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Researcher Information

last modified:2017/07/19

Professor OKAMOTO, Shigefumi

Mail Laboratory Website
Laboratory Website

Faculty, Affiliation

Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Health Sciences, Graduate School of Medical Science
Division of Health Sciences,Graduate School of Medical Science
Department of Laboratory Sciences,School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences

Laboratory

 TEL:076-265-2597 FAX:076-265-2597

Academic Background

【Academic background(Doctoral/Master's Degree)】
Tohoku University Graduate School of Dentistry Doctor Ckinical Dentistry (Oral Surgery) 199503 Completed
【Academic background(Bachelor's Degree)】
Tohoku University 199103
【Degree】
Ph. D.

Career

Japan Society for the Promotion of Science Research Fellowship for Young Scientist(1994/04/01-1996/03/31)
University of Southern California, Keck School of Medicine Dept. Mol. Microbiol. Immunol. Post Doctoral Fellow(1996/04/01-1998/10/31)
Osaka University  Sch. Dent. Dept. of Oral Microbioi. Research Associate (1998/11/15-2000/03/31)
Osaka University Graduate School of Dentistry Dept. Oral Mol. Microbiol. Research Associate(2000/04/01-2004/06/30)
Fukuoka Dental College Sec. Infect. Biol. Lecturer(2004/07/01-2006/03/31)
National Institute of Biomedical Innovation Lab. Virol. Vaccinol. Researcher(2006/04/01-2014/03/31)
Osaka University  Graduate School of Dentistry Guest Professor(2011/04/01-2013/03/31)

Year & Month of Birth

1965/10

Academic Society

Award

Specialities

Fundamental nursing、Bacteriology (including mycology)、Morphological basic dentistry

Speciality Keywords

Strptococci, Influenza virus, Superinfectious diseases, Pathogen

Research Themes

Pathogenesity of <i>Streptococcus pyogenes</i>

Study of host defence against influenza virus infection

pathogenic mechanism of severe bacterial-viral superinfection

Books

  •  Shigefumi Okamoto Medical Science Clinical Microbiological Research (2nd Edition) 2016/11/01
  •  Kayo Sugitani, Yasuko Senda, Shigefumi Okamoto Medical Science Clinical Microbial Research (2nd Edition) 2016/11/01

Papers

  •  Comparison of antimicrobial spectrum and mechanisms of organic virgin coconut oil and lauric acid against bacteria •Nagase S, Matsue M, Mori Y, Honda-Ogawa M, Sugitani K, Sumitomo T, Nakata M, Kawabata S, Okamoto S. Journal of Wellness and Health Care 41 1 2017/09/01
  •  Toll-like receptor 9 ligand D-type oligodeoxynucleotide D35 as a broad inhibitor for influenza A virus replication that is associated with suppression of neuraminidase activity Yamada H, Nagase S, Takahashi K, Sakoda Y, Kida H, Okamoto S. Antiviral Research 129 81-92 2016/05/01
  •  Neuraminidase gene homology contributes to the protective activity of influenza vaccines prepared from the influenza library Haredy AM, Yamada H, Sakoda Y, Okamatsu M, Yamamoto N, Omasa T, Ohtake H, Mori Y, Kida H, Okamoto S, Okuno Y, Yamanishi K.  Journal of General Virology 95 11 2365-2371 2014/11
  •  Dextran sulfate-resistant A/Puerto Rico/8/34 influenza virus is associated withthe emergence of specific mutations in the neuraminidase glycoprotein Yamada H, Nagao C, Haredy AM, Mori Y, Mizuguchi K, Yamanishi K, Okamoto S Antiviral Research 111 2 69-77 2014/11
  •  Neuraminidase gene homology contributes to the protective activity of influenza vaccines prepared from the influenza virus library Haredy, Ahmad M.; Yamada, Hiroshi; Sakoda, Yoshihiro; Okamatsu, Masatoshi; Yamamoto, Naoki; ?masa, Takeshi; Mori, Yasuko; Kida, Hiroshi; Okamoto, Shigefumi; Okuno, Yoshinobu; Yamanishi, Koichi Journal of General Virology 95 2365-2371 2014/01/01 

