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Researcher Information

last modified:2019/02/15

Professor TAJIMA, Atsushi

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Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Graduate School of Medical Science
Graduate School of Advanced Preventive Medical Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Department of Bioinformatics and Genomics TEL:076-265-2715 FAX:076-234-4249

Academic Background

【Academic background(Doctoral/Master's Degree)】
The Graduate University for Advanced Studies (Sokendai) Doctor Department of Biosystems Science 200203 Completed
Kyoto University Master Department of Pharmacology 199203 Completed
【Academic background(Bachelor's Degree)】
Kyoto University 199003
【Degree】
Ph.D.

Career

The University of Tokushima Graduate School Institute of Health Biosciences Associate Professor(2010/11/01-2014/08/31)
Tokai University School of Medicine(2006/10/01-2010/10/31)
The University of Tokyo Institute of Medical Science(2004/04/01-2006/09/30)
The Graduate University for Advanced Studies Department of Biosystems Sciences(2002/04/01-2004/03/31)
Toray Industries, Inc. Basic Research Laboratories(1992/04/01-1999/03/31)

Year & Month of Birth

1967/12

Academic Society

The Japan Society of Human Genentics
The American Society of Human Genetics
The Genetics Society of Japan
Japanese Cancer Association
The Molecular Biology Society of Japan
Japan Society of Obstetrics and Gynecology
The Pharmaceutical Society of Japan

Award

Specialities

Speciality Keywords

Research Themes

Books

Papers

  •  Genome-wide association study to identify a new susceptibility locus for central serous chorioretinopathy in the Japanese population. Miki A, Sakurada Y, Tanaka K, Semba K, Mitamura Y, Yuzawa M, Tajima A, Nakatochi M, Yamamoto K, Matsuo K, Imoto I, Honda S. Invest Ophthalmol Vis Sci 59 13 5542-5547 2018
  •  A successful case of neoadjuvant chemotherapy and radical hysterectomy during pregnancy for advanced uterine cervical cancer accompanied by neonatal erythroderma. Kayahashi K, Mizumoto Y, Myojo S, Mitani Y, Tajima A, Fujiwara H. J Obstet Gynaecol Res 44 10 2003-2007 2018
  •  Whole-genome sequencing in a pair of monozygotic twins with discordant cleft lip and palate subtypes. Takahashi M, Hosomichi K, Yamaguchi T, Nagahama R, Yoshida H, Maki K, Marazita ML, Weinberg SM, Tajima A. Oral Dis 24 7 1303-1309 2018
  •  Exploration of genetic factors determining cleft side in a pair of monozygotic twins with mirror-image cleft lip and palate using whole-genome sequencing and comparison of craniofacial morphology. Takahashi M, Hosomichi K, Yamaguchi T, Nagahama R, Yoshida H, Marazita ML, Weinberg SM, Maki K, Tajima A. Arch Oral Biol 96 33-38 2018
  •  Next-generation sequencing analysis identifies genomic alterations in pathological morphologies: A case of pulmonary carcinosarcoma harboring EGFR mutations. Koba H, Kimura H, Nishikawa S, Sone T, Abo M, Hara J, Hosomichi K, Tajima A, Kasahara K. Lung Cancer 122 146-150 2018

