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Researcher Information

last modified:2024/01/08

Associate Professor Hiroshi Arakawa


Faculty, Affiliation

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences Division of Pharmaceutical Sciences, Faculty of Pharmacy Institute of Medical, Pharmaceutical and Health Sciences
Assistant Professor

College and School Educational Field


Department of Membrane Transport of Biopharmaceutics,Laboratory of Molecular Pharmacotherapeutic, and Drug Metabolism and Toxicology

Academic Background

【Academic background(Doctoral/Master's Degree)】
Graduate School of Kanazawa University Doctor Graduate School of Natural Science and Technology Divisions of Life Science 2013 Completed
【Academic background(Bachelor's Degree)】
Tokyo University of Science Department of Pharmacy 2007


Kanazawa University Faculty of Pharmacy Institute of Medical, Pharmaceutical and Health Sciences Assitant Professor(2016/02/01-)
Takasaki University of Health and Wealfare Faculty of Pharmacy Assitant Professor(2013/04/01-2016/01/31)

Year & Month of Birth


Academic Society


○4th APISSX Best Presentation Award, 1st Place (2011/04)



Speciality Keywords


Research Themes

Drug Interaction via Renal Transporters

The Role of Drug Transporters on Drug Metabolism and Toxicity

Development of Novel Evaluation Systems for Pharmacokinetics

Alteration of Pharmacokinetics in Liver Dysfunction



  •  Kinetic analysis of sequential metabolism of triazolam and its extrapolation to humans using an entero-hepatic two-organ microphysiological system Arakawa H, Sugiura S, Kawanishi T, Shin K, Toyoda H, Satoh T, Sakai Y, Kanamori T, Kato Y Lab Chip. 20 3 537-47 2020/01/13
  •  Aliphatic Oxaboroles Enabling Remarkable Recognition of Diols Arakawa N, Nagao K, Murakami R, Sumida Y, Arakawa H, Inagaki F, Ohmiya H Bull Chem Soc Jpn. 2020/02/26
  •  SLC35B1 significantly contributes to the uptake of UDPGA into the endoplasmic reticulum for glucuronidation catalyzed by UDP-glucuronosyltransferases Ondo K, Arakawa H, Nakano M, Fukami T, Nakajima M Biochem Pharmacol 2020/03/12
  •  Rat Kidney Slices for Evaluation of Apical Membrane Transporters in Proximal Tubular Cells J Pharm Sci. 108 8 2798-804 2019/08
  •  Uric acid analogue as a possible xenobiotic marker of uric acid transporter Urat1 in rats Arakawa H, Amezawa N, Katsuyama T, Nakanishi T, Tamai I Drug Metab Pharmacokinet. 34 2 155-8 2019/04

