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Researcher Information

last modified:2019/04/14

Professor HONDA, Masao

Mail

Faculty, Affiliation

Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Health Sciences, Graduate School of Medical Science
Division of Health Sciences,Graduate School of Medical Science
Department of Laboratory Sciences,School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Academic Background

Career

Kanazawa University
Kanazawa University
Kanazawa University
Kanazawa University
Kanazawa University(2007/07/01-)

Year & Month of Birth

Academic Society








Award









Specialities

Liver Disease、Gastroenterology、Collagenous pathology/Allergology、Virology

Speciality Keywords

Liver Disease

Research Themes

Viral Hepatitis

NASH

Hepatokine

Hepatic fibrosis

Molecular biology of HCC

Tumor immunity

Books

  •  Yamashita T, Honda M, Kaneko S. Cancer Stem Cells - The Cutting Edge  InTech 2011
  •  Yamashita T, Honda M, Kaneko S. Molecular Genetics of Liver Neoplasia  Springer 2011
  •  Honda M, Kaneko S. New Perspectives in Cancer Research and Therapy  Research Signpost 2005
  •  Honda M, Kaneko S. Recent Res. Devel. Experimental Med  Tranworld Research Network 2004
  •  Honda M, Sakai A, Kaneko S, Kobayashi K. Frontiers in Hepatology, Liver cirrhosis Springer-Verlag 2001

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  •  Honda M, Geoff Abell, Kaneko S, Kobayashi K, Stanley M. Lemon. Frontiers in Hepatology, HCV and Related Liver Deseases  Springer-Verlag 1999
  •  本多政夫, 金子周一. 実験医学増刊 炎症-全体像を知り慢性疾患を制御する 炎症シグナル、免疫細胞のダイナミズムからがん・糖尿病などの発症機序と治療標的まで 羊土社 2014
  •  本多政夫, 金子周一. 分子消化器病 特集 消化器疾患におけるsmall RNAの役割を解明する 先端医学社 2015
  •  本多政夫, 金子周一. Hepatology Practice 3 C型肝炎の診療を極める 基本から最前線まで 文光堂 2014
  •  本多政夫, 金子周一. Hepatology Practice 3 C型肝炎の診療を極める 基本から最前線まで 文光堂 2014
  •  本多政夫, 金子周一. Hepatology Practice 4 難治性肝疾患の診療を極める 基本から最前線まで 文光堂 2014
  •  本多政夫. Hepatology Practice 1 B型肝炎の診療を極める 文光堂 2013
  •  本多政夫, 金子周一. カラー消化器病 基礎と臨床 西村書店 2013
  •  本多政夫, 金子周一. 肝疾患 Review 2012-2013 日本メディカルセンター 2012
  •  本多政夫, 山下太郎, 上田晃之, 川口和紀, 西野隆平, 鷹取元, 皆川宏貴, 金子周一. DNAチップ活用テクノロジーと応用」 シーエムシー出版 2006
  •  本多政夫, 山下太郎, 川口和紀, 金子周一. 肝疾患Review 2006-2007 日本メディカルセンター 2006
  •  本多政夫, 山下太郎, 川口和紀, 代田幸博, 金子周一.  消化器疾患最新の治療2005-2006 南江堂 2005
  •  本多政夫, 上田晃之, 金子周一. 消化器病学の進歩2005-モノグラフ- 日本消化器病学会 2005
  •  本多政夫, 山下太郎, 代田幸博, 金子周一. 先端医療シリーズ25 肝・胆・膵疾患の最新医療 先端医療技術研究所 2003
  •  本多政夫, 舘野誠, 山下太郎, 金子周一 C型慢性肝炎治療の新たなストラテジー -インターフェロン治療の今後- 先端医学社 2003
  •  本多政夫, 金子周一 メディコピア(39)ウイルス肝炎-最前線 富士レビオ社 1999
  •  鍛治恭介, 金子周一, 寺崎修一, 斉藤孝仁, 土山智也, 酒井佳夫, 蓑内慶次, 水腰英四郎, 大野秀棋, 小浦隆義, 酒井明人, 中本安成, 本多政夫, 河合博志, 松下栄紀, 卜部 健, 小林健一. 肝硬変の成因別実態1998 中外医学社 1999
  •  本多政夫, 竹内正勇, 稲垣 豊, 金子周一, 鵜浦雅志, 小林健一. 編集 田中 慧, 小原道法.  C型肝炎から肝細胞へ メジカルビュウー社 1994

Papers

  •  Induction of selenoprotein P mRNA during hepatitis C virus infection inhibits RIG-I-mediated antiviral immunity. Kazuhisa Murai, Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Hitoshi Omura, Hirofumi Misu, Yuki Kita, Yumie Takeshita, Kiyo-aki Ishii, Toshinari Takamura, Takeshi Urabe, Ryogo Shimizu, Hikari Okada, Taro Yamashita, Yoshio Sakai, Shuichi Kaneko  Cell Host & Microbe 25 4 588-601 2019/04/10
  •  Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid. Qin XY, Suzuki H, Honda M, Okada H, Kaneko S, Inoue I, Ebisui E, Hashimoto K, Carninci P, Kanki K, Tatsukawa H, Ishibashi N, Masaki T, Matsuura T, Kagechika H, Toriguchi K, Hatano E, Shirakami Y, Shiota G, Shimizu M, Moriwaki H, Kojima S. Proc Natl Acad Sci USA 115 19 4969-4974 2018/05/08
  •  Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle. Misu H, Takayama H, Saito Y, Mita Y, Kikuchi A, Ishii KA, Chikamoto K, Kanamori T, Tajima N, Lan F, Takeshita Y, Honda M, Tanaka M, Kato S, Matsuyama N, Yoshioka Y, Iwayama K, Tokuyama K, Akazawa N, Maeda S, Takekoshi K, Matsugo S, Noguchi N, Kaneko S, Takamura T. Nat Med. 23 4 508-516 2017/04/01
  •  Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C. Honda M, Takehana K, Sakai A, Tagata Y, Shirasaki T, Nishitani S, Muramatsu T, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Yamashita T, Nakamura M, Shimakami T, Yi M, Lemon SM, Suzuki T, Wakita T, Kaneko S; Hokuriku Liver Study Group. Gastroenterology 141 1 128-40 2011/07/01
  •  Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C. Honda M, Sakai A, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Yamashita T, Nakamura M, Shirasaki T, Horimoto K, Tanaka Y, Tokunaga K, Mizokami M, Kaneko S; Hokuriku Liver Study Group Gastroenterology 139 2 499-509 2010/08