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  •  A new targeted capture method using bacterial artificial chromosome (BAC) libraries as baits for sequencing relatively large genes. Koganebuchi K, Gakuhari T, Takeshima H, Sato K, Fujii K, Kumabe T, Kasagi S, Sato T, Tajima A, Shibata H, Ogawa M, Oota H. PLoS ONE 13 7 e0200170 2018
  •  The prehistoric peopling of Southeast Asia. McColl H, Racimo F, Vinner L, Demeter F, Gakuhari T, Moreno-Mayar JV, van Driem G, Gram Wilken U, Seguin-Orlando A, de la Fuente Castro C, Wasef S, Shoocongdej R, Souksavatdy V, Sayavongkhamdy T, Saidin MM, Allentoft ME, Sato T, Malaspinas AS, Aghakhanian FA, Korneliussen T, Prohaska A, Margaryan A, de Barros Damgaard P, Kaewsutthi S, Lertrit P, Nguyen TMH, Hung HC, Minh Tran T, Nghia Truong H, Nguyen GH, Shahidan S, Wiradnyana K, Matsumae H, Shigehara N, Yoneda M, Ishida H, Masuyama T, Yamada Y, Tajima A, Shibata H, Toyoda A, Hanihara T, Nakagome S, Deviese T, Bacon AM, Duringer P, Ponche JL, Shackelford L, Patole-Edoumba E, Nguyen AT, Bellina-Pryce B, Galipaud JC, Kinaston R, Buckley H, Pottier C, Rasmussen S, Higham T, Foley RA, Lahr MM, Orlando L, Sikora M, Phipps ME, Oota H, Higham C, Lambert DM, Willerslev E. Science 361 6397 88-92 2018
  •  Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation. Wakae K, Nishiyama T, Kondo S, Izuka T, Que L, Chen C, Kase K, Kitamura K, Mohiuddin M, Wang Z, Ahasan MM, Nakamura M, Fujiwara H, Yoshizaki T, Hosomochi K, Tajima A, Nakahara T, Kiyono T, Muramatsu M. Sci Rep 8 1 9745 2018
  •  Genome-wide association study identifies ERBB4 on 2q34 as a novel locus associated with sperm motility in Japanese men. Sato Y, Tajima A, Sato T, Nozawa S, Yoshiike M, Imoto I, Yamauchi A, Iwamoto T. J Med Genet 55 6 415-421 2018
  •  Foretinib overcomes entrectinib resistance associated with the NTRK1 G667C mutation in NTRK1 fusion-positive tumor cells in a brain metastasis model. Nishiyama A, Yamada T, Kita K, Wang R, Arai S, Fukuda K, Tanimoto A, Takeuchi S, Tange S, Tajima A, Furuya N, Kinoshita T, Yano S. Clin Cancer Res 24 10 2357-2369 2018
  •  Sustained clonal hematopoiesis by HLA-lacking hematopoietic stem cells without driver mutations in aplastic anemia. Imi T, Katagiri T, Hosomichi K, Zaimoku Y, Hoang Nguyen V, Nakagawa N, Tajima A, Yoshizato T, Ogawa S, Nakao S. Blood Adv 2 9 1000-1012 2018
  •  Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis. Tomioka Y, Numata S, Kinoshita M, Umehara H, Watanabe SY, Nakataki M, Iwayama Y, Toyota T, Ikeda M, Yamamori H, Shimodera S, Tajima A, Hashimoto R, Iwata N, Yoshikawa T, Ohmori T. J Psychiatry Neurosci 43 3 194-200 2018
  •  Elevated peripheral blood glutamate levels in major depressive disorder. Inoshita M, Umehara H, Watanabe SY, Nakataki M, Kinoshita M, Tomioka Y, Tajima A, Numata S, Ohmori T. Neuropsychiatr Dis Treat 14 945-953 2018
  •  Association of TUSC1 and DPF3 gene polymorphisms with male infertility. Sato Y, Hasegawa C, Tajima A, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Yamauchi A, Iwamoto T. J Assist Reprod Genet 35 2 257-263 2018
  •  In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy of targeted drugs. Kita K, Arai S, Nishiyama A, Taniguchi H, Fukuda K, Wang R, Yamada T, Takeuchi S, Tange S, Tajima A, Nakada M, Yasumoto K, Motoo Y, Murakami T, Yano S. Cancer Med 6 12 2972-2983 2017
  •  Construction of a combinatorial pipeline using two somatic variant calling methods for whole exome sequence data of gastric cancer. Kohmoto T, Masuda K, Naruto T, Tange S, Shoda K, Hamada J, Saito M, Ichikawa D, Tajima A, Otsuji E, Imoto I.  J Med Invest 64 3.4 233-240 2017
  •  Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression. Ali MAE, Fuse K, Tadokoro Y, Hoshii T, Ueno M, Kobayashi M, Nomura N, Vu HT, Peng H, Hegazy AM, Masuko M, Sone H, Arai F, Tajima A, Hirao A. Sci Rep 7 1 11442 2017
  •  Folding of the cerebral cortex requires Cdk5 in upper-layer neurons in gyrencephalic mammals. Shinmyo Y, Terashita Y, Dinh Duong TA, Horiike T, Kawasumi M, Hosomichi K, Tajima A, Kawasaki H. Cell Rep 20 9 2131 2017
  •  De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity. Nishi A, Numata S, Tajima A, Zhu X, Ito K, Saito A, Kato Y, Kinoshita M, Shimodera S, Ono S, Ochi S, Imamura A, Kurotaki N, Ueno SI, Iwata N, Fukui K, Imoto I, Kamiya A, Ohmori T. Sci Rep 7 1 2887 2017
  •  Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia. Zaimoku Y, Takamatsu H, Hosomichi K, Ozawa T, Nakagawa N, Imi T, Maruyama H, Katagiri T, Kishi H, Tajima A, Muraguchi A, Kashiwase K, Nakao S. Blood 129 21 2908-2916 2017
  •  Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study. Kasuga Y, Hata K, Tajima A, Ochiai D, Saisho Y, Matsumoto T, Arata N, Miyakoshi K, Tanaka M. Endocr J 64 4 463-475 2017
  •  Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory functions and neurogenesis. Ueda H, Sasaki K, Halder SK, Deguchi Y, Takao K, Miyakawa T, Tajima A. J Neurochem 141 1 124-136 2017
  •  An independent validation study of three single nucleotide polymorphisms at the sex hormone-binding globulin locus for testosterone levels identified by genome-wide association studies. Sato Y, Tajima A, Katsurayama M, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T. Hum Reprod Open 2017 1 hox002 2017
