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Researcher Information

last modified:2019/06/18

Assistant Professor HAZAWA, Masaharu

Mail

Faculty, Affiliation

Institute for Frontier Science Initiative

College and School Educational Field


Laboratory

Academic Background

【Degree】
Ph.D (Health Science)

Career

Institute for Frontier Science Initiative, Innovative Integrated Bio-research core, Cell Bionomics Unit(2016/01/01-)
Cancer Science Institute of Singapore, National University of Singapore(2014/01/01-2015/12/30)
National Institute of Radiological Sciences(2011/04/01-2013/12/31)

Year & Month of Birth

1982/10

Academic Society




The American Society for Cell Biology

Award



Specialities

Tumor biology、Cell biology、Molecular biology

Speciality Keywords

Epithelial Biology, Squamous cell carcinoma, Nuclear pore complex, Nuclear-cytoplasmic transport, Epigenetics, Cancer genomics

Research Themes

Nuclear pore complex composition and tissue-specific functions

Books

Papers

  •  ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation. Hazawa M†, Lin DC, Kobayashi A, Jiang YY, Xu L, Dewi FRP, Mohamed MS, Hartono, Nakada M, Meguro M, Horike SI, Koeffler HP, Wong RW.† EMBO Reports 2017
  •  High-Speed Atomic Force Microscopy Reveals Loss of Nuclear Pore Resilience as a Dying Code in Colorectal Cancer Cells. Mohamed MS, Kobayashi A, Taoka A, Watanabe-Nakayama T, Kikuchi Y, Hazawa M, Minamoto T, Fukumori Y, Kodera N, Uchihashi T, Ando T, Wong RW. ACS Nano 11 6 5567-5578 2017
  •  BCL6 promotes glioma and serves as a therapeutic target. Xu L, Chen Y, Dutra-Clarke M, Mayakonda A, Hazawa M, Savinoff SE, Doan N, Said JW, Yong WH, Watkins A, Yang H, Ding LW, Jiang YY, Tyner JW, Ching J, Kovalik JP, Madan V, Chan SL, Müschen M, Breunig JJ, Lin DC, Koeffler HP. Proc Natl Acad Sci U S A 114 15 3981-3986 2017
  •  Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma. Lin DC, Xu L, Chen Y, Yan H, Hazawa M, Doan N, Said JW, Ding LW, Liu LZ, Yang H, Yu S, Kahn M, Yin D, Koeffler HP. Cancer Res 2015
  •  The genomic landscape of nasopharyngeal carcinoma. Lin DC, Meng X, Hazawa M, Nagata Y, Varela AM, Xu L, Sato Y, Liu LZ, Ding LW, Sharma A, Goh BC, Lee SC, Petersson BF, Yu FG, Macary P, Oo MZ, Ha CS, Yang H, Ogawa S, Loh KS, Koeffler HP. Nat Genet.  2014

