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Researcher Information

last modified:2019/04/08

Professor KUNISHIMA Munetaka


Faculty, Affiliation

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences Bioorganic Chemistry

College and School Educational Field

Division of Health Sciences, Graduate School of Medical Science
Division of Cardiovascular Medicine, Graduate School of Medical Science
Division of Natural System, Graduate School of Natural Science and Technology
School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences
School of Pharmacy, College of Medical, Pharmaceutical and Health Sciences


Bioorganic Chemistry TEL:076-264-6201 FAX:076-264-6201

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kyoto University  Doctor Completed
Doctor of Pharmaceutical Science


Kobe Gakuin University

Year & Month of Birth


Academic Society


○JSPC Award for Excellence(2018/12/07)
○Astellas award for the best biomedical research 2011 (2012/10/20)
○Astellas award for the best biomedical research 2011 (2012/10/20)


Chemical pharmacy

Speciality Keywords

Research Themes

Development of molecular catalysts and new synthetic methods based on biofunctions

Discovery of effective methods for chemical modification of biomolecules available for elucidation and exploring their function



  •  Phototriggered Ketone Formation from an Aminocyclopropenone and a Carboxylic Acid Mishiro, Kenji; Yushima, Yuki; Kunishima, Munetaka J. Org. Chem. 83 21 13595 2018
  •  An isolable and bench-stable epoxidizing reagent based on triazine: Triazox Kohei Yamada, Yuki Igarashi, Tatsuki Betsuyaku, Masanori Kitamura, Koki Hirata, Kazuhito Hioki, Munetaka Kunishima Org. Lett. 20 7 2015 2018
  •  Development of triazine-based esterifying reagents containing pyridines as a nucleophilic catalyst Yamada, Kohei; Liu, Jie; Kunishima, Munetaka Org. Biomol. Chem. 16 35 6569 2018
  •  Development of radioiodine labeled acetaminophen for specific, high-contrast imaging of malignant melanoma Zhu Wen Jing,  Kobayashi Masato, Yamada Kohei, Nishi Kodai, Takahashi Kotaro, Mizutani Asuka, Nishii Ryuichi, Flores Leo G. II, Shikano Naoto, Kunishima Munetaka, Keiichi Kawai Nuclear Medicine and Biology 59 16 2018
  •  Combination Metabolomics Approach for Identifying Endogenous Substrates of Carnitine/Organic Cation Transporter OCTN1 Masuo Yusuke, Ohba Yuri, Yamada Kohei, Al-Shammari, Aya Hasan Seba Natsumi, Nakamichi Noritaka, Ogihara Takuo, Kunishima Munetaka, Kato Yukio Pharmaceutical Research 35 11 224 2018

