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Researcher Information

last modified:2020/01/22

Professor TSUCHIYA Hiroyuki

Mail Laboratory Website

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Graduate School of Phamacy
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

 TEL:076-265-2374 FAX:076-234-4261

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor 1988 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 1983
【Degree】
Medical doctor

Career

School of Medicine, Kanazawa University Department of Orthopaedic Surgery(1989/11/01-1991/06/30)
School of Medicine, Kanazawa University Department of Orthopaedic Surgery(1991/07/01-1994/03/31)
Kanazawa University Hospital Department of Orthopaedic Surgery(1994/04/01-1999/06/30)
Scool of Medicine, Kanazawa University Department of Orthopaedic Surgery(1999/07/01-2001/03/30)
Graduate School of Medical Science, Kanazawa University Department of Orthopaedic Surgery(2001/04/01-)
Graduate School of Medical Science,Kanazawa University Departmentof Orthopaedic Surgery(2010/04-)

Year & Month of Birth

1957/06

Academic Society

Japanese Orthopaedic Association

JACR
JSCO
Japanese Association of External Fixation and Limb Lengthening
Central Japan Association of Orthopaedic Surgery and Traumatology
Japanese Association of Ilizarov Method
SICOT
Internationa Society of Limb Salvage
Japanese Orthopaedic Association
International Society of Limb Salvage
Limb Lengthening and Reconstruction Society
.
The Japanese Association for the Metastasis Reserch
The Japanese Pediatric Orthopaedic Association

Award

○.(1994)
○The 8th International Exhibition Award(1995)
○jotf(1996)
○.(1998)
○.(1999)
○.(2002)
○.(2003)
○.(2003)
○.(2004)
○.(2006)
○.(2007)
○.(2008)
○.(2009)
○Best poster prize(2017/10/14)
○Gold medal award(2017/09/14)

Specialities

Musculoskeletal tumor、Bone lengthening、Reproductive medicine of bone cartilage and joint、Orthopaedic surgery

Speciality Keywords

Musculoskeletal tumor, Limb lengthening, Deformity correction, External fixation

Research Themes

Study on the treatment of musculoskeletal tumors

Study on bone lengthening

The role of fibrinolytic system in the formation of lung metastasis. Elucidation of the mechanism of lung metastasis and the development of the treatment strategy

Books

Papers

  •  Additional wide resection for soft tissue sarcoma after unplanned excision. Orthop Trans 22 278 1998
  •  Anatomic aspects of biopsy of proximal fibula. International Orthop 24 335-337 2001
  •  Ankle arthrodesis and tibial lengthening for congenital sensory neuropathy with anhidrosis. J Orthop Sci 6 430-434 2001
  •  Assessment of P-glycoprotein in patients with malignant bone and soft-tissue tumors using technetium-99m-MIBI scintigraphy. J Nucl Med 39 1179-1184 1998
  •  Blood flow measurement during distraction osteogenesis. Clin Orthop 47 229-235 1998

