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Researcher Information

last modified:2024/03/22

Professor TEI Hajime

Mail Laboratory Website

Faculty, Affiliation

Faculty of Biological Science and Technology,Institute of Science and Engineering

College and School Educational Field

Division of Natural Sciences, Graduate School of Natural Science and Technology
Division of Natural System, Graduate School of Natural Science and Technology
Course in Biosystems, School of Biological Science and Technology, College of Science and Engineering

Laboratory

Lab. Chrnonogenomics TEL:076-264-6228 FAX:076-264-6228

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kyoto University Master Graduate School of Agriculture Completed
Kyoto University Doctor Graduate School of Agriculture Completed
【Academic background(Bachelor's Degree)】
Saitama University Department of Biochemistry
【Degree】
Doctor of Philosophy

Career

Institute of Life Sciences, Mitsubishi Kasei Post doctoral Fellow(1990/04/01-1991/03/31)
Japan Society for the Promotion of Science Post doctoral Fellow(1991/04/01-1992/03/31)
Institute of Medical Science, University of Tokyo Assistant Professor(1992/04/01-2001/03/31)
Institute of Medical Science, University of Tokyo Associate Professor(2001/04/01-2004/03/31)
Institute of Life Sciences, Mitsubishi Kagaku Principal Investigator(2004/04/01-2009/03/31)
Kanazawa University Professor(2009/04/01-)

Year & Month of Birth

1959/03

Academic Society

Award

Kanazawa University Professor(2009/04/01-)
Kanazawa University Professor(2009/04/01-)

Specialities

Neurophysiology/General neuroscience

Speciality Keywords

Circadian rhythms, Suprachiasmatic Nucleus, Clock gene

Research Themes

Books

Papers

  •  Positive autoregulation delays the expression phase of mammalian clock gene Per2.  Ogawa Y, Koike N, Kurosawa G, Soga T, Tomita M, PLoS One 6 4 e18663. 2011/04
  •  The uterus sustains stable biological clock during pregnancy.  Akiyama S, Ohta H, Watanabe S, Moriya T, Hariu A, Nakahata N, Chisaka H, Matsuda T, Kimura Y, Tsuchiya S, Okamura K, Yaegashi N. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 221 4 287 2010/01
  •  Period-phase map: two-dimensional selection of circadian rhythm-related genes. 2009 Nov;3(6):487-95.  Morioka R, Arita M, Sakamoto K, Kawaguchi S, Horimoto K. IET Syst Biol 3 6 487 2009/11
  •  Genetic and molecular analysis of wild-derived arrhythmic mice.  Watanabe T, Suzuki T, Ishikawa A, Yokota Y, Ueda HR, Yamada RG, Imai S, Tomida S, Kobayashi J, Naito E, Yasuo S, Nakao N, Namikawa T, Yoshimura T, Ebihara S. PLoS One 4 1 e4301 2009/01
  •  Ontogeny of circadian organization in the rat.  Yamazaki S, Yoshikawa T, Biscoe EW, Numano R, Gallaspy LM, Soulsby S, Papadimas E, Pezuk P, Doyle SE, Sakaki Y, Block GD, Menaker M. JOURNAL OF BIOLOGICAL RHYTHMS 24 1 55 2009/02

show all

  •  Cell size homeostasis under the circadian regulation of cell division in cyanobacteria. Kitaguchi Y., Tei H., Uriu K. J. Theor. Biol. 553 111260 2022/11/21
  •  Nanoscale-tipped wire array injections transfer DNA directly into brain cells ex vivo and in vivo. Numano R, Goryu A, Kubota Y, Sawahata H, Yamagiwa S, Matsuo M, Iimura T, Tei H, Ishida M, Kawano T. FEBS Open Bio. 2022/05
  •  Complementary phase responses via functional differentiation of dual negative feedback loops Uriu K., Tei H. PLoS Comput Biol 17 3 e1008774. 2021/03
  •  A saturated reaction in repressor synthesis creates a daytime dead zone in circadian clocks. Uriu, K and Tei, H. PLoS Comput. Biol. 15 2 e1006787 2019
  •  Co-precipitation molecules hemopexin and transferrin may be key molecules for fibrillogenesis in TTR V30M amyloidogenesis. Ohta, M., Sugano, A., Hatano, N., Sato, H., Shimada, H., Niwa, H., Sakaeda, T., Tei, H., Sakaki, Y., Yamamura, K-I. and Takaoka, Y. Transgenic Res. 27 15-23 2018
  •  Phosphorylation of N-terminal regions of REV-ERBs regulates their intracellular localization.  Ohba Y., Tei, H. Genes to Cells  2018
  •  Co-precipitation molecules hemopexin and transferrin may be key molecules for fibrillogenesis in TTR V30M amyloidogenesis. Ohta, M., Sugano, A., Hatano, N., Sato, H., Shimada, H., Niwa, H., Sakaeda, T., Tei, H., Sakaki, Y., Yamamura, KI., Takaoka, Y. Transgenic Res. 27 15 2017
  •  Feedback loops interlocked at competitive binding sites amplify and facilitate genetic oscillations  Uriu K., Tei, H.  J. Theor. Biol 428 56 2017
  •  RNAi-Mediated Knockdown of Mouse Melanocortin-4 Receptor in vitro and in vivo, using an siRNA expression Construct Based on the mir-187 Precursor. Kato, M., Huang, Y-Y., Matsuo, M., Takashina, Y., Sasaki, K., Horai, Y., Juni, A., Kamijo, S., Saigo, K., Ui-Tei, K., Tei, H. Experimental Animals 66 41 2017
  •  The intrinsic microglial clock system regulates interleukin-6 expression. Nakazato, R., Hotta, S., Yamada, D., Kou, M., Nakamura, S., Takahata, Y., Tei, H., Numano, R., Hida, A., Shimba, S., Mieda, M., Hinoi, E., Yoneda, Y., Takarada, T. Glia 65 198 2017
  •  Bone Resorption Is Regulated by Circadian Clock in Osteoblasts.  Takarada T, Xu C, Ochi H, Nakazato R, Yamada D, Nakamura S, Kodama A, Shimba S, Mieda M, Fukasawa K, Ozaki K, Iezaki T, Fujikawa K, Yoneda Y, Numano R, Hida A, Tei H, Takeda S, Hinoi E. J. Bone Miner. Res.  32 872 2017
  •  In vivo bioluminescence and reflectance imaging of multiple organs in bioluminescence reporter mice by bundled-fiber-coupled microscopy. Ando Y, Sakurai T, Koida K, Tei H, Hida A, Nakao K, Natsume M, Numano R.   Biomed. Opt. Express.  7 963 2016
  •  Real-Time Recording of Circadian Per1 and Per2 Expression in the Suprachiasmatic Nucleus of Freely Moving Rats. Yamaguchi, Y., Okada, K., Mizuno, T., Ota, T., Yamada, H., Doi, M., Kobayashi, M., Tei, H., Shigeyoshi, Y., Okamura, H. J. Biol. Rhythms 31 108 2016
  •  Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex. Nangle, SN., Rosensweig, C., Koike, N., Tei, H., Takahashi, JS., Green, CB., Zheng, N. Elife 3 e03674. 2014
  •  Involvement of the down-regulation of alpha 1)-adrenergic receptor in age-related impairment of liver clock entrainment receptor in age-related impairment of liver clock entrainment Moriya, Takahiro;Nakashima, Shingo;Onozuka, Hiroshi;Saito, Yohei;Kobayashi, Tomonori;Yamamoto, Fumihiko;Ohta, Hidenobu;Tei, Hajime;Ohkubo, Yasuhito;Nakahata, Norimichi  J. PHARMACOLOGICAL SCI. 118 126 2012

