last modified：2022/05/30
Associate Professor HARADA Shin-ichi
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Center for Biomedical Research and Education TEL:076-265-2138 FAX:076-234-4209
Academic Background
【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine 1995 Completed
Career
Year & Month of Birth
1964/08
Academic Society
Award
Specialities
Neurochemistry/Neuropharmacology
Speciality Keywords
Neurotaransmission, Neurodegeneration, Neuroprotection
Research Themes
Molecular mechanisms of synaptic transmission
Research on Biological Effects of Extremely Low Frequency High Magnetic Fields
Regulation of alternative splicing of receptor for advanced glycation endproducts
Books
Papers
- A possible role of cytokines in the formation of peritoneal dissemination INTERNATIONAL JOURNAL OF ONCOLOGY 11 349-358 1997
- Functional properties of the unc-64 gene encoding a Caenorhabditis elegans syntaxin J. Biol. Chem. 273 4 2192-2198 1998/01
- Placenta growth factor (PlGF) mRNA expression in brain tumors JOURNAL OF NEURO-ONCOLOGY 40 2 123-130 1998/11
- Regulation of the UNC-18-Caenorhabditis elegans Syntaxin Complex by UNC-13 J. Neurosci. 19 12 4772-4777 1999/06
- Antisense display - a method for functional gene screening: evaluation in a cell-free system and isolation of angiogenesis-related genes NUCLEIC ACIDS RESEARCH 27 13 2591-2600 1999/07
- Effects of high ELF magnetic fields on enzyme-catalyzed DNA and RNA synthesis in vitro and on a cell-free DNA mismatch repair BIOELECTROMAGNETICS 22 4 260-266 2001/05
- Exposure of Caenorhabditis elegans to extremely low frequency high magnetic fields induces stress responses BIOELECTROMAGNETICS 22 5 333-339 2001/07
- Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75. Yokoyama K, Fukumoto K, Murakami T, Harada S, Hosono R, Wadhwa R, Mitsui Y, Ohkuma S. FEBS LETTERS 516 1-3 53-57 2002/10
- Expression of vascular endothelial growth factor D is associated with lymph node metastasis in human colorectal carcinoma. Hiroshi Funaki, Genichi Nishimura, Shin-ichi Harada, Itasu Ninomiya, Itsuro Terada, Sachio Fushida, Takashi Tani, Takashi Fujimura, Masato Kayahara, Koichi Shimizu, Tetsuo Ohta, Koichi Miwa ONCOLOGY 64 416-422 2003
- Role of Caenorhabditis elegans protein phosphatase type 1, CeGLC-7 beta, in metaphase to anaphase transition during embryonic development. Toshihiro Sassa, Hiroko Ueda-Ohba, Kei-ichiro Kitamura, Shin-ichi Harada and Ryuji Hosono EXPERIMENTAL CELL RESEARCH 287 2 350-360 2003/07
- Neuronal organization of the rat inferior colliculus participating in four major auditory pathways. Okoyama S, Ohbayashi M, Ito M, Harada S HEARING RESEARCH 218 1-2 72-80 2006/08
- Chemoprevention of glandular stomach carcinogenesis through duodenogastric reflux in rats by a COX-2 inhibitor. Oba M, Miwa K, Fujimura T, Harada S, Sasaki S, Hattori T. INTERNATIONAL JOURNAL OF CANCER 123 7 1491-1498 2008/10
- A selective cyclooxygenase-2 inhibitor prevents inflammation-related squamous cell carcinogenesis of the forestomach via duodenogastric reflux in rats. CANCER 115 2 454-464 2009/01
