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Researcher Information

last modified:2021/11/29

Associate Professor HORIKE Shin-ichi

Mail Laboratory Website

Faculty, Affiliation

Research Center for Experimental Modeling of Human Disease Division of Integrated Omics research

College and School Educational Field

Graduate School of Medical Science
United Graduate School of Child Depelopment
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

HORIKE LAB TEL:076-265-2775 FAX:076-234-4537

Academic Background

【Academic background(Bachelor's Degree)】
Shimane University Chemistry 199503
【Degree】
Life Science

Career

Tottori University Research Fellow(2000/10/01-2001/07/14)
Lawrence Berkeley National Laboratory Life Science Division Research Fellow(2001/07/15-2004/06/30)
The Hospital for Sick Children Genetics & Genome Biology Research Fellow(2004/07/01-2006/09/30)
University of Tokushima Institute for enzyme research Assistant Professor(2006/10/01-2007/10/31)
Kanazawa University(2007/11/01-2012/03/31)

Year & Month of Birth

1972/12

Academic Society





The American Society of Human Genetics in USA


International Society for Autism Research

Award

International Society for Autism Research

Specialities

Epigenetics

Speciality Keywords

Rett syndrome,Autism,Epigenetics,Genomic Imprinting

Research Themes

Characterization of autism-associated genes on human X chromosome

Chromatin higher-order structure and dynamics at the imprinted 15q11-q13 locus

Long-distance chromatin mechanisms controlling imprinted expression on 7q32

Identification of a novel regulatory element of the OXTR gene

Books

  •  Nagai, M,Meguro-Horike, M,Horike, S DNA Methylation - From Genomics to Technology INTECH 2012/03
  •  Nagai, M., Meguro-Horike, M., Horike, S.  Epigenetic defects related to assisted reproductive technologies: Large offspring syndrome (LOS) INTECH 2012/03
  •  [How the methyl-CpG binding protein-related epigenetic disease turns on the genes that produce its symptoms]. 50 8 978-84

Papers

  •  Screening of DNA Methylation at the H19 Promoter or the Distal Region of its ICR1 Ensures Efficient Detection of Chromosome 11p15 Epimutations in Russell-Silver Syndrome Shin-Ichi Horike,Jose Carlos P. Ferreira,Makiko Meguro-Horike,Sanaa Choufani,Adam C. Smith,Cheryl Shuman,Wendy Meschino,David Chitayat,Elaine Zackai,Stephen W. Scherer,Rosanna Weksberg AMERICAN JOURNAL OF MEDICAL GENETICS PART A 149A 11 2415 2009/11
  •  Construction of a novel human artificial chromosome vector for gene delivery M Katoh,F Ayabe,S Norikane,T Okada,H Masumoto,S Horike,Y Shirayoshi,M Oshimura BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 321 2 280 2004/08
  •  DLX5 expression is monoallelic and Dlx5 is up-regulated in the Mecp2-null frontal cortex Masaru Miyano,Shin-ichi Horike,Shutao Cai,Mitsuo Oshimura,Terumi Kohwi-Shigematsu JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 12 4 1188 2008/08
  •  An inversion inv(4)(p12-p15.3) in autistic siblings implicates the 4p GABA receptor gene cluster JB Vincent,SI Horike,S Choufani,AD Paterson,W Roberts,P Szatmari,R Weksberg,B Fernandez,SW Scherer JOURNAL OF MEDICAL GENETICS 43 5 429 2006/05
  •  Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome S Horike,ST Cai,M Miyano,JF Cheng,T Kohwi-Shigematsu NATURE GENETICS 37 1 31 2005/01

