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Researcher Information

last modified:2017/07/19

Associate Professor OKUDA, Hiroaki

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Neuroscience, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

 TEL:076-265-2156 FAX:076-234-4221

Academic Background

Career

Nara Medical University(2007/04/01-2016/03/31)
Kanazawa University Graduate School of Medical Science(2016/04/01-)

Year & Month of Birth

Academic Society




Award

Specialities

Neurochemistry/Neuropharmacology、Nerve anatomy/Neuropathology、Pain science、General anatomy (including histology/embryology)

Speciality Keywords

glial cell

Research Themes

the function of glial cells in chronic pain

Books

Papers

  •  Voluntary Exercise Induces Astrocytic Structural Plasticity in the Globus Pallidus. Tatsumi K, Okuda H, Morita-Takemura S, Tanaka T, Isonishi A, Shinjo T, Terada Y, Wanaka A Front Cell Neurosci. 10 165 2016
  •  Hedgehog Signaling Components Are Expressed in Choroidal Neovascularization in Laser-induced Retinal Lesion. Nochioka K, Okuda H, Tatsumi K, Morita S, Ogata N, Wanaka A. Acta Histochem Cytochem. 49 2 67-74 2016
  •  Vascular endothelial growth factor-dependent angiogenesis and dynamic vascular plasticity in the sensory circumventricular organs of adult mouse brain. Morita S, Furube E, Mannari T, Okuda H, Tatsumi K, Wanaka A, Miyata S. Cell Tissue Res. 359 3 865-884 2015
  •  Retinoic acid regulates Lhx8 expression via FGF-8b to the upper jaw development of chick embryo. Shimomura T, Kawakami M, Okuda H, Tatsumi K, Morita S, Nochioka K, Kirita T, Wanaka A. J Biosci Bioeng. 119 3 260-266 2015
  •  OASIS regulates chondroitin 6-O-sulfotransferase 1 gene transcription in the injured adult mouse cerebral cortex. Okuda H, Tatsumi K, Horii-Hayashi N, Morita S, Okuda-Yamamoto A, Imaizumi K, Wanaka A. J Neurochem. 130 5 612-625 2014

