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Researcher Information

last modified:2021/09/07

Associate Professor HAZAWA, Masaharu

Mail

Faculty, Affiliation

Institute for Frontier Science Initiative

College and School Educational Field

Division of Natural Sciences, Graduate School of Natural Science and Technology

Laboratory

Academic Background

【Degree】
Ph.D (Health Science)

Career

Institute for Frontier Science Initiative, Innovative Integrated Bio-research core, Cell Bionomics Unit(2016/01/01-)
Cancer Science Institute of Singapore, National University of Singapore(2014/01/01-2015/12/30)
National Institute of Radiological Sciences(2011/04/01-2013/12/31)

Year & Month of Birth

1982/10

Academic Society




The American Society for Cell Biology

Award



Specialities

Tumor biology、Cell biology

Speciality Keywords

Nuclear pore territory, Chromatin, Oncogene

Research Themes

Nuclear pore complex composition and tissue-specific functions

Books

Papers

  •  A light-switching pyrene probe to detect phase-separated biomolecules.  Masaharu Hazawa, Shogo Amemori, Yoshio Nishiyama, Yoshihiro Iga, Yuki Iwashima, Akiko Kobayashi, Hirohisa Nagatani, Motohiro Mizuno, Kenji Takahashi, Richard W Wong iScience 24 (8)  102865-102865 2021
  •  Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma.  Yongsheng Huang, Qian Yang, Yueyuan Zheng, Lehang Lin, Xin Xu, Xiu-E Xu, Tiago C Silva, Masaharu Hazawa, Li Peng, Haotian Cao, Yanbing Ding, Daning Lu, Benjamin P Berman, Li-Yan Xu, En-Min Li, Dong Yin Nucleic acids research 2021
  •  Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer.  Li-Yan Li, Qian Yang, Yan-Yi Jiang, Wei Yang, Yuan Jiang, Xiang Li, Masaharu Hazawa, Bo Zhou, Guo-Wei Huang, Xiu-E Xu, Sigal Gery, Ying Zhang, Ling-Wen Ding, Allen S Ho, Zachary S Zumsteg, Ming-Rong Wang, Melissa J Fullwood, Stephen J Freedland, Stephen J Meltzer, Li-Yan Xu, En-Min Li, H Phillip Koeffler, De-Chen Lin Nature communications 12 (1)  4362-4362  2021
  •  High-Speed Atomic Force Microscopy Reveals Spatiotemporal Dynamics of Histone Protein H2A Involution by DNA Inchworming.  Goro Nishide, Keesiang Lim, Mahmoud Shaaban Mohamed, Akiko Kobayashi, Masaharu Hazawa, Takahiro Watanabe-Nakayama, Noriyuki Kodera, Toshio Ando, Richard W Wong The journal of physical chemistry letters 12  (15) 3837-3846  2021
  •  Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex.  Koki Kato, Dini Kurnia Ikliptikawati, Akiko Kobayashi, Hiroya Kondo, Keesiang Lim, Masaharu Hazawa, Richard W Wong Biochemical and biophysical research communications 536 59-66  2021

