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Researcher Information

last modified:2022/03/22

Associate Professor Hitoshi Asakawa

Mail Laboratory Website

Faculty, Affiliation

Nanomaterials Research Institute Nanomaterials Research Institute

College and School Educational Field

Division of Material Chemistry, Graduate School of Natural Science and Technology
Division of Material Chemistry, Graduate School of Natural Science and Technology
School of Chemistry, College of Science and Engineering


Nanomaterials Research Institute (NanoMaRI) TEL:076-264-6337

Academic Background


Year & Month of Birth

Academic Society


○Takagi award(2006/03/15)


Thin film/Surface and interfacial physical properties、Nanomaterials chemistry、Nanobioscience、Basic chemistry

Speciality Keywords

Atomic force microscopy, Nanotechnology, Surface/interfacial chemistry

Research Themes

Atomic force microscopy for single molecular science

Self-assembly of functional molecules at solid/liquid interfaces investigated by atomic force microscopy

Molecular tip for molecular recognition AFM imaging

Molecular-scale investigation of adsorption resistance of oligo(ethylene glycol)-terminated self-assembled monolayers by atomic force microscopy

High-resolution atomic force microscopy for direct visualization of biological molecules and systems



  •  State- and water repellency-controllable molecular glass of pillar[5]arenes with fluoroalkyl groups by guest vapors Katsuto Onishi, Yoko Sakata, Shunsuke Ohtani, Shigehisa Akine, Kenichi Kato, Shixin Fa, Moe Ogasawara, Hitoshi Asakawa, Shusaku Nagano, Yoshinori Takashima, Motohiro Mizuno and Tomoki Ogoshi Chemical Science 2022/03/16
  •  Effect of Hydrophobic Chain Length on the Antioxidation Properties of Alanyl Tyrosine Dipeptide-type Surfactants Akio Ohta, Yuka Tauchi, Faisal Hossain, Yuta Sawada, Hitoshi Asakawa, Tsuyoshi Asakawa Journal of Oleo Science 71 2 215-222 2022/02/03
  •  Local Cross-Coupling Activity of Azide-Hexa(ethylene glycol)-Terminated Self-Assembled Monolayers Investigated by Atomic Force Microscopy Julie Ann Lebitania, Natsumi Inada, Masayuki Morimoto, Jiaxun You, Md. Shahiduzzaman, Tetsuya Taima, Kaito Hirata, Takeshi Fukuma, Akio Ohta, Tsuyoshi Asakawa, and Hitoshi Asakawa* Langmuir 37 50 14688–14696 2021/12/08
  •  Understanding the Polymerization of Diphenylacetylenes with Tantalum(V) Chloride and Cocatalysts: Production of Cyclic Poly(diphenylacetylene)s by Low-Valent Tantalum Species Generated in Situ Shingyo Sueyoshi, Tsuyoshi Taniguchi, Saki Tanaka, Hitoshi Asakawa, Tatsuya Nishimura, and Katsuhiro Maeda Journal of the American Chemical Society 143 39 16136–16146 2021/09/09
  •  In situ formation of photoactive B-ring reduced chlorophyll isomer in photosynthetic protein LH2 Sci Rep 2020/11/11

