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Researcher Information

last modified:2022/03/31

Professor TAMAI Ikumi

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Faculty, Affiliation

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences Membrane Transport and Biopharmaceutics

College and School Educational Field

Division of Health Sciences, Graduate School of Phamaceutical Science
Division of Pharmacy, Graduate School of Medical Science
School of Pharmacy, College of Medical, Pharmaceutical and Health Sciences
School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Membrane Transport and Biopharmaceutics TEL:076-234-4479 FAX:076-264-6284

Academic Background

【Academic background(Bachelor's Degree)】
Kanazawa University

Career

Tokyo University of Science Pharmaceutical Science Professor(2002/04/01-2008/03/31)

Year & Month of Birth

1959/01

Academic Society

JSSX
International Society for the Study of Xenobiotics
JSSX
American Society of Pharmacology and Experimental Therapeutics


American Association of Pharmaceutical Scoientists

Award



○ISSX New investigator Award(2003)
○JSSX Award(2013)

Specialities

Medical pharmacy

Speciality Keywords

transporter, drug absorption and disposition,drug-food interaction, pharmaceutics, drug-drug interaction, hyperuricemia, drug-induced toxicity, food-derived nanoparticle, DDS

Research Themes

Physiological roles of membrane transporters for drug targets

Transporters are involved in regulation of various bioactive compounds such as carnitine, uric acid, bile acid, hexose, and prostaglandins. Accordingly, transporters associated with those compounds are expected to be effective targets to maintain human health and to improve diseases. Especially, foods are known to affect those transporters, therefore, clarification of interaction of thoss etransporters with food components are expected to be used for manupulation transporter activities.

Mechanism and evaluation of alteration of serum uric acid level

Mechanism and evaluation of controlling serum uric acid level was studied. As the new mechanism, importance of BCRP in intestinal secretin of uric acid was demonstrated. Furthermore, for renal reabsorption of uric acid, cooperation of several transporters was clearly demonstrated, including URAT1, GLUT9 and SMCT1.

Roles of membrane transporters in drug efficacy and adverse events

Transporters are important factor to regulate drug absorption and disposition. Accordingly, alteration of transporter activity is a great issue for efficiacy and safety of drugs. Mechanisms of drug interaction and effect of genetic polymorphisms will provide useful information for drug discovery/development and pharmacotherapy for individualized therapy.

Evaluation of biliary excretion of drugs by novel culture of hepatocytes

Books

Papers

  •  Experimental demonstration of the unstirred water layer effect on drug transport in Caco-2 cells. Naruhashi K.,Lee ., Sai Y., Tsuji A., JOURNAL OF PHARMACEUTICAL SCIENCES 92  1502-1508 2003/01
  •  Delivery of peptide drugs to the brain by adenovirus-mediated heterologous expression of human oligopeptide transporter at the blood-brain barrier. Toyobuku, H., Sai, Y., Kagami, T., Tsuji, A. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 305  40-47 2003/04
  •  Characterization of Oatp-mediated hepatic uptake of nafcillin, a high biliary excretion type of B-lactam antibiotics Nakakariya M., Shimada D., Koibuchi H., Irokawa M., Iwanaga T., Yabuuchi H., Maeda T., PHARMACEUTICAL RESEARCH 25(3)  578-585 2008/03
  •  Influence of drugs and nutrients on transporter gene expression levels in Caco-2 and LS180 intestinal epithelial cells. Li, Q., Sai, Y., Kato, Y., Tsuji A. PHARMACEUTICAL RESEARCH 20  1119-1124 2003/08
  •  Contribution of organic anion transporting polypeptide OATP-C (SLC21A6) to hepatic elimination of opioidpeptide [D-Ala2, D-Leu2]enkephalin. Nozawa, T., Nezu, J., Sai, Y., Tsuji, A., JOURNAL OF PHARMACY AND PHARMACOLOGY 55  1013-1020 2003/07