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  •  CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway.  Kazuya Fukasawa, Takuya Kadota, Tetsuhiro Horie, Kazuya Tokumura, Ryuichi Terada, Yuka Kitaguchi, Gyujin Park, Shinsuke Ochiai, Sayuki Iwahashi, Yasuka Okayama, Manami Hiraiwa, Takanori Yamada, Takashi Iezaki, Katsuyuki Kaneda, Megumi Yamamoto, Tatsuya Kitao, Hiroaki Shirahase, Masaharu Hazawa, Richard W Wong, Tomoki Todo, Atsushi Hirao, Eiichi Hinoi Oncogene 40  (15)  2803-2815 2021
  •  TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines.  Yan-Yi Jiang, Yuan Jiang, Chun-Quan Li, Ying Zhang, Pushkar Dakle, Harvinder Kaur, Jian-Wen Deng, Ruby Yu-Tong Lin, Lin Han, Jian-Jun Xie, Yiwu Yan, Ngan Doan, Yueyuan Zheng, Anand Mayakonda, Masaharu Hazawa, Liang Xu, YanYu Li, Luay Aswad, Maya Jeitany, Deepika Kanojia, Xin-Yuan Guan, Jonathan W Said, Wei Yang, Melissa J Fullwood, De-Chen Lin, H Phillip Koeffler Gastroenterology 159 (4)  1311-1327  2020
  •  Spatiotemporally tracking of nano-biofilaments inside the nuclear pore complex core.  Mahmoud Shaaban Mohamed, Masaharu Hazawa, Akiko Kobayashi, Laurent Guillaud, Takahiro Watanabe-Nakayama, Mizuho Nakayama, Hanbo Wang, Noriyuki Kodera, Masanobu Oshima, Toshio Ando, Richard W Wong Biomaterials  256  120198-120198 2020
  •  Nucleoporin TPR (translocated promoter region, nuclear basket protein) upregulation alters MTOR-HSF1 trails and suppresses autophagy induction in ependymoma Firli Rahmah Primula Dewi, Shabierjiang Jiapaer, Akiko Kobayashi, Masaharu Hazawa , Dini Kurnia Ikliptikawati, Hartono, Hemragul Sabit, Mitsutoshi Nakada, Richard W Wong Autophagy 17 4 1001-1012 2021
  •  Karyopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines.  Masaharu Hazawa, Hironori Yoshino, Yuta Nakagawa, Reina Shimizume, Keisuke Nitta, Yoshiaki Sato, Mariko Sato, Richard W Wong, Ikuo Kashiwakura Cancers 12 4 908-908 2020
  •  Disease-specific alteration of karyopherin-α subtype establishes feed-forward oncogenic signaling in head and neck squamous cell carcinoma Hazawa M*, Sakai K, Kobayashi A, Yoshino H, Iga Y, Iwashima Y, Lim KS, Voon DC, Jiang YY, Horike S, Lin DC & Wong RW Oncogene 2019/12/10
  •  High-Speed AFM Reveals Molecular Dynamics of Human Influenza A Hemagglutinin and Its Interaction with Exosomes.  Keesiang Lim, Noriyuki Kodera, Hanbo Wang, Mahmoud Shaaban Mohamed, Masaharu Hazawa, Akiko Kobayashi, Takeshi Yoshida, Rikinari Hanayama, Seiji Yano, Toshio Ando, Richard W Wong Nano letters 20 (9)  6320-6328  2020
  •  Inflammatory and mitogenic signals drive interleukin 23 subunit alpha (IL23A) secretion independent of IL12B in intestinal epithelial cells.  Kee Siang Lim, Zachary Wei Ern Yong, Huajing Wang, Tuan Zea Tan, Ruby Yun-Ju Huang, Daisuke Yamamoto, Noriyuki Inaki, Masaharu Hazawa, Richard W Wong, Hiroko Oshima, Masanobu Oshima, Yoshiaki Ito, Dominic Chih-Cheng Voon The Journal of biological chemistry 295 19 6387-6400 2020
  •  Nucleoporin Nup58 localizes to centrosomes and mid-bodies during mitosis. Hartono, Masaharu Hazawa, Kee Siang Lim, Firli R P Dewi, Akiko Kobayashi, Richard W Wong Cell division 2019
  •  ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation. Hazawa M†, Lin DC, Kobayashi A, Jiang YY, Xu L, Dewi FRP, Mohamed MS, Hartono, Nakada M, Meguro M, Horike SI, Koeffler HP, Wong RW.† EMBO Reports 2017
  •  High-Speed Atomic Force Microscopy Reveals Loss of Nuclear Pore Resilience as a Dying Code in Colorectal Cancer Cells. Mohamed MS, Kobayashi A, Taoka A, Watanabe-Nakayama T, Kikuchi Y, Hazawa M, Minamoto T, Fukumori Y, Kodera N, Uchihashi T, Ando T, Wong RW. ACS Nano 11 6 5567-5578 2017
  •  BCL6 promotes glioma and serves as a therapeutic target. Xu L, Chen Y, Dutra-Clarke M, Mayakonda A, Hazawa M, Savinoff SE, Doan N, Said JW, Yong WH, Watkins A, Yang H, Ding LW, Jiang YY, Tyner JW, Ching J, Kovalik JP, Madan V, Chan SL, Müschen M, Breunig JJ, Lin DC, Koeffler HP. Proc Natl Acad Sci U S A 114 15 3981-3986 2017
  •  Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma. Jiang YY, Lin DC, Mayakonda A, Hazawa M, Ding LW, Chien WW, Xu L, Chen Y, Xiao JF, Senapedis W, Baloglu E, Kanojia D, Shang L, Xu X, Yang H, Tyner JW, Wang MR, Koeffler HP. Gut 2016
  •  ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma. Hazawa M, Lin DC, Handral H, Xu L, Chen Y, Jiang YY, Mayakonda A, Ding LW, Meng X, Sharma A, Samuel S, Movahednia MM, Wong RW, Yang H, Tong C, Koeffler HP. Oncogene 2016
  •  Intra- and extracellular plasminogen activator inhibitor-1 regulate effect of vitronectin against radiation-induced endothelial cell death. Hazawa M, Yasuda T, Saotome-Nakamura A, Tomiyama K, Obara C, Goto T, Tajima K. Vascul Pharmacol 2016
  •  Differentiation and Molecular Properties of Mesenchymal Stem Cells Derived from Murine Induced Pluripotent Stem Cells Derived on Gelatin or Collagen. Obara C, Takizawa K, Tomiyama K, Hazawa M, Saotome-Nakamura A, Gotoh T, Yasuda T, Tajima K. Stem Cells International 2016
  •  Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma. Lin DC, Xu L, Chen Y, Yan H, Hazawa M, Doan N, Said JW, Ding LW, Liu LZ, Yang H, Yu S, Kahn M, Yin D, Koeffler HP. Cancer Res 2015
  •  Mitigative Effects of a Combination of Multiple Pharmaceutical Drugs on the Survival of Mice Exposed to Lethal Ionizing Radiation. Hirouchi T, Ito K, Nakano M, Monzen S, Yoshino H, Chiba M, Hazawa M, Nakano A, Ishikawa J, Yamaguchi M, Tanaka K, Kashiwakura I. Curr Pharm Biotechnol. 2015
  •  The genomic landscape of nasopharyngeal carcinoma. Lin DC, Meng X, Hazawa M, Nagata Y, Varela AM, Xu L, Sato Y, Liu LZ, Ding LW, Sharma A, Goh BC, Lee SC, Petersson BF, Yu FG, Macary P, Oo MZ, Ha CS, Yang H, Ogawa S, Loh KS, Koeffler HP. Nat Genet.  2014
  •  Radiation increases the cellular uptake of exosomes through CD29/CD81 complex formation. Hazawa M, Tomiyama K, Saotome-Nakamura A, Obara C, Yasuda T, Gotoh T, Tanaka I, Yakumaru H, Ishihara H, Tajima K. Biochem Biophys Res Commun.  2014
  •  Estimation of secondary measles transmission from a healthcare worker in a hospital setting. Tajima K, Nishimura H, Hongo S, Hazawa M, Saotome-Nakamura AI, Tomiyama K, Obara C, Kato T. Int J Infect Dis. 2014
  •  Vitronectin improves cell survival after radiation injury in human umbilical vein endothelial cells. Hazawa M, Yasuda T, Noshiro K, Saotome-Nakamura A, Fukuzaki T, Michikawa Y, Gotoh T, Tajima K. FEBS Open Bio. 2012
  •  Aconitum C₂₀-diterpenoid alkaloid derivatives regulate the growth and differentiation of cord blood derived human hematopoietic stem/progenitor cells. Hazawa M, Wada K, Kashiwakura I. Phytother Res. 2012
  •  Regulation of DNA damage response and cell cycle in radiation-resistant HL60 myeloid leukemia cells. Hazawa M, Hosokawa Y, Monzen S, Yoshino H, Kashiwakura I. Oncol Rep. 2012
  •  Caspase-independent apoptosis induction of quorum-sensing autoinducer analogs against chronic myeloid leukemia K562. Hazawa M, Kudo M, Iwata T, Saito K, Takahashi K, Igarashi J, Suga H, Kashiwakura I. Invest New Drugs.  2012
  •  (-)-Epigallocatechin-3-O-gallate induces nonapoptotic cell death in leukemia cells independent of the 67 kDa laminin receptor. Hazawa M, Takahashi K, Sugata S, Kashiwakura I. J Nat Prod. 2011
  •  Structure-activity relationships between the Aconitum C20-diterpenoid alkaloid derivatives and the growth suppressive activities of Non-Hodgkin's lymphoma Raji cells and human hematopoietic stem/progenitor cells. Hazawa M, Takahashi K, Wada K, Mori T, Kawahara N, Kashiwakura I. Invest New Drugs. 2011
  •  Suppressive effects of novel derivatives prepared from Aconitum alkaloids on tumor growth. Hazawa M, Wada K, Takahashi K, Mori T, Kawahara N, Kashiwakura I. Invest New Drugs 2009