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  •  Cooperation of the Neutral and the Cationic Leaving Group Pathways in Acid-Catalyzed O-Benzylation of TriBOTs Hikaru Fujita, Naoko Hayakawa, Munetaka Kunishima J. Org. Chem. 83 17 10684 2018
  •  Imido-substituted triazines as dehydrative condensing reagents for the chemoselective formation of amides in the presence of free hydroxy groups Masanori Kitamura, Suguru Sasaki, Riho Nishikawa, Kohei Yamada, Munetaka Kunishima RCS Adv 8 22482 2018
  •  Triazine-Based Cationic Leaving Group: Synergistic Driving Forces for Rapid Formation of Carbocation Species Hikaru Fujita, Satoshi Kakuyama, Shuichi Fukuyoshi, Naoko Hayakawa, Akifumi Oda, Munetaka Kunishima J. Org. Chem. 83 8 4568 2018
  •  Study of O-Allylation using Triazine-based Reagents Kohei Yamada, Naoko Hayakawa, Hikaru Fujita, Masanori Kitamura, Munetaka Kunishima Chem. Pharm. Bull. 65 112 2017
  •  N,N'-Dimethylated benzyloxytriazinedione: A stable solid reagent for acid-catalyzed O-benzylation  Hikaru Fujita, Satoshi Kakuyama, Munetaka Kunishima Eur. J. Org. Chem. 2017 4 833 2017
  •  Development of triazine-based benzylating reagents possessing t-butyl group on the triazine core: thermally controllable reagents for the initiation of reaction Yukiko Karuo, Kohei Yamada, Munetaka Kunishima Chem. Pharm. Bull. 66 3 303-308 2018/03
  •  Development of highly electron-deficient and less sterically-hindered phosphine ligands possessing 1,3,5-triazinyl groups Kazumi Abe, Masanori Kitamura, Hikaru Fujita, Munetaka Kunishima Mol Cat. 445 87-93 2018/01
  •  Phototriggered Dehydration Condensation Using an Aminocyclopropenone Kenji Mishiro, Yuki Yushima, Munetaka Kunishima Org. Lett. 19 18 4912-4915 2017/09/01
  •  Development of a method for the synthesis of 2,4,5-trisubstituted oxazoles composed of carboxylic acid, amino acid, and boronic acid. K. Yamada, N. Kamimura, M. Kunishima. Beilstein J. Org. Chem. 13 1478-1485 2017/07/27
  •  Mild Amide-Cleavage Reaction Mediated by Electrophilic Benzylation Kohei Yamada, Yukiko Karuo, Yuichi Tsukada, Munetaka Kunishima Chem. Eur. J. 22 39 14042-14047 2016/09/19
  •  Development of a Triazine-Based tert-Butylating Reagent, TriAT-tBu Kohei Yamada, Naoko Hayakawa, Hikaru Fujita, Masanori Kitamura, Munetaka Kunishima Eur. J. Org. Chem. 2016 23 4093-4098 2016/08
  •  Alcohol- and Amine-Tolerant Synthesis of Six-Membered Cyclic Quaternary Ammonium Salts by Using a Triazine-Based Reagent Masanori Kitamura, Seina Yamamura, Kohei Yamada, Munetaka Kunishima Asian J. Org. Chem.  5 1508 2016
  •  Development of Acid-Catalyzed Fluorous Benzylating Reagents Based on a Triazinedione Core Munetaka Kunishima, Ryohei Asao, Kohei Yamada, Masanori Kitamura, Hikaru Fujita J. Fluor. Chem. 190 68-74 2016/10
  •  Role of Linkers in Tertiary Amines That Mediate or Catalyze 1,3,5-Triazine-Based Amide-Forming Reactions Masanori Kitamura, Fumitaka Kawasaki, Kouichi Ogawa, Shuichi Nakanishi, Hiroyuki Tanaka, Kohei Yamada, Munetaka Kunishima J. Org. Chem. 79 8 3709-3714 2014/04/18
  •  Potent triazine-based dehydrocondensing reagents substituted by an amido group Munetaka Kunishima, Daiki Kato, Nobu Kimura, Masanori Kitamura, Kohei Yamada, Kazuhito Hioki Beilstein J. Org. Chem. 12 1897–1903 2016/08/24
  •  Study of 1,3,5-Triazine-Based Catalytic Amide-Forming Reactions: Effect of Solvents and Basicity of Reactants Kunishima, Munetaka;Kitamura, Masanori;Tanaka, Hiroyuki;Nakakura, Ichiro;Moriya, Takahiro;Hioki, Kazuhito CHEMICAL & PHARMACEUTICAL BULLETIN 61 8 882-886 2013/08/01 
  •  Development of a New Benzylating Reagent Spontaneously Releasing Benzyl Cation Equivalents at Room Temperature Kohei Yamada, Yuichi Tsukada, Yukiko Karuo, Masanori Kitamura, Munetaka Kunishima Chem. Eur. J. 20 38 12274-12278 2014/09/15
  •  O-Benzylation of carboxylic acids using 2,4,6-tris(benzyloxy)-1,3,5-triazine (TriBOT) under acidic or thermal conditions. Kohei Yamada, Saki Yoshida, Hikaru Fujita, Masanori Kitamura, Munetaka Kunishima Eur. J. Org. Chem. 36 7997-8002 2015/12
  •  Study of the reactivities of acid-catalyzed O-benzylating reagents based on structural isomers of 1,3,5-triazine. Hikaru Fujita, Naoko Hayakawa, and Munetaka Kunishima J. Org. Chem. 80 21 11200-11205 2015/10/12
  •  4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium Chloride Masanori Kitamura, Munetaka Kunishima e-EROS Encyclopedia of Reagents for Organic Synthesis 2013/04
  •  Binding of sulforhodamine B to human serum albumin: A spectroscopic study Masanori Kitamura, Koji Murakami, Kohei Yamada, Keiichi Kawai, Munetaka Kunishima DYES AND PIGMENTS 99 3 588-593 2013/12/21