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  •  Immune responses against tumour-associated antigen-derived cytotoxic T lymphocyte epitopes in cholangiocarcinoma patients. Kida A, Mizukoshi E, Tamai T, Terashima T, Kitahara M, Arai K, Yamashita T, Fushimi K, Honda M, Kaneko S. Liver Int. 38 11 2040-2050 2018/11/01
  •  Analysis of the liver functional reserve of patients with advanced hepatocellular carcinoma undergoing sorafenib treatment: prospects for regorafenib therapy. Terashima T, Yamashita T, Sunagozaka H, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S. Hepatol Res. 48 12 956-966 2018/11/01
  •  Three renal failure cases successfully treated with ombitasvir/paritaprevir/ritonavir for genotype 1b hepatitis C virus reinfection after liver transplantation. Orita N, Shimakami T, Sunagozaka H, Horii R, Nio K, Terashima T, Iida N, Kitahara M, Takatori H, Kawaguchi K, Kitamura K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S. Clin J Gastroenterol. 12 1 63-70 2019/02/01
  •  Characteristics of immune response to tumor-associated antigens and immune cell profile in hepatocellular carcinoma patients. Inada Y, Mizukoshi E, Seike T, Tamai T, Iida N, Kitahara M, Yamashita T, Arai K, Terashima T, Fushimi K, Yamashita T, Honda M, Kaneko S. Hepatology. 69 2 653-665 2019/02/01
  •  Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Hige S, Ito Y, Mita E, Tanaka E, Mochida S, Murawaki Y, Honda M, Sakai A, Hiasa Y, Nishiguchi S, Koike A, Sakaida I, Imamura M, Ito K, Yano K, Masaki N, Sugauchi F, Izumi N, Tokunaga K, Mizokami M Nat Genet. 41 10 1105-9 2009/10/01
  •  Biological characteristics of gene expression features in pancreatic cancer cells induced by proton and X-ray irradiation. Fujinaga H, Sakai Y, Yamashita T, Arai K, Terashima T, Komura T, Seki A, Kawaguchi K, Nasti A, Yoshida K, Wada T, Yamamoto K, Kume K, Hasegawa T, Takata T, Honda M, Kaneko S. Int J Radiat Biol. Epub ahead of print 2018/12/17
  •  Serum aldo-keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis. Kanno M, Kawaguchi K, Honda M, Horii R, Takatori H, Shimakami T, Kitamura K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S. J Gastroenterol. Epub ahead of print 2019/02/01
  •  Development of novel diagnostic system for pancreatic cancer, including early stages, measuring mRNA of whole blood cells. Sakai Y, Honda M, Matsui S, Komori O, Murayama T, Fujiwara T, Mizuno M, Imai Y, Yoshimura K, Nasti A, Wada T, Iida N, Kitahara M, Horii R, Toshikatsu T, Nishikawa M, Okafuji H, Mizukoshi E, Yamashita T, Yamashita T, Arai K, Kitamura K, Kawaguchi K, Takatori H, Shimakami T, Terashima T, Hayashi T, Nio K, Kaneko S; Hokuriku Liver Study Group. Cancer Sci. Epub ahead of print 2019/02/11
  •  Adipose tissue-derived stem cells prevent fibrosis in murine steatohepatitis by suppressing IL-17-mediated inflammation. Yamato M, Sakai Y, Mochida H, Kawaguchi K, Takamura M, Usui S, Seki A, Mizukoshi E, Yamashita T, Yamashita T, Ishida K, Nasti A, Tuyen HTB, Komura T, Yoshida K, Wada T, Honda M, Kaneko S. J Gastroenterol Hepatol. Epub ahead of print 2019/03/03
  •  Serum C16:1n7/C16:0 ratio as a diagnostic marker for non-alcoholic steatohepatitis Diagnosis of NASH using serum fatty acid. Yamada K, Mizukoshi E, Seike T, Horii R, Terashima T, Iida N, Kitahara M, Sunagozaka H, Arai K, Yamashita T, Honda M, Takamura T, Harada K, Kaneko S. J Gastroenterol Hepatol. Epub ahead of print 2019/03/12
  •  Ribavirin-induced down-regulation of CCAAT/enhancer-binding protein α leads to suppression of lipogenesis. Satoh S, Onomura D, Ueda Y, Dansako H, Honda M, Kaneko S, Kato N. Biochem J. 476 1 137-149 2019/01/15
  •  POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33. Hitomi Y, ほか85名、50番目 Sci Rep. 9 1 102 2019/01/14
  •  Distinct chemotherapy-associated anti-cancer immunity by myeloid cells inhibition in murine pancreatic cancer models. Sakai Y, Miyazawa M, Komura T, Yamada T, Nasti A, Yoshida K, Takabatake H, Yamato M, Yamashita T, Yamashita T, Mizukoshi E, Okuzono M, Ho TTB, Kawaguchi K, Wada T, Honda M, Kaneko S. Cancer Sci. 110 3 903-912 2019/03/01
  •  Notch signaling facilitates hepatitis B virus covalently closed circular DNA transcription via cAMP response element-binding protein with E3 ubiquitin ligase-modulation. Wang Z, Kawaguchi K, Honda M, Hashimoto S, Shirasaki T, Okada H, Orita N, Shimakami T, Yamashita T, Sakai Y, Mizukoshi E, Murakami S, Kaneko S. Sci Rep. 9 1 1621 2019/02/07
  •  The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication. Shirasaki T, Honda M, Yamashita T, Nio K, Shimakami T, Shimizu R, Nakasyo S, Murai K, Shirasaki N, Okada H, Sakai Y, Sato T, Suzuki T, Yoshioka K, Kaneko S. Sci Rep. 8 1 13143 2018/09/03
  •  Immune Condition of Colorectal Cancer Patients Featured by Serum Chemokines and Gene Expressions of CD4+ Cells in Blood. Komura T, Yano M, Miyake A, Takabatake H, Miyazawa M, Ogawa N, Seki A, Honda M, Wada T, Matsui S, Kaneko S, Sakai Y. Can J Gastroenterol Hepatol. 2018 7436205 2018/06/11
  •  Distinct notch signaling expression patterns between nucleoside and nucleotide analogues treatment for hepatitis B virus infection. Wang Z, Kawaguchi K, Honda M, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S. Biochem Biophys Res Commun. 501 3 682-687 2018/06/27
  •  Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma. Sawai H, Nishida N, Khor SS, Honda M, Sugiyama M, Baba N, Yamada K, Sawada N, Tsugane S, Koike K, Kondo Y, Yatsuhashi H, Nagaoka S, Taketomi A, Fukai M, Kurosaki M, Izumi N, Kang JH, Murata K, Hino K, Nishina S, Matsumoto A, Tanaka E, Sakamoto N, Ogawa K, Yamamoto K, Tamori A, Yokosuka O, Kanda T, Sakaida I, Itoh Y, Eguchi Y, Oeda S, Mochida S, Yuen MF, Seto WK, Poovorawan Y, Posuwan N, Mizokami M, Tokunaga K. Sci Rep. 8 1 7958 2018/05/21
  •  Immune responses of human T lymphocytes to novel hepatitis B virus-derived peptides. Yamamiya D, Mizukoshi E, Kaji K, Terashima T, Kitahara M, Yamashita T, Arai K, Fushimi K, Honda M, Kaneko S. PLoS One. 13 6 e0198264 2018/06/01
  •  Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts hepatocellular carcinoma incidence and recurrence in nucleos(t)ide analogue therapy for chronic hepatitis B. Kawaguchi K, Honda M, Ohta H, Terashima T, Shimakami T, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Komura T, Unoura M, Kaneko S. J Gastroenterol. 53 6 740-751 2018/06/01
  •  Unexpected Replication Boost by Simeprevir for Simeprevir-resistant Variants in Genotype 1a Hepatitis C Virus. Murai K, Shimakami T, Welsch C, Shirasaki T, Liu F, Kitabayashi J, Tanaka S, Funaki M, Omura H, Nishikawa T, Suminyadorj A, Honda M, Kaneko S. Antimicrob Agents Chemother 62 7 e02601-17 2018/06/26
  •  Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection. Murata K, Asano M, Matsumoto A, Sugiyama M, Nishida N, Tanaka E, Inoue T, Sakamoto M, Enomoto N, Shirasaki T, Honda M, Kaneko S, Gatanaga H, Oka S, Kawamura YI, Dohi T, Shuno Y, Yano H, Mizokami M. Gut 67 362-371 2018/01/01
  •  Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease. Yamada K, Mizukoshi E, Seike T, Horii R, Kitahara M, Sunagozaka H, Arai K, Yamashita T, Honda M, Kaneko S. PLoS One 13 e0191026 2018/01/01
  •  Peretinoin, an Acyclic Retinoid, Inhibits Hepatitis B Virus Replication by Suppressing Sphingosine Metabolic Pathway In Vitro. Murai K, Shirasaki T, Honda M, Shimizu R, Shimakami T, Nakasho S, Shirasaki N, Okada H, Sakai Y, Yamashita T, Kaneko S. Int J Mol Sci 19 108 2017/04/01
  •  The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells. Nasti A, Sakai Y, Seki A, Buffa GB, Komura T, Mochida H, Yamato M, Yoshida K, Ho TTB, Takamura M, Usui S, Wada T, Honda M, Kaneko S. Eur J Immunol 47 2163-2174 2017/04/01
  •  Serum cytokine profiles predict survival benefits in patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective cohort study. Hayashi T, Yamashita T, Terashima T, Suda T, Okada H, Asahina Y, Hayashi T, Hara Y, Nio K, Sunagozaka H, Takatori H, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S. BMC Cancer 17 870 2017/04/01
  •  Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo. Funaki M, Kitabayashi J, Shimakami T, Nagata N, Sakai Y, Takegoshi K, Okada H, Murai K, Shirasaki T, Oyama T, Yamashita T, Ota T, Takuwa Y, Honda M, Kaneko S. Sci Rep 7 16978 2017/04/01
  •  Reactivation of Hepatitis B Virus from an isolated Anti-HBc positive patient after eradication of Hepatitis C Virus with Direct-acting Antiviral Agents. Suda T, Shimakami T, Shirasaki T, Yamashita T, Mizukoshi E, Honda M, Kaneko S. J Hepatol 67 1108-1111 2017/04/01
  •  Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma. Komura T, Takabatake H, Harada K, Yamato M, Miyazawa M, Yoshida K, Honda M, Wada T, Kitagawa H, Ohta T, Kaneko S, Sakai Y. Cancer Sci 108 2122-2129 2017/04/01
  •  Sporadic PCDH18 somatic mutations in EpCAM-positive hepatocellular carcinoma. Hayashi T, Yamashita T, Okada H, Nio K, Hara Y, Nomura Y, Hayashi T, Asahina Y, Yoshida M, Oishi N, Sunagozaka H, Takatori H, Honda M, Kaneko S. Cancer Cell Int 17 97 2017/04/01
