Matomo Sakari,Toshifumi Tsukahara,Takeshi Suzuki　Biochemical and biophysical research communications　524　1　150　2020/03/26
  • 　Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer.　Rong Wang,Tadaaki Yamada,Kenji Kita,Hirokazu Taniguchi,Sachiko Arai,Koji Fukuda,Minoru Terashima,Akihiko Ishimura,Akihiro Nishiyama,Azusa Tanimoto,Shinji Takeuchi,Koshiro Ohtsubo,Kaname Yamashita,Tomoyoshi Yamano,Akihiro Yoshimura,Koichi Takayama,Kyoichi Kaira,Yoshihiko Taniguchi,Shinji Atagi,Hisanori Uehara,Rikinari Hanayama,Isao Matsumoto,Xujun Han,Kunio Matsumoto,Wei Wang,Takeshi Suzuki,Seiji Yano　Nature communications　11　1　4607　2020/09/14
  • 　Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion.　Katsuya Sakai,Takumi Nishiuchi,Shoichiro Tange,Yoshinori Suzuki,Seiji Yano,Minoru Terashima,Takeshi Suzuki,Kunio Matsumoto　Scientific reports　10　1　16678　2020/10/07
  • 　Effective RNA Knockdown Using CRISPR-Cas13a and Molecular Targeting of the EML4-ALK Transcript in H3122 Lung Cancer Cells.　Saifullah,Matomo Sakari,Takeshi Suzuki,Seiji Yano,Toshifumi Tsukahara　International journal of molecular sciences　21　23　2020/11/24
  • 　TGF-β1 facilitates MT1-MMP-mediated proMMP-9 activation and invasion in oral squamous cell carcinoma cells.　Hirari Yamahana,Minoru Terashima,Risa Takatsuka,Chikako Asada,Takeshi Suzuki,Yoshihiro Uto,Takahisa Takino　Biochemistry and biophysics reports　27　101072　2021/09
  • 　m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.　Kusuma Suphakhong,Minoru Terashima,Sasithorn Wanna-Udom,Risa Takatsuka,Akihiko Ishimura,Takahisa Takino,Takeshi Suzuki　The Journal of biological chemistry　298　11　102554　2022/11
  • 　Potential biomarker proteins for aspiration pneumonia detected by shotgun proteomics using buccal mucosa samples: a cross-sectional case-control study.　Kohei Ogura,Maho Endo,Takashi Hase,Hitomi Negami,Kohsuke Tsuchiya,Takumi Nishiuchi,Takeshi Suzuki,Kazuhiro Ogai,Hiromi Sanada,Shigefumi Okamoto,Junko Sugama　Clin Proteomics　20　1　9　2023/03
  • 　Development of UTX-143, a selective sodium-hydrogen exchange subtype 5 inhibitor, using amiloride as a lead compound.　Yusei Shinohara,Yuki Komiya,Kashin Morimoto,Yoshio Endo,Minoru Terashima,Takeshi Suzuki,Takahisa Takino,Itasu Ninomiya,Hisatsugu Yamada,Yoshihiro Uto　Bioorg. Med. Chem.　99　117603　2024/02
  • 　Overexpression of JNK-associated leucine zipper protein induces chromosomal instability through interaction with dynein light intermediate chain 1.　Ryousuke Suzuki,Masato T Kanemaki,Takeshi Suzuki,Katsuji Yoshioka　Genes to Cells　29　1　39　2024/01
  • 　Iron regulates MT1-MMP-mediated proMMP-2 activation and cancer cell invasion.　Risa Takatsuka,Minoru Terashima,Akihiko Ishimura,Takeshi Suzuki,Takahisa Takino　Biochemical and biophysical research communications　742　151124　2025/01
  • 　The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis　Yasuto Takeuchi,Natsuko Kimura,Takahiko Murayama,Yukino Machida,Daisuke Iejima,Tatsunori Nishimura,Minoru Terashima,Yuming Wang,Mengjiao Li,Reiko Sakamoto,Mizuki Yamamoto,Naoki Itano,Yusuke Inoue,Masataka Ito,Nobuaki Yoshida,Jun-ichiro Inoue,Koichi Akashi,Hideyuki Saya,Koji Fujita,Masahiko Kuroda,Issay Kitabayashi,Dominic Voon,Takeshi Suzuki,Arinobu Tojo,Noriko Gotoh　Proceedings of the National Academy of Sciences　118　43　e2103658118　2021/10/26　
  • 　Permeable Lung Vasculature Creates Chemoresistant Endothelial Niche by Producing SERPINE1 at Breast Cancer Metastatic Sites.　Tsunaki Hongu,Sarenqiqige,Shandan,Hirokazu Kusunoki,Akihiko Ishimura,Takeshi Suzuki,Thordur Oskarsson,Noriko Gotoh　Cancer science　2025/04/11
  • 　Claudin-11 Enhances Invasive and Metastatic Abilities of Small-Cell Lung Cancer Through MT1-MMP Activation.　Shuichi Sakamoto,Hiroyuki Inoue,Takahisa Takino,Yasuko Kohda,Junjiro Yoshida,Shunichi Ohba,Ihomi Usami,Takeshi Suzuki,Manabu Kawada,Masanori Hatakeyama　Cancer science　2025/03/13
  • 　EED regulates epithelial-mesenchymal transition of cancer cells induced by TGF-β　Oktyabri, Dulamsuren; Tange, Shoichiro; Terashima, Minoru; Ishimura, Akihiko; Suzuki, Takeshi　Biochemical and Biophysical Research Communications　453　1　124-130　2014/10/10　
  • 　JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines　Tange, Shoichiro; Oktyabri, Dulamsuren; Terashima, Minoru; Ishimura, Akihiko; Suzuki, Takeshi　PLoS ONE　9　12　2014/12/26　