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  •  Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. 136) Kobayashi, D., Nozawa, T., Imai, K., Nezu, J., Tsuji, A., JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 306  703-708 2003/04
  •  Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2. Inano, A., Sai, Y., Nikaido, H., Hashimoto, N., Asano, M., Tsuji, A., BIOPHARMACEUTICS & DRUG DISPOSITION 24  357-365 2003/11
  •  Limited influence of P-glycoprotein on small-intestinal absorption of cilostazol, a high absorptive permeability drug. oyobuku, H., Ueno, K., Tsuji, A. JOURNAL OF PHARMACEUTICAL SCIENCES 92  2249-2259 2003/11
  •  Enhanced intestinal absorption of drugs by activation of peptide transporter PEPT1 using proton-releasing polymer. Nozawa, T., Toyobuku, H., Kobayashi, D., Kuruma, K., Tsuji, A., JOURNAL OF PHARMACEUTICAL SCIENCES 92  2208-2216 2003/11
  •  Involvement of estrone-3-sulfate transporters in proliferation of hormone-dependent breast cancer cells. 150) Nozawa T., Suzuki M., Takahashi K., Yabuuchi, H., Maeda T., Tsuji A., JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 311 1032-1037 2004/12
  •  Expression of organic cation transporter OCTN1 in hematopoietic cells during erythroid differentiation. Kobayashi, D., Aizawa, S., Maeda, T., Tsuboi, I., Yabuuchi, H., Nezu, J., Tsuji, T., EXPERIMENTAL HEMATOLOGY 32  1156-1162 2004/12
  •  Carnitine Content and Expression of Mitochondrial {beta}-Oxidation Enzymes in Placentas of Wild-Type (OCTN2+/+) and OCTN2 Null (OCTN2-/-) Mice. Shekhawat PS, Yang HS, Bennett MJ, Carter AL, Matern D, Ganapathy V. PEDIATRIC RESEARCH 56  323-328 2004/09
  •  Functional regions of organic cation/carnitine transporter OCTN2 (SLC22A5): Roles in carnitine recognition. Inano, A., Sai, Y., Kato, Y., Ishiguro, M. Tsuji, A. Drug Metabolism and Pharmacokinetics 19  180-188 2004/06
  •  Regulation of Drug Transporters by Farnesoid X Receptor in Mice. Maeda, T., Miyata, M., Yotsumoto, T., Kobayashi, D., Nozawa, T., , Toyama, K., Gonzalez, F.J., Yamazoe, Y. Molecular Pharmaceutics 1  281-289 2004/07
  •  Role of Anion exchange transporter PAT1 (slc26a6) in intestinal absorption of organic anions. Nozawa, T., Sugiura, S., Hashino, Y., Tsuji, A., JOURNAL OF DRUG TARGETING 12  97-104 2004/02
  •  Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier. Ishiguro, N., Nozawa, T., Tsujihata, A., Saito, A., Kishimoto, W., Yokoyama, K., Yotsumoto, T., Sakai, K., Igarashi, T. DRUG METABOLISM AND DISPOSITION 32  519-524 2004/05
  •  Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations. Nakanishi, T., China, K., Kosugi, Y., Kobayashi, D., Nezu, J., Sai, Y., Tsuji, A. Molecular Pharmaceutics 1  57-66 2004/01
  •  Functional Characterization of pH-Dependent Organic Anion Transporting Polypeptide OATP-B in Human. Nozawa, T., Imai, K., Nezu, J., Tsuji, A., JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 308  438-445 2004/02
  •  Involvement of organic anion transporting polypeptide in the transport of troglitazone sulfate: Implications for understanding troglitazone hepatotoxicity. Nozawa, T., Sugiura, S., Nakajima, M., Goto, A., Yokoi, T., Tsuji, A. DRUG METABOLISM AND DISPOSITION 32  291-294 2004/03
  •  Transporter-mediated Renal Handling of Nafamostat Mesilate. 140) Li Qing, Sai, Y., Kato, Y., Muraoka, H., Tsuji, A. JOURNAL OF PHARMACEUTICAL SCIENCES 93  262-272 2004/02
  •  OCTN2-mediated transport of carnitine in primary-cultured epididymal epithelial cells. Kobayashi, D., Irokawa, M., Maeda, T., Tsuji, A., REPRODUCTION 130  931-937 2005/01
  •  Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent benzbromarone. Iwanaga, T., Kobayashi, D., Hirayama, M., Maeda, M., DRUG METABOLISM AND DISPOSITION 33  1791-1795 2005/12
  •  Suppression of cell proliferation by inhibition of estrone-3-sulfate transporter in estrogen-dependent breast cancer cells. Nozawa, T., Suzuki, M., Yabuuchi, H., Tsuji, A., PHARMACEUTICAL RESEARCH 22  1634-1641 2005/10
  •  Regulation of testis-specific carnitine transporter (octn3) gene by proximal cis-acting elements Sp1 in mice. Maeda, T., Hirayama, M., Kobayashi, D., BIOCHEMICAL PHARMACOLOGY 70  858-868 2005/09
  •  OCTN2-mediated carnitine transport across the blood-testis barrier. Kobayashi D., Goto A., Maeda T., Tsuji A., REPRODUCTION 129  729-736 2005/06
  •  Role of organic anion transporter OATP-C in hepatic uptake of irinotecan and its active metabolite SN-38: In vitro evidence and effect of single nucleotide polymorphisms. Nozawa T., Minami H., Tsuji A., DRUG METABOLISM AND DISPOSITION 33  434-439 2005/03
  •  Fujimotyo S. Transport mechanism for aluminum citrate at the blood-brain barrier: kinetic evidence implies involvement of system Xc(-) in immortalized rat brain endothelial cells. Nagasawa K., Ito S., Kakuda T., Nagai K., Tsuji A., Fujimotyo S. TOXICOLOGY LETTERS 155  289-296 2005/02
  •  Nucleoside transport at the blood-testis barrier studied with primary-cultured Sertoli cells Kato R., Maeda T., Akaike T., JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 312  601-608 2005/02
  •  Characterization of novel sodium-dependent nucleobase transport systems at the blood-testis barrier. Kato, R., Maeda, T., Akaike, T. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 290  E968-E975 2006/05
  •  Role of polyamines derived from arginine in differentiation and proliferation of human blood cells. Maeda, T., Wakasawa, T., Shima, Y., Tsuboi, I., Aizawa, S. BIOLOGICAL & PHARMACEUTICAL BULLETIN 29  234-239 2006/02
  •  Carnitine/xenobiotic transporters in the human mammary gland epithelia, MCF12A. 160) Kwok, B., Yamauchi, A., Rajesan, R., Chen, L., Dhillon, U., Gao, W., Xu, H., Wang, B., Takahashi, S., Semple, J., Nezu, J., Tsuji, A., Harper, P. and Ito, S. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 290  R793-802 2006/03
  •  Characterization of hepatobiliary transport systems of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035. Tsuda-Tsukimoto, M., Maeda, T., Iwanaga, T., Kume, T. PHARMACEUTICAL RESEARCH 23(11)  2646-2656 2006/11
  •  Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse. ato, Y., Sugiura, M., Sugiura, T., Wakayama, T., Kubo, Y., Kobayashi, D., Sai, Y., Iseki, S., and Tsuji, A. MOLECULAR PHARMACOLOGY 70(3)  829-837 2006/09
  •  Transporter-mediated intestinal absorption of fexofenadine in rats. Kikuchi, A., Nozawa, T., Wakasawa, T., Maeda, T. Drug Metabolism and Pharmacokinetics 21  308-314 2006/06
  •  Effect of P-glycoprotein on intestinal absorption and brain penetration of anti-allergic agent bepotastine besilate. Oashi, R., Kamikozawa, Y., Sugiura, M., Fukuda, H., Yabuuchi, H. DRUG METABOLISM AND DISPOSITION 34  793-799 2006/05
  •  Carrier-mediated hepatic uptake of a novel nonrenal excretion type uric acid generation inhibitor, Y-700. 95, 336-347 JOURNAL OF PHARMACEUTICAL SCIENCES 95  336-347 2006/05
  •  Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells. Sai, Y., Kaneko, Y., Ito, S., Mitusoka, K., Kato, Y., Artursson, P. and Tsuji, A. DRUG METABOLISM AND DISPOSITION 34  1423-1431 2006/08
  •  Characterization of Human OATP2B1 (SLCO2B1) Gene Promoter Regulation. Maeda, T., Hirayama, M., Higashi, R., Sato, M. PHARMACEUTICAL RESEARCH 23  513-520 2006/05
  •  Organic anion transporting polypeptide-C mediates arsenic uptake in HEK-293 cells. Lu, W.-J.,Nezu, J., Lai M.-L. and Huang, J.-D JOURNAL OF BIOMEDICAL SCIENCE 13  525-533 2006/07
  •  Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter URAT1 Iwanaga, T., Sato, M., Maeda, T., Ogihara, T. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 320 (1)  211-217 2007/01
  •  Mechanism of the Regulation of OCTN1 Transporter (SLC22A4) by Rheumatoid Arthritis-Associated Transcriptional Factor RUNX1 and Inflammatory Cytokines. Maeda T, Hirayama M, Kobayashi D, Miyazawa K, DRUG METABOLISM AND DISPOSITION 35(3)  394-401 2007/03
  •  Involvement of organic anion transporter OAT3 in renal tubular secretion of topotecan. Matsumoto S., Yoshida K., Maeda T., JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 322(3)  1246-1252 2007/06
  •  Involvement of Bile Salt Export Pump in Flutamide-Induced Cholestatic Hepatitis. Iwanaga T., Nakakariya, M., Yabuuchi, H., Maeda, T., BIOLOGICAL & PHARMACEUTICAL BULLETIN 30(4)  739-744 2007/04