  •  The in vivo antitumor effects of type I-interferon against hepatocellular carcinoma: the suppression of tumor cell growth and angiogenesis. Enomoto H, Tao L, Eguchi R, Sato A, Honda M, Kaneko S, Iwata Y, Nishikawa H, Imanishi H, Iijima H, Tsujimura T, Nishiguchi S. Sci Rep 7 12189 2017/04/01
  •  HBcrAg predicts hepatocellular carcinoma development: An analysis using time-dependent receiver operating characteristics. Kawaguchi K, Honda M, Kaneko S. Transl Cancer Res 5 S2 S216-220 2016/04/01
  •  Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma. Honda M, Yamashita T, Yamashita T, Arai K, Sakai Y, Sakai A, Nakamura M, Mizukoshi E, Kaneko S. 15 13 191 2013/04/01
  •  Potential efficacy of therapies targeting intrahepatic lesions after sorafenib treatment of patients with hepatocellular carcinoma. Yamashita T, Horii R, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S. BMC Cancer. 16 1 338 2016/05/31
  •  Differential hepatitis C virus RNA target site selection and host factor activities of naturally occurring miR-122 3' variants.  Yamane D, Selitsky SR, Shimakami T, Li Y, Zhou M, Honda M, Sethupathy P, Lemon SM. Nucleic Acids Res. Epub ahead of print 2017/01/12
  •  De Novo Emergence of Mesenchymal Stem-Like CD105+ Cancer Cells by Cytotoxic Agents in Human Hepatocellular Carcinoma. Nomura Y, Yamashita T, Oishi N, Nio K, Hayashi T, Yoshida M, Hayashi T, Hashiba T, Asahina Y, Okada H, Sunagozaka H, Takatori H, Honda M, Kaneko S. Transl Oncol 10 2 184-189 2017/04/01
  •  Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis. Nishida N, Ohashi J, Khor SS, Sugiyama M, Tsuchiura T, Sawai H, Hino K, Honda M, Kaneko S, Yatsuhashi H, Yokosuka O, Koike K, Kurosaki M, Izumi N, Korenaga M, Kang JH, Tanaka E, Taketomi A, Eguchi Y, Sakamoto N, Yamamoto K, Tamori A, Sakaida I, Hige S, Itoh Y, Mochida S, Mita E, Takikawa Y, Ide T, Hiasa Y, Kojima H, Yamamoto K, Nakamura M, Saji H, Sasazuki T, Kanto T, Tokunaga K, Mizokami M. Sci Rep. 6 24767 2016/04/19
  •  Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate-activated protein kinase-related kinases and retinoid X receptor α. Satoh S, Mori K, Onomura D, Ueda Y, Dansako H, Honda M, Kaneko S, Ikeda M, Kato N. Hepatol Commun 1 550-563 2017/04/01
  •  Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet. Okada H, Takabatake R, *Honda M, Takegoshi K, Yamashita T, Nakamura M, Shirasaki T, Sakai Y, Shimakami T, Nagata N, Takamura T, Tanaka T, Kaneko S. Oncotarget 8 39978-39993 2017/04/01
  •  A Novel mTOR Inhibitor; Anthracimycin for the Treatment of Human Hepatocellular Carcinoma Hayashi T, Yamashita T, Okada H, Oishi N, Sunagozaka H, Nio K, Hayashi T, Hara Y, Asahina Y, Yoshida M, Hashiba T, Suda T, Shirasaki T, Igarashi Y, Miyanouchi K, Yamashita T, Honda M, Kaneko S.  Anticancer Res 37 7 3397-3403 2017/07/01
  •  Molecular Mechanism Underlying the Suppression of CPB2 Expression Caused by Persistent Hepatitis C Virus RNA Replication. Sejima H, Satoh S, Dansako H, Honda M, Kaneko S, Ikeda M, Kato N. Acta Med Okayama. 70 2 75-88 2016/04/01
  •  Post-progression survival and progression-free survival in patients with advanced hepatocellular carcinoma treated by sorafenib. Terashima T, Yamashita T, Takata N, Nakagawa H, Toyama T, Arai K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S. Hepatol Res. 46 7 650-6 2016/06/01
  •  Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts hepatocellular carcinoma incidence and recurrence in nucleos(t)ide analogue therapy for chronic hepatitis B. Kawaguchi K, Honda M, Ohta H, Terashima T, Shimakami T, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Komura T, Unoura M, Kaneko S. J Gastroenterol.  Epub ahead of print 2017/08/01
  •  Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin 28B genotypes. Honda M, Shirasaki T, Shimakami T, Sakai A, Horii R, Arai K, Yamashita T, Sakai Y, Yamashita T, Okada H, Murai K, Nakamura M, Mizukoshi E and Kaneko S. Hepatology 59 3 828-38 2014/03/01
  •  Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma. Yamashita T, Kitao A, Matsui O, Hayashi T, Nio K, Kondo M, Ohno N, Miyati T, Okada H, Yamashita T, Mizukoshi M, Honda M, Nakanuma Y, Takamura H, Ohta T, Nakamoto Y, Yamamoto M, Takayama T, Arii S, Wang XW, Kaneko S. Hepatology 60 5 1674-85 2014/11/01
  •  Impaired interferon signaling in chronic hepatitis C patients with advanced fibrosis via the transforming growth factor beta signaling pathway.  Shirasaki T, Honda M, Shimakami T, Murai K, Shiomoto T, Okada H, Takabatake R, Tokumaru A, Sakai Y, Yamashita T, Lemon SM, Murakami S, Kaneko S.  Hepatology 60 5 1519-30 2014/11/01
  •  ER stress induced impaired TLR signaling and macrophage differentiation of human monocytes. Komura T, Sakai Y, Honda M, Takamura T, Wada T, Kaneko S. Cell Immunol. 282 1 44-52 2013/04/24
  •  Gene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling. Ueda T, Honda M, Horimoto K, Aburatani S, Saito S, Yamashita T, Sakai Y, Nakamura M, Takatori H, Sunagozaka H, Kaneko S. Genomics. 101 4 238-48 2013/04/01
  •  Association of Interleukin 28B genotype and hepatocellular carcinoma recurrence in patients with chronic hepatitis C. Hodo Y, Honda M, Tanaka A, Nomura Y, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Sakai A, Sasaki M, Nakanuma Y, Moriyama M, Kaneko S. Clin Cancer Res. 19 7 1827-37 2013/04/01
  •  TSU-68 Ameliorates Hepatocellular Carcinoma Growth by Inhibiting Microenvironmental Platelet-derived Growth Factor Signaling. Hara Y, Yamashita T, Oishi N, Nio K, Hayashi T, Nomura Y, Yoshida M, Hayashi T, Hashiba T, Asahina Y, Kondo M, Okada H, Sunagozaka H, Honda M, Kaneko S. Anticancer Res. 35 3 1423-31 2015/03/01
  •  Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs. Selitsky SR, Dinh TA, Toth CL, Kurtz CL, Honda M, Struck BR, Kaneko S, Vickers KC, Lemon SM, Sethupathy P. MBio. 6 6 e01500-15 2015/12/08
  •  Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice. Okada H, Honda M, Campbell JS, Takegoshi K, Sakai Y, Yamashita T, Shirasaki T, Takabatake R, Nakamura M, Tanaka T, Kaneko S. Cancer Sci. 106 9 1143-52 2015/09/01
  •  Defeating EpCAM(+) liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma. Nio K, Yamashita T, Okada H, Kondo M, Hayashi T, Hara Y, Nomura Y, Zeng SS, Yoshida M, Hayashi T, Sunagozaka H, Oishi N, Honda M, Kaneko S.  J Hepatol. 63 5 1164-72 2015/11/01
  •  Response to Importance of confounding factors in assessing fatty acid compositions in patients with non-alcoholic steatohepatitis. Yamada K, Mizukoshi E, Sunagozaka H, Arai K, Yamashita T, Takeshita Y, Misu H, Takamura T, Kitamura S, Zen Y, Nakanuma Y, Honda M, Kaneko S. Liver Int. 35 6 1773 2015/06/01
  •  Inflammatory features of pancreatic cancer highlighted by monocytes/macrophages and CD4+ T cells with clinical impact. Komura T, Sakai Y, Harada K, Kawaguchi K, Takabatake H, Kitagawa H, Wada T, Honda M, Ohta T, Nakanuma Y, Kaneko S. Cancer Sci. 106 6 672-86 2015/06/01
  •  Blood neutrophil to lymphocyte ratio as a predictor in patients with advanced hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy. Terashima T, Yamashita T, Iida N, Yamashita T, Nakagawa H, Arai K, Kitamura K, Kagaya T, Sakai Y, Mizukoshi E, Honda M, Kaneko S. Hepatol Res. 45 9 949-59 2015/09/01
  •  Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice. Okada H, Honda M, Campbell JS, Takegoshi K, Sakai Y, Yamashita T, Shirasaki T, Takabatake R, Nakamura M, Tanaka T, Kaneko S. Cancer Sci. 106 9 1143-52 2015/06/01
  •  Genome-wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection.  Matsuura K, Sawai H, Ikeo K, Ogawa S, Iio E, Isogawa M, Shimada N, Komori A, Toyoda H, Kumada T, Namisaki T, Yoshiji H, Sakamoto N, Nakagawa M, Asahina Y, Kurosaki M, Izumi N, Enomoto N, Kusakabe A, Kajiwara E, Itoh Y, Ide T, Tamori A, Matsubara M, Kawada N, Shirabe K, Tomita E, Honda M, Kaneko S, Nishina S, Suetsugu A, Hiasa Y, Watanabe H, Genda T, Sakaida I, Nishiguchi S, Takaguchi K, Tanaka E, Sugihara J, Shimada M, Kondo Y, Kawai Y, Kojima K, Nagasaki M, Tokunaga K, Tanaka Y; Japanese Genome-Wide Association Study Group for Viral Hepatitis. Gastroenterology. Epub ahead of print 2017/02/02
  •  Post-progression survival and progression-free survival in patients with advanced hepatocellular carcinoma treated by sorafenib. Terashima T, Yamashita T, Takata N, Nakagawa H, Toyama T, Arai K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S. Hepatol Res. 2015/10/01
  •  MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells. Shirasaki T, Honda M, Shimakami T, Horii R, Yamashita T, Sakai Y, Sakai A, Okada H, Watanabe R, Murakami S, Yi M, Lemon SM, Kaneko S. J Virol. 87 9 5270-86 2013/05/01
  •  Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B. Wang X, Oishi N, Shimakami T, Yamashita T, Honda M, Murakami S, Kaneko S. World J Gastroenterol. 23 3252-3261 2017/04/01
