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Researcher Information

last modified:2017/05/23

Professor YOKOTA Takashi

Mail

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Cancer Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Division of Stem Cell Biology TEL:076-265-2205 FAX:076-234-4238

Academic Background

【Academic background(Doctoral/Master's Degree)】
The University of Tokyo Doctor 198003 Completed
The University of Tokyo Master 197703 Completed
【Academic background(Bachelor's Degree)】
The University of Tokyo 197503

Career

The Institute of Medical Science ,University of Tokyo Department of Chemistry(1980/04/01-1980/12/15)
Basic Research Laboratories ,Toray Industry,Inc. Molecular Genetics(1980/12/16-1984/03/31)
Stanford University Medical Center(1982/05/20-1983/06/30)
DNAX Research Institute for Molecular and Cellular Biology Molecular Biology(1983/07/01-1984/03/31)
DNAX Research Institute for Molecular and Cellular Biology Molecular Biology(1984/04/01-1988/05/31)
DNAX Research Institute for Molecular and Cellular Biology Molecular Biology(1988/06/01-1990/05/15)
The Institute of Medical Science, University of Tokyo Molecular and Developmental Biology(1990/05/16-1995/03/31)
The Institute of Medical Science, University of Tokyo Stem Cell Requlation(1995/04/01-2001/09/30)
Kanazawa University(2001/10/01-)

Year & Month of Birth

1953/01

Academic Society






Award


○IBC Foremost Scientists of the World(2008/09/12)
○Marquis Who's Who in the World(2007/08)
○ISI Highly Cited Researchers(2007/08)

Specialities

Pathological medical chemistry、Functional biochemistry、Molecular biology

Speciality Keywords

Research Themes

Undifferenticated property maintenance mechanism of embryo-stem cells (ES cells, self-replication, STAT3)

Books

  •  Shinwa Shibata, Teruhiko Wakayama, Takashi Yokota X chromosome inactivation in nuclear transfer ES cells. 121 2 96-101 2008/06

Papers

  •  A novel chordin-like protein inhibitor for bone morphogenetic proteins. DEVELOPMENTAL BIOLOGY 232 2 372 2001/04
  •  A selective switch-on system for self-renewal of embryonic stem cells using chimeric cytokine receptors. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 248 1 22-27 1998/07
  •  Activation of Stat3 by cytokine receptor gp130 ventralizes Xenopus embryos independently of BMP-4. DEVELOPMENTAL BIOLOGY 216 2 481-490 1999/12
  •  Bruton's tyrosine kinase-mediated interleukin-2 gene activation in mast cells: dependence on the c-Jun N-terminal kinase activation pathway. JOURNAL OF BIOLOGICAL CHEMISTRY 273 18 10979-10987 1998/05
  •  Chimeric cytokine receptor can transduce expansion signals in interleukin 6 receptor a (IL-6Ra)-, IL-11Ra-, and gp130-low to -negative primitive hematopoietic progenitors. MOLECULAR BIOLOGY OF THE CELL 10 11 3633-3642 1999/11

