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Researcher Information

last modified:2017/04/01

Professor HIGASHIDA Haruhiro

Mail Laboratory Website

Faculty, Affiliation

Research Center for Child Mental Development

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Neuroscience, Graduate School of Medical Science
United Graduate School of Child Depelopment
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Department of Biophysical Genetics TEL:076-265-2455 FAX:076-234-4236

Academic Background

【Academic background(Doctoral/Master's Degree)】
Nagoya University Doctor 197503 Completed
【Academic background(Bachelor's Degree)】
Gifu University 197103

Career

Year & Month of Birth

1947/02

Academic Society



Soc.Neurosci


Int.Soc.Neurochem

Award

Int.Soc.Neurochem
Int.Soc.Neurochem
Int.Soc.Neurochem
Int.Soc.Neurochem
Int.Soc.Neurochem
Int.Soc.Neurochem
Int.Soc.Neurochem
Int.Soc.Neurochem
Int.Soc.Neurochem
Int.Soc.Neurochem
Int.Soc.Neurochem
Int.Soc.Neurochem
Int.Soc.Neurochem
Int.Soc.Neurochem
Int.Soc.Neurochem

Specialities

、、Neurochemistry/Neuropharmacology、Neurophysiology/General neuroscience、Neurophysiology/General neuroscience

Speciality Keywords

Research Themes

Analysis of bradykinin receptor responses

Study on subtypes of muscarinic acetylcholine receptors

Cloning of K<sup>+</sup> channels

Books

  •  Slow Synaptic Responses and Modulation Springer-Verlag 1999/10
  •  Slow Synaptic Responses and Modulation Springer-Verlag 1999/10
  •  Slow Synaptic Responses and Modulation Springer-Verlag 1999/10
  •  Slow Synaptic Responses and Modulation Springer-Verlag 1999/10
  •  Slow Synaptic Responses and Modulation Springer-Verlag 1999/10

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  •  Slow Synaptic Responses and Modulation Springer-Verlag 1999/10
  •  Slow Synaptic Responses and Modulation Springer-Verlag 1999/10
  •  Slow Synaptic Responses and Modulation Springer-Verlag 1999/10

Papers

  •  ADP-ribosyl cyclase coupled with receptors via G proteins. FEBS Lett. 418 3 355-356 1997/12
  •  12-lipoxygenase overexprssion in rodent NG108-15 cells enhances the excitability by inhibiting M-type K+ channels. J. Physiol. (London) 521 Pt 3 567-574 1999/12
  •  Angiotensin II stimulates cyclic ADP-ribose formation in neonatal rat cardiac myocytes. Biochem. J. 352 Pt 1 197-202 2000/11
  •  Both linopirdine- and WAY123,398-sensitive components of IK(M,ng) are modulated by cyclic ADP ribose in NG108-15 cells. Pflugers Archiv Eur. J. Physiol. 441 2-3 228-234 2000/12
  •  cADP-ribose potentiates cytosolic Ca2+ elevation and Ca2+ entry via L-type voltage-activated Ca2+ channels in NG108-15 neuronal cells. Biochem. J. 345 Pt 2 207-215 1999/11