  •  Sorafenib suppresses extrahepatic metastasis de novo in hepatocellular carcinoma through inhibition of mesenchymal cancer stem cells characterized by the expression of CD90. Yoshida M, Yamashita T, Okada H, Oishi N, Nio K, Hayashi T, Nomura Y, Hayashi T, Asahina Y, Ohwada M, Sunagozaka H, Takatori H, Colombo F, Porretti L, Honda M, Kaneko S. Sci Rep. 7 1 11292 2017/09/01
  •  Hepatitis B Virus (HBV) Core-Related Antigen During Nucleos(t)ide Analog Therapy Is Related to Intra-hepatic HBV Replication and Development of Hepatocellular Carcinoma. Honda M, Shirasaki T, Terashima T, Kawaguchi K, Nakamura M, Oishi N, Wang X, Shimakami T, Okada H, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S. J Infect Dis. 213 7 1096-106 2016/04/01
  •  Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver Cancer. Kawaguchi K, Honda M, Yamashita T, Okada H, Shirasaki T, Nishikawa M, Nio K, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S. Am J Pathol. 186 8 2055-67 2016/06/14
  •  Beneficial Effect of Maintaining Hepatic Reserve during Chemotherapy on the Outcomes of Patients with Hepatocellular Carcinoma. Terashima T, Yamashita T, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S. Liver Cancer 6 236-249 2017/04/01
  •  Altered gene expression in T-cell receptor signalling in peripheral blood leucocytes in acute coronary syndrome predicts secondary coronary events. Takashima S, Usui S, Kurokawa K, Kitano T, Kato T, Murai H, Furusho H, Oda H, Maruyama M, Nagata Y, Usuda K, Kubota K, Takeshita Y, Sakai Y, Honda M, Kaneko S, Takamura M. Open Heart. 3 1 e000400 2016/06/30
  •  Response to chemotherapy improved hepatic reserve for patients with hepatocellular carcinoma and Child-Pugh B cirrhosis. Terashima T, Yamashita T, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S. Cancer Sci. 107 9 1263-9 2016/09/01
  •  Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model.  Takegoshi K, Honda M, Okada H, Takabatake R, Matsuzawa-Nagata N, Campbell JS, Nishikawa M, Shimakami T, Shirasaki T, Sakai Y, Yamashita T, Takamura T, Tanaka T, Kaneko S. Oncotarget. Epub ahead of print 2017/02/13
  •  Efficient Suppression of Hepatitis C Virus Replication by Combination Treatment with miR-122 Antagonism and Direct-acting Antivirals in Cell Culture Systems. Liu F, Shimakami T, Murai K, Shirasaki T, Funaki M, Honda M, Murakami S, Yi M, Tang H, Kaneko S. Sci Rep. 6 30939 2016/04/03
  •  P53, hTERT, WT-1, and VEGFR2 are the most suitable targets for cancer vaccine therapy in HLA-A24 positive pancreatic adenocarcinoma. Terashima T, Mizukoshi E, Arai K, Yamashita T, Yoshida M, Ota H, Onishi I, Kayahara M, Ohtsubo K, Kagaya T, Honda M, Kaneko S. Cancer Immunol Immunother. 63 5 479-89 2014/05/01
  •  Genome-wide association study identifies a PSMD3 variant associated with neutropenia in interferon-based therapy for chronic hepatitis C.  Iio E, Matsuura K, Nishida N, Maekawa S, Enomoto N, Nakagawa M, Sakamoto N, Yatsuhashi H, Kurosaki M, Izumi N, Hiasa Y, Masaki N, Ide T, Hino K, Tamori A, Honda M, Kaneko S, Mochida S, Nomura H, Nishiguchi S, Okuse C, Itoh Y, Yoshiji H, Sakaida I, Yamamoto K, Watanabe H, Hige S, Matsumoto A, Tanaka E, Tokunaga K, Tanaka Y.  Hum Genet. 134 3 279-89 2015/03/01
  •  Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population.  Kawashima M, Hitomi Y, Aiba Y, Nishida N, Kojima K, Kawai Y, Nakamura H, Tanaka A, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Abe M, Nakao K, Yamagiwa S, Kaneko S, Honda M, Umemura T, Ichida T, Seike M, Sakisaka S, Harada M, Yokosuka O, Ueno Y, Senju M, Kanda T, Shibata H, Himoto T, Murata K, Miyake Y, Ebinuma H, Taniai M, Joshita S, Nikami T, Ota H, Kouno H, Kouno H, Nakamuta M, Fukushima N, Kohjima M, Komatsu T, Komeda T, Ohara Y, Muro T, Yamashita T, Yoshizawa K, Nakamura Y, Shimada M, Hirashima N, Sugi K, Ario K, Takesaki E, Naganuma A, Mano H, Yamashita H, Matsushita K, Yamauchi K, Makita F, Nishimura H, Furuta K, Takahashi N, Kikuchi M, Masaki N, Tanaka T, Tamura S, Mori A, Yagi S, Shirabe K, Komori A, Migita K, Ito M, Nagaoka S, Abiru S, Yatsuhashi H, Yasunami M, Shimoda S, Harada K, Egawa H, Maehara Y, Uemoto S, Kokudo N, Takikawa H, Ishibashi H, Chayama K, Mizokami M, Nagasaki M, Tokunaga K, Nakamura M. Hum Mol Genet. Epub ahead of print 2017/01/05
  •  Impact of diabetes on recurrence of hepatocellular carcinoma after surgical treatment in patients with viral hepatitis. Komura T, Mizukoshi E, Kita Y, Sakurai M, Takata Y, Arai K, Yamashita T, Ohta T, Shimizu K, Nakamoto Y, Honda M, Takamura T, Kaneko S AMERICAN JOURNAL OF GASTROENTEROLOGY 102 9 1939-46 2007/09
  •  Adipose tissue-derived stem cells as a regenerative therapy for a mouse steatohepatitis-induced cirrhosis model. Seki A, Sakai Y, Komura T, Nasti A, Yoshida K, Higashimoto M, Honda M, Usui S, Takamura M, Takamura T, Ochiya T, Furuichi K, Wada T, Kaneko S. Hepatology 58 3 1133-42 2013/09/01
  •  Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: Implications for type 2 diabetes Takeshita, Yumie; Takamura, Toshinari; Kita, Yuki; Ando, Hitoshi; Ueda, Teruyuki; Kato, Kenichiro; Misu, Hirofumi; Sunagozaka, Hajime; Sakai, Yoshio; Yamashita, Tatsuya; Mizukoshi, Eishiro; Honda, Masao; Kaneko, Shuichi Metabolism: Clinical and Experimental 61 10 1388-1394 2012/10/01 
  •  Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis Yamada, Kazutoshi;Mizukoshi, Eishiro;Sunagozaka, Hajime;Arai, Kuniaki;Yamashita, Tatsuya;Takeshita, Yumie;Misu, Hirofumi;Takamura, Toshinari;Kitamura, Seiko;Zen, Yoh;Nakanuma, Yasuni;Honda, Masao;Kaneko, Shuichi LIVER INTERNATIONAL 35 2 582-590 2015/01/01 
  •  The development and clinical features of splenic aneurysm associated with liver cirrhosis.  Sunagozaka H, Tsuji H, Mizukoshi E, Arai K, Kagaya T, Yamashita T, Sakai A, Nakamoto Y, Honda M, Kaneko S Liver Int. 26 3 291-7 2006/04
  •  Identification of blood biomarkers of aging by transcript profiling of whole blood Nakamura, Seiji; Kawai, Kozo; Takeshita, Yumie; Honda, Masao; Takamura, Toshinari; Kaneko, Shuichi; Matoba, Ryo; Matsubara, Kenichi Biochemical and Biophysical Research Communications 418 2 313-318 2012/02/10 
  •  GENES EXPRESSION OF WHOLE BLOOD CELLS REFLECT THE DISTINCT PATHOPHYSIOLOGICAL FEATURES OF TYPE C CIRRHOSIS AND HEPATOCELLULAR CARCINOMA PATIENTS Sakai, Yoshio;Honda, Masao;Komura, Takuya;Tatsumi, Isamu;Miyazaki, Yoshitaka;Tanno, Hiroshi;Wada, Takashi;Kaneko, Shuichi HEPATOLOGY 54 0 784A-784A 2011
  •  Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Matsuzawa N, Takamura T, Kurita S, Misu H, Ota T, Ando H, Yokoyama M, Honda M, Zen Y, Nakanuma Y, Miyamoto K, Kaneko S HEPATOLOGY 46 5 1392-403 2007/11
  •  Feasibility and efficacy of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma after sorafenib Terashima, Takeshi; Yamashita, Tatsuya; Arai, Kuniaki; Sunagozaka, Hajime; Kitahara, Masaaki; Nakagawa, Hidetoshi; Kagaya, Takashi; Mizukoshi, Eishiro; Honda, Masao; Kaneko, Shuichi Hepatology Research 44 12 1179-1185 2014/01/01 
  •  Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. Ura S, Honda M, Yamashita T, Ueda T, Takatori H, Nishino R, Sunakozaka H, Sakai Y, Horimoto K, Kaneko S HEPATOLOGY 49 4 1098-112 2009/04
  •  Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes. Takamura T, Honda M, Sakai Y, Ando H, Shimizu A, Ota T, Sakurai M, Misu H, Kurita S, Matsuzawa-Nagata N, Uchikata M, Nakamura S, Matoba R, Tanino M, Matsubara K, Kaneko S BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 361 2 379-84 2007/09
  •  Impaired infiltration of immune regulatory cells into liver lobules of chronic hepatitis C patients with interferon-resistant IL28B genotype Honda, Masao;Sakai, Akito;Shirasaki, Takayoshi;Nakamura, Mikiko;Yamashita, Tatsuya;Arai, Kuniaki;Shimakami, Tetsuro;Sakai, Yoshio;Yamashita, Taro;Mizukoshi, Eishiro;Kaneko, Shuichi HEPATOLOGY 56 0 708A-708A 2012
  •  Amplification of Jagged1 copy number in tumor DNA is associated with poor survival from hepatocellular carcinoma Kawaguchi, Kazunori;Honda, Masao;Yamashita, Taro;Takatori, Hajime;Ueda, Teruyuki;Mizuno, Hideki;Nishikawa, Masashi;Kaneko, Shuichi HEPATOLOGY 56 0 618A-618A 2012
  •  Therapeutic effect of adipose derived mesenchymal stem cell to murine NASH liver cirrhosis inactivating Kupffer/Macrophage and helper T cell Seki, Akihiro;Sakai, Yoshio;Komura, Takuya;Higashimoto, Mami;Fujinaga, Haruo;Honda, Masao;Wada, Takashi;Takamura, Toshinari;Ochiya, Takahiro;Kaneko, Shuichi HEPATOLOGY 56 0 1101A-1101A 2012
  •  Diagnostic benefits of adrenocortical scintigraphy in hepatic adrenal rest tumor Ishida, Kosuke; Horii, Rika; Yamashita, Tatsuya; Arai, Kuniaki; Yamashita, Taro; Kagaya, Takashi; Sakai, Yoshio; Mizukoshi, Eishiro; Honda, Masao; Kaneko, Shuichi Journal of Japanese Society of Gastroenterology 111 10 2004-2012 2014/01/01 