  •  Blood-brain barrier transport of pramipexole, a D(2) against. Okura, T., Ito, R., Ishiguro, N., Deguchi, Y. LIFE SCIENCES 80  1564-1571 2007/04
  •  Transport of carnitine and acetylcarnitine by octn2 and octn3 into epididymal spermatozoa. Kobayashi, D., Yoshida, K., Wakayama, T., Kido, Y., Nezu, J., Iseki, S., Tsuji, A. REPRODUCTION 134(5)  651-658 2007/12
  •  Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Maeda, T., Takahashi, K., Ohtsu, N., Oguma, T., Ohnishi, T., Atsumi, R. Molecular Pharmaceutics 4  85-94 2007/01
  •  Effect of pregnane X receptor on Pharmacokinetics of cationic compounds mediated by organic cation transporter Oct1 in rats. Maeda T., Oyabu M., Yostumoto T., Higashi, R., Nagata, K., Yamazoe, Y., DRUG METABOLISM AND DISPOSITION 35(9)  1580-1586 2007/09
  •  Transport of organic cations across the blood-testis barrier. Maeda, T., Goto, A., Kobayashi, D., Molecular Pharmaceutics 4(4)  600-607 2007/08
  •  Preparation of quinoline hexose analogs as novel chloroquine-resistant malaria treatments (1). Synthesis of 4-hydroxyquinoline-beta-glucosides. Suzuki, H., Aly, N.S., Wataya, Y., Kim, H.S, Uemura D. CHEMICAL & PHARMACEUTICAL BULLETIN 55(5)  821-824 2007/05
  •  Decreased Proliferation and Erythroid Differentiation of K562 Cells by siRNA-induced Depression of OCTN1 (SLC22A4) Transporter Gene. Nakamura, T., Sugiura, S., Kobayashi, D., Yoshida, K. Yabuuchi, Y., Aizawa, S., Maeda, T., PHARMACEUTICAL RESEARCH 24(9)  1628-1635 2007/09
  •  Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers. Sato M., Iwanaga T., Mamada H., Ogihara T. Maeda T. PHARMACEUTICAL RESEARCH 58  639-646 2008/03
  •  Identification and species similarity of OATP transporters responsible for hepatic uptake of B-lactam antibiotics. Nakakariya M., Shimada T., Irokawa M., Maeda T Drug Metabolism and Pharmacokinetics 23(5)  in press 2008/10
  •  Improvement of Intestinal Absorption by Peptide-Derivation of Nonabsorbable Drug via Peptide Transporter PEPT1. Kikuchi A., Tanaka, M., Tomoyasu, T., Maeda, M., JOURNAL OF PHARMACEUTICAL SCIENCES 97  in press 2008/01
  •  Involvement of organic anion transporting polypeptide 1a5 (Oatp1a5) in the intestinal absorption of endothelin receptor antagonist in rats. Tani, T., Gram, LK., Arakawa, H., Kikuchi, A., Chiba, M., Ishii, Y., Steffansen, B., PHARMACEUTICAL RESEARCH 25 1085-1091 2008/06
  •  Oseltamivir (TamifluTM) efflux transport at the blood-brain barrier via P-glycoprotein. Morimoto K., Nakakariya M., Shirasaka Y., Kakinuma C., Fujita T., Ogihara T. DRUG METABOLISM AND DISPOSITION 36(1)  6-9 2008/01
  •  Improved intestinal membrane permeability of hexose-quinoline derivatives via the hexose transporter, SGLT1. Otake, K., Suzuki, H., Higashi, R., Yabuuchi, H., Haga, M., Maeda, T., Cook, T.J., JOURNAL OF PHARMACEUTICAL SCIENCES 97  in press 2008/12
  •  Effect of glucocorticoid receptor ligand dexamethasone on the expression of the organic cation transport in rat liver. Maeda T., Yotsumoto T., Oyabu M., Drug Metabolism Pharmacokinetics 23(1)  67-72 2008/01
  •  Decreased biosynthesis of lung surfactant constituent phosphatidylcholine due to inhibition of choline transporter by gefitinib in lung alveolar cells. Ishiguro, N., Oyabu, O., Sato, T., Maeda, M., Minami, H., PHARMACEUTICAL RESEARCH 57  417-427 2008/02
  •  Effect of palsma protein binding on in vitro-in vivo correl-ation of biliary excretion of drugs evaluated by sandwich-cultured rat hepatocytes. Fukuda H, Ohashi R, Tuda-Tsukimoto M,  DRUG METABOLISM AND DISPOSITION 58 1275-1282 2008/01
  •  Functional characterization of ergothioneine transport by rat organic cation/carnitine trasporter Octn1 (slc22a4). Nakamura T, Yoshida K, Yabuuchi H, Maeda T BIOLOGICAL & PHARMACEUTICAL BULLETIN 31 8 1580-1584 2008/01
  •  Regulation of Octn2 transporter (SLC22A5) by peroxisome proliferator activated receptor alpha. BIOLOGICAL & PHARMACEUTICAL BULLETIN 31 6 1230-1236 2008/01
  •  Changes of differentiation and proliferation in K562 cells with various levels of knowckdown of cationic amino acid trasporter 1. Maeds T.,Shima Y., Sugiura S., Aizawa S.,  Drug Metabolism Pharmacokinetics 23 3 181-187 2008/01
  •  Effects of angiotensin II receptor blockers on renal handling of uric acid in rats. Li Y., Sato M., Yanagisawa Y., Mamada H., Fukushi A., Shirasaka Y Drug Metabolism Pharmacokinetics 23 263-270 2008/01
  •  Identification and species similarity of OATP transporters responsible for hepatic uptake of B-lactam antibilitics. Nakakariya M. Shimada T., Irokawa M., Maeda T., Drug Metabolism Pharmacokinetics 23 5 347-355 2008/01
  •  Cloning of the Dog Bile Salt Export Pump (BSEP ABCB11) and Functional Comparison with the Human and Rat proteins. Yabuuchi H., Takemura M., Oka M, Ohashi R, BIOPHARMACEUTICS & DRUG DISPOSITION 29 8 441-448 2008/01
  •  Improvement of Intestinal Absorption by Peptide-Derivation of Nonabsorbable Drug via Peptide Transporter PEPT1.  Kikuchi A., Tanaka, M., Tomoyasu, T., Maeda, JOURNAL OF PHARMACEUTICAL SCIENCES 98 5 1775-1787 2008/01
  •  Stabilization of enzyme-susceptible glucoside bonds of phloridzin through conjugation with poly(gamma-glutamic acid). 199) Sakuma S, Sagawa T, Masaoka Y, Kataoka M, Yamashita S, Shirasaka Y,Kida T, Akashi M. JOURNAL OF CONTROLLED RELEASE 133 2 125-131 2009/01
  •  Concentration-Dependent Effect of Naringin on Intestinal Absorption of beta(1)-Adrenoceptor Antagonist Talinolol Mediated by P-Glycoprotein and Organic Anion Transporting Polypeptide (Oatp). 200) Shirasaka Y, Li Y, Shibue Y, Kuraoka E, Spahn-Langguth H, Kato Y, Langguth P,  PHARMACOLOGICAL RESEARCH 26 3 560-570 2009/01
  •  Transport characteristics of L-citrulline in renal apical membrane of proximal tubular cells. Biopharm Drug  201) Mitsuoka K, Shirasaka Y, Fukushi A, Sato M, Nakamura T, Nakanishi T, BIOPHARMACEUTICS & DRUG DISPOSITION 30 3 126-137 2009/01
  •  Characterization of nucleobase transport by mouse Sertoli cell line TM4. Kato R, Maeda T, Akaike T, BIOLOGICAL & PHARMACEUTICAL BULLETIN 32 3 450-455 2009/01
  •  Organic Anion Transporter OAT1 Is Involved in Renal Handling of Citrulline.  203) Nakakariya M, Shima Y, Shirasaka Y, Mitsuoka K, Nakanishi T, Tamai I. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 297 1 F71-F79 2009/01
  •  Oseltamivir (TamifluTM) is a substrate of PEPT1. 204) Ogihara T, Kano T, Wagatsuma T, Wada S, Yabuuchi H, Enomoto S, Morimoto K, Shirasaka Y, Kobayashi S, DRUG METABOLISM AND DISPOSITION 37 8 1676-1681 2009/01
  •  Direct evidence for efficient transport and minimal metabolism of L-cephalexin by oligopeptide transporter 1 in budded baculovirus fraction.  Mitsuoka K, Morohashi Y, Kubo Y, Saitoh R, Tsuji A, Kato Y. BIOLOGICAL & PHARMACEUTICAL BULLETIN 32 8 1459-1461 2009/01
  •  Hepatic Uptake of {gamma}-Butyrobetaine, a Precursor of Carnitine Biosynthesis, in Rats. 206) Fujita M, Nakanishi T, Shibue Y, Kobayashi D, Moseley RH, Shirasaka Y, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 297 681-686 2009/01
  •  Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer. 207) Maeda T., Irokawa M., Arakawa H., Kuraoka E., Nozawa T., Tateoka R.,, Itoh Y., Nakaishi T.,  JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 22 180-185 2010/01
  •  Estimation of transporters involved in the hepatobiliary transport of TA-0201CA using sandwich-cultured rat hepatocytes from normal and Mrp2-deficient rats.  Fukuda H., Ohashi R., Ohashi N., Yabuuchi H.,  DRUG METABOLISM AND DISPOSITION 38 1505-1513 2010/01
  •  Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption.  209) Nakamura T., Nakanishi T., Haruta T., Shirasaka Y., Keogh JP., Tamai I. MOLECULAR PHARMACOLOGY 7 187-195 2010/01
  •  Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat. 210) Shirasaka Y., Kuraoka E., Spahn-Langguth H., Nakanishi T., Langguth P., JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 332 181-189 2010/01
  •  Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide. Shirasaka Y., Suzuki K., Nakanishi T., Tamai I. PHARMACOLOGICAL RESEARCH 27 2141-2149 2010/01
  •  Carboxyl group-terminated polyamidoamine dendrimers bearing glucoside s inhibit intestinal hexose transporter-mediated D-glucose uptake.  212) Sakuma S., Teraoka Y., Sagawa T., Masaoka Y., Kataoka M., Yamashita S., Shirasaka Y., Ikumi Y., Kida T., Akashi M. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 75 3 366-374 2010/01