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  •  Cyclooxygenase-2 stimulates production of amyloid b-peptide in neuroblastoma x glioma hybrid Ng108-15 cells. Biochem. Biophys. Res. Commun. 281 2 483-490 2001/02
  •  Differential interactions of the C terminus and the cytoplasmic I-II loop of neuronal Ca2+ channels with G-protein a and bg subunits. J. Biol. Chem. 273 28 17595-17603 1998/07
  •  Endomorphins inhibit high-threshold Ca2+ channel currents in rodent NG108-15 cells overexpressing m-opioid receptors. J. Physiol. (Lond.) 507 Pt 1 71-75 1998/02
  •  Expression of Kv1.2 potassium channels in rat sensory ganglia: an immunohistochemical study. Ann. NY. Acad. Sci. 868 454-457 1999/04
  •  Inositol-1,3,4,5-tetrakisphosphate binding sites in control and ras-transformed NIH/3T3 fibroblasts. Biochem. Biophys. Res. Commun. 239 1 349-352 1997/10
  •  KCR1, a membrane protein that facilitates functional expression of non-inactivating K+ currents associates with rat EAG voltage-dependent K+ channels. J. Biol. Chem. 273 36,23080-23085 1998/09
  •  Localization of B2 bradykinin receptor mRNA in the rat retina and sclerocornea. Immunopharmacol. 45 1-3 51-55 1999/12
  •  Membrane-bound form of ADP-ribosyl cyclase in rat cortical astrocytes in culture. J. Neurochem. 74 2 669-675 2000/02
  •  Muscarinic acetylcholine receptor subtypes in the human iris. Brain Res. 787 2 344-347 1998/03
  •  Muscarinic receptor-mediated dual regulation of ADP-ribosyl cyclase in NG108-15 neuronal cell membranes. J. Biol. Chem. 272 50 31272-31277 1997/12
  •  Overexpression of rat synapsins in NG108-15 neuronal cells enhances functional synapse formation with myotubes. Neurosci. Lett. 260 2 93-96 1999/01
  •  Overexpression of rat frequenin in rodent NG108-15 cells enhances functional synapse formation and release of acetylcholine. J. Physiol. (London) 523 Pt 3 649-659 2001/05
  •  Sympathetic potentiation of cyclic ADP-ribose formation in rat cardiac myocytes. J. Biol. Chem. 274 47 33348-33354 1999/11
  •  Measurement of adenylyl cyclase by separating cyclic AMP on silica gel thin-layer chromatography. ANALYTICAL BIOCHEMISTRY 308 1 106-111 2002/09
  •  Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. Journal Neurochemistry 85 5 1148-1158 2003/06
  •  AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. NATURE NEUROSCIENCE 6 6 564-571 2003/06
  •  Measurement of adenylyl cyclase by separating cyclic AMP on silica gel thin-layer chromatography. ANALYTICAL BIOCHEMISTRY 308 1 106-111 2002/09
  •  Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways. Noda, Mami, Yasuda, Satsuki, Okada, Mitsuko, Higashida, Haruhiro, Shimada, Aki, Iwata, Nakao, Ozaki, Norio, Nishikawa, Kaori, Shirasawa, Sakiko, Uchida, Mayumi, Aoki, Shunsuke and Wada, Keiji JOURNAL OF NEUROCHEMISTRY 84 2 222-232 2003/01
  •  Clinical and electrophysiological characterization of a novel mutation (F193L) in the KCNQ1 gene associated with long QT syndrome. Yamaguchi, Masato, Shimizu, Masami, Ino, Hidekazu, Terai, Hidenobu, Hayashi, Kenshi, Mabuchi, Hiroshi, Hoshi, Naoto CLINICAL SCIENCE 104 4 377-382 2003/04
  •  Multiple signal transduction pathways mediated by 5-HT receptors. Noda, Mami, Aoki, Shunsuke and Wada Keiji MOLECULAR NEUROBIOLOGY 29 1 31-39 2004/02
  •  Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N terminus of HERG. Hayashi, Kenshi, Shimizu, Masami, Ino, Hidekazu, Yamaguchi, Masato, Terai, Hidenobu, Hoshi, Naoto, Terashima, Nariaki, Uno, Yoshihide, Kanaya, Honin and Mabuchi, Hiroshi CLINICAL SCIENCE 107 2 175-182 2004/08
  •  Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/macrophages. Manaka, Junko, Kuraishi, Takayuki, Shiratsuchi, Akiko, Nakai, Yuji, Henson, Peter and Nakanishi, Yoshinobu JOURNAL OF BIOLOGICAL CHEMISTRY 279 46 48466-48476 2004/11
  •  Genes required for Drosophila nervous system development identified by RNA interference. Ivanov AI, Rovescalli AC, Pozzi P, Yoo S, Mozer B, Li HP, Yu SH, Guo V, Spencer M, Nirenberg M. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME 101 46 16216-16221 2004/11
  •  Compound heterozygosity for mutations (D611Y in KCNQ1, D609G in KCNH2) associated with severe Long QT syndrome. Yamaguchi, Masato, Shimizu, Masami, Ino, Hidekazu, Terai, Hidenobu, Hayashi, Kenshi, Kaneda, Tomoya, Mabuchi, Hiroshi, Sumita, Ryo, Oshima, Tohru, Hoshi, Naoto. CLINICAL SCIENCE 108 2 143-150 2005/02
  •  Protein kinase C bound with A-kinase anchoring protein is involved in muscarinic receptor-activated modulation of M-type KCNQ potassium channels. Hoshi N, Zhang JS, Yokoyama S, Hashii M, Jin D, Noda M, Robbins J. NEUROSCIENCE RESEARCH 51 3 231-234 2005/03