show all

  •  Caffeine-assisted chemotherapy and minimized tumor excision for nonmetastatic osteosarcoma. Anticancer Res 18 657-666 1998
  •  Caffeine-assisted chemotherapy and surgical minimization for stage IIB osteosarcoma. Orthop Trans 21 336 1997
  •  Caffeine-potentiated chemotherapy and conservative surgery for high-grade soft tissue sarcomas. Anticancer Res 18 3651-3656 1998
  •  Caffeine-potentiated radiochemotherapy and function-saving surgery for high-grade soft tissue sarcoma. Anticancer Res 20 2134-2143 2000
  •  Cannulation of simple bone cyst. J Bone Joint Surg 84B 245-248 2002
  •  De novo deletions of p53 gene and wild-type p53 correlate with acquired cisplatin-resistance in human osteosarcoma OST cell line. Anticancer Res 19 5131-5138 1999
  •  Disappearance of Ewing's sarcoma following bacterial infection. A case report. Anticancer Res 17 1391-1398 1997
  •  Effect of myocutaneous inflammatory changes caused by intra-arterial chemotherapy on the outcome of patients who undergo limb-saving surgery. CANCER 91 2447-2453 2001
  •  Establishment and characterization of an acquired cisplatin-resistant subline in a human osteosarcoma cell line. Anticancer Res 18 1765-1768 1998
  •  Evaluating benign and malignant bone and soft-tissue lesions with Technetium-99m-MIBI scintigraphy. J Nucl Med 38 501-506 1997
  •  Extraskeletal myxoid chondrosarcoma with multiple skeletal metastases. J Orthop Sci 5 171-174 2000
  •  Frozen massive autograft for tumor reconstruction: in vitro and in vivo study. Orthop Trans 91 2001
  •  Genomic instability and aberrant expression of p53 correlate with acquired cisplatin-resistance in a human osteosarcoma. Orthop Trans 23 1999
  •  Intra-arterial chemotherapy combined with caffeine and minimized surgery for nonmetastatic osteosarcoma. Reg Cancer Treat 1 Suppl 23 1997
  •  Intra-arterial chemotherapy for soft-tissue sarcoma. Reg Cancer Treat 1 Suppl 26 1997
  •  Knee joint preservation and periarticular reconstruction using distraction osteogenesis for osteosarcoma. Orthop Trans 22 277-278 1998
  •  Limb salvage using distraction osteogenesis. Orthop Trans 21 393-394 1997
  •  Limb salvage using distraction osteogenesis. A classification of the technique. J Bone Joint Surg 79-B 403-411 1997
  •  Malignant transformation of a giant cell tumor 25 years after initial treatment. Clin Orthop 38 185-191 2000
  •  Marginal excision for osteosarcoma with caffeine assisted chemotherapy. Clin Orthop 358 27-35 1999
  •  Massive aoutoclaved aloografts and autografts for limb salvage surgery. Acta Orthopedica Scandinavia 68 392-395 1997
  •  Midcourse thallium-201 scintigraphy to predict tumor response in bone and soft-tissue tumors. J Nucl Med 39 1600-1604 1998
  •  Periarticular reconstruction using distraction osteogenesis after en bloc tumor resection. Orthop Trans 22 172 1998
  •  Periarticular reconstruction using distraction osteogenesis. Arch Am Acad Orthop Surg 2 68-75 1999
  •  Plasminogen activator inhibitor-1 accelerates lung metastases of human fibrosarcoma. Anticancer Res 17 313-316 1997
  •  Prediction of callus formation in distraction osteogenesis. Orthop Trans 22 262-263 1998
  •  Presacral tumor associated with the Currarino triad in an adolescent. Arch Orthop Traumatol Surg 121 114-116 2001
  •  Radio-chemotherapy combined with caffeine for soft-tissue sarcoma. A preliminary report. Reg Cancer Treat 1 Suppl 26 1997
  •  Sensitization and caffeine potentiation of cisplatin cytotoxicity resulting from introduction of wild-type p53 gene in human osteosarcoma. Anticancer Res 20 235-242 2000
  •  Simple bone cyst is not a single entity: point of view based on a literature review. Medical Hypothesis 58 87-91 2002
  •  Telomerase activity in bone and soft tissue tumors. Proceedings from 11th International Symposium on Limb Salvage 104 2001
  •  Thallium-201 SPECT in differentiating bone infarction from metastatic lesion in osteosarcoma. Clin Nucl Med 22 752-755 1997
  •  The ability of callus formation during distraction osteogenesis after chemotherapy. Orthop Trans 21 304-305 1997
  •  Total en bloc spondylectomy. A new surgical technique for primary malignant vertebral tumors. SPINE 22 324-333 1997
  •  Transplantation of osteoblast-like cells to the distracted callus in rabbits. J Bone Joint Surg 81B 125-129 1999
  •  A case report of a familial osteosarcoma-Analysis of DNA arrangement in the p53 gene-. Proceedings from 11th International Symposium on Limb Salvage 34 2002
  •  Analysis of effective factors in massive autoclaved allografts and autografts for limb salvage surgery after resection of bone tumours. Proceedings of 10th International Symposium on Limb Salvage 62-63 1999