show all

  •  An MDCK cell culture-derived formalin-inactivated influenza virus whole-virion vaccine from an influenza virus library confers cross-protective immunity by intranasal administration in mice Haredy AM, Takenaka N, Yamada H, Sakoda Y, Okamatsu M, Yamamoto N, Omasa T, Ohtake H, Mori Y, Kida H, Yamanishi K, Okamoto S Clinical and Vaccine Immunology 20 7 998-1007 2013/07
  •  Influenza virus neuraminidase contributes to the dextran sulfate-dependent suppressive replication of some influenza A virus strains Yamada H, Moriishi E, Haredy AM, Takenaka N, Mori Y, Yamanishi K, Okamoto S ANTIVIRAL RESEARCH 96 3 344-352 2012/12
  •  Comparison of the cross-reactive anti-influenza neutralizing activity of polymeric and monomeric IgA monoclonal antibodies Tanimoto T, Haredy AM, Takenaka N, Tamura S, Okuno Y, Mori Y, Yamanishi K. Okamoto S VIRAL IMMUNOLOGY 25 5 433-439 2012/10
  •  Multiple reversions of an IL2RG mutation restore T cell function in an X-linked severe combined immunodeficiency patient Kawai T, Saito M, Nishikomori R, Yasumi T, Izawa K, Murakami T, Okamoto S, Mori Y, Nakagawa N, Imai K, Nonoyama S, Wada T, Yachie A, Ohmori K, Nakahata T, Heike T JOURNAL OF CLINICAL IMMUNOLOGY 32 4 690-697 2012/09
  •  A community-based survey of varicella-zoster virus-specific immune responses in the elderly Tang H, Moriishi E, Okamoto S, Okuno Y, Iso H, Asada H, Yamanishi K, Mori Y, for the Shozu Herpes Zoster (SHEZ) Study group JOURNAL OF CLINICAL VIROLOGY 55 1 46-50 2012/09
  •  Intranasal immunization with formalin-inactivated human influenza A whole-virion vaccine alone and with split-virion vaccine with mucosal adjuvants show similar cross-protection Okamoto S, Matsuoka S, Takenaka N, Haredy AM, Tanimoto T, Gomi Y, Ishikawa T, Akagi T, Akashi M, Okuno Y, Mori Y, Yamanishi K Clinical and Vaccine Immunology 19 7 979-990 2012/07
  •  Poly-γ-glutamic acid nanoparticles and aluminum adjuvant used as an adjuvant with a single dose of Japanese encephalitis virus-like particles provides effective protection from Japanese encephalitis virus Okamoto S, Yoshii H, Matsuura M, Kojima A, Ishikawa T, Akagi T, Akashi M, Takahashi M, Yamanishi K, Mori Y Clinical and Vaccine Immunology 19 1 17-22 2012/01
  •  Systematic characterization of mucosal and systemic immune responses elicited by interleukins as mucosal vaccine adjuvant against influenza virus Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsunoda S, Tsutsumi Y JOURNAL OF VIROLOGY 84 24 12703-12712 2010/12
  •  Rapid and efficient introduction of a foreign gene into bacterial artificial chromosome-cloned varicella vaccine by Tn7-mediated site-specific transposition Somboonthum P, Koshizuka T, Okamoto S, Matsuura M, Gomi Y, Takahashi M, Yamanishi K, Mori Y VIROLOGY 402 1 215-221 2010/04
  •  Comparison of varicella-zoster virus-specific immunity of patients with diabetes mellitus and healthy individuals Okamoto S, Hata A, Sadaoka K, Yamanishi K, Mori Y JOURNAL OF INFECTIOUS DISEASES 200 10 1606-1610 2009/11
  •  Poly(gamma-glutamic acid) nano-particles combined with mucosal influenza virus hemagglutinin vaccine protects against influenza virus infection in mice Okamoto S,Matsuura M,Akagi T, Akashi M, Tanimoto T, Ishikawa T, Takahashi M, Yamanishi K, Mori Y. VACCINE 27 42 5896-5905 2009/09
  •  A novel streptococcal leucine zipper protein (Lzp) binds to human immunoglobulins Okamoto S, Terao Y, Hasuike K, Hamada S, Kawabata S BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 377 4 1128-1134 2008/12
  •  Measurement of varicella-zoster virus (VZV)-specific cell-mediated immunity — Comparison of VZV-skin test and interferon-γ ELISPOT assay Sadaoka K, Okamoto S, Gomi Y, Tanimoto T, Yoshikawa T, Asano Y, Yamanishi K, Mori Y JOURNAL OF INFECTIOUS DISEASES 198 9 1327-1333 2008/11
  •  Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory and mitogenic effects toward mouse B lymphocytes Okamoto S, Terao Y, Tamura Y, Hamada S, Kawabata S FEMS MICROBIOLOGY LETTERS 281 1 73-81 2008/04
  •  Molecular and biological characterization of histidine triad protein in group A streptococci Kunitomo E, Terao Y, Okamoto S, Rikimaru T, Hamada S, Kawabata S MICROBES AND INFECTION 10 4 414-423 2008/04
  •  Single dose of inactivated Japanese encephalitis vaccine with poly (γ-glutamic acid) nanoparticles provides effective protection from Japanese encephalitis virus Okamoto S, Yoshii H, Ishikawa T, Akagi T, Akashi M, Takahashi M, Yamanishi K, Mori Y VACCINE 26 5 589-594 2008/01