  •  Guideline on the use of new anticancer drugs for the treatment of Hepatocellular Carcinoma 2010 update Kaneko, Shuichi; Furuse, Junji; Kudo, Masatoshi; Ikeda, Kenji; Honda, Masao; Nakamoto, Yasunari; Onchi, Morikazu; Shiota, Goshi; Yokosuka, Osamu; Sakaida, Isao; Takehara, Tetsuo; Ueno, Yoshiyuki; Hiroishi, Kazumasa; Nishiguchi, Shuhei; Moriwaki, Hisataka; Yamamoto, Kazuhide; Sata, Michio; Obi, Shuntaro I.; Miyayama, Shiro; Imai, Yukinori Hepatology Research 42 6 523-542 2012/06/01 
  •  Gene expression profile of primary hepatocytes and the differential innate antiviral response of IFN-alpha and IL28B Shirasaki, Takayoshi;Honda, Masao;Shimakami, Tetsuro;Okada, Hikari;Lemon, Stanley;Murakami, Seishi;Kaneko, Shuichi HEPATOLOGY 56 0 705A-705A 2012
  •  Molecular mechanisms of hepatocarcinogenesis in chronic hepatitis C virus infection Yamashita, Taro;Honda, Masao;Kaneko, Shuichi JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 26 6 960-964 2011
  •  The Evolution of Diverse Cancer Stem Cells in Human Liver Cancer Yamashita, Taro;Honda, Masao;Nakamoto, Yasunari;Nio, Kouki;Hara, Yasumasa;Zeng, Sha Sha;Hayashi, Takehiro;Yamashita, Tatsuya;Mizukoshi, Eishiro;Wang, Xin W.;Kaneko, Shuichi HEPATOLOGY 56 0 443A-443A 2012
  •  Prognosis of autoimmune hepatitis showing acute presentation Yamamoto, Kazuhide; Miyake, Yasuhiro; Ohira, Hiromasa; Suzuki, Yoshiyuki; Zeniya, Mikio; Onji, Morikazu Morikazu; Tsubouchi, Hirohito; Yoshizawa, Kaname; Morizane, Toshio; Hibi, Toshifumi; Aoyagi, Yutaka; Nakanuma, Yasuni; Hirohara, Junko; Takikawa, Hajime; Ishibashi, Hiromi; Shimoda, Shinji; Sakisaka, Shotaro; Nakamuta, Makoto; Matsuzaki, Yasushi; Saibara, Toshiji; Ueno, Yoshiyuki; Miyakawa, Hiroshi; Kokudo, Norihiro; Egawa, Hiroto; Maehara, Yoshihiko; Mochida, Satoshi; Sakaida, Isao; Fujisawa, Tomoo; Suzuki, Kazuyuki; Inoue, Kazuaki; Ichida, Takafumi; Yokosuka, Osamu; Fukui, Hiroshi; Moriwaki, Hisataka; Mori, Mitsuru; Mori, Toshiyuki; Nagino, Masato; Sata, Naohiro; Tazuma, Susumu; Yasaka, Takahiro; Tsuyuguchi, Toshio; Shoda, Junichi; Honda, Masao; Yamaue, Hiroki; Unno, Michiaki; Hayashi, Norio Hepatology Research 43 6 630-638 2013/06/01 
  •  Effect of hepatitis C virus (HCV) NS5B-nucleolin interaction on HCV replication with HCV subgenomic replicon. Shimakami T, Honda M, Kusakawa T, Murata T, Shimotohno K, Kaneko S, Murakami S JOURNAL OF VIROLOGY 80 7 3332-40 2006/04
  •  Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis Nakamura, Minoru; Kondo, Hisayoshi; Tanaka, Atsushi; Komori, Atsumasa; Ito, Masahiro; Yamamoto, Kazuhide; Ohira, Hiromasa; Zeniya, Mikio; Hashimoto, Etsuko; Honda, Masao; Kaneko, Shuichi; Ueno, Yoshiyuki; Kikuchi, Kentaro; Shimoda, Shinji; Harada, Kenichi; Arai, Kuniaki; Miyake, Yasuhiro; Abe, Masanori; Taniai, Makiko; Saibara, Toshiji; Sakisaka, Shotaro; Takikawa, Hajime; Onji, Morikazu Morikazu; Tsubouchi, Hirohito; Nakanuma, Yasuni; Ishibashi, Hiromi Hepatology Research 45 8 846-55 2015/01/01 
  •  Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma. Nishino R, Honda M, Yamashita T, Takatori H, Minato H, Zen Y, Sasaki M, Takamura H, Horimoto K, Ohta T, Nakanuma Y, Kaneko S JOURNAL OF HEPATOLOGY 49 2 207-16 2008/08
  •  ASSOCIATION OF INTERLEUKIN 28B GENOTYPE AND HEPATOCELLULAR CARCINOMA RECURRENCE IN PATIENTS WITH CHRONIC HEPATITIS C Hodo, Yuji;Honda, Masao;Kaneko, Shuichi HEPATOLOGY 54 0 1363A-1363A 2011
  •  Protein expression profile characteristic to hepatocellular carcinoma revealed by 2D-DIGE with supervised learning. Teramoto R, Minagawa H, Honda M, Miyazaki K, Tabuse Y, Kamijo K, Ueda T, Kaneko S BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY 1784 5 764-72 2008/05
  •  Comparative proteomic and transcriptomic profiling of the human hepatocellular carcinoma. Minagawa H, Honda M, Miyazaki K, Tabuse Y, Teramoto R, Yamashita T, Nishino R, Takatori H, Ueda T, Kamijo K, Kaneko S BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 366 1 186-92 2008/02
  •  Expression profiling of peripheral-blood mononuclear cells from patients with chronic hepatitis C undergoing interferon therapy. Tateno M, Honda M, Kawamura T, Honda H, Kaneko S JOURNAL OF INFECTIOUS DISEASES 195 2 255-67 2007/01
  •  Comparative analysis of proteome and transcriptome in human hepatocellular carcinoma using 2D-DIGE and SAGE. Minagawa H, Yamashita T, Honda M, Tabuse Y, Kamijo K, Tsugita A, Kaneko S The Protein Journal 27 7 409-19 2008/12
  •  Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients. Takamura T, Misu H, Matsuzawa-Nagata N, Sakurai M, Ota T, Shimizu A, Kurita S, Takeshita Y, Ando H, Honda M, Kaneko S OBESITY RESEARCH 16 12 2601-9 2008/12
  •  Coexpression network analysis in chronic hepatitis B and C hepatic lesions reveals distinct patterns of disease progression to hepatocellular carcinoma He, Danning; Liu, Zhiping; Honda, Masao; Kaneko, Shuichi; Chen, Luonan Journal of Molecular Cell Biology 4 3 140-152 2012/06/01 
  •  Hepatitis B virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells. Oishi N, Shilagardi K, Nakamoto Y, Honda M, Kaneko S, Murakami S Cancer Sci. 98 10 1540-8 2007/10
  •  Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C Selitsky, Sara R.;Baran-Gale, Jeanette;Honda, Masao;Yamane, Daisuke;Masaki, Takahiro;Fannin, Emily E.;Guerra, Bernadette;Shirasaki, Takayoshi;Shimakami, Tetsuro;Kaneko, Shuichi;Lanford, Robert E.;Lemon, Stanley M.;Sethupathy, Praveen SCIENTIFIC REPORTS 5 7675 2015/01/01 
  •  Adipose tissue derived stromal stem cell therapy in murine ConA-derived hepatitis is dependent on myeloid-lineage and CD4+ T-cell suppression. Higashimoto M, Sakai Y, Takamura M, Usui S, Nasti A, Yoshida K, Seki A, Komura T, Honda M, Wada T, Furuichi K, Ochiya T, Kaneko S. Eur J Immunol. 43 11 2956-68 2013/11/01
  •  Characterization of naturally occurring protease inhibitor-resistance mutations in genotype 1b hepatitis C virus patients Shindo, Hiroko; Maekawa, Shinya; Komase, Kazuki; Sueki, Ryota; Miura, Mika; Kadokura, Makoto; Shindo, Kuniaki; Amemiya, Fumitake; Kitamura, Takatoshi; Nakayama, Yasuhiro; Inoue, Taisuke; Sakamoto, Minoru; Okada, Shunichi; Asahina, Yasuhiro; Izumi, Namiki; Honda, Masao; Kaneko, Shuichi; Enomoto, Nobuyuki Hepatology International 6 2 482-490 2012/04/01 
  •  DISTINCT LIVER CANCER STEM CELLS DEFINED BY EPCAM AND CD90 IN HUMAN HEPATOCELLULAR CARCINOMA Yamashita, Taro;Honda, Masao;Nakamoto, Yasunari;Mizukoshi, Eishiro;Yamashita, Tatsuya;Arai, Kuniaki;Nio, Kouki;Hara, Yasumasa;Wang, Xin W.;Kaneko, Shuichi HEPATOLOGY 54 0 449A-449A 2011
  •  Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity. Matsuzawa-Nagata N, Takamura T, Ando H, Nakamura S, Kurita S, Misu H, Ota T, Yokoyama M, Honda M, Miyamoto K, Kaneko S METABOLISM-CLINICAL AND EXPERIMENTAL 57 8 1071-7 2008/08
  •  Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean Nishida, Nao; Sawai, Hiromi; Matsuura, Kentaro; Sugiyama, Masaya; Ahn, Sanghoon; Park, Junyong; Hige, Shuhei; Kang, Jonghon; Suzuki, Kazuyuki; Kurosaki, Masayuki; Asahina, Yasuhiro; Mochida, Satoshi; Watanabe, Masaaki; Tanaka, Eiji; Honda, Masao; Kaneko, Shuichi; Orito, Etsuro; Itoh, Yoshito; Mita, Eiji; Tamori, Akihiro; Murawaki, Yoshikazu; Hiasa, Yoichi; Sakaida, Isao; Korenaga, Masaaki; Hino, Keisuke; Ide, Tatsuya; Kawashima, Minae; Mawatari, Yoriko; Sageshima, Megumi; Ogasawara, Yuko; Koike, Asako; Izumi, Namiki; Han, Kwanghyub; Tanaka, Yasuhito; Tokunaga, Katsushi; Mizokami, Masashi PLoS ONE 7 6 2012/06/21 
  •  Altered hepatic gene expression profiles associated with myocardial ischemia. Ootsuji H, Honda M, Kaneko S, Usui S, Okajima M, Okada H, Sakai Y, Takamura T, Horimoto K, Takamura M. Circ Cardiovasc Genet. 3 1 68-77 2010/02
  •  Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C Tanaka, Yasuhito; Kurosaki, Masayuki; Nishida, Nao; Sugiyama, Masaya; Matsuura, Kentaro; Sakamoto, Naoya; Enomoto, Nobuyuki; Yatsuhashi, Hiroshi; Nishiguchi, Shuhei; Hino, Keisuke; Hige, Shuhei; Itoh, Yoshito; Tanaka, Eiji; Mochida, Satoshi; Honda, Masao; Hiasa, Yoichi; Koike, Asako; Sugauchi, Fuminaka; Kaneko, Shuichi; Izumi, Namiki; Tokunaga, Katsushi; Mizokami, Masashi Human Molecular Genetics 20 17 3507-3516 2011/09/01 
  •  CD14+monocytes are vulnerable and functionally impaired under ER stress in patients with type 2 diabetes. Komura T, Sakai Y, Honda M, Takamura T, Matsushima K, Kaneko S DIABETES 59 3 634-43 2010/03
  •  Comprehensive gene expression analysis of 5'-end of mRNA identified novel intronic transcripts associated with hepatocellular carcinoma. Hodo Y, Hashimoto S, Honda M, Yamashita T, Suzuki Y, Sugano S, Kaneko S, Matsushima K GENOMICS 95 4 217-23 2010/04
  •  La protein required for internal ribosome entry site-directed translation is a potential therapeutic target for hepatitis C virus replication. Shirasaki T, Honda M, Mizuno H, Shimakami T, Okada H, Sakai Y, Murakami S, Wakita T, Kaneko S JOURNAL OF INFECTIOUS DISEASES 202 1 75-85 2010/07
  •  Common transcriptional signature of tumor-infiltrating mononuclear inflammatory cells and peripheral blood mononuclear cells in hepatocellular carcinoma patients. Sakai Y, Honda M, Fujinaga H, Tatsumi I, Mizukoshi E, Nakamoto Y, Kaneko S CANCER RESEARCH 68 24 10267-79 2008/12