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  •  Inhibition of Wnt/β-catenin pathway by Dickkopf-1 [corrected] affects midfacial morphogenesis in chick embryo. Kawakami M, Okuda H, Tatsumi K, Kirita T, Wanaka A. J Biosci Bioeng. 117 6 664-669 2014
  •  Chondroitin sulfate proteoglycan tenascin-R regulates glutamate uptake by adult brain astrocytes. Okuda H, Tatsumi K, Morita S, Shibukawa Y, Korekane H, Horii-Hayashi N, Wada Y, Taniguchi N, Wanaka A. J Biol Chem. 289 5 2620-2631 2014
  •  Geissoschizine methyl ether, an alkaloid from the Uncaria hook, improves remyelination after cuprizone-induced demyelination in medial prefrontal cortex of adult mice. Morita S, Tatsumi K, Makinodan M, Okuda H, Kishimoto T, Wanaka A. Neurochem Res. 39 1 59-67 2014
  •  Changes in endothelial cell proliferation and vascular permeability after systemic lipopolysaccharide administration in the subfornical organ. Morita-Takemura S, Nakahara K, Tatsumi K, Okuda H, Tanaka T, Isonishi A, Wanaka A. J Neuroimmunol 15 298 132-137 2016
  •  Hedgehog Signaling Modulates the Release of Gliotransmitters from Cultured Cerebellar Astrocytes. Okuda H, Tatsumi K, Morita-Takemura S, Nakahara K, Nochioka K, Shinjo T, Terada Y, Wanaka A. Neurochem Res. 41 1-2 278-289 2016
  •  Heterogeneous vascular permeability and alternative diffusion barrier in sensory circumventricular organs of adult mouse brain. Morita S, Furube E, Mannari T, Okuda H, Tatsumi K, Wanaka A, Miyata S. Cell Tissue Res. 363 2 497-511 2016
  •  Oligodendrocyte plasticity with an intact cell body in vitro. Makinodan M, Okuda-Yamamoto A, Ikawa D, Toritsuka M, Takeda T, Kimoto S, Tatsumi K, Okuda H, Nakamura Y, Wanaka A, Kishimoto T. PLoS One. 8 6 e66124 2013
  •  Olanzapine stimulates proliferation but inhibits differentiation in rat oligodendrocyte precursor cell cultures. Kimoto S, Okuda A, Toritsuka M, Yamauchi T, Makinodan M, Okuda H, Tatsumi K, Nakamura Y, Wanaka A, Kishimoto T. Prog Neuropsychopharmacol Biol Psychiatry. 35 8 1950-1956 2011
  •  Chondroitin sulfate demarcates astrocytic territories in the mammalian cerebral cortex. Horii-Hayashi N, Tatsumi K, Matsusue Y, Okuda H, Okuda A, Hayashi M, Yano H, Tsuboi A, Nishi M, Yoshikawa M, Wanaka A. Neurosci Lett. 483 1 67-72 2010
  •  Olanzapine increases cell mitotic activity and oligodendrocyte-lineage cells in the hypothalamus. Yamauchi T, Tatsumi K, Makinodan M, Kimoto S, Toritsuka M, Okuda H, Kishimoto T, Wanaka A. Neurochem Int. 57 5 565-571 2010
  •  Dysbindin regulates the transcriptional level of myristoylated alanine-rich protein kinase C substrate via the interaction with NF-YB in mice brain. Okuda H, Kuwahara R, Matsuzaki S, Miyata S, Kumamoto N, Hattori T, Shimizu S, Yamada K, Kawamoto K, Hashimoto R, Takeda M, Katayama T, Tohyama M. PLoS One. 5 1 e8773 2010
  •  Transient activation of Notch signaling in the injured adult brain. Tatsumi K, Okuda H, Makinodan M, Yamauchi T, Makinodan E, Matsuyoshi H, Manabe T, Wanaka A. J Chem Neuroanat. 39 1 15-19 2010
  •  Environmental enrichment stimulates progenitor cell proliferation in the amygdala. Okuda H, Tatsumi K, Makinodan M, Yamauchi T, Kishimoto T, Wanaka A. J Neurosci Res. 87 16 3546-3553 2009
  •  Demyelination in the juvenile period, but not in adulthood, leads to long-lasting cognitive impairment and deficient social interaction in mice. Makinodan M, Yamauchi T, Tatsumi K, Okuda H, Takeda T, Kiuchi K, Sadamatsu M, Wanaka A, Kishimoto T. Prog Neuropsychopharmacol Biol Psychiatry. 33 6 978-985 2009
  •  Yi-gan san restores behavioral alterations and a decrease of brain glutathione level in a mouse model of schizophrenia. Makinodan M, Yamauchi T, Tatsumi K, Okuda H, Noriyama Y, Sadamatsu M, Kishimoto T, Wanaka A. J Brain Dis. 12 1 42741 2009
  •  Dysbindin engages in c-Jun N-terminal kinase activity and cytoskeletal organization. Kubota K, Kumamoto N, Matsuzaki S, Hashimoto R, Hattori T, Okuda H, Takamura H, Takeda M, Katayama T, Tohyama M. Biochem Biophys Res Commun. 379 2 191-195 2009
  •  Olig2-expressing progenitor cells preferentially differentiate into oligodendrocytes in cuprizone-induced demyelinated lesions. Islam MS, Tatsumi K, Okuda H, Shiosaka S, Wanaka A. Neurochem Int. 54 3 192-198 2009

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「新たな疼痛モデルを用いた痛みの発生メカニズム・伝達経路の解明」(2016-2018) 
○「グリア主導で神経回路活動は改変できるか?ー三つ組みシナプス仮説の実証ー」(2015-2017) 
○「淡蒼球アストロサイトの形態機能連関ーパーキンソン病の新しい治療法開発にむけてー」(2014-2016) 
○「新規細胞外マトリックスDACSのアストロサイトおよび神経細胞における機能解析」(2012-2014) 
○「神経再生を阻害する糖鎖修飾メカニズムの解析と人為制御」(2011-2014) 
○「転写因子OASISによる神経軸索伸展抑制機構の解析と再生医療への応用の可能性」(2010-2011) 
○「大脳皮質の臨界期を制御する新規プロテオグリカン類の同定と機能解析」(2009-2010) 
○「 大脳皮質由来オリゴデンドロサイト前駆細胞の多分化能性と移植後における動態解析」(2008-2009) 

Classes (Bachelors)

○Human Anatomy(2017)

Classes (Graduate Schools)

○Principles of Anatomy(2017)
○Functional Anatomy(2017)
○Functional Anatomy(2017)
○Functional Anatomy(2016)
○Functional Anatomy(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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