  •  Anatomical consideration for biopsy of proximal lesion. Proceedings of 10th International Symposium on Limb Salvage 81-82 1999
  •  Angiogenesis inhibitor TNP-470 suppresses tumor growth and metastasis of fibrosarcoma both in vitro and in vivo. Proceedings from 11th International Symposium on Limb Salvage 61-62 2001
  •  Ankle arthrodesis and lengthening for congenital sensory neuropathy with anhidrosis (CSNA) ? a case report. Book of Abstract-ASAMI Congress-Rome 91 2001
  •  Bilateral symmetrical cysts in the upper tibiae in a skeletally mature patient: might they be simple bone cyst? J Orthop Sci 6 595-600 2001
  •  Caffeine-potentiated chemotherapy following radiation for high grade soft tissue sarcoma. Proceedings of the 10th International Symposium on Limb Salvage 72-73 1999
  •  Clinical outcome of caffeine-potentiated chemotherapy for high grade soft tissue sarcoma. Proceedings from 11th International Symposium on Limb Salvage 105-108 2001
  •  De novo deletions of p53 gene and wild-type p53 are associated with acquired resistance to CDDP in human osteosarcoma cells. Proceedings of 10th International Symposium on Limb Salvage 16 1999
  •  De novo deletions of p53 protein are associated with acquired resistance to cisplatin in human osteosarcoma cells. Proceedings from 11th International Symposium on Limb Salvage 110 2001
  •  Distraction osteogenesis after irradiation in a rabbit model. Book of Abstract-ASAMI Congress-Rome 74 2001
  •  Effects of myocutaneous inflammatory changes caused by intra-arterial infusion chemotherapy on limb-sparing surgery. Proceedings of 10th International Symposium on Limb Salvage 105 1999
  •  Expression of Fas ligand in human osteosarcoma. Proceedings of 10th International Symposium on Limb Salvage 106 1999
  •  Histological analysis of an autoclaved autograft of the femur which was extirpated two years after implantation. Proceedings of 10th International Symposium on Limb Salvage 112-113 1999
  •  Intentional marginal excision for osteosarcoma of the proximal fibula with preservation of the common peroneal nerve. Proceedings from 11th International Symposium on Limb Salvage 124 2001
  •  Intermediate follow up (more than 3 years) of TES surgery. Proceedings from 11th International Symposium on Limb Salvage 50 2001
  •  Introduction of a wild-type p53 gene enhances sensitivity to cisplatin and caffeine on human osteosarcoma cells. Proceedings of 10th International Symposium on Limb Salvage 80 1999
  •  Joint preservation and reconstruction with distraction osteogenesis for juxta-articular osteosarcoma. Proceedings from 11th International Symposium on Limb Salvage 115-118 2001
  •  Long-term outcome after reconstruction with an autoclaved bone graft for limb salvage surgery. Proceedings from 11th International Symposium on Limb Salvage 184-190 2001
  •  Measurement of blood flow during distraction osteogenesis using technetium scintigraphy. Book of Abstract-ASAMI Congress-Rome 127-128 2001
  •  Measurement of blood flow using technetium scintigraphy during distraction osteogenesis after tumor resection. Proceedings from 11th International Symposium on Limb Salvage 36 2001
  •  Midcourse thallium-201 scintigraphy to predict tumor response to chemotherapy in bone and soft tissue tumors. Proceedings of 10th International Symposium on Limb Salvage 17-18 1999
  •  Periarticular tumor renonstruction using distraction osteogenesis. Proceedings of the 10th International Symposium on Limb Salvage 60 1999
  •  Prediction of multidrug resistance using technetium-99m-MIBI scintigraphy in malignant bone and soft tissue tumor. Proceedings of 10th International Symposium on Limb Salvage 18-19 1999
  •  Prognosis of patients with metastatic osteosarcoma in the lung: The Japanese musculoskeletal oncology group study of 280 patients. Proceedings from 11th International Symposium on Limb Salvage 80-83 2001
  •  Results of an intramedullary nailing with bone cement for metastatic tumor of the proximal femur. Proceedings of 10th International Symposium on Limb Salvage 11 1999
  •  Surgical strategy for spinal metastasis. Proceedings of 10th International Symposium on Limb Salvage 10 1999
  •  Tibial lengthening over an intramedullary nail. Influence of an intramedullary nail on the limb lengthening. Book of Abstract-ASAMI Congress-Rome 92-93 2001
  •  Tumor growth potential after tumoral and instrumental contamination: an in-vivo comparative study of T-saw, Gigli saw, and scalpel. J Orthop Sci 6 424-429 2001
  •  Usefulness of Tc-99m MAA for preventing skin or muscle damage caused by intra-arterial chemotherapy. Proceedings from 11th International Symposium on Limb Salvage 146 2001