  •   Quantitation of Talinolol in Rat Plasma By LC-MS-MS. 213) Li Y., Shirasaka Y., Langguth P.,  JOURNAL OF CHROMATOGRAPHIC SCIENCE 48 367-370 2010/01
  •  Impact of System L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: A possible target for combination therapy with antiproliferative aminopeptidase inhibitors.  214)Fan X., Ross D.D., Arakawa H., Ganapathy V., Nakanishi T.: BIOCHEMICAL PHARMACOLOGY 80 6 811-818 2010/01
  •  Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver. 215) Sugiura T., Kato S., Shimizu T., Wakayama T., Nakamichi N., Kubo Y., Iwata D., Suzuki K., Soga T., Asano M., Iseki S., Tamai I., Tsuji A., Kato Y. DRUG METABOLISM AND DISPOSITION 38 1665-1672 2010/01
  •  Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7),  Sato M., Mamada H., Anzai N., Shirasaka Y., Nakanishi T., BIOLOGICAL & PHARMACEUTICAL BULLETIN 33 3 498-503 2010/01
  •  Involvement of choline transporter-like (CTL) proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine syntesis via increased choline uptake.  217) Nakamura R., Ishiguro N., Oyabu M., Nakanishi T., Shirasaka Y., Maeda T., BIOLOGICAL & PHARMACEUTICAL BULLETIN 33 4 691-696 2010/01
  •  Organic cation transporter-mediated renal secretion of ipratropium and tiotropium in rats and humans.  218) Nakanishi T, Haruta T, Shirasaka Y,  DRUG METABOLISM AND DISPOSITION 39 1 117-122 2010/01
  •  The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans. 219) Imanaga J, Kotegawa T, Imai H, Tsutsumi K, Yoshizato T, Ohyama T, Shirasaka Y, Tateishi T, Ohashi K.  Pharmacognet Genomics 21 2 84-93 2011/01
  •  Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats.  Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats.  BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1808 6 1441-1447 2011/01
  •  Intestinal Absorption Mechanism of Tebipenem Pivoxil, a Novel Oral Carbapenem: Involvement of Human OATP Family in Apical Membrane Transport. 221) Kato K., Shirasaka Y., Kuraoka E., Kikuchi A., Iguchi M., Suzuki H., Shibasaki S., Kurosawa T., Tamai I. MOLECULAR PHARMACOLOGY 7 5 1747-1756 2011/01
  •  Differential Effect of Grapefruit Juice on Intestinal Absorption of Statins Due to Inhibition of Organic Anion Transporting Polypeptide and/or P-Glycoprotein.  227) Shirasaka Y., Suzuki K., Nakanishi T., Tamai I.  JOURNAL OF PHARMACEUTICAL SCIENCES 100 9 3843-3853 2011/01
  •  Intestinal Absorption of HMG-CoA Reductase Inhibitor Pitavastatin Mediated by Organic Anion Transporting Polypeptide and P-Glycoprotein/Multidrug Resistance 1.  222) Shirasaka Y, Suzuki K, Shichiri M, Nakanishi T, Drug Metab Pharmacokint 26 2 171-179 2011/01
  •  Effect of milk on the pharmacokinetics of oseltamivir in healthy volunteers.  228) Morimoto K, Kishimura K, Nagami T, Kodama N, Ogama Y, Yokoyama M, Toda S, Chiyoda T, Shimada R, Inano A, Kano T, Tamai I, Ogihara T. JOURNAL OF PHARMACEUTICAL SCIENCES 100 9 3854-3861 2011/01
  •  Influence of preparation method on polynucleotide conformation and pharmacological activity of lipoplex. 223) Saheki A, Fukui Y, Hoshi Y, Fukui H, Seki J, INTERNATIONAL JOURNAL OF PHARMACEUTICS 406 1-2 117-121 2011/01
  •  Total Syntheses of (-) - and (+)- Goniomitine.  224) Mizutani M, Inagaki F, Nakanishi T, Yanagihara C, Tamai I, Mukai C. ORGANIC LETTERS 13 1796-1799 2011/01
  •  Quantitative time-lapse imaging (QTLI)-based analysis of drug-drug interaction mediated by hepatobiliary transporter, multidrug associated protein 2, in sandwich-cultured rat hepatocytes.  225) Nakanishi T, Shibue Y, Fukuyama Y, Yoshida K, Fukuda H, Shirasaka Y, DRUG METABOLISM AND DISPOSITION 39 6 984-991 2011/01
  •  Putative transport mechanism and intracellular fate of anti-18F-FACBC (Trans-1amino-18F-fluorocyclobutanecarboxylic acid) in human prostate cancer. 226) Okudaira H., Shikano N., Nishii R., Miyagi T., Yoshimoto M., Kobayashi M., Ohe K., Nakanishi T., Tamai I., Namiki M., Kawai K. JOURNAL OF NUCLEAR MEDICINE 52 5 822-829 2011/01
  •  Oxaliplatin Transport Mediated by Organic Cation/Carnitine Transporters OCTN1 and OCTN2 in Overexpressing Human Embryonic Kidney 293 Cells and Rat Dorsal Root Ganglion Neurons.  229) Jong NN, Nakanishi T, Liu JJ, Tamai I, McKeage MJ. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 338 2 537-547 2011/01
  •  Differential Effect of Grapefruit Juice on Intestinal Absorption of Statins Due to Inhibition of Organic Anion Transporting Polypeptide and/or P-Glycoprotein. Shirasaka Y., Suzuki K., Nakanishi T., Tamai I JOURNAL OF PHARMACEUTICAL SCIENCES 100 9 3843-3853 2011/09
  •  Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture. Nakanishi T., Fukushi A., Sato M., Shirasaka Y.,Tamai I ほか3名 MOLECULAR PHARMACOLOGY 8 6 2142-2150 2011/12
  •  Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy (Review). Nakanishi T., Tamai I JOURNAL OF PHARMACEUTICAL SCIENCES 100 9 3731-3750 2011/05
  •  Carnitine precursor γ-butyrobetaine is a novel substrate of the Na+- and Cl--dependent GABA transporter Gat2. Nakanishi T., Fukuyama Y., Fujita M., Shirasaka Y., Tamai I Drug Metabolism and Pharmacokinetics 26 6 632-636 2011/10
  •  Effect of back pressure on emulsification of lipid nanodispersions in a high-pressure homogenizer.  Saeki A., Seki J., Nakanishi T., Tamai I International Journal of pharmaceutics 422 1-2 489-494 2012/01
  •  Synthesis of [¹¹C]uric acid, using [¹¹C]phosgene, as a possible biomarker in PET imaging for diagnosis of gout. Yashio K., Katayama Y., Takashima T., Tamai I 他5名 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22 1 115-119 2012/11
  •  Species differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals. Meda H., Kodaira H., Tamai 他 4名 XENOBIOTICA 42 7 649-659 2012/07
  •  Novel LC-MS/MS Method for Simultaneous Quantification of KW-7158, a New Drug Candidate for Urinary Incontinence and Bladder Hyperactivity, and its Metabolites in Rat Plasma: A Pharmacokinetic Study in Male and Female Rats. Maeda H., Fujita K., Kobayashi H., Tamai I 他2名 Arzneimittelforschung 62 5 213-221 2012/05
  •  Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2. Hosomi A., Nakanishi T., Fujita T., Tamai I PLoS One 7 2 e30456 2012/12
  •  Functional Pleiotropy of Organic Anion Transporting Polypeptide OATP2B1 Due to Multiple Binding Sites. Shirasaka Y., Mori T., Shichiri M., Nakanishi T., Tamai I Drug Metabolism and Pharmacokinetics 28 2 153-158 2012/06
  •  Involvement of functional groups on the surface of carboxyl group-terminated polyamidoamine dendrimers bearing arbutin in inhibition of Na⁺/glucose cotransporter 1 (SGLT1)-mediated D-glucose uptake.  Sakuma S., Kanamitsu S., Tamai I 他9名 MOLECULAR PHARMACOLOGY 2 9(4) 922-929 2012/04
  •  Application of quantitative time-lapse imaging (QTLI) for evaluation of Mrp2-based drug-drug interaction induced by liver metabolites. Nakanishi T., Ikenaga M., Fukuda H., Matsunaga N., Tamai I TOXICOLOGY AND APPLIED PHARMACOLOGY 263 2 244-250 2012/09
  •  Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: Possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions.  Arakawa H., Nakanishi T., Tamai I 他5名 BIOCHEMICAL PHARMACOLOGY 84 8 1070-1077 2012/10
  •  Cancer cells uptake porphyrins via heme carrier protein 1. Hiyama K., Matsui H., Tamura M., Tamai I他9名 Jounal Porphyrins Phthalocyanines 16 1-8 2012/01
  •   Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5. ArakawaH., Shirasaka Y., Haga M., Nakanishi T., Tamai I BIOPHARMACEUTICS & DRUG DISPOSITION 33 6 332-341 2012/09
  •  Physiologically-based pharmacokinetic (PBPK) modeling: it is here to stay (Review). Rostami-Hodjegan A., Tamai I., Pang S BIOPHARMACEUTICS & DRUG DISPOSITION 33 2 47-50 2012/03
  •  Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs (Review). Nakanishi T., Tamai I Drug Metabolism and Pharmacokinetics 27 1 106-121 2012/02
  •  Oral drug delivery utilizing intestinal OATP transporters (Review). Tamai I Advanced Drug Delivery Reviews 64 6 508-514 2012/05
  •  Major Active Components in Grapefruit, Orange and Apple Juices Responsible for OATP2B1-Mediated Drug Interactions. Shirasaka Y., Shichiri M., Mori T., Nakanishi, Tamai I JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 102 280-288 2013/01
  •  Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate. Nakanishi T, Ohya K, Shimada S, Anzai N, Tamai I Nephrology Dialysis Transplantation 28 603-611 2013/03