  •  Generation of a recombinant Oka varicella vaccine expressing a mumps virus hemagglutinin-neuraminidase protein as a polyvalent live vaccine Somboonthum P, Yoshii H, Okamoto S, Koike M, Gomi Y, Uchiyama Y, Takahashi M, Yamanishi K, Mori Y. VACCINE 27 52 8741-8755 2007/11
  •  Influenza hemagglutinin vaccine with poly (γ-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity Okamoto S, Yoshii H, Akagi T, Akashi M, Ishikawa T, Okuno Y, Takahashi M, Yamanishi K, Mori Y VACCINE 25 49 8270-8278 2007/10
  •  Water-insoluble α-glucans from Streptococcus sobrinus induce inflammatory immune responses Okamoto S,Terao Y,Kaminishi H,Hamada S,Kawabata S Interface Oral Health Science 2007 243-247 2007/09
  •  Inflammatory immune responses by water-insoluble α-glucans Okamoto S, Terao Y, Kaminishi H, Hamada S, Kawabata S JOURNAL OF DENTAL RESEARCH 86 3 242-248 2007/03
  •  Protective immunity against Streptococcus pyogenes challenge in mice following immunization with fibronectin-binding protein Terao Y, Okamoto S, Kataoka K, Hamada S, Kawabata S JOURNAL OF INFECTIOUS DISEASES 192 12 2081-2091 2005/12
  •  Systemic immunization with streptococcal immunoglobulin-binding protein Sib35 induces protective immunity against group A Streptococcus challenge in mice Okamoto S, Tamura Y, Terao Y, Hamada S, Kawabata S. VACCINE 23 40 4852-4859 2005/09
  •  The Streptococcus pyogenes capsule is required for adhesion of bacteria to virus-infected alveolar epithelial cells and lethal bacterial-viral superinfection Okamoto S, Kawabata S, Terao Y, Fujitaka H, Okuno Y, Hamada S. INFECTION AND IMMUNITY 72 10 6068-6073 2004/10
  •  Proapoptotic effect of proteolytic activation of matrix metalloproteinases by Streptococcus pyogenes thiol proteinase/Streptococcus pyrogenic exotixin B. Tamura F, Nakagawa R, Akuta T, Okamoto S, Hamada S, Maeda H, Kawabata S, Akaike T INFECTION AND IMMUNITY 72 8 4836-4847 2004/08
  •  Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza-Streptococcus pyogenes superinfection Okamoto S, Kawabata S, Fujitaka H, Uehira T, Okuno Y, Hamada S VACCINE 22 21-22 2887-2893 2004/07
  •  A model of invasive type of Streptococcus pyogenes infection after intranasal infection in influenza A virus Okamoto S,Kawabata S,Nakagawa I,Okuno Y,Goto T,Sano K,Hamada S International Congress Series 1263 733-736 2004/07
  •  Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice Okamoto S, Kawabata S, Nakagawa I, Okuno Y, Goto T, Sano K, Hamada S. JOURNAL OF VIROLOGY 77 7 4104-4112 2003/04
  •  Administration of superantigens protects mice from lethal Listeria monocytogenes infection by enhancing cytotoxic T cells. Okamoto S, Kawabata S, Nakagawa I, Hamada S. INFECTION AND IMMUNITY 69 11 6633-6642 2001/11
  •  Extracellular nicotinamide adenine dinucleotide induces T cell apoptosis in vivo and in vitro Liu ZX, Ajipa O, Okamoto S, Govindarajan S, Dennert G JOURNAL OF IMMUNOLOGY 167 9 4942-4947 2001/11
  •  Fas-mediated apoptosis causes elimination of virus-specific cytotoxic T cells in the virus-infected liver. Liu ZX, Govindarajan S, Okamoto S, Dennert G JOURNAL OF IMMUNOLOGY 166 5 3035-3041 2001/03
  •  NK cells cause liver injury and facilitate the induction of T cell-mediated immunity to a viral liver infection Liu ZX, Govindarajan S, Okamoto S, Dennert G JOURNAL OF IMMUNOLOGY 164 12 6480-6486 2000/06
  •  Fas- and tumor necrosis factor receptor 1-dependent but not perforin-dependent pathways cause injury in livers infected with an adenovirus construct in mice.  Liu ZX, Govindarajan S, Okamoto S, Dennert G.  HEPATOLOGY 31 3 665-673 2000/03
  •  Expression of ADP-ribosyltransferase on normal T lymphocytes and effects of nicotinamide adenine dinucleotide on their function.  Okamoto S, Azhipa O, Yu Y, Russo E, Dennert G JOURNAL OF IMMUNOLOGY 160 9 4190-4198 1998/05
  •  Superantigenicity of helper T-cell mitogen (SPM-2) isolated from culture supernatants of Streptococcus pyogenes.  Rikiishi H, Okamoto S, Sugawara S, Tamura K, Liu ZX, Kumagai K. IMMUNOLOGY 91 3 406-413 1997/04
  •  Molecular cloning of a functional murine arginine-specific mono ADP ribosyltransferase and its expression in lymphoid cells.  Yu Y, Okamoto S, Nemoto E, Dennert G DNA AND CELL BIOLOGY 16 2 235-244 1997/02
  •  Isolation of a new superantigen with potent mitogenic activity to murine T cells from Streptococcus pyogenes.  Nemoto E, Rikiishi H, Sugawara S, Okamoto S, Tamura K, Maruyama Y, Kumagai K.  FEMS Immunology and Medical Microbiology 15 2-3 81-91 1996/09
  •  Elevated production of interleukin 6 by hepatic MNC correlates with ICAM-1 expression on the hepatic sinusoidal endothelial cells in autoimmune MRL/lpr mice.  Ohteki T, Okamoto S, Nakamura M, Nemoto E, Kumagai E.  IMMUNOLOGY LETTERS 36 2 145-152 1993/05