  •  A Practical Method for p-Methoxybenzylation of Hydroxy Groups Using 2,4,6-Tris(p-methoxybenzyloxy)-1,3,5-triazine (TriBOT-PM) Kohei Yamada, Hikaru Fujita, Masanori Kitamura, Munetaka Kunishima Synthesis  45 21 2989-2997 2013/11
  •  Synthesis of pyrrolidinium salts using a triazine-based reagent under mild conditions Kitamura, Masanori; Yamamura, Seina; Kobayashi, Hiroko; Yamamoto, Mariko; Tada, Kayo; Hioki, Kazuhito; Yamada, Kohei; Kunishima, Munetaka Chemistry Letters 43 10 1593-1595 2014/10/05 
  •  A Novel Acid-Catalyzed O‐Benzylating Reagent with the Smallest Unit of Imidate Structure ORGANIC LETTERS 14 19 907 2012/10
  •  A new method using 2-chloro-4,6-dimethoxy-1,3,5-triazine for facile elimination of dimethylamino group in Eschenmoser’s methylenation for synthesis of a,b-unsaturated esters TETRAHEDRON LETTERS 54 13 1758 2013/03/27
  •  Specific labeling of streptavidin for better understanding of ligand modification in modular method for affinity labeling (MoAL) Kunishima, Munetaka; Kato, Daiki; Nakanishi, Shuichi; Kitamura, Masanori; Yamada, Kohei; Terao, Keiji; Asano, Tomoya Chemical and Pharmaceutical Bulletin 62 11 1146-1150 2014/11/01 
  •  Synthesis and evaluation of iodinated cyclopropanecarboxylic acid {3-[6-(phenylamino)-pyrimidin-4-ylamino]-phenyl}-amides as EGFR-TK imaging agents Yoshimoto, Mitsuyoshi;Kimura, Sadaaki;Yamada, Kohei;Hirata, Masahiko;Ohmomo, Yoshiro;Kunishima, Munetaka;Kawai, Keiichi;Fujii, Hirofumi JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 56 0 S373-S373 2013 
  •  One-Pot Preparation of Oxazol-5(4H)-ones from Amino Acids in Aqueous Solvents Fujita, Hikaru;Kunishima, Munetaka CHEMICAL & PHARMACEUTICAL BULLETIN 60 7 907-912 2012
  •  Substrate-Selective Dehydrocondensation at an Interface of Micelles and Emulsions of Common Surfactants ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 51 9 2080 2012/02
  •  N-Isopropyl-p-iodoamphetamine Hydrochloride (IMP) is Predominantly Metabolized by CYP2C19 DRUG METABOLISM AND DISPOSITION 40 5 843 2012/05
  •  One-Pot Preparation of Oxazol-5(4H)-ones from Amino Acids in Aqueous Solvents CHEMICAL & PHARMACEUTICAL BULLETIN 60 7 907 2012/07
  •  Study on 1,3,5-Triazine Chemistry in Dehydrocondensation: Gauche Effect on the Generation of Active Triazinylammonium Species CHEMISTRY-A EUROPEAN JOURNAL 18 15856 2012/10
  •  Labeling study of avidin by modular method for affinity labeling (MoAL). Nakanishi S,Tanaka H,Hioki K,Yamada K,Kunishima M BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20 23 7050-3 2010/10
  •  Convenient modular method for affinity labeling (MoAL method) based on a catalytic amidation. Kunishima M,Nakanishi S,Nishida J,Tanaka H,Morisaki D,Hioki K,Nomoto H CHEMICAL COMMUNICATIONS 37 5597-9 2009/08
  •  New approach to oligotriazoles using a cobalt complex of propargyl azides as a synthetic component Yuichi Tsukada, Kohei Yamada, and Munetaka Kunishima Tetrahedron Lett. 52 3358-60 2011/05
  •  Unusual Rate Enhancement of Bimolecular Dehydrocondensation Forming Amides at the Interface of Micelles of Fatty Acid Salt M. Kunishima, H. Imada, K. Kikuchi, K. Hioki, J. Nishida, S. Tani Angew. Chem. Int. Ed 44 7254-7257 2005/11
  •  Primary-Amine-Specific Lactamization of -Amino Acids by an Artificial Cyclotransferase Based on [18]Crown-6 M. Kunishima, K. Hioki, T. Moriya, J. Morita, T. Ikuta, S. Tani Angew. Chem. Int. Ed. 45 1252-55 2006/02
  •  Spontaneous membrane fusion induced by chemical formation of ceramides in a lipid bilayer. Kunishima M,Tokaji M,Matsuoka K,Nishida J,Kanamori M,Hioki K,Tani S J Am Chem Soc 128 45 14452-3 2006/11
  •  A Study on Medicinal Plants from Malaysia Focused on Acalypha siamensis OLIV. ex GAGE. Isolation and Structure of a New Tetraterpene, Acalyphaser A. H. Kambara, T. Yamada, M. Tsujioka, S. Matsunaga, R. Tanaka, H. I. Ali, C. Wiart, M. Yusof, H. Hassan, A. Hanifah, Z. M. Fauzi, N. H. Mazlan, M. Jay, M. Kunishima, E. Akaho Chem. Biodiver 3 1301-6 2006/05
  •  Development of Chlorotriazine Polymer Dehydrocondensing Reagents (Poly-Trzs)  M. Kunishima, K. Yamamoto, K. Hioki, T. Kondo, M. Hasegawa, S. Tani Tetrahedron 63 2604-12 2007/03
  •  Immobilized Triazine-type Dehydrocondensing Reagents for Carboxamide Formation: ROMP-Trz-Cl and ROMP(OH)-Trz-Cl K. Hioki, S. Kameyama, S. Tani, M. Kunishima Chem. Pharm. Bull. 55 825-8 2007/05
  •  Convenient one-pot synthesis of 2-oxazolines from carboxylic acids. Hioki K,Takechi Y,Kimura N,Tanaka H,Kunishima M Chem Pharm Bull (Tokyo) 56 12 1735-7 2008/12
  •  Direct Preparation of Primary Amides by Reaction of Carboxylic Acids and Ammonia in Alcohols Using DMT-MM T. Mizuhara, K. Hioki, M. Yamada, H. Sasaki, D. Morisaki, M. Kunishima Chem Lett. 37 12 1190-91 2008/12