- Local angiotensin II-generation in human gastric cancer: correlation with tumor progression through the activation of ERK1/2, NF-kappaB and survivin. Kinoshita J, Fushida S, Harada S, Yagi Y, Fujita H, Kinami S, Ninomiya I, Fujimura T, Kayahara M, Yashiro M, Hirakawa K, Ohta T INTERNATIONAL JOURNAL OF ONCOLOGY 34 6 1573-1582 2009/06
- PSK enhances the efficacy of docetaxel in human gastric cancer cells through inhibition of nuclear factor-kappaB activation and survivin expression. INTERNATIONAL JOURNAL OF ONCOLOGY 36 3 593-600 2010/03
- Tumor-derived trypsin enhances proliferation of intrahepatic cholangiocarcinoma cells by activating protease-activated receptor-2. Nakanuma S, Tajima H, Okamoto K, Hayashi H, Nakagawara H, Onishi I, Takamura H, Kitagawa H, Fushida S, Tani T, Fujimura T, Kayahara M, Ohta T, Wakayama T, Iseki S, Harada S INTERNATIONAL JOURNAL OF ONCOLOGY 36 4 793-800 2010/04
- Regulation of alternative splicing of the receptor for advanced glycation endproducts (RAGE) through G-rich cis-elements and heterogenous nuclear ribonucleoprotein H. JOURNAL OF BIOCHEMISTRY 147 5 651-659 2010/05
- Biodistribution of humanized anti-VEGF monoclonal antibody/bevacizumab on peritoneal metastatic models with subcutaneous xenograft of gastric cancer in mice. Yagi Y, Fushida S, Harada S, Tsukada T, Kinoshita J, Oyama K, Fujita H, Ninomiya I, Fujimura T, Kayahara M, Kinuya S, Yashiro M, Hirakawa K, Ohta T CANCER CHEMOTHERAPY AND PHARMACOLOGY 66 4 745-753 2010/09
- Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 29 1 149-159 2010/11
- Role of transcription factors in small intestinal ischemia-reperfusion injury and tolerance induced by ischemic preconditioning. TRANSPLANTATION PROCEEDINGS 42 9 3406-3413 2010/11
- Angiotensin II induces tumor progression and fibrosis in intrahepatic cholangiocarcinoma through an interaction with hepatic stellate cells. Okamoto K, Tajima H, Ohta T, Nakanuma S, Hayashi H, Nakagawara H, Onishi I, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Tani T, Fujimura T, Kayahara M, Harada S, Wakayama T, Iseki S INTERNATIONAL JOURNAL OF ONCOLOGY 37 5 1251-1259 2010/11
- Adiponectin receptor-1 expression is associated with good prognosis in gastric cancer. Tsukada T, Fushida S, Harada S, Terai S, Yagi Y, Kinoshita J, Oyama K, Tajima H, Fujita H, Ninomiya I, Fujimura T, Ohta T. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 11 30 107-118 2011/11
- Sodium valproate blocks the transforming growth factor (TGF)-β1 autocrine loop and attenuates the TGF-β1-induced collagen synthesis in a human hepatic stellate cell line. Watanabe T, Tajima H, Hironori H, Nakagawara H, Ohnishi I, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Tani T, Fujimura T, Ota T, Wakayama T, Iseki S, Harada S. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 28 6 919-925 2011/12
- Gene amplification of ESR1 in breast cancers - Fact or fiction? A fluorescence in situ hybridization and multiplex ligation-dependent probe amplification study. JOURNAL OF PATHOLOGY 227 1 6-16 2012/01
- Valproic acid, a histone deacetylase inhibitor, enhances radiosensitivity in esophageal squamous cell carcinoma. Shoji M, Ninomiya I, Makino I, Kinoshita J, Nakamura K, Oyama K, Nakagawara H, Fujita H, Tajima H, Takamura H, Kitagawa H, Fushida S, Harada S, Fujimura T, Ohta T. INTERNATIONAL JOURNAL OF ONCOLOGY 40 6 2140-2146 2012/06