show all

  •  Catalytic oxygenation of olefin with dioxygen and tetra-t-butylphthalocyanine complexes in the presence of sodium borohydride T Sugimori,S Horike,S Tsumura,M Handa,K Kasuga INORGANICA CHIMICA ACTA 283 1 275 1998/12
  •  Preparation and some properties of perfluoroalkoxy-substituted phthalocyanine complexes of iron(III), nickel(II) and zinc(II) T Sugimori,S Horike,M Handa,K Kasuga INORGANICA CHIMICA ACTA 278 2 253 1998/09
  •  Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role in Beckwith-Wiedemann syndrome S Horike,K Mitsuya,M Meguro,N Kotobuki,A Kashiwagi,T Notsu,TC Schulz,Y Shirayoshi,M Oshimura HUMAN MOLECULAR GENETICS 9 14 2075 2000/09
  •  A translocation t(6;7)(p11-p12;q22) associated with autism and mental retardation: localization and identification of candidate genes at the breakpoints John B. Vincent,Sanaa Choufani,Shin-ichi Horike,Beata Stachowriak,Martin Li,Fred J. Dill,Christian Marshal,Monica Hrynchak,Elizabeth Pewsey,Kennedy C. Ukadike,Jan M. Friedman,Anand K. Srivastava,Stephen W. Scherer PSYCHIATRIC GENETICS 18 3 101 2008/06
  •  Pancreatic solitary fibrous tumor causing ectopic adrenocorticotropic hormone syndrome Keigo Murakami,Yasuhiro Nakamura,Saulo J. A. Felizola,Ryo Morimoto,Fumitoshi Satoh,Kentaro Takanami,Hideki Katakami,Seiichi Hirota,Yoshiyu Takeda,Makiko Meguro-Horike,Shin-ichi Horike,Michiaki Unno,Hironobu Sasano MOLECULAR AND CELLULAR ENDOCRINOLOGY 436 C 268 2016/11
  •  Neuron-specific impairment of inter-chromosomal pairing and transcription in a novel model of human 15q-duplication syndrome Makiko Meguro-Horike,Dag H. Yasui,Weston Powell,Diane I. Schroeder,Mitsuo Oshimura,Janine M. LaSalle,Shin-ichi Horike HUMAN MOLECULAR GENETICS 20 19 3798 2011/10
  •  Oxytocin for Male subjects with autism spectrum Disorder and comorbid intellectual Disabilities: a randomized Pilot study Toshio Munesue,Hiroyuki Nakamura,Mitsuru Kikuchi,Yui Miura,Noriyuki Takeuchi,Tokie Anme,Eiji Nanba,Kaori Adachi,Kiyotaka Tsubouchi,Yoshimichi Sai,Ken-ichi Miyamoto,Shin-ichi Horike,Shigeru Yokoyama,Hideo Nakatani,Yo Niida,Hirotaka Kosaka,Yoshio Minabe,Haruhiro Higashida FRONTIERS IN PSYCHIATRY 7 JAN 2016/01 
  •  Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation Long Guo,Hiroshi Yamashita,Ikuyo Kou,Aki Takimoto,Makiko Meguro-Horike,Shin-ichi Horike,Tetsushi Sakuma,Shigenori Miura,Taiji Adachi,Takashi Yamamoto,Shiro Ikegawa,Yuji Hiraki,Chisa Shukunami PLOS GENETICS 12 1 2016/01 
  •  MMCT-mediated chromosome engineering technique applicable to functional analysis of lncRNA and nuclear dynamics. Meguro-Horike M,Horike S Methods in molecular biology (Clifton, N.J.) 2014/12 
  •  Aging-associated impairment in metabolic compensation by subcutaneous adipose tissue promotes diet-induced fatty liver disease in mice. Taketani H,Nishikawa T,Nakajima H,Kodo K,Sugimoto S,Aoi W,Horike SI,Meguro-Horike M,Ishiba H,Seko Y,Umemura A,Yamaguchi K,Moriguchi M,Yasui K,Itoh Y Diabetes, metabolic syndrome and obesity : targets and therapy 12 1473 2019
  •  Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia Mitsuhiro Kometani,Takashi Yoneda,Masashi Demura,Hiroshi Koide,Koshiro Nishimoto,Kuniaki Mukai,Celso E. Gomez-Sanchez,Tadayuki Akagi,Takashi Yokota,Shin-ichi Horike,Shigehiro Karashima,Isamu Miyamori,Masakazu Yamagishi,Yoshiyu Takeda SCIENTIFIC REPORTS 7 1 11205 2017/09 
  •  Aberrant CpG methylation of the imprinting control region KvDMR1 detected in assisted reproductive technology-produced calves and pathogenesis of large offspring syndrome Noboru Hori,Makoto Nagai,Muneyuki Hirayama,Tomokazu Hirai,Keisuke Matsuda,Michiko Hayashi,Takaichi Tanaka,Tadashi Ozawa,Shin-ichi Horike ANIMAL REPRODUCTION SCIENCE 122 3-4 303 2010/12