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  •  Photo-sensitive 2D Arrangement of -OH/H2O on Brookite TiO2(210) Journal of Physical Chemistry C 2020/09/03
  •  Chiral Monolayers with Achiral Tetrapod Molecules on Highly Oriented Pyrolytic Graphite Hitoshi Asakawa, Sayaka Matsui, Quang Thang Trinh, Hajime Hirao, Yasuhide Inokuma, Tomoki Ogoshi, Saki Tanaka, Kayo Komatsu, Akio Ohta, Tsuyoshi Asakawa, Takeshi Fukuma J Phys Chem C 2019/03/18
  •  Development of Biofuel Cell Using a Complex of Highly Oriented Immobilized His-Tagged Enzyme and Carbon Nanotube Surface Through a Pyrene Derivative  Hitoaki Sakamoto, Ayano Koto, Ei-ichiro Takamura, Hitoshi Asakawa, Takeshi Fukuma, Takenori Satomura, Shin-Ichiro Suye Journal of Nanoscience and Nanotechnology 19 6 3551-3557 2019/06/01
  •  Solubilization of Genistein in Phospholipid Vesicles and Their Atioxidant Capacity  Shunya Yamamoto, Akio Ohta, Faisal Hossain, Gemala Anjani, Hitoshi Asakawa, Tsuyoshi Asakawa J Oleo Sci 68 1 61-66 2019/12/12
  •  Study of the Antioxidative Properties of Several Amino Acid‐Type Surfactants and their Synergistic Effect in Mixed Micelle  Akio Ohta Faisal Hossain Hitoshi Asakawa Tsuyoshi Asakawa Journal of Surfactants and Detergents 23 2 99-108 2019/09/11
  •  One-Step Synthesis of One-Dimensional Supramolecular Assemblies Composed of Helical Macromolecular Building Blocks Yuya Wada, Ken-ichi Shinohara, Hitoshi Asakawa, Sayaka Matsui, Tetsuya Taima, Tomoyuki Ikai Journal of the American Chemical Society 141 35 13995-14002 2019/08/13
  •  Enhanced Aggregation of Stimuli Responsive Surfactants by Esterolytic Reactions Tsuyoshi Asakawa, Akina Fujii, Nodoka Yoneda, Akio Ohta, Hitoshi Asakawa Journal of Oleo Science 68 6 537ー580 2019/05/16
  •  Solubilization of Genistein in Phospholipid Vesicles and Their Antioxidant Capacity Shunya Yamamoto, Akio Ohta, Faisal Hossain, Gemala Anjani, Hitoshi Asakawa, Tsuyoshi Asakawa Journal of Oleo Science 68 1 61-66 2019/01/01
  •  Study of Antioxidative Properties of Some Mono Amino‐Acid‐Type and Dipeptide‐Type Surfactants Faisal Hossain, Akio Ohta, Yumi Yamane, An‐na Shizuka, Hitoshi Asakawa, Tsuyoshi Asakawa Journal of Surfactants and Detergents 21 5 733-744 2018/08/03
  •  Selective oxidation of B800 bacteriochlorophyll a in photosynthetic light-harvesting protein LH2 Yoshitaka Saga, Kiyoshiro Kawano, Yuji Otsuka, Michie Imanishi, Yukihiro Kimura, Sayaka Matsui, Hitoshi Asakawa Scientific Reports 9 3636 2019/03/06
  •  Ring shape-dependent self-sorting of pillar[n]arenes assembled on a surface Tomoki Ogoshi, Shu Takashima, Natsumi Inada, Hitoshi Asakawa, Takeshi Fukuma, Yoshiaki Shoji, Takashi Kajitani, Takanori Fukushima, Tomofumi Tada, Tomonori Dotera, Takahiro Kakuta, Tada-aki Yamagishi  Communications Chemistry 1 2018/12/07
  •  Direct Imaging of Atomic-Scale Surface Structures of Brookite TiO2 Nanoparticles by Frequency Modulation Atomic Force Microscopy in Liquid Hitoshi Asakawa, Eero Holmström, Adam S. Foster, Sunao Kamimura, Teruhisa Ohno, Takeshi Fukuma J. Phys. Chem. C 122 42 24085–24093 2018/10/03
  •  Selective Removal of B800 Bacteriochlorophyll a from Light-Harvesting Complex 2 of the Purple Photosynthetic Bacterium Phaeospirillum molischianum Yoshitaka Saga, Keiya Hirota, Sayaka Matsui, Hitoshi Asakawa, Hiroshi Ishikita, Keisuke Saito Biochemistry 57 21 3075–3083 2018/05/17
  •  Aggregation Behavior of Disulfide Linked Gemini Surfactants Compared to that of Double Tailed Surfactants Yukina Takano, Tsuyoshi Asakawa, Mayumi Inai, Akio Ohta, Hitoshi Asakawa Journal of Oleo Science 66 12 1321-1328 2017/12/01
  •  Aggregation and pH Responsive Behavior of Thioester Surfactants and Formation of Disulfide Linkages in Aqueous Solutions Tsuyoshi Asakawa, Yukina Takano, Akio Ohta, Hitoshi Asakawa Journal of Oleo Science 67 2 199-206 2018/02/01
  •  Self-assembled monolayers of sulfonate-terminated alkanethiols investigated by frequency modulation atomic force microscopy in liquid Hitoshi Asakawa, Natsumi Inada, Kaito Hirata, Sayaka Matsui, Takumi Igarashi, Norihisa Oku, Norinobu Yoshikawa, Takeshi Fukuma Nanotechnology 28 45 455603 2017/10/16