  •  Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma. Yamashita T, Honda M, Takatori H, Nishino R, Minato H, Takamura H, Ohta T, Kaneko S. JOURNAL OF HEPATOLOGY 50 1 100-10 2009/01
  •  dUTP pyrophosphatase expression correlates with a poor prognosis in hepatocellular carcinoma. Takatori H, Yamashita T, Honda M, Nishino R, Arai K, Yamashita T, Takamura H, Ohta T, Zen Y, Kaneko S Liver Int. 30 3 438-46 2010/03
  •  POSITIVE ANTI-GP210 ANTIBODIES IS A SIGNIFICANT RISK FACTOR FOR BILE DUCT LOSS, HEPATITIS AND POOR BIOCHEMICAL RESPONSE TO URSODEOXYCHOLIC ACID TREATMENT THAT LEAD TO MORE SEVERE PROGRESSION IN JAPANESE PATIENTS WITH PRIMARY BILIARY CIRRHOSIS Nakamura, Minoru;Ito, Masahiro;Kondo, Hisayoshi;Yamamoto, Kazuhide;Ohira, Hiromasa;Zeniya, Mikio;Tanaka, Atsushi;Hashimoto, Etsuko;Honda, Masao;Kaneko, Shuichi;Ueno, Yoshiyuki;Kikuchi, Kentaro;Shimoda, Shinji;Komori, Atsumasa;Harada, Kenichi;Sakisaka, Shotaro;Takikawa, Hajime;Onji, Morikazu;Onishi, Saburo;Tsubouchi, Hirohito;Nakanuma, Yasuni;Ishibashi, Hiromi HEPATOLOGY 54 0 1208A-1209A 2011
  •  A randomized phase II trial of intra-arterial chemotherapy using SM-11355 (Miriplatin) for hepatocellular carcinoma Okusaka, Takuji; Kasugai, Hiroshi; Ishii, Hiroshi; Kudo, Masatoshi; Sata, Michio; Tanaka, Katsuaki; Shioyama, Yasukazu; Chayama, Kazuaki; Kumada, Hiromitsu; Yoshikawa, Masaharu; Seki, Toshihito; Saito, Hidetsugu; Hayashi, Naoaki; Shiratori, Keiko; Okita, Kiwamu; Sakaida, Isao; Honda, Masao; Kusumoto, Yukio; Tsutsumi, Takuya; Sakata, Kenji Investigational New Drugs 30 5 2015-2025 2012/10/01 
  •  Pure red cell aplasia associated with concomitant use of mycophenolate mofetil and ribavirin in post-transplant recurrent hepatitis C. Hodo Y, Tsuji K, Mizukoshi E, Yamashita T, Sakai A, Nakamoto Y, Honda M, Kaneko S TRANSPLANT INTERNATIONAL 19 2 170-1 2006/02
  •  Endothelial to mesenchymal transition via transforming growth factor-beta1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension. Kitao A, Sato Y, Sawada-Kitamura S, Harada K, Sasaki M, Morikawa H, Shiomi S, Honda M, Matsui O, Nakanuma Y AMERICAN JOURNAL OF PATHOLOGY 175 2 616-26 2009/08
  •  Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation. Yamashita T, Honda M, Nio K, Nakamoto Y, Yamashita T, Takamura H, Tani T, Zen Y, Kaneko S CANCER RESEARCH 70 11 4687-97 2010/06
  •  microRNA-122 Abundance in Hepatocellular Carcinoma and Non-Tumor Liver Tissue from Japanese Patients with Persistent HCV versus HBV Infection Spaniel, Carolyn; Honda, Masao; Selitsky, Sara R.; Yamane, Daisuke; Shimakami, Tetsuro; Kaneko, Shuichi; Lanford, Robert E.; Lemon, Stanley M. PLoS ONE 8 10 2013/10/09 
  •  Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors Kurosaki, Masayuki;Tanaka, Yasuhito;Nishida, Nao;Sakamoto, Naoya;Enomoto, Nobuyuki;Honda, Masao;Sugiyama, Masaya;Matsuura, Kentaro;Sugauchi, Fuminaka;Asahina, Yasuhiro;Nakagawa, Mina;Watanabe, Mamoru;Sakamoto, Minoru;Maekawa, Shinya;Sakai, Akito;Kaneko, Shuichi;Ito, Kiyoaki;Masaki, Naohiko;Tokunaga, Katsushi;Izumi, Namiki;Mizokami, Masashi JOURNAL OF HEPATOLOGY 54 3 439-448 2011
  •  Comparative Analysis of Various Tumor-Associated Antigen-Specific T-Cell Responses in Patients with Hepatocellular Carcinoma Mizukoshi, Eishiro;Nakamoto, Yasunari;Arai, Kuniaki;Yamashita, Tatsuya;Sakai, Akito;Sakai, Yoshio;Kagaya, Takashi;Yamashita, Taro;Honda, Masao;Kaneko, Shuichi HEPATOLOGY 53 4 1206-1216 2011
  •  Differential gene expression profiling in blood from patients with digestive system cancers. Honda M, Sakai Y, Yamashita T, Yamashita T, Sakai A, Mizukoshi E, Nakamoto Y, Tatsumi I, Miyazaki Y, Tanno H, Kaneko S; Hokuriku Liver Study Group BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 400 1 7-15 2010/09
  •  The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma Zeng, Shasha; Yamashita, Taro; Kondo, Mitsumasa; Nio, Kouki; Hayashi, Takehiro; Hara, Yasumasa; Nomura, Yoshimoto; Yoshida, Mariko; Hayashi, Tomoyuki; Oishi, Naoki; Ikeda, Hiroko; Honda, Masao; Kaneko, Shuichi Journal of Hepatology 60 1 127-134 2014/01/01 
  •  MICRORNA-27A REGULATES LIPID METABOLISM AND INHIBITS HCV REPLICATION IN HUMAN HEPATOMA CELL LINE Shirasaki, Takayoshi;Honda, Masao;Tokumaru, Norihiro;Shimakami, Tetsuro;Kawaguchi, Kazunori;Mizuno, Hideki;Shigeyama, Isamu;Yi, MinKyung;Lemon, Stanley;Murakami, Seishi;Kaneko, Shuichi HEPATOLOGY 54 0 1345A-1345A 2011
  •  MALNUTRITION IMPAIRS INTERFERON SIGNALING THROUGH MTOR AND FOXO PATHWAYS IN PATIENTS WITH CHRONIC HEPATITIS C Honda, Masao;Takehana, Kenji;Sakai, Akito;Shirasaki, Takayoshi;Yamashita, Tatsuya;Kawaguchi, Kazunori;Arai, Kuniaki;Shimakami, Tetsuro;Sakai, Yoshio;Yamashita, Taro;Mizukoshi, Eishiro;Nishitani, Shinobu;Tagata, Yusuke;Kaneko, Shuichi HEPATOLOGY 54 0 843A-844A 2011
  •  No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations Sawai, Hiromi; Nishida, Nao; Mbarek, Hamdi; Matsuda, Koichi; Mawatari, Yoriko; Yamaoka, Megumi; Hige, Shuhei; Kang, Jonghon; Abe, Koichi; Mochida, Satoshi; Watanabe, Masaaki; Kurosaki, Masayuki; Asahina, Yasuhiro; Izumi, Namiki; Honda, Masao; Kaneko, Shuichi; Tanaka, Eiji; Matsuura, Kentaro; Itoh, Yoshito; Mita, Eiji; Korenaga, Masaaki; Hino, Keisuke; Murawaki, Yoshikazu; Hiasa, Yoichi; Ide, Tatsuya; Ito, Kiyoaki; Sugiyama, Masaya; Ahn, Sanghoon; Han, Kwanghyub; Park, Junyong; Yuen, Man Fung; Nakamura, Yusuke; Tanaka, Yasuhito; Mizokami, Masashi; Tokunaga, Katsushi BMC Medical Genetics 13 2012/06/19 
  •  Induction of elastin expression in vascular endothelial cells relates to hepatoportal sclerosis in idiopathic portal hypertension: Possible link to serum anti-endothelial cell antibodies Sato, Yasunori; Ren, Xiangshan; Harada, Kenichi; Sasaki, Motoko; Morikawa, Hiroyasu; Shiomi, Susumu; Honda, Masao; Kaneko, Shuichi; Nakanuma, Yasuni Clinical and Experimental Immunology 167 3 532-542 2012/03/01 
  •  Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C virus and its susceptibility to interferon. Hiraga N, Imamura M, Tsuge M, Noguchi C, Takahashi S, Iwao E, Fujimoto Y, Abe H, Maekawa T, Ochi H, Tateno C, Yoshizato K, Sakai A, Sakai Y, Honda M, Kaneko S, Wakita T, Chayama K FEBS LETTERS 581 10 1983-7 2007/05
  •  Expression of multidrug resistance-associated protein 3 and cytotoxic T cell responses in patients with hepatocellular carcinoma. Mizukoshi E, Honda M, Arai K, Yamashita T, Nakamoto Y, Kaneko S JOURNAL OF HEPATOLOGY 49 6 946-54 2008/12
  •  Virological effects and safety of combined double filtration plasmapheresis (DFPP) and interferon therapy in patients with chronic hepatitis C: A preliminary study. Yamashita T, Arai K, Sakai A, Mizukoshi E, Sakai Y, Kagaya T, Nakamoto Y, Honda M, Wada T, Yokoyama H, Kaneko S HEPATOLOGY RESEARCH 36 3 167-75 2006/11
  •  New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia Nishida, Nao; Sawai, Hiromi; Kashiwase, Koichi; Minami, Mutsuhiko; Sugiyama, Masaya; Seto, Wai-Kay; Yuen, Manfung; Posuwan, Nawarat; Poovorawan, Yong; Ahn, Sanghoon; Han, Kwanghyub; Matsuura, Kentaro; Tanaka, Yasuhito; Kurosaki, Masayuki; Asahina, Yasuhiro; Izumi, Namiki; Kang, Jonghon; Hige, Shuhei; Yamamoto, Tatsuya Ide Kazuhide; Sakaida, Isao; Murawaki, Yoshikazu; Itoh, Yoshito; Tamori, Akihiro; Orito, Etsuro; Hiasa, Yoichi; Honda, Masao; Kaneko, Shuichi; Mita, Eiji; Suzuki, Kazuyuki; Hino, Keisuke; Tanaka, Eiji; Mochida, Satoshi; Watanabe, Masaaki; Eguchi, Yuichiro; Masaki, Naohiko; Murata, Kazumoto; Korenaga, Masaaki; Mawatari, Yoriko; Ohashi, Jun; Kawashima, Minae; Tokunaga, Katsushi; Mizokami, Masashi PLoS ONE 9 2 e86449 2014/02/10 
  •  Differential interferon signaling in liver lobule and portal area cells under treatment for chronic hepatitis C. Honda M, Nakamura M, Tateno M, Sakai A, Shimakami T, Shirasaki T, Yamashita T, Arai K, Yamashita T, Sakai Y, Kaneko S JOURNAL OF HEPATOLOGY 53 5 817-26 2010/11
  •  A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim HJ, Lee IK, Minokoshi Y, Saito Y, Takahashi K, Yamada Y, Takakura N, Kaneko S Cell Metab. 12 5 483-95 2010/11
  •  Involvement of chromatin remodeling enzyme CHD4 in chemoresistance of EpCAM plus hepatic cancer stem cells Nio, Kouki;Yamashita, Taro;Honda, Masao;Okada, Hikari;Kaneko, Shuichi HEPATOLOGY 56 0 278A-278A 2012
  •  ITPA gene variant protects against anemia induced by pegylated interferon-α and ribavirin therapy for Japanese patients with chronic hepatitis C. Sakamoto N, Tanaka Y, Nakagawa M, Yatsuhashi H, Nishiguchi S, Enomoto N, Azuma S, Nishimura-Sakurai Y, Kakinuma S, Nishida N, Tokunaga K, Honda M, Ito K, Mizokami M, Watanabe M HEPATOLOGY RESEARCH 40 11 1063-1071 2010/11
  •  A phase I study of vaccination with human telomerase reverse transcriptase-derived peptide in patients with hepatocellular carcinoma Mizukoshi, Eishiro;Yamashita, Tatsuya;Arai, Kuniaki;Sunagozaka, Hajime;Yamashita, Taro;Honda, Masao;Kaneko, Shuichi HEPATOLOGY 56 0 490A-490A 2012