  •  Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21).  Tamai I BIOPHARMACEUTICS & DRUG DISPOSITION 34 1 29-44 2013/01
  •  Functional cooperation of SMCTs and URAT1 for renal reabsorption transport of urate.  Lu Y, Nakanishi T, Tamai I Drug Metabolism and Pharmacokinetics 102 1 280-288 2013/09
  •  Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes. Matsunaga N, Nunoya KI, Okada M, Ogawa M, Tamai I DRUG METABOLISM AND DISPOSITION 41 4 735-743 2013/04
  •  Long-Lasting Inhibitory Effect of Apple and Orange Juices, but Not Grapefruit Juice, on OATP2B1-Mediated Drug Absorption. Shirasaka Y, Shichiri M, Murata Y, Mori T, Nakanishi T, Tamai I DRUG METABOLISM AND DISPOSITION 41 3 615-621 2013/03
  •  Transport of the dopamine D2 agonist pramipexole by rat organic cation transporter OCT1 and OCT2 in kidney. Ishiguro N., Saito A., Yokoyama K., Morikawa M., Igarashi T., 33 495-499 2005
  •  L-Arginine import via cationic transporter CAT1 is essential for both differentiation and proliferation of erythrocytes. Shima, Y., Maeda, T., Aizawa, S., Kobayashi, D., Kato, R., 107 1352-1356 2006
  •  Effects of angiotensin II receptor blockers on renal handling of uric acid in rats. Li Y., Sato M., Yanagisawa Y., Mamada H., Fukushi A., Mikami K., Shirasaka Y., Tamai I.  195) Li Y., Sato M., Yanagisawa Y., Mamada H., Fukushi A., Mikami K., Shirasaka Y., Tamai I.  23 4 263-270 2008
  •  Changes of differentiation and proliferation in K562 cells with various levels of knowckdown of cationic amino acid transporter 1 194) Maeda T., Shima Y., Sugiura S., Aizawa S., Tamai I.  Drug Metab. Pharmacoki.  23 3 181-187 2008
  •  Regulation of Octn2 transporter (SLC22A5) by peroxisome proliferator activated receptor alpha 193) Maeda T., Wakasawa T., Funabashi M., Fukushi A., Fujita M., Motojima K., Tamai I. Biol. Pharm. Bull.,  31 6 1230-1236 2008
  •  Effect of plasma protein binding on in vitro-in vivo correlation of biliary excretion of drugs evaluated by sandwich-cultured rat hepatocytes. Fukuda H., Ohashi R., Tsuda-Tsukimoto M. Tamai I.  Drug Metab. Dispos., 36 1275-1282 2008
  •  Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of {beta}-lactam antibiotics. Kato Y., Takahara S., kato S., Kubo Y., Sai Y., Tamai I., Yabuuchi H., Tsuji A. 36 1088-1096 2008
  •  Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats Sato, Masanobu;Wakayama, Tomohiko;Mamada, Hideaki;Shirasaka, Yoshiyuki;Nakanishi, Takeo;Tamai, Ikumi BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1808 6 1441-1447 2011
  •  Putative Transport Mechanism and Intracellular Fate of Trans-1-Amino-3-F-18-Fluorocyclobutanecarboxylic Acid in Human Prostate Cancer Okudaira, Hiroyuki;Shikano, Naoto;Nishii, Ryuichi;Miyagi, Tohru;Yoshimoto, Mitsuyoshi;Kobayashi, Masato;Ohe, Kazuyo;Nakanishi, Takeo;Tamai, Ikumi;Namiki, Mikio;Kawai, Keiichi JOURNAL OF NUCLEAR MEDICINE 52 5 822-829 2011
  •  The effects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans Imanaga, Junko;Kotegawa, Tsutomu;Imai, Hiromitsu;Tsutsumi, Kimiko;Yoshizato, Tsuneaki;Ohyama, Tetsuji;Shirasaka, Yoshiyuki;Tamai, Ikumi;Tateishi, Tomonori;Ohashi, Kyoichi PHARMACOGENETICS AND GENOMICS 21 2 84-93 2011
  •  Intestinal Absorption of HMG-CoA Reductase Inhibitor Pitavastatin Mediated by Organic Anion Transporting Polypeptide and P-Glycoprotein/Multidrug Resistance 1 Shirasaka, Yoshiyuki;Suzuki, Kensuke;Shichiri, Megumi;Nakanishi, Takeo;Tamai, Ikumi DRUG METABOLISM AND PHARMACOKINETICS 26 2 171-179 2011
  •  Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes Nakanishi, Takeo;Shibue, Yuta;Fukuyama, Yoko;Yoshida, Kenji;Fukuda, Hajime;Shirasaka, Yoshiyuki;Tamai, Ikumi DRUG METABOLISM AND DISPOSITION 39 6 984-991 2011
  •  Organic Cation Transporter-Mediated Renal Secretion of Ipratropium and Tiotropium in Rats and Humans Nakanishi, Takeo;Haruta, Tsunemitsu;Shirasaka, Yoshiyuki;Tamai, Ikumi DRUG METABOLISM AND DISPOSITION 39 1 117-122 2011
  •  Influence of preparation method on polynucleotide conformation and pharmacological activity of lipoplex Saheki, Akira;Fukui, Yoshiharu;Hoshi, Yuji;Fukui, Hiroshi;Seki, Junzo;Tamai, Ikumi INTERNATIONAL JOURNAL OF PHARMACEUTICS 406 42006 117-121 2011
  •  Total Syntheses of (-)- and (+)-Goniomitine Mizutani, Masaya;Inagaki, Fuyuhiko;Nakanishi, Takeo;Yanagihara, Chihiro;Tamai, Ikumi;Mukai, Chisato ORGANIC LETTERS 13 7 1796-1799 2011
  •  Physiologically based pharmacokinetic (PBPK) modeling: It is here to stay! Rostami-Hodjegan, Amin;Tamai, Ikumi;Pang, K. Sandy BIOPHARMACEUTICS & DRUG DISPOSITION 33 2 47-50 2012
  •  Genetic Polymorphisms of OATP Transporters and Their Impact on Intestinal Absorption and Hepatic Disposition of Drugs Nakanishi, Takeo;Tamai, Ikumi DRUG METABOLISM AND PHARMACOKINETICS 27 1 106-121 2012
  •  Transporter-mediated drug interaction. 143 5 243-248 2014
  •  Putative roles of organic anion transporting polypeptides (OATPs) in cell survival and progression of human cancers. Nakanishi T, Tamai I. Biopharm Drug Dispos. 35 8 463-484 2014
  •   Accumulation of Trans-1-Amino-3-[18F]Fluorocyclobutanecarboxylic Acid in Prostate Cancer due to Androgen-Induced Expression of Amino Acid Transporters. Okudaira H, Oka S, Ono M, Nakanishi T, Schuster DM, Kobayashi M, Goodman MM, Tamai I, Kawai K, Shirakami Y. Mol Imaging Biol. 16 6 756-764 2014
  •  SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria.  Chino Y, Samukawa Y, Sakai S, Nakai Y, Yamaguchi JI, Nakanishi T, Tamai I. Biopharm Drug Dispos 35 7 391-404 2014
  •   Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers. Akamine Y, Miura M, Komori H, Saito S, Kusuhara H, Tamai I, Ieiri I, Uno T, Yasui-Furukori N Eur J Clin Pharmacol, 70 1087-1095 2014
  •  Transport mechanisms of hepatic uptake and bile excretion in clinical hepatobiliary scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan.  Kobayashi M, Nakanishi T, Nishi K, Higaki Y, Okudaira H, Ono M, Tsujiuchi T, Mizutani A, Nishii R, Tamai I, Arano Y, Kawai K. Nucl Med Biol. 41 338-342 2014
  •  Substrate- and dose dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B1. Shirasaka Y, Mori T, Murata Y. Nakanishi T, Tamai I. Pharm Res 31 2035-204 2014
  •  Mathematical Modeling of the in Vitro Hepatic Disposition of Mycophenolic Acid and Its Glucuronide in Sandwich-Cultured Human Hepatocytes.  Matsunaga N, Wada S, Nakanishi T, Ikenaga M, Ogawa M, Tamai I. Mol Pharm 11 568-579 2014
  •  How does whisky lower serum urate level? Lu Y, Nakanishi T, Tamai I Phytother Res 28 788-790 2014
  •   More relevant prediction for in vivo drug interaction of candesartan cilexetil on hepatic bile acid transporter BSEP using sandwich-cultured hepatocytes.  Fukuda H, Nakanishi T, Tamai I Drug Metab Pharmacokinet. 29 94-96 2014
  •  In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells Lu, Yang;Nakanishi, Takeo;Hosomi, Atsushi;Komori, Hisakazu;Tamai, Ikumi JOURNAL OF PHARMACY AND PHARMACOLOGY 67 2 170-177 2015 
  •  In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells Lu Y, Nakanishi T, Hosomi A, Komori H, Tamai I. J Pharm Pharmacol. 67 2 170-177 2015
  •  High-dose short-term administration of naringin did not alter talinolol pharmacokinetics in humans. Nguyen MA, Staubach P, Tamai I, Langguth P.  Eur J Pharm Sci 68 36-42 2015
  •  Modeling approach for multiple transporters-mediated drug-drug interaction in sandwich-cultured human hepatocytes: Effect of cyclosporine A on hepatic disposition of mycophenolic acid phenyl-glucuronide Matsunaga N, Suzuki K, Nakanishi T, Ogawa M, Imawaka H, Tamai I Drug Metab Pharmacokinet 30 142-148 2015
  •  Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug-drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys.  Watanabe M, Watanabe T, Yabuki M, Tamai I Drug Metab Pharmacokinet. 30 198-204 2015
  •  Organic anion transporting polypeptide 2B1 expression correlates with uptake of estrone-3-sulfate and cell proliferation in estrogen receptor-positive breast cancer cells. Matsumoto J, Ariyoshi N, Sakakibara M, Nakanishi T, Okubo Y, Shiina N, Fujisaki K, Nagashima T, Nakatani Y, Tamai I, Yamada H, Takeda H, Ishii I. Drug Metab Pharmacokinet 30 2 133-141 2015
