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Researcher Information

last modified:2018/09/19

Associate Professor ARAI, Kuniaki

Laboratory Website

Faculty, Affiliation

University Hospital

College and School Educational Field


Laboratory

Disease control and homeostasis

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor 200203 Completed
【Academic background(Bachelor's Degree)】
Kyoto University 199703
【Degree】
MD and PhD

Career

Kanazawa University Hospital Gastroenterology(2002/04/01-)

Year & Month of Birth

1972/07

Academic Society










Award

Specialities

Gastroenterology

Speciality Keywords

Research Themes

treatment for hepatic tumor

Radiofrequency ablation (RFA), chemotherapy

Imaging for hepatic tumor

Books

Papers

  •  Severe veno-occlusive disease/sinusoidal obstruction syndrome after deceased-donor and living-donor liver transplantation. Takamura H, Nakanuma S, Hayashi H, Tajima H, Kakinoki K, Kitahara M, Sakai S, Makino I, Nakagawara H, Miyashita T, Okamoto K, Nakamura K, Oyama K, Inokuchi M, Ninomiya I, Kitagawa H, Fushida S, Fujimura T, Onishi I, Kayahara M, Tani T, Arai K, Yamashita T, Yamashita T, Kitamura H, Ikeda H, Kaneko S, Nakanuma Y, Matsui O, Ohta T. Transplant Proc. 46 10 3523-35355 2014 
  •  Feasibility and efficacy of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma after sorafenib. Terashima T, Yamashita T, Arai K, Sunagozaka H, Kitahara M, Nakagawa H, Kagaya T, Mizukoshi E, Honda M, Kaneko S. Hepatol Res. 44 12 1179-1185 2014 
  •  Blood neutrophil to lymphocyte ratio as a predictor in patients with advanced hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy. Terashima T, Yamashita T, Iida N, Yamashita T, Nakagawa H, Arai K, Kitamura K, Kagaya T, Sakai Y, Mizukoshi E, Honda M, Kaneko S. Hepatol Res. 45 9 949-959 2015 
  •  Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis. Nakamura M, Kondo H, Tanaka A, Komori A, Ito M, Yamamoto K, Ohira H, Zeniya M, Hashimoto E, Honda M, Kaneko S, Ueno Y, Kikuchi K, Shimoda S, Harada K, Arai K, Miyake Y, Abe M, Taniai M, Saibara T, Sakisaka S, Takikawa H, Onji M, Tsubouchi H, Nakanuma Y, Ishibashi H. Hepatol Res. 45 8 846-855 2015 
  •  Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis. Yamada K, Mizukoshi E, Sunagozaka H, Arai K, Yamashita T, Takeshita Y, Misu H, Takamura T, Kitamura S, Zen Y, Nakanuma Y, Honda M, Kaneko S. Liver Int. 35 2 582-590 2015 

