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Researcher Information

last modified:2019/06/22

Assistant Professor UENO, Masaya

Mail

Faculty, Affiliation

Cancer Research Institute Cancer Research Institute, Division of Molecular Genetics

College and School Educational Field


Laboratory

Academic Background

Career

UCLA(2011/04/01-2013/09/30)
UCLA(2009/04/01-2011/03/31)
Osaka University(2006/04/01-2009/03/31)
Cancer Research Institute, Kanazawa University(2001/05/01-2006/03/31)

Year & Month of Birth

1973/04

Academic Society



Award


Specialities

Developmental biology

Speciality Keywords

Developmental hematology, Leukemia, Placental development

Research Themes

Understanding of molecular mechanisms regulates drug-resistance in leukemia

Books

Papers

  •  Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells. Peng H*, Kasada A*, Ueno M*, Hoshii T, Tadokoro Y, Nomura N, Ito C, Takase Y, Vu HT, Kobayashi M, Xiao B, Worley PF, Hirao A (* co-first authors). Biochem Biophys Res Commun. 2017
  •  Hes1 suppresses acute myeloid leukemia development through FLT3 repression. Kato T, Sakata-Yanagimoto M, Nishikii H, Ueno M, Miyake Y, Yokoyama Y, Asabe Y, Kamada Y, Muto H, Obara N, Suzukawa K, Hasegawa Y, Kitabayashi I, Uchida K, Hirao A, Yagita H, Kageyama R, Chiba S. Leukemia 2015
  •  c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface. Ueno M, Lee LK, Chhabra A, Kim YJ, Sasidharan R, Van Handel B, Wang Y, Kamata M, Kamran P, Sereti KI, Ardehali R, Jiang M, Mikkola HK. Dev Cell 2013
  •  Essential role of endothelial class II PI3K-C2alpha in angiogenesis and vascular barrier function. Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, OkamotoY, Du W, Qi X, Asanuma K, Sugihara K, Aki S, Miyazawa H, Biswas K, Nagakura C, Ueno M, Iseki S, Schwartz RJ, Okamoto H, Sasaki T, Matsui O, Asano M, Adams RH, Takakura N, Takuwa Y. Nat Med 2012
  •  Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling.  Chhabra A, Lechner AJ, Ueno M, Acharya A, Van Handel B, Wang Y, Iruela-Arispe ML, Tallquist MD, Mikkola HK. Dev Cell 2012