show all

  •  Cloning and expression pattern of a Xenopus pronephros-specific gene, XSMP-30. MECHANISMS OF DEVELOPMENT 92 2 273 2000/04
  •  Cytoplasmic domains of the leukemia inhibitory factor receptor required for STAT3 activation, and inducing differentiation and growth arrest of myeloid leukemic cells. BLOOD 93 6 1934-1941 1999/03
  •  Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulaitng factor receptor. MOLECULAR AND CELLULAR BIOLOGY 18 2 742-752 1998/02
  •  Four P-like elements are required for optimal transcription of the mouse IL-4 gene: involvement of a distinct set of nuclear factor of activated T cells and activator protein-1 family proteins. INTERNATIONAL IMMUNOLOGY 9 9 1329-1338 1997/09
  •  Molecular cloning of a novel Xenopus spalt gene (sal-3). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 264 1 151-156 1999/10
  •  Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. DEVELOPMENT 128 16 3105 2001/08
  •  Recombinant adenovirus vectors for cytokine gene therapy in mice. J. Allergy Clin. Immunol. 103 5 S471 1999/05
  •  STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO JOURNAL 18 15 4261 1999/08
  •  Th2 specific DNase I hypersensitive sites in the murine IL-13 and IL-4 intergenic region. INTERNATIONAL IMMUNOLOGY 10 12 1981-1985 1998/12
  •  Xenopus FK 506-binding protein homolog induces a secondary axis in frog embryos, which is inhibited by coexisting BMP 4 signaling. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 239 2 585-591 1997/10
  •  Involvement of Ras in extraembryonic endoderm differentiation of embryonic stem cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 313 3 475-481 2004/01
  •  CD9 is associated with leukemia inhibitory factor-mediated maintenance of embryonic stem cells. MOLECULAR BIOLOGY OF THE CELL 13 4 1274-1281 2002/04
  •  Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity. GENOME RESEARCH 12 12 1921-1928 2002/12
  •  GABPalpha regulates Oct-3/4 expression in mouse embryonic stem cells. Keita Kinoshita, Hiroki Ura, Tadayuki Akagi, Masayuki Usuda, Hiroshi Koide, Takashi Yokota. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 353 686-691 2007/02
  •  Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells. Yukinari Takao, Takashi Yokota, Hiroshi Koide. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 353 699-705 2007/02
  •  Functional analysis of the effect of forced activation of STAT3 on M1 mouse leukemia cells. Yoshida, T., Iwamoto, T., Adachi, K., Yokota, T., Miyake, Y., Hamaguchi, M. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 15 2 269-275 2005/02
  •  A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. Nakayama, N., Han, C., Cam, L., Lee, J.I., Pretorius, J., Fisher, S., Rosenfeld, R., Scully, S., Duryea, D., Chow, G., Nishinakamura, R., Yokota, T., Zhang, K. DEVELOPMENT 131 229-240 2004/01
  •  Reciprocal inhibition between MyoD and STAT3 in the regulation of growth and differentiation of myoblasts. Kataoka, Y., Matsumura, I., Ezoe,S., Nakata, S., Takigawa, E., Sato, Y., Kawasaki, A., Yokota, T., Nakajima, K., Felsani, A., Kanakura, Y. JOURNAL OF BIOLOGICAL CHEMISTRY 278 45 44178-44187 2003/11
  •  Zinc-finger protein Sall2 is not essential for embryonic and kidney development. Sato, A., Matsumoto, Y., Koide, U., Kataoka, Y., Yoshida, N., Yokota, T., Asashima, M., Nishinakamura, R. MOLECULAR AND CELLULAR BIOLOGY 23 62-69 2003/01
  •  LSSIG is a novel murine leukocyte specific GPCR that is induced by the activation of STAT3. Senga, T., Iwamoto, S., Yoshida, T., Yokota, T., Adachi, K., Azuma, E., Hamaguchi, M., Iwamoto, T. BLOOD 101 1185-1187 2003/02
  •  Alterations of endothelin-converting enzyme expression in early and advanced stage of human coronary atherosclerosions. Hai, E., Ikura, Y., Naruko, T., Shirai, N., Yoshimi, N., Kayo, S., Ugama, Y., Fujino, H., Ohsawa, M., Tazawa, K., Yokota, T., Ueda, M. IINTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 13 649-654 2004/05
  •  Synergy of Eed and Tsix in the repression of Xist gene and X-chromosome inactivation. Shinwa Shibata, Takashi Yokota, Anton Wutz EMBO JOURNAL 27 13 1816-1826 2008/07
  •  Alterlation of histone tail modifications in the Xist locus in wild-type and Tsix-muatnt male embryonic stem cells during differentiation. Shinwa Shibata, Takashi Yokota EXPERIMENTAL ANIMALS 57 2 153-157 2008/04
  •  Stat3 upregulates expression of nicotinamide N-methyltransferase, a possible tumor marker. Mikio Tomida, Hideki Ohtake, Takashi Yokota, Yasuhito Kobayashi,, Masafumi Kurosumi. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 134 5 551-559 2008/05
  •  Stat3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells. Hiroki Ura, Masayuki Usuda, Keita Kinoshita, Chuanhai Sun, Keitaro Mori, Tadayuki Akagi, Takahiko Matsuda, Hiroshi Koide, Takashi Yokota. JOURNAL OF BIOLOGICAL CHEMISTRY 283 15 9713-9723 2008/04
  •  Stem cell-specific expression of Dax1 is conferred by STAT3 and Oct3/4 in embryonic stem cells. Chuanhai Sun, Yuhki Nakatake, Hiroki Ura, Tadayuki Akagi, Hitoshi Niwa, Hiroshi Koide, Takashi Yokota BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 372 1 91-96 2008/07
  •  Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3. Cinelli, P., Casanova, E.A., Yokota, t., et al. BMC Developmental Biology 8 57 2008/05
  •  Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells. Sun, C., Nakatake, Y., Akagi, T., Ura, H., Matsuda, T., Nishiyama, A., Koide, H., Koo, M.S.H., Niwa, H. and Yokota, T. MOLECULAR AND CELLULAR BIOLOGY 29 16 4574-4583 2009/08
  •  A stem cell-derived gene (Sddr) negatively regulates differentiation of embryonic stem cells Miura, M., Ueda, A., Takao, Y., Nishimura, E.K., Koide, H. and Yokota, T. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 54 33-39 2010/07
  •  Eed/Sox2 regulatory loop controls ES cell self-renewal through histone methylation and acetylation Ura, H., Murakami, K., Akagi, T., Kinoshita, K., Yamaguchi, S., Masui, S., Niwa, H., Koide, H. and Yokota, T. EMBO JOURNAL 30 11 2190-2204 2011/05
  •  Dax1 associates with Esrrb and regulates its function in embryonic stem cells. Uranishi, K., Akagi, T., Sun, C., Koide, H. , Yokota, T. MOLECULAR AND CELLULAR BIOLOGY 33 10 2056-2066 2013/05