show all

  •  Bile Duct Obstruction Leads to Increased Intestinal Expression of Breast Cancer Resistance Protein With Reduced Gastrointestinal Absorption of Imatinib Kawanishi T, Arakawa H, Masuo Y, Nakamichi N, Kato Y J Pharm Sci. 108 9 3130-7 2019/05/14
  •  Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1. Omote S, Matsuoka N, Arakawa H, Nakanishi T, Tamai I. Sci Rep. 18 1 9237 2018/06/18
  •  Reduction Effect of Calcium Alginate on Blood Triglyceride Levels Causing the Inhibition of Hepatic and Total Body Accumulation of Fat in Rats Kasahara F, Kato T, Idota Y, Takahashi H, Kakinuma C, Yano K, Arakawa H, Hara K, Miyajima C, Ogihara T Biol Pharm Bull. 42 3 365-72 2019/05/01
  •  Organic Cation Transporter 1 Is Responsible for Hepatocellular Uptake of the Tyrosine Kinase Inhibitor Pazopanib Ellawatty WEA, Masuo Y, Fujita KI, Yamazaki E, Ishida H, Arakawa H, Nakamichi N, Abdelwahed R, Sasaki Y, Kato Y. Drug Metab Dispos. 46 1 33-40 2018
  •  Evaluation of the metabolic capability of primary human hepatocytes in three-dimensional cultures on microstructural plates. Koyama S, Arakawa H, Itoh M, Masuda N, Yano K, Kojima H, Ogihara T. Biopharm Drug Dispos. 39 4 187-195 2018/04
  •  Inhibitory effect of crizotinib on creatinine uptake by renal secretory transporter OCT2. Arakawa H, Omote S, Tamai I Journal of Pharmaceutical Sciences 106 9 899-903 2017/03/13
  •  Preliminary Evaluation of Three-Dimensional Primary Human Hepatocyte Culture System for Assay of Drug-Metabolizing Enzyme-Inducing Potential Arakawa H, Kamioka H, Jomura T, Koyama S, Idota Y, Yano K, Kojima H, Ogihara T Biol Pharm Bull. 40 7 967-74 2017/07
  •  Usefulness of kidney slices for functional analysis of apical reabsorptive transporters. Arakawa H, Washio I, Matsuoka N, Kubo H, Staub AY, Nakamichi N, Ishiguro N, Kato Y, Nakanishi T, and Tamai I. Sci. Rep. 7 1 12814 2017/10/09
  •  Possible interaction of quinolone antibiotics with peptide transporter 1 in oral absorption of peptide-mimetic drugs. Arakawa H, Kamioka H, Kanagawa M, Hatano Y, Idota Y, Yano K, Morimoto K, Ogihara T. Biopharm Drug Dispos. 37 1 39-45 2016
  •  Different regulation of P-glycoprotein function between Caco-2 and Caki-1 cells by ezrin, radixin and moesin proteins. Yano K, Otsuka K, Kato Y, Kawabata H, Ohmori S, Arakawa H, Ogihara T. J Pharm Pharmacol. 68 3 361-7 2016/02/17
  •  Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity. Ogihara T, Arakawa H, Jomura T, Idota Y, Koyama S, Yano K, Kojima H. J. Toxicol. Sci. 42 599 2017
  •  Interaction of Peptide Transporter 1 With D-Glucose and L-Glutamic Acid; Possible Involvement of Taste Receptors. Arakawa H, Ohmachi T, Ichiba K, Kamioka H, Tomono T, Kanagawa M, Idota Y, Hatano Y, Yano K, Morimoto K, Ogihara T. J Pharm Sci. 105 1 339-42 2016/01/13
  •  Cholesterol-Lowering Effect of Calcium Alginate in Rats. Idota Y, Kogure Y, Kato T, Ogawa M, Kobayashi S, Kakinuma C, Yano K, Arakawa H, Miyajima C, Kasahara F, Ogihara T. Biol Pharm Bull. 39 1 62-7 2016
  •  Role of OATP2A1 in PGE(2) secretion from human colorectal cancer cells via exocytosis in response to oxidative stress Kasai T, Nakanishi T, Ohno Y, Shimada H, Nakamura Y, Arakawa H, Tamai I. Experimental Cell Research 341 2 123-131 2016/02/02
  •  Relationship between Physical Parameters of Various Metal Ions and Binding Affinity for Alginate Idota Y, Kogure Y, Kato T, Yano K, Arakawa H, Miyajima C, Kasahara F, Ogihara T. Biological and Pharmaceutical Bulletin 39 11 1893-1896 2016/07/26
  •  Utility of human hepatocyte spheroids for evaluation of hepatotoxicity. Ogihara T, Iwai H, Inoue Y, Katagi J, Matsumoto N, Motoi-Ohtsuji M, Kakiki M, Kaneda S, Nagao T, Kusumoto K, Ozeki E, Jomura T, Tanaka S, Ueda T, Ohta T, Ohkura T, Arakawa H, Nagai D. Fundam. Toxicol. Sci. 2 41 2015
  •  Recommended Daily Dose of Sesame Lignans Has No Influence on Oral Absorption of P-Glycoprotein Substrates in Rats. Tomono T, Otsuka K, Yano K, Kanagawa M, Arakawa H, Ogihara T. Biol Pharm Bull. 38 12 1960-3 2015
  •  Evaluation of human hepatocytes cultured by three-dimensional spheroid systems for drug metabolism. Ohkura T, Ohta K, Nagao T, Kusumoto K, Koeda A, Ueda T, Jomura T, Ikeya T, Ozeki E, Wada K, Naitoh K, Inoue Y, Takahashi N, Iwai H, Arakawa H, Ogihara T. Drug Metab Pharmacokinet. 29 5 373-8 2014/04/01
  •  Multiple Linear Regression Analysis Indicates Association of P-Glycoprotein Substrate or Inhibitor Character with Bitterness Intensity, Measured with a Sensor. Yano K, Mita S, Morimoto K, Haraguchi T, Arakawa H, Yoshida M, Yamashita F, Uchida T, Ogihara T. J Pharm Sci. 104 9 2789-94 2014/12/24
  •  Evaluation of a thiodipeptide, L-phenylalanyl-Ψ[CS-N]-L-alanine, as a novel probe for peptide transporter 1. Arakawa H, Saito S, Kanagawa M, Kamioka H, Yano K, Morimoto K, Ogihara T. Drug Metab Pharmacokinet. 29 6 470-4 2014
  •  Characterization of cesium uptake mediated by a potassium transport system of bacteria in a soil conditioner. Zhang P, Idota Y, Yano K, Negishi M, Kawabata H, Arakawa H, Morimoto K, Tsuji A, Ogihara T. Biol Pharm Bull. 37 4 604-7 2014
  •  Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions. Arakawa H, Nakanishi T, Yanagihara C, Nishimoto T, Wakayama T, Mizokami A, Namiki M, Kawai K, Tamai I. Biochem Pharmacol 84 8 1070-7 2012/08/01
  •  Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5. Arakawa H, Shirasaka Y, Haga M, Nakanishi T, Tamai I. Biopharm Drug Dispos 33 6 332-41 2012/08/30
  •  Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer. Maeda T, Irokawa M, Arakawa H, Kuraoka E, Nozawa T, Tateoka R, Itoh Y, Nakanishi T, Tamai I. J Steroid Biochem Mol Biol. 122 4 180-5 2010/06/06
  •  Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with anti-proliferative aminopeptidase inhibitors. Fan X, Ross DD, Arakawa H, Ganapathy V, Tamai I, Nakanishi T. Biochem Pharmacol. 80 6 811-8 2010/05/26
  •  Involvement of organic anion transporting polypeptide 1a5 (Oatp1a5) in the intestinal absorption of endothelin receptor antagonist in rats. Tani T, Gram LK, Arakawa H, Kikuchi A, Chiba M, Ishii Y, Steffansen B, Tamai I. Pharm Res. 25 5 1085-91 2007/10/24

Conference Presentations

  • Utility of Three Dimensional Culture of Human Hepatocytes for Evaluation of Drug Metabolism Profile, Toxicity and Enzyme Induction.(conference:The 1st Workshop for Japan-Korea Young Scientists on Pharmaceutics.)(2016/07/24)


Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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