show all

  •  Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression. Ali MAE, Fuse K, Tadokoro Y, Hoshii T, Ueno M, Kobayashi M, Nomura N, Vu HT, Peng H, Hegazy AM, Masuko M, Sone H, Arai F, Tajima A, Hirao A. Sci Rep. 2017
  •  Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance. Hegazy AM, Yamada D, Kobayashi M, Kohno S, Ueno M, Ali MA, Ohta K, Tadokoro Y, Ino Y, Todo T, Soga T, Takahashi C, Hirao A. J Biol Chem. 2016
  •  Association of a murine leukaemia stem cell gene signature based on nucleostemin promoter activity with prognosis of acute myeloid leukaemia in patients. Ali MA, Naka K, Yoshida A, Fuse K, Kasada A, Hoshii T, Tadokoro Y, Ueno M, Ohta K, Kobayashi M, Takahashi C, Hirao A. Biochem Biophys Res Commun. 2014
  •  Loss of Tsc1 accelerates malignant gliomagenesis when combined with oncogenic signals. Yamada D, Hoshii T, Tanaka S, Hegazy AM, Kobayashi M, Tadokoro Y, Ohta K, Ueno M, Ali MA, Hirao A. J Biochem. 2014
  •  Requirement of SLD5 for early embryogenesis. Mohri T*, Ueno M*, Nagahama Y, Gong ZY, Asano M, Oshima H, Oshima M, Fujio Y, Takakura N (*co-first authors). PLoS One. 2013
  •  Up-regulation of PSF1 promotes the growth of breast cancer cells. Nakahara I, Miyamoto M, Shibata T, Akashi-Tanaka S, Kinoshita T, Mogushi K, Oda K, Ueno M, Takakura N, Mizushima H, Tanaka H, Ohta T. Genes Cells. 2010
  •  Hematopoietic stem cell development in the placenta. Gekas C, Rhodes KE, Vanhandel B, Chhabra A, Ueno M, Mikkola HK. Int J Dev Biol. 2010
  •  Placenta as a newly identified source of hematopoietic stem cells.  Lee L, Ueno M, Van Handel BJ, Mikkola HK. Curr Opin Hematol.  2010
  •  Cell populations with high levels of PSF1 transcriptional activity exhibit high tumorigenic and metastatic capacity in a mouse xenograft model. Nagahama Y, Ueno M, Miyamoto S, Morii E, Minami T, Mochizuki N, Saya H, Takakura N.  Cancer Res. 2010
  •  PSF3 marks malignant colon cancer and has a role in cancer cell proliferation. Nagahama Y, Ueno M, Haraguchi N, Mori M, Takakura N. Biochem Biophys Res Commun. 2010
  •  Identification and characterization of stem cell-specific transcription of PSF1 in spermatogenesis. Han Y, Ueno M, Nagahama Y, Takakura N. Biochem Biophys Res Commun.  2009
  •  Both alleles of PSF1 are required for maintenance of pool size of immature hematopoietic cells and acute bone marrow regeneration. Ueno M, Itoh M, Sugihara K, Asano M, Takakura N. Blood 2008
  •  Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis. Kidoya H, Ueno M, Yamada Y, Mochizuki N, Nakata M, Yano T, Fujii R, Takakura N. EMBO J. 2008
  •  Involvement of MDR1 Function In Proliferation of Tumor Cells. Katoh SY, Ueno M, Takakura N. J Biochem. 2008
  •  EphB4 overexpression on B16 melanoma cells affects arterial-venous patterning in tumor angiogenesis. Huang X, Yamada Y, Kidoya K, Naitoh H, Nagahama Y, Kong L, Katoh S, Ueno M, Takakura N. Cancer Res. 2007
  •  Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration. Ishida Y, Kimura A, Kondo T, Hayashi T, Ueno M, Takakura N, Matsushima K, Mukaida N. Am J Pathol. 2007
  •  Differential cell division history between neutrophils and macrophages in their development from granulocyte-macrophage progenitors. Sugimoto Y, Katayama N, Masuya M, Miyata E, Ueno M, Ohishi K, Nishii K, Takakura N, Shiku H. Br J Hematol. 2006
  •  Platelet derived growth factor receptor alpha is essential for establishing a microenvironment that supports definitive erythropoiesis. Li WL, Yamada Y, Ueno M, Nishikawa S, Nishikawa S, Takakura N. J Biochem. 2006
  •  Identification and characterization of mouse PSF1-binding protein, SLD5. Kong L, Ueno M, Itoh M, Yoshioka K, Takakura N. Biochem Biophys Res Commun. 2005
  •  PSF1 is Essential for Early Embryogenesis in Mice. Ueno M, Itoh M, Kong L, Sugihara K, Asano M, Takakura N. Mol Cell Biol. 2005
  •  Hematopoietic cells regulate the angiogenic switch during tumorigenesis. Okamoto R, Ueno M, Yamada Y, Takahashi N, Sano H, Suda T, Takakura N. Blood 2005
  •  Abnormal blood vessel development in mice lacking presenilin-1. Nakajima M, Yuasa S, Ueno M, Takakura N, Koseki H, Shirasawa T. Mech Dev. 2003
  •  Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein. Nobuhisa I, Takizawa M, Takaki S, Inoue H, Okita K, Ueno M, Takatsu K, Taga T. Mol Cell Biol. 2003
  •  Genomic organization and characterization of the mouse ELYS gene. Okita K, Nobuhisa I, Takizawa M, Ueno M, Kimura N, Taga T. Biochem Biophys Res Commun. 2003
  •  Requirement of gp130 signaling for the AGM hematopoiesis. Takizawa M, Nobuhisa I, Igarashi K, Ueno M, Nakashima K, Kitamura T, Taga T. Exp Hematol. 2003
  •  Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues. Kimura N, Takizawa M, Okita K, Natori O, Igarashi K, Ueno M, Nakashima K, Nobuhisa I, Taga T. Genes Cells. 2002
  •  Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7. Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T. Genes Cells. 2001
  •  Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion. Ueno M, Igarashi K, Kimura N, Okita K, Takizawa M, Nobuhisa I, Kojima T, Kitamura T, Samulowitz U, Vestweber D, Shimomura T, Suda T, Nakashima K, Taga T. Biochem Biophys Res Commun. 2001
  •  Genomic organization, sequence and chromosomal localization of the mouse Tbr2 gene and a comparative study with Tbr1. Ueno M, Kimura N, Nakashima K, Saito-Ohara F, Inazawa J, Taga T. Gene 2000
  •  Differential induction of JE/MCP-1 in subclones from a murine macrophage cell line, RAW 264.7: role of kappaB-3 binding protein. Ueno M, Sonoda Y, Funakoshi M, Mukaida N, Nose K, Kasahara T. Cytokine 2000
  •  A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain. Kimura N, Nakashima K, Ueno M, Kiyama H, Taga T. Brain Res Dev Brain Res. 1999
  •  A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. Kimura N, Ueno M, Nakashima K, Taga T. J Biochem. 1999
  •  A suppressive role of p125FAK protein tyrosine kinase in hydrogen peroxide-induced apoptosis of T98G cells.  Sonoda Y, Kasahara T, Yokota-Aizu E, Ueno M, Watanabe S. Biochem Biophys Res Commun. 1997

Conference Presentations

  • Placental trophoblasts regulate both primitive and definitive hematopoiesis during development.(conference:ISEH 2010 Meeting)(2010)
  • HGF/c-Met signaling pathway governs syncytiotrophoblast stem cell maintenance and cell polarity during placental development.(conference:ISSCR 10th Annual Meeting)(2012)

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「mTOR複合体2による白血病の治療耐性制御機構の解明」(2017-2019) 
○「静止期制御因子を指標とした造血幹細胞不均一性の解明」(2014-2016) 
○「がん幹細胞の自己複製の分子基盤の解明」(2008-2008) 
○「生態学的適所における造血幹細胞分裂の分子基盤の解明」(2008-2011) 
○「PSF1およびSLD5の幹細胞分裂における機能解析」(2007-2008) 
○「がん組織における血管リモデリング機構」(2005-2009) 
○「造血幹細胞に特異的に発現し機能する新規核因子NFREDの機能解析」(2005-2006) 
○「造血幹細胞制御に関わる血管内皮細胞由来幹細胞因子の遺伝子プロファイリング」(2004-2007) 
○「TIE2受容体により制御を受ける遺伝子の同定」(2003-2003) 
○「浸潤型血管内皮細胞および定常型血管内皮細胞の特異的生理活性に関わる遺伝子の同定」(2002-2003) 
○「血管新生における分子基盤の解明とその制御」(2002-2004) 
○「造血幹細胞の発生・自己複製に関わる分子クローニングとその機能解析」(2001-2003) 

Classes (Bachelors)

Classes (Graduate Schools)

○Stem Cell Biology(2017)
○Stem Cell Biology(2017)
○Seminar on Tumor Biology(2016)
○Stem Cell Biology(2016)
○Stem Cell Biology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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