  •  Reversible Changes in the Structural Features of Photosynthetic Light-Harvesting Complex 2 by Removal and Reconstitution of B800 Bacteriochlorophyll a Pigments Yoshitaka Saga, Keiya Hirota, Hitoshi Asakawa, Kazufumi Takao, Takeshi Fukuma Biochemistry 56 27 3484-3491 2017/06/28
  •  Hydration Structure of Brookite TiO2 (210) Eero Holmstrom, Simiam Ghan, Hitoshi Asakawa, Yasuhiro Fujita, Takeshi Fukuma, Sunao Kamimura, Teruhisa Ohno, Adam S. Foster J. Phys. Chem. C 121 38 20790-20801 2017/09/05
  •  Semi-in situ atomic force microscopy imaging of intracellular neurofilaments under physiological conditions through the 'sandwich' method Sato, F. Asakawa, H. Fukuma, T. Terada, S. Microscopy (Oxf) 65 316-324 2016/03/08
  •  Efficiency improvement in the cantilever photothermal excitation method using a photothermal conversion layer Inada, N. Asakawa, H. Kobayashi, T. Fukuma, T. Beilstein J Nanotechnol 7 409-417 2016/03/10
  •  Flattened-Top Domical Water Drops Formed through Self-Organization of Hydrophobin Membranes: A Structural and Mechanistic Study Using Atomic Force Microscopy Yamasaki, R. Takatsuji, Y. Asakawa, H. Fukuma, T. Haruyama, T. ACS Nano 10 81-87 2015/12/01
  •  Structural and Electrochemical Properties of Self-organized HFBI Membranes on Different Types of Substrates Yamasaki, Ryota Asakawa, Hitoshi Fukuma, Takeshi Haruyama, Tetsuya Electrochemistry 83 11 969-973 2015
  •  Fabrication of electron beam deposited tip for atomic-scale atomic force microscopy in liquid Miyazawa, K. Izumi, H. Watanabe-Nakayama, T. Asakawa, H. Fukuma, T. Nanotechnology 26 10 105707 2015/03/13
  •  Electrochemical properties of honeycomb-like structured HFBI self-organized membranes on HOPG electrodes Yamasaki, R. Takatsuji, Y. Lienemann, M. Asakawa, H. Fukuma, T. Linder, M. Haruyama, T. Colloids Surf B Biointerfaces 123 2014/12/03
  •  Atomic force microscopy visualization of hard segment alignment in stretched polyurethane nanofibers prepared by electrospinning Sakamoto, H. Asakawa, H. Fukuma, T. Fujita, S. Suye, S. Science and Technology of Advanced Materials 15 1 015008 2014/02/10
  •  Molecular-scale surface structures of oligo(ethylene glycol)-terminated self-assembled monolayers investigated by frequency modulation atomic force microscopy in aqueous solution Inada, N. Asakawa, H. Matsumoto, Y. Fukuma, T. Nanotechnology 25 30 305602 2014/08/01
  •  Note: High-speed Z tip scanner with screw cantilever holding mechanism for atomic-resolution atomic force microscopy in liquid Akrami, Seyed Mohammad Reza; Miyata, Kazuki; Asakawa, Hitoshi; Fukuma, Takeshi Review of Scientific Instruments 85 12 2014/12/01 
  •  Electrochemical properties of honeycomb-like structured HFBI self-organized membranes on HOPG electrodes Yamasaki, Ryota; Takatsuji, Yoshiyuki; Lienemann, Michael; Asakawa, Hitoshi; Fukuma, Takeshi; Linder, Markus Ben; Haruyama, Tetsuya Colloids and Surfaces B: Biointerfaces 123 803-808 2014/11/01 
  •  Significant improvements in stability and reproducibility of atomic-scale atomic force microscopy in liquid Akrami, Seyed Mohammad Reza; Nakayachi, H.; Watanabe-Nakayama, T.; Asakawa, Hitoshi; Fukuma, Takeshi Nanotechnology 25 45 2014/11/14 
  •  Tissular model/sensor seamless system for qualified analysis and its characterization BIOCHEMICAL ENGINEERING JOURNAL 52 1 110–115 2010/10
  •  Molecular-scale arrangement and mechanical strength of phospholipid/cholesterol mixed bilayers investigated by frequency modulation atomic force microscopy in liquid Takeshi Fukuma NANOTECHNOLOGY 20 26 264008 2009/07 
  •  The amphiphilic protein HFBII as a genetically taggable molecular carrier for the formation of a self-organized functional protein layer on a solid surface LANGMUIR 26 16 8841–8844 2009/09
  •  Spurious-free cantilever excitation in liquid by piezoactuator with flexure drive mechanism Takeshi Fukuma REVIEW OF SCIENTIFIC INSTRUMENTS 80 10 103703 2009/10
  •  Atomic-scale distribution of water molecules at the mica-water interface visualized by three-dimensional scanning force microscopy PHYSICAL REVIEW LETTERS 104 1  016101 2010/01