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「皮膚常在菌叢の変化に着目した褥瘡後感染症の原因解析及びその予防・緩和ケアの検討」(2017-2020) 
○「東南アジア諸国における肺炎球菌の疫学解析と新規病原性の探索」(2016-2019) 
○「インフルエンザウイルス―口腔細菌混合感染による致死的感染症発症とその機構」(2014-2016) 
○「皮膚常在菌叢の変化に着目した褥瘡後感染症の原因解析及びその予防・緩和ケアの検討」(2017-2020) 
○「鳥インフルエンザウイルスの増殖能を決定するアミノ酸変異の解析.」(2012-2014) 
○「粘膜免疫により産生される粘膜分泌型抗インフルエンザ抗体の交叉防御機構の解析」(2011-2013) 
○「インフルエンザ感染による肺炎レンサ球菌の組織侵入増強に関わる分子群同定とその機能」(2009-2010) 
○「ヒトヘルペスウイルスの病原性発現に関与する因子の同定と機能解析.」(2008-2010) 
○「インフルエンザ―細菌の混合感染での重症肺炎発症に関する病原因子の検索」(2006-2007) 
○「 A群レンサ球菌のフィブロネクチン結合タンパクの感染防御抗原としての可能性」(2006-2007) 
○「口腔レンサ球菌由来の不溶性グルカンによる炎症性免疫応答と歯周病発症との関連」(2004-2005) 
○「免疫担当細胞に対して分子凝態を呈するレンサ球菌由来タンパク質の同定および機能解析」(2004-2005)
○「ゲノム機能解析による口腔内経粘膜レンサ球菌感染症の分子病態の解明」(2002-2004) 
○「インフルエンザウイルスとの混合感染で発症する劇症型A群レンサ球菌感染症の病因解析」(2002-2003) 
○「A群レンサ球菌表層タンパクを介する細胞侵入機構の解析および同感染症制御法への応用」(2002-2003) 
○「劇症型GAS感染症と好中球、筋細胞表面ADPリボシル転移酵素活性との因果関係」(2000-2001) 
○「歯周病原性細菌の線毛DNAワクチン接種によるマウスの粘膜免疫応答の誘導」(2000-2001) 
○「将来出現が予想される新型インフルエンザに即応できる次世代ワクチンの臨床応用に向けた研究」 

