本文へジャンプ

研究者情報

データ更新日:2024年03月29日

FRANZ CLEMENS MARTIN (ふらんつ くれめんす まーていん) 准教授 FRANZ, Clemens Martin

所属組織・役職等

ナノ生命科学研究所

教育分野

所属研究室等

学歴

職歴

生年月

所属学会

学内委員会委員等

受賞学術賞

専門分野

専門分野キーワード

研究課題

著書

論文

  • Benzylguanine Thiol Self-Assembled Mono layers for the Immobilization of SNAP-tag Proteins on Microcontact-Printed Surface Structures LANGMUIR 26巻 9号 6097頁 2010/05 査読有 研究論文(学術雑誌)
  • Creating ultrathin nanoscopic collagen matrices for biological and biotechnological applications SMALL 3巻 6号 956頁 2007/06 査読有 研究論文(学術雑誌)
  • Retinal Pigment Epithelium Cell Alignment on Nanostructured Collagen Matrices CELLS TISSUES ORGANS 194巻 6号 443頁 2011 査読有 研究論文(学術雑誌)
  • Alignment and Cell-Matrix Interactions of Human Corneal Endothelial Cells on Nanostructured Collagen Type I Matrices INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 51巻 12号 6303頁 2010/12 査読有 研究論文(学術雑誌)
  • Phosphoinositide 3-kinase C2 beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanism MOLECULAR BIOLOGY OF THE CELL 17巻 9号 3729頁 2006/09 査読有 研究論文(学術雑誌)