Conference Presentations

  • 21 Years since Discovery of the Mammalian Per1 Gene(conference:International Symposium on Biological Rhythms)(2018/10/19)
  • Molecular Mechanism of Circadian Clock -from Drosophila to Mammals-(conference:Neuro Global Symposium "Sex on the brain")(2018/02/20)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「新規ポリA鎖長決定法を用いた翻訳と転写を結ぶ遺伝子発現制御プラットフォームの構築」(2012-2012) 
○「新規ポリA鎖長決定法を用いた概日リズムが見られるmRNAのゲノムワイド検索」(2011-2011) 
○「Period1誘導化合物の位相前進作用の解明とそれを用いた内的脱同調モデルの構築」(2023-2025) 

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Group Seminar of Biology(2018)
○Cell Physiology A(2018)
○Advanced Biology Lab(2018)
○Animal Physiology Lab(2018)
○Research Seminar in Biology (1)(2018)
○Research Seminar in Biology (2)(2018)
○Research Work in Biology(1)(2018)
○Research Work in Biology(2)(2018)
○Cell Biology(2018)
○Cell Biology(2018)
○Basic Biology Lab(2018)
○Cell Physiology B(2018)
○Research Work in Biology(2)(2017)
○Research Seminar in Biology (2)(2017)
○Cell Physiology(2017)
○Research Seminar in Biology (1)(2017)
○Research Work in Biology(1)(2017)
○Cell Biology(2017)
○Animal Physiology Lab(2017)
○Introduction to Biology, Material Engineering and Geosciences A(2017)
○Cell Biology(2017)
○Cell Physiology(2016)
○Research Seminar in Biology (2)(2016)
○Research Work in Biology(1)(2016)
○Gene・Genome・Neuron・Time・Life(2016)
○Animal Physiology Lab(2016)
○Research Work in Biology(2)(2016)
○Research Seminar in Biology (1)(2016)
○Cell Biology(2016)
○Cell Biology(2016)
○Gene・Genome・Neuron・Time・Life(2016)

Classes (Graduate Schools)

○Research Skills B(2018)
○Research work in Systems Biology(2018)
○Research Skills A(2018)
○Basic Exercise in Systems Biology(2018)
○Basic Systems Biology A(2018)
○Basic Systems Biology B(2018)
○Genomic Systems Biology B(2018)
○Chrnogenomics(2018)
○Exercise in Systems Biology 2B(2018)
○Exercise in Systems Biology 2A(2018)
○Exercise in Systems Biology 1B(2018)
○Exercise in Systems Biology 1A(2018)
○Exercise in Systems Biology 1B(2017)
○Research work in Systems Biology(2017)
○Basic Systems Biology A(2017)
○Research work in Systems Biology(2017)
○Exercise in Systems Biology 2A(2017)
○Research Skills B(2017)
○Basic Systems Biology B(2017)
○Basic Exercise in Systems Biology(2017)
○Basic Systems Biology B(2017)
○Basic Systems Biology A(2017)
○Research Skills A(2017)
○Chrnogenomics(2017)
○Chrnogenomics(2017)
○Chrnogenomics(2017)
○Chrnogenomics(2017)
○Exercise in Systems Biology 2B(2017)
○Exercise in Systems Biology 1A(2017)
○Genomic Systems Biology B(2017)
○Basic Systems Biology A(2016)
○Genomic Systems Biology B(2016)
○Basic Systems Biology B(2016)
○Chrnogenomics(2016)
○Basic Exercise in Systems Biology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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