show all

  •  P53, hTERT, WT-1, and VEGFR2 are the most suitable targets for cancer vaccine therapy in HLA-A24 positive pancreatic adenocarcinoma. Terashima T, Mizukoshi E, Arai K, Yamashita T, Yoshida M, Ota H, Onishi I, Kayahara M, Ohtsubo K, Kagaya T, Honda M, Kaneko S. Cancer Immunol Immunother. 63 5 479-489 2014 
  •  A phase I/II study of S-1 with sorafenib in patients with advanced hepatocellular carcinoma. Ooka Y, Chiba T, Ogasawara S, Arai K, Suzuki E, Tawada A, Yamashita T, Kanai F, Kaneko S, Yokosuka O. Invest New Drugs. 32 4 723-728 2014 
  •  The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial. Takeshita Y, Takamura T, Honda M, Kita Y, Zen Y, Kato K, Misu H, Ota T, Nakamura M, Yamada K, Sunagozaka H, Arai K, Yamashita T, Mizukoshi E, Kaneko S. Diabetologia. 57 5 878-890 2014 
  •  Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes. Honda M, Shirasaki T, Shimakami T, Sakai A, Horii R, Arai K, Yamashita T, Sakai Y, Yamashita T, Okada H, Murai K, Nakamura M, Mizukoshi E, Kaneko S. Hepatology.  59 3 828-838 2014 
  •  Immunological features of T cells induced by human telomerase reverse transcriptase-derived peptides in patients with hepatocellular carcinoma. Mizukoshi E, Nakagawa H, Kitahara M, Yamashita T, Arai K, Sunagozaka H, Fushimi K, Kobayashi E, Kishi H, Muraguchi A, Kaneko S. Cancer Lett. 364 2 98-105 2015 
  •  Phase I trial of multidrug resistance-associated protein 3-derived peptide in patients with hepatocellular carcinoma. Mizukoshi E, Nakagawa H, Kitahara M, Yamashita T, Arai K, Sunagozaka H, Iida N, Fushimi K, Kaneko S. Cancer Lett.  369 1 242-249 2015 
  •  Hepatitis B Virus (HBV) Core-Related Antigen During Nucleos(t)ide Analog Therapy Is Related to Intra-hepatic HBV Replication and Development of Hepatocellular Carcinoma. Honda M, Shirasaki T, Terashima T, Kawaguchi K, Nakamura M, Oishi N, Wang X, Shimakami T, Okada H, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S. J Infect Dis. 213 7 1096-1106 2016 
  •  Response to chemotherapy improves hepatic reserve for patients with hepatocellular carcinoma and Child-Pugh B cirrhosis. Terashima T, Yamashita T, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S. Cancer Sci. 107 9 1263-1269 2016 
  •  Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver Cancer. Kawaguchi K, Honda M, Yamashita T, Okada H, Shirasaki T, Nishikawa M, Nio K, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S. Am J Pathol. 186 8 2055-2067 2016 
  •  Potential efficacy of therapies targeting intrahepatic lesions after sorafenib treatment of patients with hepatocellular carcinoma. Terashima T, Yamashita T, Horii R, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S. BMC Cancer.  16 338-346 2016 
  •  Post-progression survival and progression-free survival in patients with advanced hepatocellular carcinoma treated by sorafenib. Terashima T, Yamashita T, Takata N, Nakagawa H, Toyama T, Arai K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S. Hepatol Res. 46 7 650-656 2016 
  •  Myeloid-derived suppressor cells correlate with patient outcomes in hepatic arterial infusion chemotherapy for hepatocellular carcinoma. Mizukoshi E, Yamashita T, Arai K, Terashima T, Kitahara M, Nakagawa H, Iida N, Fushimi K, Kaneko S. Cancer Immunol Immunother. 65 6 715-725 2016 
  •  Slowly progressive insulin-dependent diabetes in a patient with primary biliary cirrhosis with portal hypertension-type progression. Takeshita Y, Takamura T, Inoue O, Okumura M, Kato K, Sunagozaka H, Arai K, Misu H, Nakamura M, Nakanuma Y, Kaneko S. INTERNAL MEDICINE 51 1 79-82 2012/01
  •  Expression of chondroitin-glucuronate C5-epimerase and cellular immune responses in patients with hepatocellular carcinoma. Mizukoshi E, Fushimi K, Arai K, Yamashita T, Honda M, Kaneko S. Liver Int. 32 10 1516-1526 2012/11
  •  Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population. Nakamura M, Kaneko S, Arai K 他 77名 AMERICAN JOURNAL OF HUMAN GENETICS 91 4 721-728 2012/10
  •  Randomized, Phase II Study Comparing Interferon Combined with Hepatic Arterial Infusion of Fluorouracil plus Cisplatin and Fluorouracil Alone in Patients with Advanced Hepatocellular Carcinoma. Yamashita T, Arai K, Sunagozaka H, Ueda T, Terashima T, Yamashita T, Mizukoshi E, Sakai A, Nakamoto Y, Honda M, Kaneko S. ONCOLOGY 81 5-6 281-290 2011/11
  •  Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes. Misu H, Takamura T, Matsuzawa N, Shimizu A, Ota T, Sakurai M, Ando H, Arai K, Yamashita T, Honda M, Yamashita T, Kaneko S. DIABETOLOGIA 50 2 268-277 2007/02