全て表示

  • Observing growth steps of collagen self-assembly by time-lapse high-resolution atomic force microscopy JOURNAL OF STRUCTURAL BIOLOGY 154巻 3号 232頁 2006/06 査読有 研究論文(学術雑誌)
  • RPE Cell Adhesion, Polarization and Directional Migration on Nanostructured Collagen Matrices Ulbrich, S,Friedrichs, J,Valtink, M,Murovski, S,Franz, C,Zubaty, V,Funk, RHW,Engelmann, K Investigative Ophthalmology & Visual Science 47巻 13号 2875頁 2006 査読有 研究論文(学術雑誌)
  • Analyzing focal adhesion structure by atomic force microscopy JOURNAL OF CELL SCIENCE 118巻 22号 5315頁 2005/11 査読有 研究論文(学術雑誌)
  • Signalling to Rho GTPases in cell motility EUROPEAN JOURNAL OF CELL BIOLOGY 83巻 45頁 2004/03 査読無
  • p120 catenin associates with microtubules - Inverse relationship between microtubule binding and Rho GTPase regulation JOURNAL OF BIOLOGICAL CHEMISTRY 279巻 8号 6588頁 2004/02 査読有 研究論文(学術雑誌)
  • Characterization of protein phosphorylation by mass spectrometry using immobilized metal ion affinity chromatography with on-resin beta-elimination and Michael addition ANALYTICAL CHEMISTRY 75巻 13号 3232頁 2003/07 査読有 研究論文(学術雑誌)
  • Studying collagen self-assembly by time-lapse high-resolution atomic force microscopy Franz, Clemens M,Muller, Daniel J Atomic Force Microscopy in Biomedical Research 97頁 2011 査読有
  • Two-Component Polymer Scaffolds for Controlled Three-Dimensional Cell Culture ADVANCED MATERIALS 23巻 11号 1341頁 2011/03 査読有 研究論文(学術雑誌)
  • Atomic Force Microscopy: A Versatile Tool for Studying Cell Morphology, Adhesion and Mechanics CELLULAR AND MOLECULAR BIOENGINEERING 1巻 4号 289頁 2008/12 査読有 研究論文(学術雑誌)
  • Revealing early steps of alpha(2)beta(1) integrin-mediated adhesion to collagen type I by using single-cell force spectroscopy MOLECULAR BIOLOGY OF THE CELL 18巻 5号 1634頁 2007/05 査読有 研究論文(学術雑誌)
  • Cellular remodelling of individual collagen fibrils visualized by time-lapse AFM JOURNAL OF MOLECULAR BIOLOGY 372巻 3号 594頁 2007/09 査読有 研究論文(学術雑誌)
  • Tailored three-dimensional microstructure scaffolds for cell culture EUROPEAN JOURNAL OF CELL BIOLOGY 89巻 57頁 2010/03 査読無
  • Inverse Regulation between Integrin alpha 2 beta 1 and Laminin Receptors. MOLECULAR BIOLOGY OF THE CELL 22巻 2011 査読無
  • Molecular-scale topographic cues induce the orientation and directional movement of fibroblasts on two-dimensional collagen surfaces JOURNAL OF MOLECULAR BIOLOGY 349巻 2号 380頁 2005/06 査読有 研究論文(学術雑誌)
  • Migration of Human Corneal Endothelial Cells (HCEC) on a Nanostructured Collagen Matrix Gruschwitz, R,Friedrichs, J,Valtink, M,Franz, C,Zubaty, V,Funk, RHW,Engelmann, K Investigative Ophthalmology & Visual Science 47巻 13号 2717頁 2006 査読有 研究論文(学術雑誌)
  • Cell migration in development and disease DEVELOPMENTAL CELL 2巻 2号 153頁 2002/02 査読有 研究論文(学術雑誌)
  • Elastic Fully Three-dimensional Microstructure Scaffolds for Cell Force Measurements ADVANCED MATERIALS 22巻 8号 868頁 2010/02 査読有 研究論文(学術雑誌)
  • Designed 3D polymer scaffolds to study the migration of cancer cells with altered nuclear mechanics. MOLECULAR BIOLOGY OF THE CELL 22巻 2011 査読無
  • Studying integrin-mediated cell adhesion at the single-molecule level using AFM force spectroscopy Franz, Clemens M,Taubenberger, Anna,Puech, Pierre-Henri,Muller, Daniel J Science Stke 2007巻 406号 pl5頁 2007 査読有 研究論文(学術雑誌)
  • Phosphorylation and intracellular localization of p120 catenin. Franz, Clemens Martin Doctoral Thesis 2003 査読無 学位論文(博士)
  • Lumican inhibits cell migration through alpha 2 beta 1 integrin EXPERIMENTAL CELL RESEARCH 316巻 17号 2922頁 2010/10 査読有 研究論文(学術雑誌)
  • High-speed atomic force microscopy simultaneous to advanced optical microscopy EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 44巻 S78頁 2015/07 査読無
  • Investigating differential cell-matrix adhesion by directly comparative single-cell force spectroscopy Dao, Lu,Gonnermann,Carina,Franz, Clemens Martin Journal of Molecular Recognition 26巻 11号 578頁 2013 査読有 研究論文(学術雑誌)
  • Integrin α2β1 as a negative regulator of the laminin receptors α6β1 and α6β4 Micron 148巻 103106頁 2021/09 査読有 研究論文(学術雑誌)
  • Directing nuclear deformation on micropillared surfaces by substrate geometry and cytoskeleton organization Badique, F,Stamov, D. R,Davidson, P,Veuillet, M,Laurent, G,Reiter, G,Freund, J.N,Franz, C. M,Anselme, K Biomaterials 34巻 2号 2991頁 2013 査読有 研究論文(学術雑誌)
  • Inverting adherent cells for visualizing ECM interactions at the basal cell side Gudzenko, Tetyana,Franz, Clemens M Ultramicroscopy 128巻 01-Sep頁 2013 査読有 研究論文(学術雑誌)