  •  Prostaglandin transporter (PGT/SLCO2A1) protects the lung from bleomycin-induced fibrosis.  Nakanishi T, Hasegawa Y, Mimura R, Wakayama T, Uetoko Y, Komori H, Akanuma S, Hosoya K, Tamai I. PloS One.  10 4 e0123895 2015
  •   The change of pharmacokinetics of fexofenadine enantiomers through the single and simultaneous grapefruit juice ingestion.  Akamine Y, Miura M, Komori H, Tamai I, Ieiri I, Yasui-Furukori N, Uno T. Drug Metab Pharmacokinet.  30 5 3092-3100 2015
  •  Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluridine using human small intestinal epithelial cells. Takahashi K, Yoshisue K, Chiba M, Nakanishi T, Tamai I  J Pharm Sci. 104 9 3146-3153 2015
  •  Saturable hepatic excretion of gemcitabine involves biphasic uptake mediated by nucleoside transporters equilibrative nucleoside transporter 1 and 2. Shimada T, Nakanishi T, Tajima H, Yamazaki M, Yokono R, Takabayashi M, Shimada T, Sawamoto K, Miyamoto KI, Kitagawa H, Ohta T, Tamai I, Sai Y. J Pharm Sci 104 9 3162-3169 2015
  •  OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion Shimada H, Nakamura Y, Nakanishi T, Tamai I Biochem Pharmacol 98 4 629-638 2015
  •   Very sustained drug absorption. Donovan MD, Polli JE, Langguth P, Tamai I, Vig B, Yu LX. Gordon L. Amidon J Pharm Sci. 104 9 3164-3169 2015
  •   Interaction of drug or food with drug transporters in intestine and liver.  Takeo Nakanishi, Ikumi Tamai Curr Drug Metab, 16 9 753-764 2015
  •  Local drug-drug interaction of donepezil with cilostazol at breast cancer resistance protein (ABCG2) increases drug accumulation in heart.  Takeuchi R, Shinozaki K, Nakanishi T, Tamai I. Drug Metab Dispos 44 1 68-74 2016
  •  Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of CPT-11.  Fujita D, Saito Y, Nakanishi T, Tamai I. Drug Metab Dispos.  44 1 1-7 2016
  •  Analysis of metabolic pathway of bosentan and cytotoxicity of bosentan metabolites based on a quantitative modeling of metabolism and transport in sandwich-cultured human hepatocytes. Matsunaga N, Kaneko N, Staub AY, Nakanishi T, Nunoya KI, Imawaka H, Tamai I Drug Metab Dispos 44 1 16-27 2016
  •  A retrospective study of treatment and prophylaxis of ifosfamide-induced hemorrhagic cystitis in pediatric and adolescent and young adult (AYA) patients with solid tumors. Saito Y, Kumamoto T, Makino Y, Tamai I, Ogawa C, Terakado H. Jpn J Clin Oncol. 45 9 856-861 2016
  •  Drug Transporters: Role and Importance in ADME and Drug Development 2016/09
  •  Carrier-mediated prodrug uptake to improve the oral bioavailability of polar drugs: an application to an oseltamivir analogue. Incecayir T, Sun J, Tsume Y, Xu Hao, Gose T, Nakanishi T, Tamai I, Hilfinger J, Lipka E, Amidon GL.  J Pharm Sci.  105 2 925-934 2016
  •  Role of OATP2A1 in PGE2 secretion from human colorectal cancer cells via exocytosis in response to oxidative stress.  Kasai T, Nakanishi T, Ohno Y, Shimada H, Nakamura Y, Arakawa H, Tamai I. Exp Cell Res. 341 2 123-131 2016
  •  Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3.  Gose T, Nakanishi T, Kamo S, Shimada H, Otake K, Tamai I Prostaglandins Other Lipid Mediat 122 10-17 2016
  •  Molecular localization and characterization of multiple binding sites of organic anion transporting polypeptide 2B1 (OATP2B1) as the mechanism for substrate and modulator dependent drug-drug interaction. Hoshino Y, Fujita D, Nakanishi T, Tamai I.  Med Chem Commun.  7 1757-1782 2016
  •  A retrospective study of treatment and prophylaxis of ifosfamide-induced hemorrhagic cystitis in pediatric and adolescent and young adult (AYA) patients with solid tumors. 277) Saito Y, Kumamoto T, Makino Y, Tamai I, Ogawa C, Terakado H. Jpn J Clin Oncol 45 9 856-861 2016
  •   A novel role of OATP2A1/SLCO2A1 in a murine model of colon cancer.  Nakanishi T, Ohno Y, Aotani R, Maruyama S, Shimada H, Kamo S, Oshima H, Oshima M, Schuetz JD, Tamai I.  Sci Rep 7 16567 2017
  •  Co-localization of microsomal prostaglandin E synthase-1 with cyclooxygenase-1 in layer II of murine placental syncytiotrophoblasts Inagaki M, Nishimura T, Akanuma SI, Nakanishi T, Tachikawa M, Tamai I, Hosoya KI, Nakashima E, Tomi M. Placenta 53 76-82 2017
  •  Revisiting the role of gut wall in the face of orally administered drugs: Why now and to what effect? Rostami-Hodjegan A, Tamai I, Pang S.  Biopharm Drug Dispos.  38 87-93 2017
  •   Roles of organic anion transporting polypeptide 2A1 (OATP2A1/SLCO2A1) in regulating the pathophysiological actions of prostaglandins.  Nakanishi T, Tamai I. AAPS Journal 20 1 13 2017
  •  Contribution of equilibrative nucleoside transporter(s) to intestinal basolateral and apical transporters of anticancer trifluridine.  Takahashi K, Yoshisue K, Chiba M, Nakanishi T, Tamai I.  Biopharm Drug Dispos.  39 1 38-46 2017
  •  Usefulness of kidney slices for functional analysis of apical reabsorptive transporters.  Arakawa H, Washio I, Matsuoka N, ubo H, Staub AY, Nakamichi N, Ishiguro N, Nakanishi T, Tamai I. Sci Rep 7 12814 2017
  •   Different involvement of OAT in renal disposition of oral anticoagulants rivaroxaban, dabigatran and apixaban. Tsuruya Y, Nakanishi T, Komori H, Wang X, Ishiguro N, Kito T, Ikukawa K, Kishimoto W, Ito S, Schaefer O, Ebner T, Yamamura N, Kusuhara H, Tamai I. J Pharm Sci 106 2524-2534 2017
  •   Impact of FDA-approved drugs on the prostaglandin transporter OATP2A1/SLCO2A1.  Kamo S, Nakanishi T, Aotani R, Nakamura Y, Gose T, Tamai I. J Pharm Sci 106 2483-2490 2017
  •   Association of miR-145 with statin-induced skeletal muscle toxicity in human rhabdomyosarcoma RD cells. Saito S, Nakanishi T, Shirasaki Y, Nakajima M, Tamai I.  J Pharm Sci 106 2873-2880 2017
  •  Possible increase of serum creatinine levels by crizotinib due to inhibition of organic cation transporter 2 Arakawa H, Omote S, Tamai I.  J Pharm Sci 106 2899-2903 2017
  •  Comparative evaluation of dehydroepiandrosterone sulfate (DHEAS) potential to predict hepatic OATP transporter-based drug-drug interactions. Nishizawa, K., Nakanishi T. Tamai I.  Drug Metab. Dispos., 45 2 224-227 2017
  •  Impact of organic cation transporters (OCT-SLC22A) on differential diagnosis of intrahepatic lesions. Visentin M, van Rosmalen BV, Hiller C, Bieze M, Hofstetter L, Verheij J, Kullak-Ublick GA, Koepsell H, Phoa SS, Tamai I, Bennink RJ, van Gulik TM, Stieger B. Drug Metab Dispos 45 2 166-173 2017
  •   Sandwichh-cultured hepatocytes for mechanistic understanding of hepatic disposition of parent drugs and metabolites by transporter-enzyme interplay.  Matsunaga N, Fukuchi Y, Imawaka H, Tamai I Drug Metab Dispos 2018
  •   Hyperuricemia enhances intracellular urate accumulation via down-regulation of cell-surface BCRP/ABCG2 expression in vascular endothelial cells. Komori H, Yamada K, Tamai I.   Biochim Biophys Acta 1860 973-980 2018
  •  Impact of breast cancer resistance protein expression on the in vitro efficacy of anticancer drugs in pancreatic cancer cell lines.  Washio I, Nakanishi T, Ishiguro N, Yamamura N, Tamai I.  Drug Metab Dispos 46 214-222 2018
  •  Different Efflux Transporter Affinity and Metabolism of 99mTc-2-Methoxyisobutylisonitrile and 99mTc-Tetrofosmin for Multidrug Resistance Monitoring in Cancer.  Kobayashi M, Tsujiuchi T, Okui Y, Mizutani A, Nishi K, Nakanishi T, Nishii R, Fukuchi K, Tamai I, Kawai K. Pharm Res 36 1 18- 2018
  •  Cyclophosphamide-induced hemorrhagic cystitis in young patients with solid tumore. Saito Y, Kumamoto Y, Shiraiwa M, Sonoda T, Arakawa A, Aoki Y, Hashimoto H, Tamai I, Ogawa C, Terakado H.  Asia-Pacific J Clin Oncol 2018
  •  Apple-derived Nanoparticles Modulate Expression of Organic-Anion- Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells. Fujita D, Arai T, Komori H, Shirasaki Y, Wakayama T, Nakanishi T, Tamai I Mol Pharm 15 5772-5780 2018
  •  Contribution of Equilibrative Nucleoside Transporters 1 and 2 to Gemcitabine Uptake in Pancreatic Cancer Cells Hioki M, Shimada T, Yuan T, Nakanishi T, Tajima H, Yamazaki M, Yokono R, Takabayashi M, Sawamoto K, Akashita G, Miyamoto K-I, Ohta T, Tamai I, Shimada T, Sai Y.  Biopharm Drug Dispos, 39 256-264 2018
  •  Prostaglandin transporter OATP2A1/SLCO2A1 is essential for body temperature regulation during fever. Nakamura Y, Nakanishi T, Shimada H, Shimizu J, Aotani R, Maruyama S, Higuchi K, Okura T, Deguchi Y, Tamai I J Neurosci 38 5584-5595 2018
  •  Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1. Omote S, Matsuoka N, Arakawa H, Nakanishi T, Tamai I Sci Rep 8 1 9327 2018