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

○Development of new external fixators
○Development of immunotherapy for bone and soft-tissue tumors
○Development of the treatment to promote bone formation

Grant-in-Aid for Scientific Research

○「骨肉腫におけるp53発現制御によるシスプラチン耐性の克服」(1997-) 
○「骨肉腫におけるp53発現制御によるシスプラチン耐性の克服」(1998-) 
○「カフェインによるP53遺伝子を介在した骨肉腫のシスプラチン耐性克服」(1999-) 
○「カフェインによるp53遺伝子を介在した骨肉腫のシスプラチン耐性克服」(2000-) 
○「肉腫に対する制癌剤の耐性克服に関する研究」(1997-) 
○「骨軟部腫瘍に対するMTTassayに関する研究」(1998-) 
○「骨軟部腫瘍に対するMTTassayに関する研究」(1990-) 
○「ヒト骨肉腫に対するビタミンD3の抗腫瘍効果ならびに分化誘導効果の検討」(1991-) 
○「ヒト骨肉腫に対するビタミンD3の抗腫瘍効果ならびに分化誘導効果の検討」(1992-) 
○「肺転移に対するターゲット療法」(1993-) 
○「プラスミノーゲンアクチベ-ターインヒビター1の活性に基づいた肺転移形成と抑制」(1994-) 
○「転移のメカニズム(清水班)」(1994-) 
○「正常間葉系細胞への骨形成因子(rhBMP-2)遺伝子導入による延長仮骨形成促進」(2002-) 
○「正常間葉系細胞への骨形成因子(rhBMP-2)遺伝子導入による延長仮骨形成促進」(2003-) 
○「抗癌剤およびカフェイン封入リポゾームを用いた骨肉腫の治療とテーラーメイド化学療法」(2004-) 
○「抗癌剤およびカフェイン封入リポゾームを用いた骨肉腫の治療とテーラーメイド医療」(2005-) 
○「抗癌剤およびカフェイン封入リポゾームを用いた骨肉腫の治療とテーラーメイド化学療法」(2006-) 
○「悪性骨腫瘍に対する凍結免疫療法の確立」(2012-2013) 
○「蛍光イメージングを用いた骨軟部腫瘍の進展機序解明と治療戦略」(2011-2013) 

Classes (Bachelors)

○Orthopaedics(BSL)(2017)
○Musculaskeletal System(2017)
○Musculaskeletal System(2016)
○Orthopaedics(BSL)(2016)

Classes (Graduate Schools)

○Restorative Medicine of Musculoskeletal System(2017)
○Restorative Medicine of Musculoskeletal System(2017)
○Restorative Medicine of Musculoskeletal System(2017)
○Restorative Medicine of Musculoskeletal System(2016)
○Restorative Medicine of Musculoskeletal System(2016)
○Research Ethics(2016)
○Research Ethics(2016)
○Restorative Medicine of Musculoskeletal System(2016)
○Research Ethics(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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