  • Cadherin-11 promotes neural crest cell spreading by reducing intracellular tension - Mapping adhesion and mechanics in neural crest explants by atomic force microscopy Blaue, Carina,Kashef, Jubin,Franz, Clemens M Seminars in Cell & Developmental Biology 73巻 95頁 2018/01 査読有 研究論文(学術雑誌)
  • Coupled mechanical mapping and interference contrast microscopy reveal viscoelastic and adhesion hallmarks of monocyte differentiation into macrophages Nanoscale 15巻 29号 12255頁 2023 研究論文(学術雑誌) 
  • Simulation atomic force microscopy for atomic reconstruction of biomolecular structures from resolution-limited experimental images PLOS Computational Biology 18巻 3号 e1009970頁 2022/03/16 査読有 研究論文(学術雑誌) 
  • An ultra-wide scanner for large-area high-speed atomic force microscopy with megapixel resolution Scientific Reports 11巻 1号 2021/12 査読有 研究論文(学術雑誌) 
  • Induction of ligand promiscuity of αVβ3 integrin by mechanical force. Journal of cell science 2020/03/19 査読有
  • Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress CELL DEATH & DISEASE 7巻 e2461頁 2016/11 査読有 研究論文(学術雑誌)
  • Cell type-specific adaptation of cellular and nuclear volume in micro-engineered 3D environments BIOMATERIALS 69巻 121頁 2015/11 査読有 研究論文(学術雑誌)
  • Studying early stages of fibronectin fibrillogenesis in living cells by atomic force microscopy MOLECULAR BIOLOGY OF THE CELL 26巻 18号 3190頁 2015/09 査読有 研究論文(学術雑誌)
  • Quantitative methods for analyzing cell-cell adhesion in development DEVELOPMENTAL BIOLOGY 401巻 1号 165頁 2015/05 査読有 研究論文(学術雑誌)
  • Assay for characterizing the recovery of vertebrate cells for adhesion measurements by single-cell force spectroscopy FEBS LETTERS 588巻 19号 3639頁 2014/10 査読有 研究論文(学術雑誌)
  • Force-controlled manipulation of single cells: from AFM to FluidFM TRENDS IN BIOTECHNOLOGY 32巻 7号 381頁 2014/07 査読有 研究論文(学術雑誌)
  • Covalent and Density-Controlled Surface Immobilization of E-Cadherin for Adhesion Force Spectroscopy PLOS ONE 9巻 3号 e93123頁 2014/03 査読有 研究論文(学術雑誌)
  • Quantitative analysis of type I collagen fibril regulation by lumican and decorin using AFM JOURNAL OF STRUCTURAL BIOLOGY 183巻 3号 394頁 2013/09 査読有 研究論文(学術雑誌)
  • Ultra-thin, transparent, porous substrates as 3D culture scaffolds for engineering ASC spheroids for high-magnification imaging Journal of Materials Chemistry B 8巻 31号 6999頁 2020 査読有 研究論文(学術雑誌) 
  • Coupled mechanical mapping and interference contrast microscopy reveal viscoelastic and adhesion hallmarks of monocytes differentiation into macrophages 2022/11/29 査読無 
  • Atomic reconstruction of biomolecular structures from AFM images and quantitative validation of experimental data using simulated AFM scanning 2021/06/28 査読無 
  • Quantitating membrane bleb stiffness using AFM force spectroscopy and an optical sideview setup INTEGRATIVE BIOLOGY 7巻 3号 356頁 2015 査読有 研究論文(学術雑誌)
  • Multifunctional polymer scaffolds with adjustable pore size and chemoattractant gradients for studying cell matrix invasion BIOMATERIALS 35巻 2号 611頁 2014/01 査読有 研究論文(学術雑誌)
  • Ligand binding promiscuity of αVβ3 integrin is enlarged in response to mechanical force Bachmann, Michael,Schäfer, Markus,Weißenbruch, Kai,Mykuliak, Vasyl,Heiser, Lia,Franz, Clemens M,Hytüen, Vesa,Wehrle-Haller, Bernhard,Bastmeyer, Martin bioRxiv 200493頁 2018/11 査読無 研究論文(学術雑誌)
  • Multiparametric BioAFM Imaging with Simultaneous Advanced Optical Microscopy. MOLECULAR BIOLOGY OF THE CELL 27巻 2016 査読無
  • Applications of Atomic Force Microscopy and Single-Cell Force Spectroscopy in Cell Adhesion Franz, Clemens M Microscopy and Analysis 26巻 3号 2012 査読無 研究論文(学術雑誌)
  • Tspan8 is expressed in breast cancer and regulates E-cadherin / catenin signalling and metastasis accompanied by increased circulating extracellular vesicles Voglstaetter,Maren R,Thomsen, Andreas,Nouvel, Jerome,Koch, Arend,Navarro, Elena Grueso,Gainey-Schleicher, Tanja,Khanduri, Richa,Groß, Andrea,Rossner, Florian,Blaue, Carina,Franz, Clemens Martin,Veil, Marina,Puetz, Gerhard,Hippe, Andreas,Dindorf, Jochen,Kashef, Jubin,Thiele, Wilko,Homey, Bernhard,Greco, Celine,Boucheix, Claude,Baur, Andreas,Erbes, Thalia,Waller, Cornelius F,Follo, Marie,Hossein, Ghamartaj,Sers, Christine,Sleeman, Jonathan,Nazarenko, Irina The Journal of Pathology 2019/04 査読有 研究論文(学術雑誌)
  • Cadherin-11 localizes to focal adhesions and promotes cell-substrate adhesion NATURE COMMUNICATIONS 7巻 10909頁 2016/03 査読有 研究論文(学術雑誌)
  • Imaging collagen type I fibrillogenesis with high spatiotemporal resolution ULTRAMICROSCOPY 149巻 86頁 2015/02 査読有 研究論文(学術雑誌)