  •  Effect of clozapine on DNA methylation in peripheral leukocytes from patients with treatment-resistant schizophrenia. Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T. Int J Mol Sci 18 3 632 2017
  •  A partial nuclear genome of the Jomons who lived 3000 years ago in Fukushima, Japan. Kanzawa-Kiriyama H, Kryukov K, Jinam TA, Hosomichi K, Saso A, Suwa G, Ueda S, Yoneda M, Tajima A, Shinoda KI, Inoue I, Saitou N. J Hum Genet 62 2 213-221 2017
  •  Whole-exome sequencing analysis of supernumerary teeth occurrence in Japanese individuals. Takahashi M, Hosomichi K, Yamaguchi T, Yano K, Funatsu T, Adel M, Haga S, Maki K, Tajima A. Hum Genome Var 4 16046 2017
  •  Cumulative effects of the plasma total homocysteine-related genetic variants on schizophrenia risk. Kinoshita M, Numata S, Tajima A, Nishi A, Muraki S, Tsuchiya A, Umehara H, Watanabe SY, Imoto I, Ohmori T. Psychiatry Res 246 833-837 2016
  •  A replication study of a candidate locus for follicle-stimulating hormone levels and association analysis for semen quality traits in Japanese men. Sato Y, Tajima A, Katsurayama M, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T. J Hum Genet 61 11 911-915 2016
  •  Calcium signaling pathway is associated with the long-term clinical response to selective serotonin reuptake inhibitors (SSRI) and SSRI with antipsychotics in patients with obsessive-compulsive disorder. Umehara H, Numata S, Tajima A, Nishi A, Nakataki M, Imoto I, Sumitani S, Ohmori T. PLoS One 11 6 e0157232 2016
  •  A homozygous mutation of VWA3B causes cerebellar ataxia with intellectual disability. Kawarai T, Tajima A, Kuroda Y, Saji N, Orlacchio A, Terasawa H, Shimizu H, Kita Y, Izumi Y, Mitsui T, Imoto I, Kaji R. J Neurol Neurosurg Psychiatry 87 6 656-662 2016
  •  CRISPR/Cas9-mediated gene knockout in the mouse brain using in utero electroporation. Shinmyo Y, Tanaka S, Tsunoda S, Hosomichi K, Tajima A, Kawasaki H. Sci Rep 6 20611 2016
  •  A de novo mutation of the LDL receptor gene as the cause of familial hypercholesterolemia identified using whole exome sequencing. Tada H, Hosomichi K, Okada H, Kawashiri M, Nohara A, Inazu A, Tomizawa S, Tajima A, Mabuchi H, Hayashi K. Clin Chim Acta 453 194–196 2016
  •  How 'circumpolar' is Ainu music? Musical and genetic perspectives on the history of the Japanese archipelago. Savage PE, Matsumae H, Oota H, Stoneking M, Currie TE, Tajima A, Gillan M, Brown S. Ethnomusicology Forum 24 3 443-467 2015
  •  The impact of next-generation sequencing technologies on HLA research. Hosomichi K, Shiina T, Tajima A, Inoue I. J Hum Genet 60 11 665-673 2015
  •  No association between the COMT Val158Met polymorphism and the long-term clinical response in obsessive-compulsive disorder in the Japanese population. Umehara H, Numata S, Tajima A, Kinoshita M, Nakaaki S, Imoto I, Sumitani S, Ohmori T. Hum Psychopharmacol Clin Exp 30 5 372-376 2015
  •  Evaluation of an association between plasma total homocysteine and schizophrenia by a Mendelian randomization analysis. Numata S, Kinoshita M, Tajima A, Nishi A, Imoto I, Ohmori T. BMC Med Genet 16 54 2015
  •  Sex differences of leukocytes DNA methylation adjusted for estimated cellular proportions. Inoshita M, Numata S, Tajima A, Kinoshita M, Umehara H, Yamamori H, Hashimoto R, Imoto I, Ohmori T. Biol Sex Differ 6 11 2015
  •  An association study of four candidate loci for human male fertility traits with male infertility. Sato Y, Tajima A, Tsunematsu K, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T. Hum Reprod 30 6 1510-1514 2015
  •  Lack of replication of four candidate SNPs implicated in human male fertility traits: a large-scale population-based study. Sato Y, Tajima A, Tsunematsu K, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T. Hum Reprod 30 6 1505-1509 2015
  •  Model-based verification of hypotheses on the origin of modern Japanese revisited by Bayesian inference based on genome-wide SNP data. Nakagome S, Sato T, Ishida H, Hanihara T, Yamaguchi T, Kimura R, Mano S, Oota H; The Asian DNA Repository Consortium. Mol Biol Evol 32 6 1533-1543 2015
  •  Blood diagnostic biomarkers for major depressive disorder using multiplex DNA methylation profiles: discovery and validation. Numata S, Ishii K, Tajima A, Iga JI, Kinoshita M, Watanabe S, Umehara H, Fuchikami M, Okada S, Boku S, Hishimoto A, Shimodera S, Imoto I, Morinobu S, Ohmori T. Epigenetics 10 2 135-141 2015
  •  Comparative proteomics and network analysis identify PKC epsilon underlying long-chain fatty acid signaling. Yonezawa T, Kurata R, Tajima A, Cui X, Maruta H, Nakaoka H, Nakajima K, Inoko H. Journal of Proteomics & Bioinformatics 7 11 340-346 2014
  •  Aberrant DNA methylation of blood in schizophrenia by adjusting for estimated cellular proportions. Kinoshita M, Numata S, Tajima A, Ohi K, Hashimoto R, Shimodera S, Imoto I, Takeda M, Ohmori T. Neuromolecular Med 16 4 697-703 2014
  •  Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia. Nishi A, Numata S, Tajima A, Kinoshita M, Kikuchi K, Shimodera S, Tomotake M, Ohi K, Hashimoto R, Imoto I, Takeda M, Ohmori T. Schizophr Bull 40 5 1154-1163 2014