  •  Membrane Transporters Contributing to PGE2 Distribution in Central Nervous System. Nakamura Y, Nakanishi T, Tamai I Biol Pharm Bull 41 9 1337-1347 2018
  •  Contribution of equilibrative nucleoside transporter(s) to intestinal basolateral and apical transporters of anticancer trifluridine. Takahashi K, Yoshisue K, Chiba M, Nakanishi T, Tamai I  Biopharm Drug Dispos 39 1 38-46 2018
  •  In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys, and human.  Koyanagi T, Yano K, Kim S, Murayama N, Yamazaki H, Tamai I.  Xenobiotica 49 8 887-894 2019
  •  Membrane Transporters Contributing to PGE2 Distribution in Central Nervous System. Nakamura Y, Nakanishi T, Tamai I Biol Pharm Bull 41 9 1337-1347 2018
  •   Effect of endogenous P-glycoprotein expression on anticancer drug resistance in colon cancer cell lines. Washio I, Nakanishi T, Ishiguro N, Bister B, Tamai I. Biopharm Drug Dispos.  40 1 32-43 2019
  •  Experimental evidence for re-secretion of PGE2 across rat alveolar epithelium by OATP2A1/SLCO2A1-mediated transcellular transport.  Nakanishi T, Takashima H, Uetoko Y, Komori H, Tamai I J Pharmacol Exp Ther, 368 2 317-325 2019
  •  Uric acid analogue as a possible xenobiotic marker of uric acid transporter Urat1 in Rats. Arakawa H, Amezawa N, Katsuyama T, Nakanishi T, Tamai I Drug Metab Pharmacokinet 2019
  •  Identification of MRP2 as a targetable factor limiting oxaliplatin accumulation and response in gastrointestinal cancer. Myint K, Biswas R, Li Y, Jong N, Jamieson S, Liu J, Han C, Squire C, Merien F, Lu J, Nakanishi T, Tamai I, MxKeage M Sci Rep 9 1 2245 2019
  •  Quantification of prostaglandin E2 in interstitial fluid from hypothalamic region of free moving mice.  Nakamura Y, Sakaguchi T, Tamai I, Nakanishi T.  Bio-protocol 9 15 2019
  •  Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.  Nishizawa K, Yoda N, Morokado F, Komori H, Nakanishi T, Tamai I. PLoS One, 14 4 e0214862 2019
  •  Rat kidney slices for evaluation of apical membrane transporters in proximal tubular cells. Arakawa H, Kubo H, Washio I, Staub AY, Nedachi S, Ishiguro N, Nakanishi T, Tamai I. J Pharm Sci 108 8 2798-2804 2019
  •  Identification of the catechin uptake transporter responsible for intestinal absorption of epigallocatechin gallate in mice. Ishii S, Kitazawa H, Mori T, Kirino A, Nakamura S, Osaki N, Shimotoyodome A, Tamai I,  Sci Rep 9 1 11014 2019
  •  Imaging of hepatic drug transporters with [131I]6-β-iodomethyl- 19-norcholesterol. Kobayashi M, Nishi K, Mizutani A, Hokama T, Matsue M, Tsujikawa T, Nakanishi T, Nishii R, Tamai I, Kawai K.  Sci Rep 9 1 13413 2019
  •  Pharmacokinetic/pharmacodynamics modeling and simulation of dotinurad, a novel uricosuric agent, in healthy volunteers.  Motoki K, Igarashi T, Omura K, Nakatani H, Iwanaga T, Tamai I, Ohashi T.  Pharmacol Res Perspect e00533 2019
  •  ABCG2 requires a single aromatic amino acid to "clamp" substrates and inhibitors into the binding pocket.  Gose T, Shafi T, Fukuda Y, Das S, Wang Y, Allcock A, Gavan McHarg A, Lynch J, Chen T, Tamai I, Shelat A, Ford RC, Schuetz JD.  FASEB Journal 34 4890-4903 2020
  •  Pillar[6]arene acts as a biosensor for quantitative detection of a vitamin metabolite in crude biological samples. Ueno M, Tomita T, Arakawa H, Kakuta T, Yamagishi T, Terakawa J, Daikoku T, Horike S, Si S, Kurayoshi K, Ito C, Kasahara A, Tadokoro Y, Kobayashi M, Fukuwatari T, Tamai I, Hirao A, Ogoshi T. Communication Chemistry COMMSCHEM 20-0311B 2020
  •  Renal reabsorptive transport of uric acid precursor xanthine by URAT1 and GLUT9. Arakawa H, Amezawa N, Kawakatsu Y, Tamai I.  Biological Pharmaceutical Bulletin  43 1892-1798 2020
  •  [131I]MIBG exports via MRP transporters and inhibition of the MRP transporters improves accumulation of [131I]MIBG in neuroblastoma. Kobayashi M, Mizutani A, Nishi K, Muranaka Y, Nishii R, Shikano N, Nakanishi T, Tamai I, Kleinerman ES, Kawai K. Nucl Med Biol. 90-91 49-54 2020
  •   The inhibitors of the apical sodium-dependent bile acid transporter (ASBT) as promising drugs. Saveleva EE, Tyutrina ES, Nakanishi T, Tamai I, Salmina AB.  Biomed Khim, 66 3 185-195 2020
  •  Identification of the uptake transporter responsible for distribution of acotiamide into stomach tissue.  Hirayama M, Hoshino Y, Yoshii K, Toda R, Kawabata Y, Nakanishi T, Tamai I.  Molecular Pharmaceutics 17 1071-1079 2020
  •  Contribution of prostaglandin transporter OATP2A1/SLCO2A1 to placenta-to-maternal hormone signaling and labor induction.  Inagaki M, Nishimura T, Nakanishi T, Shimada H, Noguchi S, Akanuma SI, Tachikawa M, Hosoya KI, Tamai I, Nakashima E, Tomi M.  iScience 23 5 101098 2020
  •  Mathematical modeling analysis of hepatic uric acid disposition using human sandwich-cultured hepatocytes. Wada S, Matsunaga N, Tamai I. Drug Metabolism and Pharmacokinetics 35 432-440 2020
  •  Post-transcriptional regulation of OATP2B1 transporter by a microRNA, miR-24 Liu W, Nakano M, Nakanishi T, Nakajima M, Tamai I. Drug Metabolism and Pharmacokinetics 35 432-440 2020
  •  Toxicological implication of prostaglandin transporter SLCO2A1 inhibition by cigarette smoke in exacerbation of lung inflammation. Nakanishi T, Sakiyama S, Takashima H, Honda R, Shumba M, Nakamura Y, Kasahara K, Tamai I. Toxicology and Applied Pharmacology 405 115201 2020
  •  Transport mechanism and affinity of [99mTc]mercaptoacetyltriglycine ([99mTc]MAG3) on the apical membrane of renal proximal tubule cells. Kobayashi M, Nishi K, Mizutani A, Okudaira H, Nakanishi T, Shikano N, Nishii R, Tamai I, Kawai K. Nucl Med Biol. 15 84-85 33-37 2020
  •  A novel fluorescence-based method to evaluate ileal apical sodium-dependent bile acid transporter ASBT.  Zhu Q, Komori H, Imamura R, Tamai I J Pharm Sci 110 1392-1400 2021
  •  Assessment of drug transporters involved in the urinary secretion of [99mTc]dimercaptosuccinic acid. Kobayashi M, Mizutani A, Okamoto T, Muranaka Y, Nishi K, Nishi R, Shikano N, Nakanishi T, Tamai I, Kleinerman ES, Kawai K. Nucl Med Biol. 94-95 92-97 2201
  •  MicroRNAs in apple-derived nanoparticles modulate intestinal expression of OATP2B1/SLCO2B1 in humans.  Arai M, Komori H, Fujita D, Tamai I,  Pharmaceutical Research 38 3 523-530 2021
  •  Drug transcellular transport assay using a high porosity honeycomb film. Nakazono Y, Arakawa A, Nishino M, Yamaki I, Oba T, Tomotoshi K, Kakinuma C, Ogihara T, Tamai I. Biological Pharmaceutical Bulletin  2021
  •  Poria cocos reduces blood lipid levels by inhibiting sodium-dependent intestinal and hepatic bile acid transporters. Cai H, Cheng Y, Zhu Q, Kong Q, Chen X, Tamai I, Lu Y. Drug Metabolism and Disposition  49 5 353-360 2021
  •  Uptake pathway of apple-derived nanoparticle by intestinal cells to deliver its cargo.  Arai M, Komori H, Fujita D, Tamai I, Pharm Res 38 3 523-530 2021
  •  CD38 activation by monosodium urate crystals contributes to inflammatory response in macrophages.  Wen S, Arakawa S, Tamai I.  Biochem Biophys Res Commun 581 6-11 2021
  •   3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents.  Konno S, Kobayashi K, Senda M, Funai Y, Seki Y, Tamai I, Schäkel L, Sakata K, Pillaiyar T, Taguchi A, Taniguchi A, Gütschow M, Müller CE, Takeuchi K, Hirohama M, Kawaguchi A, Kojima M, Senda T, Shirasaka Y, Kamitani W, Hayashi YJ. Med Chem. acs.jmedchem.1c00665. 2021
  •   Inhibition of the Hepatic Uptake of 99mTc-Tetrofosmin Using an Organic Cation Transporter Blocker. Nishi K, Kobayashi M, Kikuchi M, Mizutani A, Muranaka Y, Tamai I, Kawai K, Kudo T.  Pharmaceutics 13 7 1073 2021
  •  Influence of osmolality on gastrointestinal fluid volume and drug absorption: potential impact on oral salt supplementation. Takemura M, Tanaka Y, Inoue K, Tamai I, Shirasaka Y.  J Pharm Health Care Sci.  7 1 29 2021
  •  Multiple Transport Mechanisms Involved in the Intestinal Absorption of Metformin: Impact on the Nonlinear Absorption Kinetics. Shirasaka Y, Seki M, Hatakeyama M, Kurokawa Y, Uchiyama H, Takemura M, Yasugi Y, Kishimoto H, Tamai I, Wang J, Inoue K.   J Pharm Sci 2022
  •  Evaluation of platinum anticancer drug-induced kidney injury in primary culture of rat kidney tissue slices by using gas-permeable plates.  Arakawa H, Nagao Y, Nedachi S, Shirasaka Y, Tamai I.  Biol Pharm Bull.  45 3 316-322 2022

