Jump to contents

Researcher Information

last modified:2019/10/21

Assistant Professor FLECHSIG, Holger

Faculty, Affiliation

WPI Nano Life Science Institute

College and School Educational Field


Laboratory

Academic Background

Career

Ochanomizu University Department of Information Sciences Researcher(2017/11/01-2018/01/31)
Hiroshima University Graduate School of Science Researcher(2017/04/01-2018/01/31)
Hiroshima University Graduate School of Science Assistant Professor(2015/04/01-2017/03/31)
Hiroshima University Graduate School of Science Researcher(2014/02/01-2015/03/31)
Fritz Haber Institute of the Max Planck Society Department of Physical Chemistry Postdoc(2011/12/01-2014/01/31)

Year & Month of Birth

Academic Society

Award

Specialities

Biophysics

Speciality Keywords

theoretical/computational biophysics, protein dynamics, molecular machines/motors, molecular modelling

Research Themes

Books

  •  H. Flechsig Molecular Motors - Nanoscale engines of the cell and their structurally resolved modeling. VHS Publishing 2012

Papers

  •  Simple mechanics of protein machines H. Flechsig, A.S. Mikhailov  J. R. Soc. Interface 16 155 20190244 2019 
  •  Design of elastic networks with evolutionary optimized long-range communication as mechanical models of allosteric proteins. H. Flechsig Biophys. J. 113 558-571 2017 
  •  Deciphering intrinsic inter-subunit couplings that lead to sequential hydrolysis of F1-ATPase ring. L. Dai, H. Flechsig, J. Yu Biophys. J. 113 1440-1453 2017 
  •  Tracing entire operation cycles of molecular motor hepatitis C virus helicase in structurally resolved dynamical simulations. H. Flechsig, A.S. Mikhailov Proc. Natl. Acad. Sci. USA 107 20875-20880 2010 
  •  Towards synthetic molecular motors: a model elastic-network study. A. Sarkar, H. Flechsig, A.S. Mikhailov New J. Phys. 18 043006 2016 

show all

  •  Non-RVD mutations that enhance the dynamics of the TAL repeat array along the superhelical axis improve TALEN genome editing efficacy. N. Tochio, K. Umehara, J. Uewaki, H. Flechsig, M. Kondo, T. Dewa, T. Sakuma, T. Yamamoto, T. Saitoh, Y. Togashi, S. Tate Scientific Reports 6 37887 2016 
  •  Nucleotide-induced conformational dynamics in ABC transporters from structure-based coarse grained modelling. H. Flechsig Front. Phys. 4 3 2016 
  •  TALEs from a spring - superelasticity of Tal effector protein structures. H. Flechsig PLoS ONE 9 10 e109919 2014 
  •  In silico investigation of conformational motions in superfamily 2 helicase proteins. H. Flechsig, D. Popp, A.S. Mikhailov PLoS ONE 6 7 e21809 2011 
  •  On the spectral gap in Andreev graphs. H. Flechsig, S. Gnutzmann Proc. Symp. Pure Math 77 381-395 2008
  •  Computational biology approach to uncover hepatitis C virus helicase operation. H. Flechsig W. J. Gastroenterol. 20 3401-3409 2014 
  •  Elastic network modeling of molecular motor HCV helicase: Inchworm translocation and DNA unzipping cycles. H. Flechsig, A.S. Mikhailov Dynamics Days Europe 2009 (Network and Time Series 6 pp 11) 6 11 2009
  •  Structurally Resolved Coarse-Grained Modeling of Motor Protein Dynamics H. Flechsig 2012 
  •  Gap-Statistics in Andreev-Graphs H. Flechsig 2006
  •  Designed Elastic Networks: Models of Complex Protein Machinery H. Flechsig, Y. Togashi Int. J. Mol. Sci. 19 10 3152 2018 
  •  Coarse-Grained Protein Dynamics Studies Using Elastic Network Models Y. Togashi, H. Flechsig Int. J. Mol. Sci. 19 12 3899 2018 
  •  Analyzing Fluctuation Properties in Protein Elastic Networks with Sequence-Specific and Distance-Dependent Interactions R. Amyot, Y. Togashi, H. Flechsig Biomolecules 9 10 549 2019 

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○Biophysics「Design principles of protein structures with allosteric control」(2016-2020) 
○Biophysics「Minority biology」(2015-2016) 

Classes (Bachelors)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

To Page Top