Conference Presentations

  • Functions of Baf53a in proliferation and epigenetics status of embryonic stem cells.(2016/05/28)
  • A novel 2 amino acids deletion of the transcription factor C/EBP epsilon leads to neutrophil-specific granule deficiency (SGD).(conference:The 13th Stem Cell Research Symposium)(2015/05/29)
  • Molecular characterization of a novel 2 amino acids deletion of C/EBP epsilon in SGD.(2015/10/16)
  • The Nanog/Zfp57 axis regulates anchorage-independent growth(2014/05/30)
  • Zfp296 functions as transcriptional repressor and activator together with histon modification enzymes.(2014/09/24)

show all

  • A case of neutrophil-specific granule deficiency presenting with recurrent pyogenic infection of the skin; pathological and molecular analysis of a novel C/EBPε mutation.(conference:The 16th Biennial Meeting of the European Society for Immunodeficiencies)(2014/10/29)
  • Aberrant expression of monocyte markers on granulocytes from patients with neutrophil-specific granule deficiency.(conference:The 11th Congress of Asian Society for Pediatric Research)(2015/04/14)
  • Identification of ES cell-specific transcription factor ZFP57 as a novel oncogene.(conference:The 12th Annual Meeting of International Society for Stem Cell Research)(2014/06/19)
  • A novel 2 amino acids deletion in the leucine zipper domain of C/EBPε leads to neutrophil-specific granule deficiency (SGD).(conference:The 56th America Society of Hematology Annual Meeting.)(2014/12/06)
  • Identification of an ES-specific gene Zfp57 as a novel oncogene(2013/05/17)

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「ヒト胚幹細胞(ES細胞)における自己複製・分化機構の解析」(2001-) 
○「幹細胞の未分化性維持機構の解析」(2002-) 
○「ES細胞の未分化/分化のスイッチ機構の解析」(2005-) 
○「ES細胞の多能性を維持する転写因子STAT3の標的遺伝子群の探索」(2000-) 
○「幹細胞の未分化状態維持機構の解析」(2002-) 
○「アンチセンス転写によるXist遺伝子エピジェネティックス制御メカニズムの研究」(2004-) 
○「オーファン核内受容体LRH-1によるES細胞の増殖制御機構」(2008-) 
○「ES細胞と癌幹細胞におけるシグナル伝達分子制御機構の解析」(2006-) 
○「幹細胞の自己複製機構・分化機構の解析」(2007-)
○「がん幹細胞治療のための基盤技術開発」(2007-) 
○「がん幹細胞およびES細胞のシグナル伝達機構の解析」(2008-) 
○「ES細胞におけるエピジェネティクス制御機構の解析」(2008-) 
○「胚性幹細胞におけるエピジェネティクス制御機構の解析」(2009-) 
○「がん幹細胞および胚性幹細胞のシグナル伝達機構の解析」(2009-) 
○「胚性幹細胞における自己複製機構の解析」(2010-2011) 

Classes (Bachelors)

○Lecture on Life in Campus and Society(2017)
○Laboratory animal science and stem cell biology(2017)
○Laboratory animal science and stem cell biology(2016)
○Lecture on Life in Campus and Society(2016)
○Aninmal experiment and stem cell biology(2016)
○Lecture on Life in Campus and Society(2015)

Classes (Graduate Schools)

○Stem Cell Biology(2017)
○Stem Cell Biology(2017)
○Stem Cell Biology(2017)
○Stem Cell Biology(2016)
○Stem Cell Biology(2016)
○Stem Cell Biology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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