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Researcher Information

last modified:2017/04/01

Professor HORI Osamu


Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Neuroscience, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences


Department of Neuroanatomy TEL:076-265-2162 FAX:076-234-4222

Academic Background

【Academic background(Bachelor's Degree)】
Osaka University 198903


Year & Month of Birth


Academic Society

Japan Neuroscience Society



Nerve anatomy/Neuropathology

Speciality Keywords

glia, neuronal death, stress response

Research Themes

Stress Response of Cells in Central Nervous System

Development of neuronal cell protecting drugs and anti-stress drugs



  •  Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease JOURNAL OF CELL BIOLOGY 157 1151-1160 2002/06
  •  SERP1/RAMP4 stabilizes membrane proteins during stress and facilitates subsequent glycosylation. JOURNAL OF CELL BIOLOGY 147 1195-1204 1999/12
  •  ORP150 protects against hypoxia/ischemia-induced neuronal death. NATURE MEDICINE 7 317-323 2001/12
  •  Role of Herp in the endoplasmic reticulum stress response. GENES TO CELLS 9 5 457-469 2004/05
  •  Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress. MOLECULAR AND CELLULAR BIOLOGY 26 2006

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  •  Does ORP150/HSP12A protect dopaminergic neurons against MPTP/MPP(+)-induced neurotoxicity? 9, 589-595 2007
  •  Methoxyflavones protect cells against endoplasmic reticulum (ER) stress and neurotoxin. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 292 1, C353-C361 2007
  •  Vaticanol B, a resveratrol tetramer, regulates endoplasmic reticulum (ER) stress and inflammation. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 293 1  C411-8 2007
  •  A dibenzoylmethane (DBM) derivative protects dopaminergic neurons against both oxidative stress and endoplamic reticulum (ER) stress. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 293 6, C1884-94 2007
  •  Inactivation of brain mitochondrial Lon protease by peroxynitrite precedes electron transport chain dysfunction. NEUROCHEMISTRY INTERNATIONAL 2008

Conference Presentations

Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Classes (Bachelors)

○Basic Health Science(2016)
○Human Embryology(2016)
○Extended Exercise for Basic Medical Sciences(2016)
○Presentation and Debate (Freshman Seminar II)(2016)
○Freshman Seminar I(2016)

Classes (Graduate Schools)

○Medical Sciences(2016)
○Molecular Targeting in the Central Nervous System(2016)
○Recent Advance in Medicine(2016)
○Principles of Anatomy(2016)
○Seminar on Up-to-Date(2016)
○Molecular Targeting in the Central Nervous System(2016)
○Cancer Medicine Up-Todate(2016)
○Neuroscience Up-To-Date(2016)
○Recent Advance in Medicine(2016)
○Molecular Targeting in the Central Nervous System(2016)
○Recent Advance in Cancer Medicine(2016)
○Environmental Science Up-To-Date(2016)
○Recent Advance in Cardiovascular Medicine(2016)
○Cardiovascular Medicine Up-To-Date(2016)
○Recent Advance in Environmental Science(2016)
○Recent Advance in Neuroscience(2016)
○Seminar on Up-to-Date(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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