Conference Presentations

Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「二本鎖脂質分子の膜内での化学合成によって誘起される膜の形態変化に関する研究 」(2006-2007) 
○「ホスト化合物を利用した人工アシル基転移酵素モデルの開発とその応用 」(2002-2004) 

Classes (Bachelors)

○Lecture on Life in Campus and Society(2018)
○Graduation Research in Pharmacy 2(2018)
○Graduation Research in Pharmacy 1(2018)
○Graduation Research in Pharmaceutical Sciences 2(2018)
○Graduation Research in Pharmaceutical Sciences 1(2018)
○Laboratory Rotation 3(2018)
○Laboratory Rotation 1(2018)
○Experiments in Organic Chemistry(2018)
○Seminar in Pharmaceutical Sciences(2018)
○Presentation and Debate (Freshman Seminar II)(2018)
○Graduation Research in Pharmacy 4(2018)
○Graduation Research in Pharmacy 3(2018)
○Introduction to Region-studies(2018)
○Organic Chemistry 1(2018)
○Biology and Organic Chemistry(2018)
○Seminar in Pharmacy 1(2018)
○Experiments in Organic Chemistry(2017)
○Organic Chemistry 1(2017)
○Biology and Organic Chemistry(2017)
○Lecture on Life in Campus and Society(2017)
○Organic Chemistry 1(2016)
○Lecture on Life in Campus and Society(2016)
○Biology and Organic Chemistry(2016)
○Laboratory Rotation 1(2016)
○Experiments in Organic Chemistry(2016)

Classes (Graduate Schools)

○Learning Recent Advancement in Pharmaceutical Sciences(2018)
○Interdisciplinary Seminar(2018)
○Pharmaceutical Research Practice II(2018)
○Pharmaceutical Research Practice I(2018)
○Pharmaceutical Sciences Practice II(2018)
○Advanced Course of Pharmachemistry(2018)
○Pharmaceutical Sciences Practice I(2018)
○Advanced Seminar on Pharmachemistry(2018)
○Advanced Course of Organic Chemistry(2018)
○Research Training in Pharmaceutical Sciences(2018)
○Introduction to Discovering Molecular Probes(2018)
○Bioorganic Chemistry(2017)
○Advanced Seminar on Pharmachemistry(2017)
○Organic Chemistry Focused on Biological Functions(2017)
○Advanced Course of Organic Chemistry(2017)
○Advanced Organic Chemistry III(2017)
○Advanced Pharmacognosy(2017)
○Advanced Organic Chemistry IV(2017)
○Advanced Course of Pharmachemistry(2017)
○Bioorganic Chemistry(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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