Conference Presentations

  • Supramolecular assembly at interfaces investigated by atomic force microscopy(conference:1st WPI NanoLSI-iCeMS Joint Symposium on Nanoimaging and Advanced Materials for Life Science)(2020/01/24)
  • Molecular-scale host-guest complex formation investigated by FM-AFMand HS-AFM(conference:The 1st International Conference on Big Data and Machine Learning in Microscopy)(2020/01/16)
  • Molecular-scale distribution and dynamics of host-guest complexes investigated by FM-AFM and HS-AFM(conference:The 3rd NanoLSI International Symposium)(2019/08/08)


Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Exercise II in Applied Chemistry(2021)
○Laboratory Course I(2021)
○Laboratory Course I(2021)
○Physical Chemistry I for Application(2021)
○Laboratory Course I(2020)
○Laboratory Course I(2020)
○Physical Chemistry I for Application(2020)
○Exercise II in Applied Chemistry(2020)
○Freshman Seminar I(2020)
○Laboratory Course I(2019)
○Physical Chemistry I for Application(2019)
○Laboratory Course I(2019)
○Exercise II in Applied Chemistry(2019)
○Laboratory Course I(2018)
○Exercise II in Applied Chemistry(2018)
○Physical Chemistry I for Application(2018)
○Laboratory Course I(2017)
○Laboratory Course I(2017)
○Exercise II in Applied Chemistry(2017)
○Physical Chemistry I for Application(2017)
○Laboratory Course I(2016)
○Physical Chemistry I for Application(2016)
○Exercise II in Applied Chemistry(2016)

Classes (Graduate Schools)

○Introduction to Nano Science(2020)
○Fundamentals of Nanoscale Measurement Technology(2020)
○Introduction of Energy and Environmental Program(2020)
○Advanced Seminar(2020)
○Surface Analytical Chemistry(2020)
○Applied Chemical Thermodynamics(2020)
○Introduction of Energy and Environmental Program(2020)
○Physical Chemistry of Self-Assembly(2020)
○Introduction of Energy and Environmental Program(2019)
○Applied Chemical Thermodynamics(2019)
○Surface Analytical Chemistry(2019)
○Advanced Seminar(2019)
○Advanced Practice(2019)
○Introduction of Energy and Environmental Program(2019)
○Physical Chemistry of Self-Assembly(2019)
○Introduction of Energy and Environmental Program(2018)
○Surface Analytical Chemistry(2018)
○Applied Chemical Thermodynamics(2018)
○Physical Chemistry of Self-Assembly(2018)
○Surface Analytical Chemistry(2017)
○Physical Chemistry of Self-Assembly(2017)
○Introduction of Energy and Environmental Program(2017)
○Applied Chemical Thermodynamics(2017)
○Surface Analytical Chemistry(2017)
○Surface Analytical Chemistry(2017)
○Surface Analytical Chemistry(2017)
○Applied Chemical Thermodynamics(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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