Classes (Bachelors)

○Clinial Practice of Pathologic Microbiology(2017)
○Bacterial Toxicology(2017)
○Practice in Pathogenic Microbiology(2017)
○Presentation and Debate (Freshman Seminar II)(2017)
○Presentation and Debate (Freshman Seminar II)(2017)
○General Microbiology(2017)
○Pathogenic Microbiology 1(2017)
○Immunology(2017)
○Introduction to Infection Control(2017)
○Bacterial Toxicology(2016)
○Immunology(2016)
○Pathogenic Microbiology 1(2016)
○General Microbiology(2016)
○Clinial Practice of Pathologic Microbiology(2016)
○Practice in Pathogenic Microbiology(2016)
○Laboratory Medicine of Blood Transfusion(2016)
○Lecture and Practice of Hematology(2016)
○Introduction to Infection Control(2016)
○Toxicology(2015)
○Immunology(2015)

Classes (Graduate Schools)

○An Introduction to Medical Laboratory Sciences:Lec(2017)
○Infectious/Pathogenic Agents: Seminar(2017)
○Infectious/Pathogenic Agents: Lecture(2017)
○Molecular Biology for Laboratory Medicine:Research(2017)
○Molecular Biology for Laboratory Medicine: Lecture(2017)
○Molecular Biology for Laboratory Medicine: Seminar(2017)
○Adv. Mol. Biol. for Laboratory Medicine: Research(2017)
○Infectious/Pathogenic Agents: Seminar(2016)
○Molecular Biology for Laboratory Medicine: Seminar(2016)
○Adv. Mol. Biol. for Laboratory Medicine: Research(2016)
○Molecular Biology for Laboratory Medicine: Lecture(2016)
○An Introduction to Medical Laboratory Sciences:Lec(2016)
○Molecular Biology for Laboratory Medicine:Research(2016)
○Infectious/Pathogenic Agents: Lecture(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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