Conference Presentations

  • Cancer specific alteration and dynamics of nuclear pore proteins establish oncogenic signalling(conference:invited seminar at Deportment of Hematology, West China Hospital, Sichuan University)(2019/02/28)
  • Disease-specific alteration of karyopherin-alpha subtypes establishes feedforward oncogenic signaling in squamous cell carcinoma. (conference:The 2018 ASCB | EMBO Meeting)(2018/12/28)
  • The Spatiotemporal dynamics of nucleoporin Nup58 during cell division(conference:第41回日本分子生物学会年会)(2018/11/28)
  • Nuclear transport system caused by disease-specific Karyopherin alternation(conference:Joint Annual Meeting of 70th JSCB and 51st JSDB)(2018/06/05)
  • An oncogenic role of Tpr in Ependymoma(conference:Joint Annual Meeting of 70th JSCB and 51st JSDB)(2018/06/05)

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  • The role of nucleoporin NUP58 during division(conference:Joint Annual Meeting of 70th JSCB and 51st JSDB)(2018/06/05)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○2022「がん悪性化の根幹であるマスター転写因子の発現誘導メカニズムの解明」(2020-2022) 
○「皮膚組織幹細胞特異的エピジェネティクス制御機構を標的とした扁平上皮癌治療戦略」(2017-2019) 
○「線溶因子を介したVNプロセッシング制御と細胞死制御機構の解明」(2013-2015) 

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Recombinant Dna Technology Lab(2017)
○Gene・Genome・Neuron・Time・Life(2016)
○Gene・Genome・Neuron・Time・Life(2016)
○Recombinant Dna Technology Lab(2016)
○Recombinant Dna Technology Lab(2016)

Classes (Graduate Schools)

○Integrated Systems Biology A(2017)
○Integrated Systems Biology B(2017)

International Project

International Students

Lecture themes

Others (Social Activities)

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