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Researcher Information

last modified:2023/03/14

Associate Professor SAKAI, Katsuya

Laboratory Website

Faculty, Affiliation

Cancer Research Institute

College and School Educational Field


Tumor dynamics and regulation TEL:076-264-6747

Academic Background


Kanazawa University(2020/09-)
Kanazawa University(2010/04-2020/09)
Osaka university(2008/04-2010/03)
Osaka university(2003/12-2008/03)
Bayer Yakuhin Co Ltd(1998/04-2003/12)

Year & Month of Birth


Academic Society



Speciality Keywords

Receptor Growth factor Cancer Chemical Biology Peptide Protein Engineering

Research Themes



  •  Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions  Sakai K, Sugano-Nakamura N, Mihara E, Rojas-Chaverra NM, Watanabe S, Sato H, Imamura R, Voon DCC, Sakai I, Yamasaki C, Tateno C, Shibata M, Suga H, Takagi J, Matsumoto K Nature Biomedical Engineering 2022
  •  A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration. 2. Hino N, Matsuda K, Maryu G, Sakai K, Imamura R, Matsumoto K, Aoki K, Terai K, Hirashima T, Matsuda M. Developmental Cell 57 17 2290-2304 2022
  •  Dimer interface in natural variant NK1 is dispensable for HGF-dependent Met receptor activation. Yumiko Tahira, Katsuya Sakai, Hiroki Sato, Ryu Imamura, and Kunio Matsumoto International Journal of Molecular Sciences 22 9240 2021
  •  Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins. Emiko Mihara, Satoshi Watanabe, Nasir K. Bashiruddin, Nozomi Nakamura, Kyoko matoba, Yumi Sano, Rumit Maini, Yizhen Yin, Katsuya Sakai, Takao Arimori, Kunio Matsumoto, Hiroaki Suga and Junichi Takagi Nature Communications 12 1543 2021
  •  De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist. Komatsu, Y. Terasaka N, Sakai K, Mihara E, Wakabayashi R, Matsumoto K, Hilvert D, and Suga H.  iScience 24 103302 2021