  •  EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. amashita T, Ji J, Budhu A, Forgues M, Yang W, Wang HY, Jia H, Ye Q, Qin LX, Wauthier E, Reid LM, Minato H, Kaneko S, Tang ZY, Wang XW. GASTROENTEROLOGY 136 3 1012-24 2009/03
  •  HCV INFECTIVITY VARIATION AND HVR1 QUASISPECIES SELECTION ARE ASSOCIATED WITH THE DISTRIBUTION OF HCV E1/E2 SYNONYMOUS MUTATIONS Kawaguchi, Kazunori;Honda, Masao;Shirasaki, Takayoshi;Emerson, Suzanne U.;Purcell, Robert H.;Kaneko, Shuichi HEPATOLOGY 54 0 1352A-1353A 2011
  •  IMPAIRED IFN SIGNALING IN CHRONIC HEPATITIS C WITH ADVANCED FIBROSIS STAGE TROUGH TGF-beta SIGNALING PATHWAY Tokumaru, Norihiro;Honda, Masao;Shirasaki, Takayoshi;Shimakami, Tetsuro;Kawaguchi, Kazunori;Kaneko, Shuichi HEPATOLOGY 54 0 1331A-1331A 2011
  •  HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A2/B1, ASSOCIATED WITH HUMAN TELOMERASE REVERSE TRANSCRIPTASE, IS IDENTIFIED AS A POTENTIAL BIOMARKER FOR HEPATOCELLULAR CARCINOMA BASED ON PROTEOMICS ANALYSIS Mizuno, Hideki;Honda, Masao;Shirasaki, Takayoshi;Yamashita, Taro;Kaneko, Shuichi HEPATOLOGY 54 0 1307A-1307A 2011
  •  alpha-FETOPROTEIN-PRODUCING HEPATOMA CELLS HAVE INCREASED JAGGED1 GENE COPY NUMBERS AND THEIR GROWTH CAN BE SUPPRESSED BY GAMMA SECRETASE INHIBITOR Kawaguchi, Kazunori;Honda, Masao;Yamashita, Taro;Takatori, Hajime;Ueda, Teruyuki;Kanno, Masataka;Nishikawa, Masashi;Kaneko, Shuichi HEPATOLOGY 54 0 1290A-1290A 2011
  •  3 ' SUPPLEMENTARY BASE-PAIR INTERACTIONS OF MIR-122 WITH HEPATITIS C VIRUS RNA CONTRIBUTE TO STABILIZATION OF THE HCV RNA GENOME Shimakami, Tetsuro;Jangra, Rohit K.;Welsch, Christoph;Yamane, Daisuke;Hensley, Lucinda;Honda, Masao;Kaneko, Shuichi;Lemon, Stanley HEPATOLOGY 54 0 405A-405A 2011
  •  Efficacy and safety of hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma Yamashita, Tatsuya;Terashima, Takeshi;Arai, Kuniaki;Sunagozaka, Hajime;Yamashita, Taro;Mizukoshi, Eishiro;Sakai, Akito;Honda, Masao;Kaneko, Shuichi HEPATOLOGY 56 0 471A-471A 2012
  •  Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development Okada, Hikari;Honda, Masao;Campbell, Jean S.;Sakai, Yoshio;Yamashita, Taro;Shirasaki, Takayoshi;Tanaka, Takuji;Fausto, Nelson;Kaneko, Shuichi HEPATOLOGY 56 0 614A-614A 2012
  •  The acyclic retinoid Peretinoin inhibits hepatitis C virus replication and infectious virus release in vitro. Shimakami, Tetsuro; Honda, Masao; Shirasaki, Takayoshi; Takabatake, Riuta; Liu, Fanwei; Murai, Kazuhisa; Shiomoto, Takayuki; Funaki, Masaya; Yamane, Daisuke; Murakami, Seishi; Lemon, Stanley M.; Kaneko, Shuichi Scientific reports 4 2014/01/01 
  •  The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: A randomised controlled trial Takeshita, Yumie; Takamura, Toshinari; Honda, Masao; Kita, Yuki; Zen, Yoh; Kato, Kenichiro; Misu, Hirofumi; Ota, Tsuguhito; Nakamura, Mikiko; Yamada, Kazutoshi; Sunagozaka, Hajime; Arai, Kuniaki; Yamashita, Tatsuya; Mizukoshi, Eishiro; Kaneko, Shuichi Diabetologia 57 5 878-890 2014/01/01 
  •  Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma Sunagozaka, Hajime; Honda, Masao; Yamashita, Taro; Nishino, Ryuhei; Takatori, Hajime; Arai, Kuniaki; Yamashita, Tatsuya; Sakai, Yoshio; Kaneko, Shuichi International Journal of Cancer 129 7 1576-1585 2011/10/01 
  •  Expression of chondroitin-glucuronate C5-epimerase and cellular immune responses in patients with hepatocellular carcinoma Mizukoshi, Eishiro; Fushimi, Kazumi; Arai, Kuniaki; Yamashita, Tatsuya; Honda, Masao; Kaneko, Shuichi Liver International 32 10 1516-1526 2012/11/01 
  •  Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma Yamashita, Taro; Honda, Masao; Nakamoto, Yasunari; Baba, Masayo; Nio, Kouki; Hara, Yasumasa; Zeng, Shasha; Hayashi, Takehiro; Kondo, Mitsumasa; Takatori, Hajime; Yamashita, Tatsuya; Mizukoshi, Eishiro; Ikeda, Hiroko; Zen, Yoh; Takamura, Hiroyuki; Wang, Xin Wei; Kaneko, Shuichi Hepatology 57 4 1484-1497 2013/04/01 
  •  Acyclic retinoid and branched chain amino acids improve liver fibrosis and reduce tumorigenesis in mice fed an atherogenic high-fat diet Takegoshi, Kai;Honda, Masao;Okada, Hikari;Kondo, Mitsumasa;Yamashita, Taro;Matsuzawa, Naoto;Takamura, Toshinari;Tanaka, Takuji;Kaneko, Shuichi HEPATOLOGY 56 0 770A-770A 2012
  •  Inhibition of Hepatitis C Virus Replication by Acyclic Retinoid Shimakami, Tetsuro;Honda, Masao;Shirasaki, Takayoshi;Lemon, Stanley;Kaneko, Shuichi HEPATOLOGY 56 0 713A-714A 2012
  •  Blood neutrophil to lymphocyte ratio as a predictor in patients with advanced hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy Terashima, Takeshi; Yamashita, Tatsuya; Iida, Noriho; Yamashita, Taro; Nakagawa, Hidetoshi; Arai, Kuniaki; Kitamura, Kazuya; Kagaya, Takashi; Sakai, Yoshio; Mizukoshi, Eishiro; Honda, Masao; Kaneko, Shuichi Hepatology Research 2014/01/01 
  •  A case of Crohn's disease that showed hepatic portal venous gas and perforation of small intestine at the time of balloon-assisted enteroscopy Yano, Masaaki; Takatori, Hajime; Kitamura, Kazuya; Kagaya, Takashi; Mizukoshi, Eishiro; Sakai, Akito; Honda, Masao; Tsukada, Tomoya; Fushida, Sachio; Kaneko, Shuichi Gastroenterological Endoscopy 56 9 3358-3364 2014/01/01 
  •  [A case report of S-1 monotherapy for advanced hepatocellular carcinoma]. Yamashita, Tatsuya; Arai, Kuniaki; Terashima, Takeshi; Sunagozaka, Hajime; Shimakami, Tetsuro; Yamashita, Taro; Mizukoshi, Eishiro; Sakai, Akito; Honda, Masao; Kaneko, Shuichi Gan to kagaku ryoho. Cancer & chemotherapy 39 9 1435-1437 2012/09/01 
  •  MicroRNA expression profiling in serum and liver of patients with chronic hepatitis C Horii, Rika;Honda, Masao;Sakai, Akito;Nakamura, Mikiko;Kaneko, Shuichi HEPATOLOGY 56 0 692A-692A 2012
  •  Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes. Misu H, Takamura T, Matsuzawa N, Shimizu A, Ota T, Sakurai M, Ando H, Arai K, Yamashita T, Honda M, Yamashita T, Kaneko S DIABETOLOGIA 50 2 268-77 2007/02
  •  Different signaling pathways in the livers of patients with chronic hepatitis B or chronic hepatitis C.  Honda M, Yamashita T, Ueda T, Takatori H, Nishino R, Kaneko S HEPATOLOGY 44 5 1122-38 2006/11
  •  Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population Nakamura, Minoru; Nishida, Nao; Kawashima, Minae; Aiba, Yoshihiro; Tanaka, Atsushi; Yasunami, Michio; Nakamura, Hitomi; Komori, Atsumasai; Nakamuta, Makoto; Zeniya, Mikio; Hashimoto, Etsuko; Ohira, Hiromasa; Yamamoto, Kazuhide; Onji, Morikazu Morikazu; Kaneko, Shuichi; Honda, Masao; Yamagiwa, Satoshi; Nakao, Kazuhiko; Ichida, Takafumi; Takikawa, Hajime; Seike, Masataka; Umemura, Takeji; Ueno, Yoshiyuki; Sakisaka, Shotaro; Kikuchi, Kentaro; Ebinuma, Hirotoshi; Yamashiki, Noriyo; Tamura, Sumihito; Sugawara, Yasuhiko; Mori, Akira; Yagi, Shintaro; Shirabe, Ken; Taketomi, Akinobu; Arai, Kuniaki; Monoe, Kyoko; Ichikawa, Tatsuki; Taniai, Makiko; Miyake, Yasuhiro; Kumagi, Teru; Abe, Masanori; Yoshizawa, Kaname; Joshita, Satoru; Shimoda, Shinji; Honda, Koichi; Takahashi, Hiroki; Hirano, Katsuji; Takeyama, Yasuaki; Harada, Kenichi; Migita, Kiyoshi; Ito, Masahiro; Yatsuhashi, Hiroshi; Fukushima, Nobuyoshi; Ota, Hajime; Komatsu, Tatsuji; Saoshiro, Takeo; Ishida, Jinya; Kouno, Hirotsugu; Kouno, Hirotaka; Yagura, Michiyasu; Kobayashi, Masakazu; Muro, Toyokichi; Masaki, Naohiko; Hirata, Keiichi; Watanabe, Yukio; Nakamura, Yoko; Shimada, Masaaki; Hirashima, Noboru; Komeda, Toshiki; Sugi, Kazuhiro; Koga, Michiaki; Ario, Keisuke; Takesaki, Eiichi; Maehara, Yoshihiko; Uemoto, Shinji; Kokudo, Norihiro; Tsubouchi, Hirohito; Mizokami, Masashi; Nakanuma, Yasuni; Tokunaga, Katsushi; Ishibashi, Hiromi American Journal of Human Genetics 91 4 721-728 2012/10/05 
  •  Pro-angiogenic cytokines for prediction of outcomes in patients with advanced hepatocellular carcinoma Miyahara, Koji; Nouso, Kazuhiro; Morimoto, Youichi; Takeuchi, Yasuto; Hagihara, Hiroaki; Kuwaki, Kenji; Onishi, Hideki; Ikeda, Fusao; Miyake, Yasuhiro; Nakamura, Shinichiro; Shiraha, Hidenori; Takaki, Akinobu; Honda, Masao; Kaneko, Shuichi; Sato, Takahisa; Sato, Shuichi; Obi, Shuntaro I.; Iwadou, Shouta; Kobayashi, Yoshiyuki; Takaguchi, Kouichi; Kariyama, Kazuya; Takuma, Yoshitaka; Takabatake, Hiroyuki; Yamamoto, K.; Yamamoto, Kazuhide; Morimoro, Yuki; Takuma, Yoshitaka; Takabatake, Hiroyuki; Fujioka, Shinichi; Osawa, Toshiya; Kariyama, Kazuya; Toshimori, Junichi; Kobashi, Haruhiko; Miyatake, Hirokazu; Uematsu, Shuji; Okamoto, Ryoichi; Araki, Yasuyuki; Tatsukawa, Masafumi; Yabushita, Kazuhisa; Shimoe, Toshinari; Sakaguchi, Kohsaku; Sakata, Tatsuro; Kaneyoshi, Toshihiko; Miyashita, Manabi; Makino, Yasuhiro; Moriya, Akio; Ando, Masaharu; Baba, Nobuyuki; Seno, Tomonori; Nagano, Takuya; Matsumoto, Eiji; Takayama, Hiroki British Journal of Cancer 109 8 2072-2078 2013/10/15 
  •  GLYCOGENE EXPRESSION ANALYSIS IN THE LIVER OF CHRONIC HEPATITIS B AND C COMPLICATED WITH HCC ENABLES TO IDENTIFY INFECTION SPECIFIC AND TUMOR SPECIFIC GLYCOGENES USEFUL FOR CLINICAL BIOMARKER Shigeyama, Isamu;Honda, Masao;Ueda, Teruyuki;Shirasaki, Takayoshi;Yamashita, Taro;Sakai, Yoshio;Kaneko, Shuichi HEPATOLOGY 54 0 1303A-1303A 2011