  •  Induction of interleukin-6 in dorsal root ganglion neurons after gradual elongation of rat sciatic nerve. Osamura N, Ikeda K, Ito T, Tomita K, Yokoyama S. EXPERIMENTAL NEUROLOGY 195 1 61-70 2005/09
  •  Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca(2+)-mobilizing second messenger. Structure--activity relationship of the N1-ribose moiety. Kudoh T, Fukuoka M, Ichikawa S, Murayama T, Ogawa Y, Hashii M, Kunerth S, Weber K, Guse AH, Potter BV, Matsuda A, Shuto S. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 127 24 8846-8855 2005/06
  •  Amplification of depolarization-induced and ryanodine-sensitive cytosolic Ca2+ elevation by synthetic carbocyclic analogs of cyclic ADP-ribose and their antagonistic effects in NG108-15 neuronal cells. Hashii M, Shuto S, Fukuoka M, Kudoh T, Matsuda A JOURNAL OF NEUROCHEMISTRY 94 2 316-323 2005/07
  •  Acetylcholine stimulates cyclic ADP-ribose formation via M1 muscarinic receptors in rat superior cervical ganglion. Zhang JS, Jin D BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 335 3 920-924 2005/09
  •  Induction of tumor necrosis factor-alpha in Schwann cells after gradual elongation of rat sciatic nerve. Hagiwara N, Ikeda K, Tomita K, Yokoyama S. J Orthop Sci. 10 6 614-621 2005/11
  •  Bradykinin activates ADP-ribosyl cyclase in neuroblastoma cells: intracellular concentration decrease in NAD and increase in cyclic ADP-ribose. Salmina A, Hashii M, Yokoyama S, Zhang JS, Noda M, Zhong ZG, Jin D. FEBS LETTERS 580 20 4857-4860 2006/09
  •  Identification of calreticulin as a marker for phagocytosis of apoptotic cells in Drosophila. Kuraishi T, Manaka J, Kono M, Ishii H, Yamamoto N, Koizumi K, Shiratsuchi A, Lee BL,Nakanishi Y. EXPERIMENTAL CELL RESEARCH 313 3 500-510 2007/02
  •  Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca(2+) signalling in rodent NG108-15 neuroblastoma cells. Bowden SE, Yokoyama S, Salmina A, Hashii M, Hoshi N, Zhang JS, Knijnik R, Noda M, Zhong ZG, Jin D, Higashida K, Takeda H, Akita T, Kuba K, Yamagishi S, Shimizu N, Takasawa S, Okamoto H, Robbins J. NEUROSCIENCE RESEARCH 57 3 339-346 2007/03
  •  CD38 is critical for social behaviour by regulating oxytocin secretion. Jin, D., Liu, HX., Hirai, H., Torashima, T., Nagai, T., Lopatina, O., Shnayder, NA., Yamada, K., Noda, M., Seike, T., Fujita, K., Takasawa, S., Yokoyama, S., Koizumi, K., Shiraishi, Y., Tanaka, S., Hashii, M., Yoshihara, T., Higashida, K., Islam, MS., Yamada, N., Hayashi, K., Noguchi, N., Kato, I., Okamoto, H., Matsushima, A., Salmina, A., Munesue, T., Shimizu, N., Mochida, S., Asano, M. NATURE 446 7131 41-45 2007/03
  •  Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-riboseor Ca(2+) concentrations is involved in autoregulation of oxytocin secretionin the hypothalamus and posterior pituitary in male mice Lopatina O, Liu HX, Amina S, Hashii M, 2009/06
  •  Design and synthesis of 4",6"-unsaturated cyclic ADP-carbocyclic ribose as a Ca2+ -mobilizing agent. Kudou, T., Weber, K., Guse, A. H., Potter, B. V. L., Hashii, M., Arisawa, M., Matsuda, A. & Shuto, S. TETRAHEDRON LETTERS 49 3976-3979 2008
  •  Design and synthesis of 4",6"-unsaturated cyclic ADP-carbocyclic-ribose, a Ca2+ -mobilizing agent selectively active in T cells. Kudou, T., Murakami, T., Hashii, M., Sakurai, T., Maechling, C., Spiess, B., Weber, K., Guse, A. H., Potter, B. V. L., Arisawa, M., Matsuda, A. & Shuto, S. TETRAHEDRON 64 9754-9765 2008
  •  Locomotor activity, ultrasonic vocalization and oxytocin levels in infant CD38 knockout mice. Liu HX, Lopatina O, Higashida C, Tsuji T, Kato I, Takasawa S, Okamoto H, Yokoyama S, Neurosci Lett. 448 1 67-70 2008/12
  •  Genetic analyses of roundabout (ROBO) axon guidance receptors in autism. Anitha A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Ouchi Y, Sugiyama T, Koizumi K, Takei N, Yoshikawa T, Mori N. Am J Med Genet B Neuropsychiatr Genet. 147B 7 1019-1027 2008/10
  •  Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system. Salmina AB, Olovyannikova RY, Hashii M, Yokoyama S, Koizumi K, Jin D, Liu HX, Lopatina O, Amina S, Islam MS, Huang JJ, Noda M NEUROCHEMISTRY INTERNATIONAL 51 2-4 192-199 2007/07
  •  RNA interference screen to identify genes required for Drosophila embryonic nervous system development. Koizumi K, Yoo S, Islam MS, Ivanov AI, Guo V, Pozzi P, Yu SH, Rovescalli AC, Tang D, Nirenberg M. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME 104 13 5626-5631 2007/03
  •  Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses. Johansson JU, Lilja L, Chen XL, Meister B, Noda M, Zhong ZG, Yokoyama S, Berggren PO, Bark C Brain Res Mol Brain Res 138 2 215-227 2005/08