  •  Active K-RAS induces the coherent rotation of epithelial cells: A model for collective cell invasion in vitro. Hirata E,Ichikawa T,Horike SI,Kiyokawa E Cancer science 109 12 4045 2018/10
  •  Baf53a is involved in survival of mouse ES cells, which can be compensated by Baf53b Bo Zhu,Atsushi Ueda,Xiaohong Song,Shin-ichi Horike,Takashi Yokota,Tadayuki Akagi SCIENTIFIC REPORTS 7 1 14059 2017/10 
  •  Pathologic Active mTOR Mutation in Brain Malformation with Intractable Epilepsy Leads to Cell-Autonomous Migration Delay Sae Hanai,Sayuri Sukigara,Hongmei Dai,Tomoo Owa,Shin-ichi Horike,Taisuke Otsuki,Takashi Saito,Eiji Nakagawa,Naoki Ikegaya,Takanobu Kaido,Noriko Sato,Akio Takahashi,Kenji Sugai,Yuko Saito,Masayuki Sasaki,Mikio Hoshino,Yu-ichi Goto,Schuichi Koizumi,Masayuki Itoh AMERICAN JOURNAL OF PATHOLOGY 187 5 1177 2017/05 
  •  Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes Keith W. Dunaway,M. Saharul Islam,Rochelle L. Coulson,S. Jesse Lopez,Annie Vogel Ciernia,Roy G. Chu,Dag H. Yasui,Isaac N. Pessah,Paul Lott,Charles Mordaunt,Makiko Meguro-Horike,Shin-ichi Horike,Ian Korf,Janine M. LaSalle CELL REPORTS 17 11 3035 2016/12
  •  Identification of novel distant regulatory element in the OXTR gene locus Shin-Ichi Horike,Makiko Meguro,Saya Numata,Toshiya Honda,Gensaku Okada,Shigeru Yokoyama,Haruhiro Higashida GENES & GENETIC SYSTEMS 91 6 351 2016/12
  •  Development of a Highly Potent Analogue and a Long-Acting Analogue of Oxytocin for the Treatment of Social Impairment-Like Behaviors. Wataru Ichinose,Stanislav M Cherepanov,Anna A Shabalova,Shigeru Yokoyama,Teruko Yuhi,Hiroaki Yamaguchi,Ayu Watanabe,Yasuhiko Yamamoto,Hiroshi Okamoto,Shinichi Horike,Junpei Terakawa,Takiko Daikoku,Mizuki Watanabe,Nariyasu Mano,Haruhiro Higashida,Satoshi Shuto Journal of medicinal chemistry 62 7 3297 2019/04/11
  •  Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2. Tatsunori Nishimura,Asuka Nakata,Xiaoxi Chen,Kurumi Nishi,Makiko Meguro-Horike,Soichiro Sasaki,Kenji Kita,Shin-Ichi Horike,Kaori Saitoh,Keiko Kato,Kaori Igarashi,Takahiko Murayama,Susumu Kohno,Chiaki Takahashi,Naofumi Mukaida,Seiji Yano,Tomoyoshi Soga,Arinobu Tojo,Noriko Gotoh Oncogene 38 14 2464 2019/04
  •  Biallelic KARS pathogenic variants cause an early-onset progressive leukodystrophy. Masayuki Itoh,Hongmei Dai,Shin-Ichi Horike,John Gonzalez,Yoshikazu Kitami,Makiko Meguro-Horike,Ichiro Kuki,Shuichi Shimakawa,Harumi Yoshinaga,Yoko Ota,Tetsuya Okazaki,Yoshihiro Maegaki,Shin Nabatame,Shin Okazaki,Hisashi Kawawaki,Naoto Ueno,Yu-Ichi Goto,Yoichi Kato Brain : a journal of neurology 142 3 560 2019/03/01
  •  Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II. Yoshimichi Takeda,Masashi Demura,Fen Wang,Shigehiro Karashima,Takashi Yoneda,Mitsuhiro Kometani,Atsushi Hashimoto,Daisuke Aono,Shin-Ichi Horike,Makiko Meguro-Horike,Masakazu Yamagishi,Yoshiyu Takeda Journal of the American Heart Association 7 10 2018/05/08
  •  Bromodomain protein BRD4 inhibitor JQ1 regulates potential prognostic molecules in advanced renal cell carcinoma Takashi Sakaguchi,Hirofumi Yoshino,Satoshi Sugita,Kazutaka Miyamoto,Masaya Yonemori,Yoichi Osako,Makiko Meguro-Horike,Shin-Ichi Horike,Masayuki Nakagawa,Hideki Enokida Oncotarget 9 33 23003 2018/05/01
  •  ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation Masaharu Hazawa,De-Chen Lin,Akiko Kobayashi,Yan-Yi Jiang,Liang Xu,Firli Rahmah Primula Dewi,Mahmoud Shaaban Mohamed,Hartono,Mitsutoshi Nakada,Makiko Meguro-Horike,Shin-Ichi Horike,H Phillip Koeffler,Richard W Wong EMBO Reports 19 1 73 2018 
  •  15q11.2-13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain Dag H. Yasui,Haley A. Scoles,Shin-ichi Horike,Makiko Meguro-Horike,Keith W. Dunaway,Diane I. Schroeder,Janine M. LaSalle HUMAN MOLECULAR GENETICS 20 22 4311 2011/11