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  •  Peptide-Conjugated Tip for Fast and Selective Molecular Recognition Imaging by High-Speed Atomic Force Microscopy. Puppulin L, Kanayama D, Terasaka, N, Sakai K, Kodera N, Umeda K, Sumino A, Marchesi A, Weilin W, Tanaka Hideo, Fukuma T, Suga H, Matsumoto K, and Shibata, M.  ACS Appl. Mater. Interfaces  13 54817–54829 2021
  •  Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion. 2) Sakai K†, Nishiuci T, Tange S, Suzuki Y, Yano S, Terashima M, Suzuki T, Matsumoto K Scientific Reports 10 16678 2020
  •  Cyclic Peptide-Based Biologics Regulating HGF-MET.  Hiroki Sato, Ryu Imamura, Hiroaki Suga, Kunio Matsumoto, and Katsuya Sakai International Journal of Molecular Sciences  21 7977 2020
  •  Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor. Sakai K, Passioura T, Sato H, Ito K, Furuhashi H, Umitsu M, Takagi J, Kato Y, Mukai H, Warashina S, Zouda M, Watanabe Y, Yano S, Shibata M, Suga H, Matsumoto K. Nature Chemical Biology 2019
  •  Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach.  Jangphattananont N, Sato H, Imamura R, Sakai K, Terakado Y, Murakami K, Barker N, Oshima H, Oshima M, Takagi J, Kato Y, Yano S, Matsumoto K. International Journal of Molecular Sciences  20 2019
  •  The constitutive high affinity Met binding site in the kringle domain is dispensable for the signaling activity of hepatocyte growth factor.  Umitsu M, Sakai K, Tamura-Kawakami K, Matsumoto K, Takagi J. Journal of Biochemistry 2019
  •  Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer.  Miao W, Sakai K, Sato H, Imamura R, Jangphattananont N, Takagi J, Nishita M, Minami Y, Matsumoto K Cancer Science  110 3340-3349  2019
  •  MET activation by a macrocyclic peptide agonist that couples to biological responses differently from HGF in a context-dependent manner. Miao W, Sakai K, Imamura R, Ito K, Suga H, Sakuma T, Yamamoto T, Matsumoto K. International journal of molecular sciences 19 10 3141 2018
  •  Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist.  Miao W, Sakai K, Ozawa N, Nishiuchi T, Suzuki Y, Ito K, Morioka T, Umitsu M, Takagi J, Suga H, Matsumoto K.  Scientific Reports 8 16492 2018
  •  Probing conformational and functional states of human hepatocyte growth factor by a panel of monoclonal antibodies Masataka Umitsu, Katsuya Sakai, Satoshi Ogasawara, Mika K. Kaneko, Ryoko Asaki, Keiko Tamura-Kawakami, Yukinari Kato, Kunio Matsumoto & Junichi Takagi Scientific Reports 6 2016
  •  Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma Adachi E, Sakai K, Nishiuchi T, Imamura R, Sato H, Matsumoto K Oncotarget 7 70779-70793 2016
  •  Hepatocyte growth factor and Met in drug discovery. Sakai K, Aoki S, and Matsumoto K Journal od Biochemistry 157 271-284 2015
  •  Artificial human Met agonists based on macrocycle scaffolds. Ito K, Sakai K, Suzuki Y, Ozawa N, Hatta T, Natsume T, Matsumoto K, and Suga H Nature Communications 6 2015
  •  Inhibition of transforming growth factor-β signaling potentiates tumor cell invasion into collagen matrix induced by fibroblast-derived hepatocyte growth factor. Oyanagi J, Kojima N, Sato H, Higashi S, Kikuchi K, Sakai K, Matsumoto K, and Miyazaki K Experimental Cell Research 326 267-279 2014
  •  HGF-Met Pathway in Regeneration and Drug Discovery. Matsumoto K, Funakoshi H, Takahashi H, and Sakai K Biomedicines 2 275-300 2014
  •  Lower gefitinib dose led to earlier resistance acquisition before emergence of T790M mutation in EGFR mutated lung cancer model. Hayakawa H, Ichihara E, Ninomiya T, Takata S, Ohashi K, Masayuki Yasugi, Sakai K, Matsumoto K, Takigawa N, Tanimoto M, and Kiura K.  Cancer Science 104 1440-1446 2013
  •  Met/HGF receptor activation is regulated by juxtamembrane Ser985 phosphorylation in hepatocytes. CYTOKINE 62 446-452 2013/04
  •  Oral Administration of a Novel Long-Acting Prostacyclin Agonist With Thromboxane Synthase Inhibitory Activity for Pulmonary Arterial Hypertension. 77 2127-2133 2013/05
  •  α-Lipoic acid-induced inhibition of proliferation and met phosphorylation in human non-small cell lung cancer cells. CANCER LETTERS 335 2 472-478 2013/07
  •  Suppression of fibrogenic gene expression and liver fibrosis using a synthetic prostacyclin agonist. 7. Xu Q, Sakai K, Nakayama M, Suzuki Y, Tambo C, Sakai Y, and Matsumoto K Biomedical research 34 241-250 2013
  •  Hepatocyte growth factor twenty years on: much more than a growth factor Takahiro Nakamura, Katsuya Sakai, Toshikazu Nakamura, Kunio Matsumoto. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY suppl 1 188-202 2011/01
  •  Suppression of acute hepatic injury by a synthetic prostacyclin agonist through hepatocyte growth factor expression. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 302 420-429 2012/02
  •  Hepatocyte growth factor twenty years on: Much more than a growth factor Nakamura, Takahiro;Sakai, Katsuya;Nakamura, Toshikazu;Matsumoto, Kunio JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 26 0 188-202 2011
  •  HGF-Antagonists: Structure, Activities, and Anti-cancer Approach Sakai, Katsuya;Nakamura, Takahiro;Kinoshita, Takayoshi;Nakamura, Toshikazu;Matsumoto, Kunio CURRENT SIGNAL TRANSDUCTION THERAPY 6 2 191-199 2011
  •  Pleural Mesothelioma Instigates Tumor-associated Fibroblasts to Promote Progression via a Malignant Cytokine Network. i Li, Wei Wang, Tadaaki Yamada, Kunio Matsumoto, Katsuya Sakai, Yoshimi Bando, Hisanori Uehara, Yasuhiko Nishioka, Saburo Sone, Shotaro Iwakiri, Kazumi Itoi, Teruhiro Utsugi, Kazuo Yasumoto, Seiji Yano AMERICAN JOURNAL OF PATHOLOGY 179 3 1483-1493 2011/09
  •  HGF-Antagonists: Structure, Activities, and Anti-cancer Approach. Katsuya Sakai, Takahiro Nakamura, Takayoshi Kinoshita, Toshikazu Nakamura, Kunio Matsumoto Current Signal Transduction Therapy 6 2 191-199 2011/05
  •  Anti-Cancer approach with NK4: Bivalent action and mechanisms.  Takahiro Nakamura, Katsuya Sakai, Toshikazu Nakamura, Kunio Matsumoto. Anti-Cancer Agents in Medicinal Chemistry 10 1 36-46 2010/01
  •  Inhibition of Met/HGF receptor and angiogenesis by NK4 Leads to suppression of tumor growth and migration in malignant pleural mesothelioma. Yoshinori Suzuki, Katsuya Sakai, Junko Ueki, Qing Xu, Takahiro Nakamura, Shimada H, Toshikazu Nakamura, Kunio Matsumoto INTERNATIONAL JOURNAL OF CANCER 127 8 1948-1957 2010/10
  •  3-D collagen-dependent cell surface expression of MT1-MMP and MMP-2 activation regardless of integrin β1 function and matrix stiffness Katsuya Sakai, Takahiro Nakamura, Yoshinori Suzuki, Takafumi Imizu, and Kunio Matsumoto BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 412 1 98-103 2011/08
  •  p27 nuclear localization and growth arrest caused by perlecan knockdown in human endothelial cells.  Katsuya Sakai, Kiyomasa Oka, Kunio Matsumoto, Toshikazu Nakamura BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 392 3 403-408 2010/02

Conference Presentations

  • MET受容体の人為制御と活性化の構造基盤(2020/09/15)
  • Peptide-grafted Proteins and Nanometorology for Targeting and Understanding of Growth Factor Receptor(conference:1st WPI NanoLSI-iCeMS Joint Symposium)(2020/01/23)
  • HGF/MET receptor: Approaches using macrocyclic peptides and atomic force microscopy(2019/09/27)
  • Artificial Met receptor agonist based on nonstandard cyclic peptides


Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

○Tumor Biology(2017)
○Tumor Biology(2017)
○Seminar on Tumor Biology(2016)
○Tumor Biology(2016)
○Tumor Biology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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