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Researcher Information

last modified:2018/06/06

Associate Professor MATSUSHITA, Takashi

Mail Laboratory Website

Faculty, Affiliation

University Hospital

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Cardiovascular Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

 TEL:076-265-2342 FAX:076-234-4270

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor 200603 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 199903

Career

Duke University, Department of Immunology(2007/04/01-)
金沢大学大学院医学系研究科(2010/04/01-)

Year & Month of Birth

1974/06

Academic Society






Award














Specialities

Dermatology

Speciality Keywords

Research Themes

Systemic sclerosis

Regulatory B cell

Cytokine

Books

  •  Identifying Regulatory B Cells (B10 cells) That Produce IL-10 In Mice.  677 99-111 2011/02

Papers

  •  A novel splenic B1 regulatory cell subset suppresses an allergic disease via PI3K-Akt pathway activation. Matsushita T, et al J Allergy Clin Immunol. 138 4 1170-1182 2016/04
  •  Characterization of a Rare IL-10-Competent B Cell Subset in Man That Parallels Mouse Regulatory B10 Cells. Iwata Y*, Matsushita T*, Horikawa, DiLillo, Yanaba, Venturi, Szabolcs, Bernstein, Magro, Williams, Hall, St.Clair, and Tedder TF (*equal contribution) BLOOD 117 530-41 2011/01
  •  Regulatory B Cells (B10 Cells) and Regulatory T Cells Have Independent Roles in Controlling Experimental Autoimmune Encephalomyelitis Initiation and Late-Phase Immunopathogenesis. Matsushita T, Horikawa M, Iwata Y, Tedder TF JOURNAL OF IMMUNOLOGY 185 2240-2252 2010/05
  •  Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression.  Matsushita T, Yanaba K, Bouaziz JD, Fujimoto M, Tedder TF JOURNAL OF CLINICAL INVESTIGATION 118 3420-30 2008/10
  •  BAFF Antagonist Attenuates the Development of Skin Fibrosis in Tight-Skin Mice. Matsushita T, Fujimoto M, Hasegawa M, Matsushita Y, Komura K, Ogawa F, Watanabe R, Takehara K, Sato S. JOURNAL OF INVESTIGATIVE DERMATOLOGY 127 2772-80 2007/10

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  •  Elevated Serum BAFF Levels in Patients with Systemic Sclerosis (SSc): Enhanced BAFF Signaling in SSc B Lymphocytes. Matsushita T, Hasegawa M, Yanaba K, Kodera M, Takehara K, Sato S ARTHRITIS AND RHEUMATISM 54 192-201 2006/02
  •  Inhibitory Role of CD19 in the Progression of Experimental Autoimmune Encephalomyelitis by Regulating Cytokine Response. Matsushita T, Fujimoto M, Hasegawa M, Komura K, Takehara K, Tedder TF, Sato S AMERICAN JOURNAL OF PATHOLOGY 168 812-21 2006/08
  •  A novel splenic B1 regulatory cell subset suppresses an allergic disease via PI3K-Akt pathway activation.  Matsushita T, Le Huu D, Kobayashi T, Hamaguchi Y, Hasegawa M, Naka K, Hirao A, Muramatsu M, Takehara K, Fujimoto M J Allergy Clin Immunol.  138 4 1170-1182 2016
  •   Decreased Levels of Regulatory B cells in Patients with Systemic Sclerosis: Association with autoantibody production and disease activity.  Matsushita T, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M Rheumatology (Oxford). 55 2 263-7 2016
  •  Scleroderma: recent lessons from murine models and implications for future therapeutics. Matsushita T, et al.  Expert Review of Dermatology in press 2013/10
  •  Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease.  Le Huu D, Matsushita T (corresponding author), et al.  BLOOD 121 3274-3283 2013/01
  •  FTY720 ameliorates murine Scl-cGVHD by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin.  Le Huu D, Matsushita T (corresponding author), et al ARTHRITIS AND RHEUMATISM 65 1624-1635 2013/01
  •  IL-6 blockade attenuates the development of murine sclerodermatous chronic graft-versus-host disease. Le Huu D, Matsushita T (corresponding author), et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY 132 2752-2761 2012/01

Conference Presentations

  • A unique CD9+CD80+ regulatory B cell inhibits contact hypersensitivity response.(conference: JSID 2016)
  • A novel splenic B1 regulatory B cell subset with a unique CD9+CD80+ phenotype suppresses an allergic disease via PI3K-Akt pathway activation. (conference:ESDR 2016)(2016)

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「全身性強皮症におけるEffector B細胞の役割についての検討」(2017-2019) 
○「強皮症モデルマウスにおけるサイトカイン産生B細胞の役割」(2016-) 
○「全身性強皮症ならびに強皮症モデルマウスにおけるSyk阻害剤の有効性の検討」(2014-2016) 
○「全身性強皮症におけるregulatory B細胞の機能解析および新規治療法の開発」(2013-2015) 
○「制御性B細胞におけるPI3Kシグナルによる制御機構の解析」(2011-2012) 
○「全身性強皮症患者および線維化モデルマウスにおける制御性B細胞の解析」(2011-2013) 
○「Sclerodermatous GVHDマウスにおける制御性B細胞の役割」(2010-2010) 
○「BAFFアンタゴニストによる強皮症モデルマウスの治療」(2006-2007) 

Classes (Bachelors)

Classes (Graduate Schools)

○Angiogenesis and Connective Tissue Metabolism(2017)
○Angiogenesis and Connective Tissue Metabolism(2017)
○Angiogenesis and Connective Tissue Metabolism(2016)
○Angiogenesis and Connective Tissue Metabolism(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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