Conference Presentations

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

○Identification of novel molecular targets that interact with cancer genes

Grant-in-Aid for Scientific Research

○「ゲノムへの挿入変異を利用した疾患関連遺伝子の単離とその機能解析」(2009-2011)　
○「白血病ウイルス感染による病原性発現に関与する細胞性因子の解析」(2009-2010)　
○「ゲノムへの挿入変異を利用した疾患関連遺伝子の単離とその機能解析」(2009-)　
○「白血病ウイルス感染による病原性発現に関与する細胞性因子の解析」(2009-)　
○「ゲノム不安定性を示すマウスを利用した新しいがん抑制遺伝子の単離とその機能解析」(2009-)　
○「両アリルへの挿入変異導入を利用した疾患原因遺伝子の単離と機能解析」(2008-)　
○「ゲノム不安定性を示すマウスを利用した新しいがん抑制遺伝子の単離とその機能解析」(2008-)　
○「白血病ウイルス感染による病原性発現に関わる細胞性因子の同定と解析」(2008-)　
○「両アリルへの挿入変異導入を利用した疾患原因遺伝子の単離と機能解析」(2007-)　
○「白血病ウイルス感染による病原性発現に関わる細胞性因子の同定と解析」(2007-)　
○「ウイルス挿入変異法で同定されたエピゲノム制御因子による疾患発症機構の解析」(2012-2014)　

Competitive research funding,Contribution

Collaborative research,Consignment study

○Functional analysis of Jmjd5 candidate cancer gene identified by retroviral insertional mutagenesis(2010-2011)
○Functional analysis of Jmjd5 candidate cancer gene identified by retroviral insertional mutagenesis(2009-)

Classes (Bachelors)

Classes (Graduate Schools)

○Cancer molecular pathology 1(2017)
○Tumor Virology(2017)
○Tumor Virology(2017)
○Environment and Health -Introductory(2017)
○Biology of Cancer 1B(2017)
○Biology of Cancer 1A(2017)
○Cancer molecular pathology 1(2017)
○Tumor Virology(2017)
○Cancer molecular pathology 1(2017)
○Cancer molecular pathology 1(2017)
○Molecular Oncology(2017)
○Cancer molecular pathology 1(2016)
○Tumor Virology(2016)
○Tumor Virology(2016)
○Environment and Health -Introductory(2016)
○Tumor Virology(2016)
○Biology of Cancer 1B(2016)
○Biology of Cancer 1A(2016)
○Molecular Oncology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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