Conference Presentations

  • Surrogacy of time to progression for overall survival in advanced hepatocellular carcinoma treated with systemic therapy: A systematic review and eta-analysis of randomized controlled trials.(conference:ASCO-GI 2018)(2018/01/19)
  • NASH患者における肝線維化と血清AKR1B10との関連(2018/04/19)
  • Characteristics and Functional Regulation of Dendritic Cells in Hepatitis B Patients(2018/11/09)
  • Immune response to tumor-associated antigens and immune vell profiles in NASH-related hepatocellular carcinoma(2018/11/12)
  • Adipose tissue derived stromal/stem cells alleviated hepatic fibrosis development induced by IL17-mediated stellate cell activation in NASH mice.(2018/11/11)

show all

  • Levocarnitine improves Liver Histology and the Development of Hepatocellular Carcinoma in the Atherogenic High-Fat Diet Nash-HCC Mouse Model(2018/11/11)
  • Inactivation of transcriptional repressor capicua confers chemoresistance to sorafenib in hepatocellular carcinoma(2018/11/12)
  • Mint3 is a novel molecular target expressed in well-differentiated AFP-negative HCC for prevention of cancer progression.(2018/11/10)
  • A Liver-Derived Secretory Protein, LECT2, Enhances the Innate Immune Response and Suppresses RIG-I Mediated Virus Infection(2018/11/10)
  • A liver-derived secretory protein, LECT2, restores the impaired plasmacytoid dendritic cells function by HBV and protects hepatocytes against HBV infection(conference:2018 International HBV Meeting The Molecular Biology of Hepatitis B Viruses)(2018/10/05)
  • Dendritic cell functions and characteristic gene expression profiles in hepatitis B virus-infected patients(2017/10/31)
  • Identification of novel HLA-A24-restricted endogenous CTL epitopes derived from HBV genotype C(conference:AASLD2017)(2017/10/22)
  • Inhibitory effect of acyclic retinoid on hepatitis B virus replication(conference:AASLD2017)(2017/10/22)
  • A liver-derived secretory protein, LECT2, activates plasmacytoid dendritic cells and protects hepatocytes from HBV infection(conference:AASLD2017)(2017/10/22)
  • Promoted liver fibrosis and malignant phenotype in HCV/PDGF-C transgenic mouse are accompanied by abnormal expression of the glycolysis-related gene pyruvate kinase M(conference:AASLD2017)(2017/10/23)
  • Immunomodulation of aggressive liver cancer by EpCAM+ cancer stem cells thorough the activation of CCL20-CCR6 axis(conference:AASLD2017)(2017/10/23)
  • The utility of the serum C16:1n7/C16:0 ratio as a diagnostic marker of non-alcoholic steatohepatitis(conference:AASLD2017)(2017/10/23)
  • Notch signaling inhibition is associated with degradation of intrahepatic HBV by ITCH in an ubiquitin-dependent manner(conference:AASLD2017)(2017/10/22)
  • Nucleos(t)ide analogues and interferon affect intranuclear HBV genome in vitro via Notch signaling modification,independent of the ubiquitin-proteasome system(conference:AASLD2017)(2017/10/22)
  • IFN-λ3 induces dendritic cell maturation independent of type I IFN(conference:AASLD2017)(2017/10/21)
  • mRNA for selenoprotein P, a hepatokine, binds RIG-I protein and inhibits the RIG-I-mediated type I interferon response(2017/10/21)
  • Regulation of Hepatitis C Virus Infection by Long Non-Coding RNA(2017/10/21)
  • MicroRNA-10a is associated with the impaired liver functions in patients with advanced stage of chronic hepatitis C(2017/10/21)
  • Osteopontin regulates IFN signaling and HCV replication in cancer stem cells(2017/10/21)
  • Serum Cytokine Profiles Predict Survival Benefits in Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib: a Retrospective Cohort Study(conference:AASLD2017)(2017/10/20)
  • Genome-wide methylation analysis identified a new intrahepatic angiogenesis marker associated with induction of tumorigenesis after successful eradication of HCV(2017/10/21)
  • Unexpected Enhancement of Replication Capacity by Simeprevir for Simeprevir-Resistant Variants in Genotype 1a Hepatitis C Virus(2017/10/21)
  •  (2017/06/09)
  • Strategy for the Treatment for Chronic Hepatitis C Patients in Japan(conference:2nd international symposium on viral Hepatitis)(2015/06/23)
  • HBcrAg during nucleos(t)ide analog therapy are related to intra-hepatic HBV replication and development of hepatocellular carcinoma.(conference:AASLD2015)(2015/11/16)
  • HBcrAg during nucleos(t)ide analog therapy are related to intra-hepatic HBV replication and development of hepatocellular carcinoma(conference:International Meeting on Molecular Biology of Hepatitis B Viruses 2015)(2015/10/05)
  • 動脈硬化高脂肪食マウスモデルにおける非環式レチノイドの脂肪化・肝発癌抑制効果の検討(2015/12/03)
  • Treatment of HCV-infected patients in Japan and an Experimental Model of HCV Infection(2014/12/10)
  • Impaired IFN signaling in chronic hepatitis C patients with advanced fibrosis via the TGF-β signaling pathway(2014/09/07)
  • C型慢性肝炎IL28Bマイナー遺伝子多型例における肝内ISG高値と治療抵抗性の機序(2013/06/06)
  • Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin 28B genotypes. パラレルセッション(口演)(conference:AASLD2013)(2013/11/05)
  • Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin 28B genotypes.(conference:HCV2013)(2013/10/08)

Arts and Fieldwork

Patent

Theme to the desired joint research

○IFNL4の臨床応用
○HBV

Grant-in-Aid for Scientific Research

○「Nucleotide analogue製剤のサイトカイン誘導を利用してB型肝炎のドラックフリーを目指す治療法の開発および創薬に関する研究」(2018-2020) 
○「NAFLD/NASH肝組織リン酸化活性プロファイリングと新規治療標的分子の同定」(2018-2020) 
○「DOCK12ノックダウンによりcccDNA排除の新規抗HBV治療応用への基礎研究」(2018-2020) 
○「肝線維化に伴うリモデリングを正常化する新規治療法の開発」(2017-2019) 
○「C型肝炎ウイルス排除後の病態、生命予後、QOLに関する包括的研究」(2017-2019) 
○「肝硬変における炎症細胞社会の解明」(2017-2021) 
○「C型肝炎における慢性肝炎から発がんに至る病態の解明と制御に関する研究」(2016-2018) 
○「C型肝炎の新たな治療関連因子及び治癒後の病態進展・改善に関連する宿主因子等の同定を目指したゲノムワイド研究」(2016-2018) 
○「IFNλ4 の機能的役割の解明及び新規診断法・治療法の開発」(2016-2018) 
○「C型肝炎における慢性肝炎から発がんに至る病態の解明と制御に関する研究」(2016-2018) 
○「包括的1細胞遺伝子発現解析を用いたB型肝炎ウイルス感染機構の解明」(2016-) 
○「肝炎ウイルス治療後の肝発癌機序とバイオマーカーの同定に関する研究」(2015-2017) 
○「内分泌器官としての肝臓病学の確立」(2014-2018) 
○「ゲノム網羅的解析によるB型肝炎ウイルス感染の病態関連遺伝子の同定と新規診断法の開発」(2014-2016) 
○「肝炎ウイルス複製を支持する新規肝癌由来培養細胞の樹立」(2014-2015) 
○「C型肝炎の新規診断法や新規治療法を開発するためのゲノムワイド関連解析の手法を用いた宿主因子の解析に関する研究」(2013-2015) 
○「C型慢性肝炎治療成績の向上と肝発癌阻止を目指した分子基盤の確立」(2012-2014) 
○「過栄養状態の肝臓が産生するタンパクと生活習慣病の関連」(2011-2013) 
○「ウイルス性肝炎に対する応答性を規定する宿主因子も含めた情報のデータベース構築・治療応用に関する研究」(2010-2012) 
○「肝がんの新規治療法に関する研究」(2009-2011) 
○「C型慢性肝炎インターフェロン療法の応答・不応答に関わる宿主遺伝子の探索」(2009-2011) 
○「肝炎ウイルスの培養系を用いた新規肝炎治療法の開発」(2007-2009) 
○「末梢血単核球の発現プロファイルと肝病態」(2007-2008) 
○「テーラーメイド治療を目指した肝炎ウイルスデータベース構築に関する研究」(2007-2009) 
○「C型肝炎ウイルス増殖に関わる宿主因子の同定とその肝病態における役割」(2005-2006) 
○「C型肝炎ウイルス増殖に関わる宿主因子の同定」(2002-2003) 
○「C型肝炎ウイルスの蛋白翻訳開始機構に関する検討」(1998-1999) 
○「インターフェロンによるC型肝炎ウイルス蛋白翻訳抑制機構の解明」(2000-2001) 

Classes (Bachelors)

○Microbiology Genetics(2018)
○Introduction of Clinical Medicine(2018)
○Introduction of Clinical Medicine(2018)
○Research Project(2018)
○Lecture and Practice of Virology(2018)
○Pathogenic Microbiology 2(2018)
○Pathophysiology 1(2018)
○Introduction to Practical Medicine(2018)
○Experimental Course of Clinical Physiology II(2018)
○Laboratory of Serology and Immunology(2018)
○Presentation and Debate (Freshman Seminar II)(2018)
○Presentation and Debate (Freshman Seminar II)(2017)
○Experimental Course of Clinical Physiology(2017)
○Introduction of Clinical Medicine(2017)
○Introduction of Clinical Medicine(2017)
○Pathogenic Microbiology 2(2017)
○Lecture and Practice of Virology(2017)
○Presentation and Debate (Freshman Seminar II)(2017)
○Introduction to Practical Medicine(2017)
○Microbiology Genetics(2017)
○Introduction to Practical Medicine(2017)
○Laboratory of Serology and Immunology(2017)

Classes (Graduate Schools)

○Molecular Biology of Tumor: Lecture(2018)
○Molecular Biology of Tumor: Seminar(2018)
○Laboratory Oncology: Lecture(2018)
○Laboratory Oncology: Seminar(2018)
○Laboratory Oncology: Research(2018)
○Advanced Laboratory Oncology: Research(2018)
○Introduction to Medicine(2018)
○An Introduction to Medical Laboratory Sciences:Lec(2018)
○Fostering the independence of researchers(2018)
○omics(2017)
○Fostering the independence of researchers(2017)
○Molecular Biology of Tumor: Lecture(2017)
○An Introduction to Medical Laboratory Sciences:Lec(2017)
○Molecular Biology of Tumor: Seminar(2017)
○Laboratory Oncology: Research(2017)
○Introduction to Medicine(2017)
○Laboratory Oncology: Lecture(2017)
○Laboratory Oncology: Seminar(2017)
○Advanced Laboratory Oncology: Research(2017)

International Project

International Students

Lecture themes

Others (Social Activities)

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