  •  Localization of an hTERT repressor region on human chromosome 3p21.3 using chromosome engineering. Satoshi Abe,Hiromi Tanaka,Tomomi Notsu,Shin-Ichi Horike,Chikako Fujisaki,Dong-Lai Qi,Takahito Ohhira,David Gilley,Mitsuo Oshimura,Hiroyuki Kugoh Genome integrity 1 1 6 2010/05/26
  •  Amplicons in breast cancers analyzed by multiplex ligation-dependent probe amplification and fluorescence In Situ hybridization. Ooi A,Inokuchi M,Horike SI,Kawashima H,Ishikawa S,Ikeda H,Nakamura R,Oyama T,Dobash Y Human pathology 85 33 2018/10
  •  Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation Long Guo,Hiroshi Yamashita,Ikuyo Kou,Aki Takimoto,Makiko Meguro-Horike,Shin-Ichi Horike,Tetsushi Sakuma,Shigenori Miura,Taiji Adachi,Takashi Yamamoto,Shiro Ikegawa,Yuji Hiraki,Chisa Shukunami PLoS Genetics 12 1 e1005802 2016
  •  UBE3A-mediated regulation of imprinted genes and epigenome-wide marks in human neurons S. Jesse Lopez,Keith Dunaway,M. Saharul Islam,Charles Mordaunt,Annie Vogel Ciernia,Makiko Meguro-Horike,Shin-ichi Horike,David J. Segal,Janine M. LaSalle EPIGENETICS 12 11 982 2017 
  •  Molecular genetic analysis of inherited protein C deficiency caused by the novel large deletion across two exons of PROC. Tomoki Togashi,Makiko Meguro-Horike,Satomi Nagaya,Sayaka Sugihara,Tatsuo Ichinohe,Yuhei Araiso,Koichi Yamaguchi,Kotaro Mori,Yuta Imai,Kana Kuzasa,Shin-Ichi Horike,Hidesaku Asakura,Atsushi Watanabe,Eriko Morishita Thrombosis research 188 115 2020/03/10
  •  Peripubertal High Fat Diet Promotes c-Myc Stabilization in Mammary Gland Epithelium. Nilakshi Kulathunga,Susumu Kohno,Paing Linn,Yuuki Nishimoto,Shin-Ichi Horike,Mikhail I Zaraiskii,Sharad Kumar,Hayato Muranaka,Chiaki Takahashi Cancer science 2020/05/21
  •  Effect of potassium on DNA methylation of aldosterone synthase gene. Yoshimichi Takeda,Masashi Demura,Fen Wang,Shigehiro Karashima,Takashi Yoneda,Mitsuhiro Kometani,Daisuke Aomo,Atsushi Hashimoto,Shin-Ichi Horike,Makiko Meguro-Horike,Yoshiyu Takeda Journal of hypertension 39 5 1018 2021/03/03
  •  Disease-specific alteration of karyopherin-α subtype establishes feed-forward oncogenic signaling in head and neck squamous cell carcinoma. Masaharu Hazawa,Kie Sakai,Akiko Kobayashi,Hironori Yoshino,Yoshihiro Iga,Yuki Iwashima,Kee Sing Lim,Dominic Chih-Cheng Voon,Yan-Yi Jiang,Shin-Ichi Horike,De-Chen Lin,Richard W Wong Oncogene 39 10 2212 2019/12/10
  •  A novel urinary microRNA biomarker panel for detecting gastric cancer. Hiroyasu Iwasaki,Takaya Shimura,Tamaki Yamada,Yusuke Okuda,Makoto Natsume,Mika Kitagawa,Shin-Ichi Horike,Hiromi Kataoka Journal of gastroenterology 54 12 1061 2019/12
  •  Activation-induced cytidine deaminase is a possible regulator of cross-talk between oocytes and granulosa cells through GDF-9 and SCF feedback system. Takashi Iizuka,Kousho Wakae,Masanori Ono,Takuma Suzuki,Yasunari Mizumoto,Kouichi Kitamura,Shin-Ichi Horike,Masamichi Muramatsu,Hiroshi Fujiwara Scientific reports 11 1 3833 2021/02/15
  •  Genetic analysis of a compound heterozygous patient with congenital factor X deficiency and regular replacement therapy with a prothrombin complex concentrate. Togashi T,Nagaya S,Nagasawa M,Meguro-Horike M,Nogami K,Imai Y,Kuzasa K,Sekiya A,Horike SI,Asakura H,Morishita E International journal of hematology 111 1 51 2019/10
  •  Genetic and epigenetic analyses of aldosterone-producing adenoma with hypercortisolemia. Mitsuhiro Kometani,Takashi Yoneda,Masashi Demura,Daisuke Aono,Yuko Gondoh,Shigehiro Karashima,Koshiro Nishimoto,Masanori Yasuda,Shin-Ichi Horike,Yoshiyu Takeda Steroids 151 108470 2019/11
  •  The lack of terminal tubule cells in the submandibular gland of mice deficient in submandibular gland protein C. Hiroki Nakata,Jumpei Terakawa,Shin-Ichi Horike,Takiko Daikoku,Shoichi Iseki Cell and tissue research 2020/05/16