  •  Combined therapy of transcatheter hepatic arterial embolization with intratumoral dendritic cell infusion for hepatocellular carcinoma: clinical safety. Nakamoto Y, Mizukoshi E, Tsuji H, Sakai Y, Kitahara M, Arai K, Yamashita T, Yokoyama K, Mukaida N, Matsushima K, Matsui O, Kaneko S. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 147 2 296-305 2007/02
  •  Impact of diabetes mellitus on prognosis of patients infected with hepatitis C virus. Kita Y, Mizukoshi E, Takamura T, Sakurai M, Takata Y, Arai K, Yamashita T, Nakamoto Y, Kaneko S. Metabolism 56 12 1682-8 2007/12
  •  Impact of diabetes on recurrence of hepatocellular carcinoma after surgical treatment in patients with viral hepatitis. Komura T, Mizukoshi E, Kita Y, Sakurai M, Takata Y, Arai K, Yamashita T, Ohta T, Shimizu K, Nakamoto Y, Honda M, Takamura T, Kaneko S. AMERICAN JOURNAL OF GASTROENTEROLOGY 102 9 1939-46 2007/09
  •  Expression of multidrug resistance-associated protein 3 and cytotoxic T cell responses in patients with hepatocellular carcinoma. Mizukoshi E, Honda M, Arai K, Yamashita T, Nakamoto Y, Kaneko S. JOURNAL OF HEPATOLOGY 49 6 946-954 2008/12
  •  Enhancement of tumor-specific T-cell responses by transcatheter arterial embolization with dendritic cell infusion for hepatocellular carcinoma. Mizukoshi E, Nakamoto Y, Arai K, Yamashita T, Mukaida N, Matsushima K, Matsui O, Kaneko S. INTERNATIONAL JOURNAL OF CANCER 51 5 536-542 2010/03
  •  Histological course of nonalcoholic fatty liver disease in Japanese patients: tight glycemic control, rather than weight reduction, ameliorates liver fibrosis. Hamaguchi E, Takamura T, Sakurai M, Mizukoshi E, Zen Y, Takeshita Y, Kurita S, Arai K, Yamashita T, Sasaki M, Nakanuma Y, Kaneko S. DIABETES CARE 33 2 284-6 2010/02
  •  dUTP pyrophosphatase expression correlates with a poor prognosis in hepatocellular carcinoma. Takatori H, Yamashita T, Honda M, Nishino R, Arai K, Yamashita T, Takamura H, Ohta T, Zen Y, Kaneko S. Liver Int. 30 3 438-46 2010/03
  •  Differential interferon signaling in liver lobule and portal area cells under treatment for chronic hepatitis C. Honda M, Nakamura M, Tateno M, Sakai A, Shimakami T, Shirasaki T, Yamashita T, Arai K, Yamashita T, Sakai Y, Kaneko S. JOURNAL OF HEPATOLOGY 53 5 817-26 2010/11
  •  Expression of epithelial-mesenchymal transition markers in locally recurrent hepatocellular carcinoma after radiofrequency ablation. Tajima H, Ohta T, Shoji Y, Watanabe T, Makino I, Hayashi H, Nakagawara H, Onishi I, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Tani T, Fujimura T, Kayahara M, Arai K, Yamashita T, Kaneko S, Zen Y. Experimental and therapeutic medicine 1 2 347-350 2010/04
  •  Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization. Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, Kakinoki K, Fujita Y, Marukawa Y, Arai K, Yamashita T, Mukaida N, Matsushima K, Matsui O, Kaneko S. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 163 2 165-77 2011/02
  •  Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma. Sunagozaka H, Honda M, Yamashita T, Nishino R, Takatori H, Arai K, Yamashita T, Sakai Y, Kaneko S. INTERNATIONAL JOURNAL OF CANCER 129 7 1576-85 2011/10
  •  Comparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma. Mizukoshi E, Nakamoto Y, Arai K, Yamashita T, Sakai A, Sakai Y, Kagaya T, Yamashita T, Honda M, Kaneko S. HEPATOLOGY 53 4 1206-1216 2011/04
  •  Frequency of CD45RO+ subset in CD4+CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma. Takata Y, Nakamoto Y, Nakada A, Terashima T, Arihara F, Kitahara M, Kakinoki K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S. CANCER LETTERS 307 2 165-173 2011/08

Conference Presentations

  • Contrast-enhanced ultrasonography for evaluating treatment of sorafenib in hepatocellular carcinoma.(conference:WFUMB2013)(2013/05/03)
  • Assessment of the therapeutic response of hepatocellular carcinoma treated with radiofrequency ablation : comparison of contrast-enhanced ultrasonography and computed tomography.(conference:WFUMB2013)(2013/05/03)
  • A review of the cost - effectiveness analysis of treatment with direct acting antivirals for chronic hepatitis C.(conference:2016APDW)(2016/11/04)

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「新規ケモカイン製剤の免疫賦活効果による肝癌の再発抑制効果をめざした免疫療法の開発」(2011-2013) 

Classes (Bachelors)

Classes (Graduate Schools)

○Disease Control and Homeotasis(2017)
○Disease Control and Homeotasis(2017)
○Disease Control and Homeotasis(2016)
○Disease Control and Homeotasis(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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