Conference Presentations

  • Human population history in the southwestern coastal region of Sea of Okhotsk, inferred from ancient genome analysis(conference:SMBE 2018)(2018/07/11)
  • Complex human histories of Northeast Asia revealed by correlations between genes, languages and music(conference:SMBE 2018)(2018/07/11)
  • Comprehensive genotyping and phenotyping in patients with severe hypercholesterolemiaHuman genome analysis of supernumerary teeth(conference:ESC Congress 2017)(2017/08/28)
  • New NGS HLA typing by targeted enrichment procedure, capture method(conference:42nd Annual Meeting of the American Society for Histocompatibility & Immunogenetics)(2016/09/27)
  • Association analysis of polymorphisms with high-risk group of gestational diabetes mellitus in a Japanese population(conference:68th Annual Congress of the Japan Society of Obstetrics and Gynecology)(2016/04/22)

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  • A multi-omics approach toward understanding the genetic and epigenetic bases of human complex disease and traits(conference:Scientific lectures in China Agricultural University)(2016/01/08)
  • Trio-based exome sequencing identified de novo non-synonymous missense mutations in schizophrenia(conference:Neuroscience 2015)(2015/10/15)
  • Cancer 'omics' in biomarker identification(conference: International Symposium on Tumor Biology in Kanazawa)(2015/04/08)

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「高等哺乳動物を用いた脳神経系形成メカニズムの解明」(2017-2020) 
○「環境及び併存疾患がIgG4関連疾患の発症進展に与える影響」(2017-2019) 
○「ヒト造精機能障害に関わる分子基盤の全容解明を目指した統合的ゲノム・エピゲノム解析」(2015-2017) 
○「咬合に起因するエピジェネティックな変化」(2015-2016) 
○「飼育環境による学習効率への影響をラット海馬の脳波変化から読み取る」(2014-2016) 
○「自己炎症性症候群モデルマウスにおけるマスト細胞活性化機構の解明と分子標的薬開発」(2013-2015) 

Classes (Bachelors)

○Human Genetics(2018)
○Basic Health Science(2018)
○Human Genetics(2017)
○Basic Health Science(2017)
○Basic Health Science(2016)
○Frontier in Basic Medical Sciences(2015)
○English III(2015)

Classes (Graduate Schools)

○Bioinformatics(2018)
○omics(2018)
○Environment and Heredity(2018)
○Itemized Lectures of Bioinformatics and Genomics(2018)
○Environment and Health -Introductory(2018)
○Preventive Medicine(2018)
○Environment and Health(2018)
○Bioinformatics(2017)
○omics(2017)
○Environment and Heredity(2017)
○Itemized Lectures of Bioinformatics and Genomics(2017)
○Introduction to Basic Medical Science(2017)
○Introduction to Basic Medical Science(2017)
○Environment and Health -Introductory(2017)
○Preventive Medicine(2017)
○Environment and Health(2017)
○Bioinformatics(2016)
○omics(2016)
○Environment and Heredity(2016)
○Itemized Lectures of Bioinformatics and Genomics(2016)
○Environment and Health -Introductory(2016)
○Preventive Medicine(2016)
○Environment and Health(2016)
○Introduction to Basic Medical Science(2015)
○Environment and Health -Introductory(2015)
○Preventive Medicine(2015)
○Environment and Health(2015)

International Project

International Students

Lecture themes

Others (Social Activities)

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