  • Quantitative analysis of type I collagen fibril regulation by lumican and decorin using AFM JOURNAL OF STRUCTURAL BIOLOGY 183巻 3号 394頁 2013/09 査読有 研究論文(学術雑誌)
  • Revealing non-genetic adhesive variations in clonal populations by comparative single-cell force spectroscopy EXPERIMENTAL CELL RESEARCH 318巻 17号 2155頁 2012/10 査読有 研究論文(学術雑誌)
  • Controlling Fibronectin Fibrillogenesis Using Visible Light Frontiers in Molecular Biosciences 7巻 2020/07/08 査読有 研究論文(学術雑誌) 
  • Nanoscale topographic changes on sterilized glass surfaces affect cell adhesion and spreading JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 102巻 8号 2755頁 2014/08 査読有 研究論文(学術雑誌)
  • Biphasic reinforcement of nascent adhesions by vinculin Journal of Molecular Recognition 2023/03/29 査読有 研究論文(学術雑誌) 
  • Observing Dynamic Conformational Changes within the Coiled-Coil Domain of Different Laminin Isoforms Using High-Speed Atomic Force Microscopy International Journal of Molecular Sciences 25巻 4号 1951頁 2024/02/06 査読有 研究論文(学術雑誌) 
  • S100A11 promotes focal adhesion disassembly via myosin II-driven contractility and Piezo1-mediated Ca2+ entry Journal of Cell Science 137巻 2号 2024/01/15 査読有 研究論文(学術雑誌) 
  • S100A11 promotes focal adhesion disassembly via myosin II-driven contractility and Piezo1-mediated Ca2+entry Tareg Omer Mohammed,You-Rong Lin,Kai Weissenbruch,Kien Xuan Ngo,Yanjun Zhang,Noriyuki Kodera,Martin Bastmeyer,Yusuke Miyanari,Azuma Taoka,Clemens M. Franz bioxriv 2023/07 研究論文(学術雑誌)
  • Structural heterogeneity of the ion and lipid channel TMEM16F Nature Communications 15巻 1号 2024/01/02 査読有 研究論文(学術雑誌) 
  • Biphasic reinforcement of nascent adhesions by vinculin Hella Baumann, Melanie Schwingel, Marcello Sestu, Anna Burcza, Susanna Marg, Wolfgang Ziegler, Anna V Taubenberger, Daniel J. Muller, Martin Bastmeyer, Clemens M. Franz Journal of Molecular Recognition 2023/03/29
  • Coupled mechanical mapping and interference contrast microscopy reveal viscoelastic and adhesion hallmarks of monocytes differentiation into macrophages Mar Eroles, Javier Lopez-Alonso, Alexandre Ortega, Thomas Boudier, Khaldoun Gharzeddine, Frank Lafont, Clemens Martin Franz, Arnaud Millet, Claire Valoteau, Felix Rico bioRxiv 2022/11/29 査読無 原著論文
  • Simulation atomic force microscopy for atomic reconstruction of biomolecular structures from resolution-limited experimental images R Amyot, A Marchesi, CM Franz, I Casuso, H Flechsig PLOS Computational Biology 2022/03/16 査読有
  • An ultra-wide scanner for large-area high-speed atomic force microscopy with megapixel resolution Arin Marchesi, Kenichi Umeda, Takumi Komekawa, Takeru Matsubara, Holger Flechsig, Toshio Ando, Shinji Watanabe, Noriyuki Kodera, Clemens M Franz Scientific Reports 2021/06/21 査読有
  • Integrin α2β1 as a negative regulator of the laminin receptors α6β1 and α6β4 Lu Dao, Carina Blaue, Clemens M Franz Micron 2021/09/01 査読有
  • Atomic reconstruction of biomolecular structures from AFM images and quantitative validation of experimental data using simulated AFM scanning Romain Amyot, Arin Marchesi, Clemens Martin Franz, Ignacio Casuso, Holger Flechsig bioRxiv 2021/06/01 査読無
  • Ultra-thin, transparent, porous substrates as 3D culture scaffolds for engineering ASC spheroids for high-magnification imaging Yoshitaka Suematsu, Ya An Tsai, Shinji Takeoka, Clemens M Franz, Satoshi Arai, Toshinori Fujie Journal of Materials Chemistry B 8巻 31号 6999-7008頁 2000/06/19 査読有
  • Controlling fibronectin fibrillogenesis using visible light Tetyana Gudzenko, Clemens Martin Franz Front. Mol. Biosci. 2020/07/08 査読有 原著論文 研究論文(学術雑誌)
  • Tspan8 is expressed in breast cancer and regulates E‐cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles  Voglstaetter, Maren R, Thomsen, Andreas, Nouvel, Jerome, Koch, Arend, Navarro, Elena Grueso, Gainey-Schleicher, Tanja, Khanduri, Richa, Groß, Andrea, Rossner, Florian, Blaue, Carina, Franz, Clemens Martin, Veil, Marina, Puetz, Gerhard, Hippe, Andreas, Dindorf, Jochen, Kashef, Jubin, Thiele, Wilko, Homey, Bernhard, Greco, Celine, Boucheix, Claude, Baur, Andreas, Erbes, Thalia, Waller, Cornelius F, Follo, Marie, Hossein, Ghamartaj, Sers, Christine, Sleeman, Jonathan, Nazarenko, Irina  The Journal of Pathology  248巻 4号 421-437頁 2019/04/14 査読有 原著論文
  • Induction of ligand promiscuity of αVβ3 integrin by mechanical force. Michael Bachmann, Markus Schäfer, Vasyl V Mykuliak, Marta Ripamonti, Lia Heiser, Kai Weißenbruch, Sarah Krübel, Clemens M Franz, Vesa P Hytönen, Bernhard Wehrle-Haller, Martin Bastmeyer  Journal of cell science 2020/03/19 査読有