Conference Presentations

  • A noncoding imprinted RNA, MESTIT1 is essential for the repression in cis of KLF14(conference:62th Annual Meeting; The American Society of Human Genetics)(2012/11/06)
  • The spliced lncRNA SNORD116HG is essential for the high order chromatin dynamics of the MAGEL2 and NDN locus over long distance.(2018/09/19)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「生後早期の母子関係を評価する新規バイオマーカーの開発 -発達障害回避を目指して-」(2019-2020) 
○「Y染色体微小重複が男性不妊症に与える影響-Y染色体は微小欠失だけではない-」(2019-2021) 
○「性特異的なエピゲノム制御による自閉症発症機序の解明」(2019-2021) 
○「染色体の空間的配置と組織特異的遺伝子発現制御機構の解明」(2011-2012) 
○「LINE1配列のストランド特異的分布とMARを介したクロマチン制御機構の解明」(2016-2018) 
○「神経細胞特異的なクロマチンダイナミクスを司る分子の同定」(2013-2015) 
○「性特異的なエピゲノム制御による自閉症発症機序の解明」(2019-2021) 
○「15q11-13染色体ペアリングに着目した自閉症発症機構の解明」(2009-2010) 
○「核マトリックスを介した長鎖ncRNA,UBE3A-ATSのクロマチン制御機構」(2010-2011) 
○「ヒトDMRにおける母性メチル化インプリント確立メカニズムの解明」(2011-2012) 
○「インプリント長鎖非コードRNAの核内動態とクロマチンダイナミクスの解析」(2012-2013) 
○「エピジェネティック因子MBD5による発達障害発症機序の解明」(2014-2016) 
○「核内足場クロマチン構造を介したncRNA, IPWの作動機序の解明」(2015-2016) 
○「レット症候群の診断と予防・治療法確立のための臨床および生物科学の集学的研究」(2009-2011) 
○「レット症候群の早期診断と治療を目指した統合的研究」(2013-) 

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Neuro- and Physiological Psychology A(2020)
○Neuropsychology A(2020)
○Laboratory animal science and stem cell biology(2020)

Classes (Graduate Schools)

○Seminar on Animal Experimentation(2017)
○Seminar on Advanced Medical Science(2017)
○Gene Engineering Basic Course(2017)
○Seminar on Animal Experimentation(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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