Conference Presentations

  • Local DDI of Donepezil with Cilostazol Increases Drug Accumulation in Heart (conference:ASPET 2017 Annual Meeting at Experimental Biology )(2017/04/26)
  • 尿酸と尿糖- トランスポーターによる調節と変動 - (2017/07/26)
  • 尿酸と尿糖 - トランスポーターによる調節と変動 - (2017/07/06)
  • Food-Drug and Drug-Drug Interactions (conference:MEET the EXPERT, Transporter Conference)(2017/11/28)
  • 毒性理解のための薬物動態的アプローチ: トランスポーターと全身・局所曝露 (2017/07/10)

show all

  • Mechanism of SGLT2 Inhibitor-Induced Decrease of Serum Uric Acid (SUA) Level (conference:89th Annual Meeting of the Japanese Pharmacological Society)(2016/03/10)
  • Drug-Food Interaction and Evaluation (2016/10/13)
  • Quantitative Prediction of Hepatic Disposition of Drugs and Metabolites by In Vitro Sandwich-Cultured Hepatocytes and In Vivo Biomarker(conference:19th International Conference on Cytochrome P450, Biochemistry, Biophysics, and Biotechnology)(2015/06/13)
  • Usefulness of Sandwich-cultured Hepatocytes in Studying Hepatic Drug Disposition and Interaction.(conference:The 44th Annual Meeting of Korean Society of Pharmaceutics Science and Technology)(2014/11/27)
  • Pharmacological and Pathophysiological Significance of OATP Transporters (2016/03/16)
  • Drug-induced changes in serum uric acid level explained by transporters found in clinical studies.(2015/11/13)
  • OATP Transporters: Pharmacological and Pathophysiological Significance(conference: MEET the EXPERT Transporter Conference)(2015/05/13)
  • Impact of breast cancer resistance protein (BCRP/ABCG2) on chemotherapy; its function and gene regulation in cancer cells. 45th Annual Meeting of The Korean Society of Pharmaceutical Sciences and Technology (KSPST). (conference:45th Annual Meeting of The Korean Society of Pharmaceutical Sciences and Technology (KSPST))(2015/11/20)
  • Transporters: Targets for Drug Delivery and for Chemotherapy(conference:1st AROADME Workshop)(2014/09/14)
  • Multiple Mechanisms of Juice Effect on Intestinal Uptake Transporters, Symposium on Drug-Drug Interactions(conference:19th NA-ISSX/29th JSSX Meeting)(2014/10/22)
  • 尿酸生合成前駆体xanthineおよびhypoxanthineの尿細管再吸収輸送(2019/02/14)
  • Regulation of intestinal OATP2B1 by microRNA contained in apple-derived nanoparticle as cargo(2019/12/10)
  • An impact of plasm prostaglandin E2 on the progression of non-alcoholic fatty liver diseases(2019/12/10)
  • Usefulness of combination of uricosuric agent with XOR inhibitor to decrease purine pool(2019/12/10)
  • Kidney toxicity of diclofenac acylglucuronide evaluated by precision cut-kidney slices in rats(2019/12/10)
  • ABCG2 Q141K変異体の発現局在に及ぼす翻訳後修飾の影響 (2019/07/20)
  • DDI・DFIによるOATP2B1の活性変動機構の多様性(2019/10/16)
  • Food Effect on Intestinal Transporters ASBT and OATP2B1(conference:10th SOLVO’s Meet the Experts Transporter Conference)(2019/11/14)
  • Regulation of intestinal OATP2B1 by food-derived microRNA through apple nanoparticles(conference:BioMedical Transporters 2019)(2019/08/02)
  • Regulatory effect of apple-derived nanoparticle on intestinal organic anion transporting polypeptide (OATP) 2B1 (conference:ISEV2019)(2019/04/26)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

○Hyperuricemia
○Drug-Food Interaction
○Drug-Drug Interaction on Transporters

Grant-in-Aid for Scientific Research

○「血清尿酸値を感受する尿酸センサーの同定と生理作用」(2021-2023) 
○「ナトリウム共役能動輸送型糖輸送体を標的としたセラノスティクス薬剤の確立」(2021-2024) 
○「ダウン症候群モデルマウスを用いた精子形成障害の新規原因遺伝子の探索」(2021-2023) 
○2021「果実ナノ粒子含有マイクロRNAを介した食品由来高分子による消化管機能調節」(2020-2021) 
○2023「消化管水分調節機構の定量的解明に基づく薬物吸収動態予測システムの確立」(2020-2023) 
○「輸送体上での食品との相互作用が及ぼす医薬品の動態・作用変動に関する研究」(2016-2019) 
○「マイクロRNAによるOATP輸送体の発現調節機構に基づく薬物療法最適化」(2016-2018) 
○「併用薬物による局所組織濃度変動に起因したドネペジルの心毒性発現に関する研究」(2014-2015) 
○「細胞内オルガネラ膜トランスポーター活性の定量的可視化による薬物の細胞毒性評価」(2009-2010) 
○「尿酸動態調節機構の解明に基づく血清尿酸値変動評価システムの樹立」(2009-2011) 
○「有機アニオン輸送体を介した薬物の肝移行性調節とその種差」(2007-2008) 
○「トランスポーターを標的分子とした新規乳癌ホルモン療法システム」(2005-) 
○「トランスポーター発現プロファイルに基づく細胞分化・増殖制御手法」(2005-)
○「トランスポーター介在型毒性発現機構」(2003-)

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Entrepreneur: Practical Strategy(2017)
○General Pharmacy 1(2017)
○Manufacturing Pharmacy(2017)
○World of Coffee(2017)
○Basic Drug Development(2017)
○World of Coffee(2017)
○General Pharmacy 2(2017)
○Entrepreneur: Practical Strategy(2017)
○Medicinal Chemistry(2017)
○Experiments in Pharmaceutical Practice 2(2017)
○Laboratory Rotation 2(2016)
○General Pharmacy 1(2016)
○Medicinal Chemistry(2016)
○Basic Drug Development(2016)
○Manufacturing Pharmacy(2016)
○General Pharmacy 2(2016)
○Experiments in Pharmaceutical Practice 2(2016)
○Entrepreneur: Practical Strategy(2016)
○World of Coffee(2016)
○World of Coffee(2016)
○Entrepreneur: Practical Strategy(2016)

Classes (Graduate Schools)

○Introduction to Presicion Medicine(2017)
○Molecular Biopharmaceutics(2017)
○Pharmaceutical Therapeutics(2017)
○Advanced Seminar on Precision Medicine(2017)
○Advanced Course of Pharmacological Studies for Drug Development(2017)
○Molecular Mechanisms of Drug Response(2017)
○Molecular Pharmacology(2017)
○Molecular Mechanisms of Drug Response(2016)
○Molecular Pharmaceutics(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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