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「膜電位依存性カリウムMチャンネルの遺伝子クローニング」(1997-) 
○「脳型ADPリボシールシクラーゼの精製とcDNAクローニング」(1997-) 
○「脳型ADPリボシールシクラーゼの精製とcDNAクローニング」(1998-) 
○「脳型ADPリボシールシクラーゼの精製とcDNAクローニング」(1999-) 
○「神経細胞でサイクリックADPリボースは真のセカンドメッセンジャーか」(2000-) 
○「受容体とカップルするADPリボシールシクラーゼ分子の個体レベルでの解析」(2000-) 
○「神経細胞でサイクリックADPリボースは真のセカンドメッセンジャーか」(2001-) 
○「受容体とカップルするADPリボシールシクラーゼ分子の固体レベルでの解析」(2001-) 
○「ドーパミン受容体とカップルするADPリボース環状化酵素:パーキンソン病脳への応用」(2003-2005) 
○「ラット新生仔脳及びCD38ノックアウトマウス脳のADPリボシルシクラーゼの精製」(2004-2006) 
○「Aキナーゼアンカータンパク(AKAP)依存的シナプス後電位:終止の分子メカニズム」(2005-2005) 
○「社会認識に関わる分子の神経化学的解析による自閉症の解明と治療」(2007-2009) 

Classes (Bachelors)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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