講演・口頭発表等

  • Intracellular Exploration by Nanoprobe Microscopy(会議名:Colloquium on Complex and Biologial Systems, Potsdam University)(2022/07/15)
  • Intracellular Exploration by High-Speed AFM (会議名:Bio-Seminars at Karlsruhe Institute of Technology)(2022/07/18)
  • Using an Ultrawide High-Speed AFM Scanner for Intracellular Exploration(会議名:AFM Biomed Conference 2022)(2022/09/01)
  • High-Speed AFM for Intracellular Exploration(会議名:European Phys2Biomed Network Progress Meeting)(2021/09/21)
  • Cell Mechanics Measurements using AFM(会議名:Bruker JPK Webinar)(2021/11/19)

全て表示

  • Imaging Myosin II-driven Stress Fiber Contraction in De-roofed Cells by High-Speed AFM (会議名:8th Multifrequency AFM Conference )(2020/10/30)
  • Imaging Myosin II-driven Stress Fiber Contraction in De-roofed Cells by High-Speed AFM(会議名:NanoLSI-iCeMs Joint Symposium)(2020/01/24)
  • Mapping adhesion and elasticity changes in tissues during the transition from collective to single-cell migration (会議名:ISPM 2019 )(2019/05/26)
  • Analysing directional co-migration of cancer cells and cancer-associated fibroblasts along fibronectin nanotracks by live-cell HS-AFM and 3D holography imaging (会議名:WPI Site Visit )(2019/07/24)
  • Mapping adhesion and elasticity changes in tissues during the transition from collective to single-cell migration (会議名:Joint UBI-NanoLSI workshop )(2019/09/22)

その他(報告書など)

芸術・フィールドワーク

特許

共同研究希望テーマ

科研費

競争的資金・寄付金等

共同研究・受託研究実績

A-STEP採択課題

学域・学類担当授業科目

大学院担当授業科目

他大学の客員教授

教育活動(FD)に関する研究

国際事業協力

留学生参加の社会活動

審議会等の参加

講演可能なテーマ

その他公的社会活動

このページの先頭へ