- Angiotensin II enhances epithelial-to-mesenchymal transition through the interaction between activated hepatic stellate cells and the stromal cell-derived factor-1/CXCR4 axis in intrahepatic cholangiocarcinoma. Okamoto K, Tajima H, Nakanuma S, Sakai S, Makino I, Kinoshita J, Hayashi H, Nakamura K, Oyama K, Nakagawara H, Fujita H, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Fujimura T, Harada S, Wakayama T, Iseki S, Ohta T. INTERNATIONAL JOURNAL OF ONCOLOGY 41 2 573-582 2012/08
- The role of human peritoneal mesothelial cells in the fibrosis and progression of gastric cancer. Tsukada T, Fushida S, Harada S, Yagi Y, Kinoshita J, Oyama K, Tajima H, Fujita H, Ninomiya I, Fujimura T, Ohta T. INTERNATIONAL JOURNAL OF ONCOLOGY 41 2 476-482 2012/08
- Low-dose paclitaxel modulates tumour fibrosis in gastric cancer. Tsukada T, Fushida S, Harada S, Terai S, Yagi Y, Kinoshita J, Oyama K, Tajima H, Ninomiya I, Fujimura T, Ohta T. INTERNATIONAL JOURNAL OF ONCOLOGY 42 4 1167-1174 2013/04
- Validated Liquid Culture Monitoring System for Lifespan Extension of Caenorhabditis elegans through Genetic and Dietary Manipulations. Win MT, Yamamoto Y, Munesue S, Han D, Harada S, Yamamoto H. Aging and Disease 4 4 178-185 2013/06
- Advantages of the rapid double-staining method for intraoperative detection of micrometastasis in sentinel lymph nodes. Ojima T, Kinami S, Nakamura K, Oyama K, Inokuchi M, Fujita H, Ninomiya I, Fushida S, Fujimura T, Kitamura S, Harada S, Ohta T. ONCOLOGY REPORTS 30 3 1067-1072 2013/07
Conference Presentations
Others
- Exposure of Caenorhabditis elegans to Extremely Low Frequency High Magnetic Fields Induces Stress Responses. Miyakawa, T., Yamada, S., Harada, S., Ishimori, T., Yamamoto, H. and Hosono, R. 22 5 333-339 2001
- Essential role for nuclear factor kappaB in ischemic preconditioning for ischemia-reperfusion injury of the mouse liver. Funaki, Hiroshi; Shimizu, Koichi; Harada, Shin-ichi; Tsuyama, Hiroshi; Fushida, Sachio; Tani, Takashi; Miwa, Koichi 2002/08
- Effect of porto-systemic shunting on NOS expression after extended hepatectomy in rats. Hayashi H, Shimizu K, Tani T, Takamura H, Takeshita M, Nakamura K, Ninomiya I, Fushida S, Harada S, Kayahara M. 39 1 78-85 2009/01
- A selective cyclooxygenase-2 inhibitor prevents inflammation-related squamous cell carcinogenesis of the forestomach via duodenogastric reflux in rats Oba M, Miwa K, Fujimura T, Harada S, Sasaki S, Oyama K, Ohta T, Hattori T 115 2 454-464 2009/01
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「シナプス終末で働く遺伝子群の共役的発現制御機構の解明」(1998-)
○「シナプス終末で働く遺伝子群の共役的発現制御機構の解明」(1999-)
○「sec遺伝子による新たなシナプス伝達制御機構の解明」(2000-)
○「sec遺伝子による新たなシナプス伝達制御機構の解明」(2001-)
○「Exocyst複合体を介した新たなシナプス伝達制御機構の解明」(2003-)
○「生体内特定活動ニューロンをモニターするベクター系の開発」(1999-)
○「Exocyst複合体を介した新たなシナプス伝達制御機構の解明」(2002-)
○「胃癌腹膜転移における診断法の開発とアンギオテンシン系を介した線維化機構とその制御」(2005-)
○「神経系における低周波交流磁界刺激感受メカニズムの解明」(2005-)
○「胃癌腹膜転移における診断法の開発とアンギオテンシン系を介した線維化機構とその制御」(2006-)
○「神経系における低周波交流磁界刺激感受メカニズムの解明」(2006-)
○「胃癌腹膜播種におけるTGFβおよびアンギオテンシン系を介した分子標的治療の開発」(2007-2008)
○「マイクロ駆動機構を持つ針状磁気抵抗効果プローブによる低侵襲・非破壊計測の開発」(2010-2013)
○「腹膜播種発生に関わる腹膜中皮細胞の間葉系形質転換と造腫瘍性についての実験的検討」(2010-2013)
Competitive research funding,Contribution
Collaborative research,Consignment study
○Development of low invasive diagnostic bio-chips(2003-2006)