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  •  Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma. Jiang YY, Lin DC, Mayakonda A, Hazawa M, Ding LW, Chien WW, Xu L, Chen Y, Xiao JF, Senapedis W, Baloglu E, Kanojia D, Shang L, Xu X, Yang H, Tyner JW, Wang MR, Koeffler HP. Gut 2016
  •  ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma. Hazawa M, Lin DC, Handral H, Xu L, Chen Y, Jiang YY, Mayakonda A, Ding LW, Meng X, Sharma A, Samuel S, Movahednia MM, Wong RW, Yang H, Tong C, Koeffler HP. Oncogene 2016
  •  Radiation increases the cellular uptake of exosomes through CD29/CD81 complex formation. Hazawa M, Tomiyama K, Saotome-Nakamura A, Obara C, Yasuda T, Gotoh T, Tanaka I, Yakumaru H, Ishihara H, Tajima K. Biochem Biophys Res Commun.  2014
  •  Intra- and extracellular plasminogen activator inhibitor-1 regulate effect of vitronectin against radiation-induced endothelial cell death. Hazawa M, Yasuda T, Saotome-Nakamura A, Tomiyama K, Obara C, Goto T, Tajima K. Vascul Pharmacol 2016
  •  Differentiation and Molecular Properties of Mesenchymal Stem Cells Derived from Murine Induced Pluripotent Stem Cells Derived on Gelatin or Collagen. Obara C, Takizawa K, Tomiyama K, Hazawa M, Saotome-Nakamura A, Gotoh T, Yasuda T, Tajima K. Stem Cells International 2016
  •  Estimation of secondary measles transmission from a healthcare worker in a hospital setting. Tajima K, Nishimura H, Hongo S, Hazawa M, Saotome-Nakamura AI, Tomiyama K, Obara C, Kato T. Int J Infect Dis. 2014
  •  Vitronectin improves cell survival after radiation injury in human umbilical vein endothelial cells. Hazawa M, Yasuda T, Noshiro K, Saotome-Nakamura A, Fukuzaki T, Michikawa Y, Gotoh T, Tajima K. FEBS Open Bio. 2012
  •  Mitigative Effects of a Combination of Multiple Pharmaceutical Drugs on the Survival of Mice Exposed to Lethal Ionizing Radiation. Hirouchi T, Ito K, Nakano M, Monzen S, Yoshino H, Chiba M, Hazawa M, Nakano A, Ishikawa J, Yamaguchi M, Tanaka K, Kashiwakura I. Curr Pharm Biotechnol. 2015
  •  Aconitum C₂₀-diterpenoid alkaloid derivatives regulate the growth and differentiation of cord blood derived human hematopoietic stem/progenitor cells. Hazawa M, Wada K, Kashiwakura I. Phytother Res. 2012
  •  Regulation of DNA damage response and cell cycle in radiation-resistant HL60 myeloid leukemia cells. Hazawa M, Hosokawa Y, Monzen S, Yoshino H, Kashiwakura I. Oncol Rep. 2012
  •  (-)-Epigallocatechin-3-O-gallate induces nonapoptotic cell death in leukemia cells independent of the 67 kDa laminin receptor. Hazawa M, Takahashi K, Sugata S, Kashiwakura I. J Nat Prod. 2011
  •  Caspase-independent apoptosis induction of quorum-sensing autoinducer analogs against chronic myeloid leukemia K562. Hazawa M, Kudo M, Iwata T, Saito K, Takahashi K, Igarashi J, Suga H, Kashiwakura I. Invest New Drugs.  2012
  •  Structure-activity relationships between the Aconitum C20-diterpenoid alkaloid derivatives and the growth suppressive activities of Non-Hodgkin's lymphoma Raji cells and human hematopoietic stem/progenitor cells. Hazawa M, Takahashi K, Wada K, Mori T, Kawahara N, Kashiwakura I. Invest New Drugs. 2011
  •  Suppressive effects of novel derivatives prepared from Aconitum alkaloids on tumor growth. Hazawa M, Wada K, Takahashi K, Mori T, Kawahara N, Kashiwakura I. Invest New Drugs 2009

Conference Presentations

  • Cancer specific alteration and dynamics of nuclear pore proteins establish oncogenic signalling(conference:invited seminar at Deportment of Hematology, West China Hospital, Sichuan University)(2019/02/28)
  • Disease-specific alteration of karyopherin-alpha subtypes establishes feedforward oncogenic signaling in squamous cell carcinoma. (conference:The 2018 ASCB | EMBO Meeting)(2018/12/28)
  • The Spatiotemporal dynamics of nucleoporin Nup58 during cell division(conference:第41回日本分子生物学会年会)(2018/11/28)
  • Nuclear transport system caused by disease-specific Karyopherin alternation(conference:Joint Annual Meeting of 70th JSCB and 51st JSDB)(2018/06/05)
  • An oncogenic role of Tpr in Ependymoma(conference:Joint Annual Meeting of 70th JSCB and 51st JSDB)(2018/06/05)

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  • The role of nucleoporin NUP58 during division(conference:Joint Annual Meeting of 70th JSCB and 51st JSDB)(2018/06/05)

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「皮膚組織幹細胞特異的エピジェネティクス制御機構を標的とした扁平上皮癌治療戦略」(2017-2019) 
○「線溶因子を介したVNプロセッシング制御と細胞死制御機構の解明」(2013-2015) 

Classes (Bachelors)

○Recombinant Dna Technology Lab(2017)
○Gene・Genome・Neuron・Time・Life(2016)
○Gene・Genome・Neuron・Time・Life(2016)
○Recombinant Dna Technology Lab(2016)
○Recombinant Dna Technology Lab(2016)

Classes (Graduate Schools)

○Integrated Systems Biology A(2017)
○Integrated Systems Biology B(2017)

International Project

International Students

Lecture themes

Others (Social Activities)

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