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Researcher Information

last modified:2022/05/30

Professor MINAMOTO Toshinari

Mail Laboratory Website
Laboratory Website

Faculty, Affiliation

Cancer Research Institute Division of Translational and Clinical Oncology

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science


Division of Translational and Clinical Oncology TEL:076-265-2792 FAX:076-234-4529

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine Pathology 198703 Completed
【Academic background(Bachelor's Degree)】
Juntendo University 198303
M.D., Ph.D.


Kanazawa University Cancer Research Institute Professor(2001/07/01-)

Year & Month of Birth

Academic Society

Japan Surgical Society
The Japanese Society of Gastroenterological Surgery

Japanese Cancer Association
Japan Society of Clinical Oncology
Japan Gastroenterological Endoscopy Society
Japanese Society of Gastroenterology
The Japanese Society of Gastroenterological Cancer Screening
The Japanese Gastric Cancer Association
Japan Society of Coloproctology
The Japan Pancreas Society
The Japanese Society of Pathology
The Japanese Society for Gastroenterological Carcinogenesis
The Japanese Association for Metastasis Research
The Japan Society of Human Genetics

American Association for Cancer Research
International Society of Preventive Oncology
World Society of Gastroenterology


World Society of Gastroenterology
○Award from the YASUDA Foundation(1996/01/06)
○Award from the Hokkoku Cancer Research Promotion Foundation(2001/10/11)
○Award from the Hokkoku Cancer Research Promotion Foundation(2001/10/11)
○Award from the Naito Foundation(2003/03/20)
○Alterations in transcription factors in human cancers(2003/11/05)
○Award from the Hokkoku Cancer Research Promotion Foundation(2011/07/27)


gastroenterology surgical oncology、Surgical oncology、cancer molecular oncology molecular diagnosis、Digestive surgery、Pathological medical chemistry

Speciality Keywords

Gastrointestinal oncology, Surgical and molecular oncology

Research Themes

Establishment of tissue material resources of human gastrointestinal cancer

It is important to realize molecular and cellular characteristics of cancer cells in the primary cancers for translational cancer research. This resource consists of matched pairs of tumor and non-neoplastic (normal) tissues obtained from the surgical specimen of gastric and colorectal cancer patients, biomaterials (e.g., nucleic acids, protein) prepared from these tissues and the clinical and histopathological characteristics of the patients.

Surgical oncology for gastrointestinal cancer

This research program is to clarify surgical oncology characteristics of gastrointestinal cancer and to translate the achievements to the fields responsible for diagnosis and treatment of cancer patients in clinical setting as well as to cancer research.

Molecular oncology of gastrointestinal cancer

This research program is to clarify molecular and cellular characteristics of gastrointestinal cancer toward development of the novel strategies and modalities for diagnosis and treatment of cancer.


  •  Minamoto T Detection and characterization of oncogene mutations in preneoplastic and early neoplastic lesions Humana Press 291 263-78 2005
  •  Motoo Y, Shimasaki T, Minamoto T Gemcitabine changes the gene expression in human pancreatic cancer cells: search for new therapeutic molecular targets Springer Verlag (Berlin) 33-38 2009/01
  •  Nakada M, Kita D, Hayashi Y, Kawakami K, Hamada JI, Minamoto T RNAi in malignant brain tumors: relevance to molecular and translational research Springer Verlag (Berlin) 107-129 2010/01
  •  Nakada M, Minamoto T, Pyko I, hayashi Y, Hamada JI The pivotal roles of GSK3β in glioma biology InTech-Open Access Publisher 印刷中 2011/11
  •  Minamoto T, Kotake M, Nakada M, Shimasaki T, Motoo Y, Kawakami K Distinct pathologic role for glycogen synthase kinase 3β in colorectal cancer progression InTech -Open Access Publisher- (Croatia) 印刷中 2012/02


  •  Sclerosing pancreatitis showing repidly progressive changes with recurrent mass formation. Motoo Y, Minamoto T, Watanabe H, Sakai J, Okai T, Sawabu N INTERNATIONAL JOURNAL OF PANCREATOLOGY 21 1 85-90 1997/02
  •  Is p53 overexpression the risk factor for metastases in early invasive colorectal carcinoma? Sory A, Minamoto T, Ohta T, Yamashita K, Sawaguchi K, Mai M, Misiuna P. GI Cancer 2 2 119-27 1997/02
  •  Quantitative Enriched PCR (QEPCR), a highly sensitive method for detection of K-ras oncogene mutation. Ronai Z, Minamoto T HUMAN MUTATION 10 4 322-5 1997/04
  •  Conformation-dependent phosphorylation of p53. Adler V, Pincus MR, Minamoto T, Fuchs SY, Bluth MJ, Brandt-Rauf PW, Friedman F, Chen JM, Wang XW, Harris CC, Ronai Z. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94 5 1686-91 1997/05
  •  Combined analysis of microsatellite instability and K-ras mutation increases detection incidence of normal and tumor samples from colorectal cancer patients. Minamoto T, Esumi H, Ochiai A, Belitsky G, Mai M, Sugimura T, Ronai Z. CLINICAL CANCER RESEARCH 3 8 1413-7 1997/08

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  •  Does p53 overexpression cause metastases in early invasive colorectal adenocarcinoma? Sory A, Minamoto T, Ohta T, Yamashita K, Sawaguchi K, Mai M, Misiuna P. EUROPEAN JOURNAL OF SURGERY 163 9 685-92 1997/09
  •  Collagen production by cultured human retinal pigment epithelial cells. Kigasawa K, Ishikawa H, Obazawa H, Minamoto T, Nagai Y, Tanaka Y. Tokai J Exp Clin Med 23 3 147-51 1998/06
  •  Environmental factors as regulators and effectors of multistep carcinogenesis. Minamoto T, Mai M, Ronai Z. 20 4 519-27 1999/04
  •  Analysis of JNK, Mdm2 and p14ARF contribution to the regulation of mutant p53 stability. Buschmann T, Minamoto T, Wagle N, Fuchs SY, Adler V, Mai M, Ronai Z. JOURNAL OF MOLECULAR BIOLOGY 295 4 1009-21 2000/01
  •  K-ras mutation: early detection in molecular diagnosis and risk assessment of colorectal, pancreas and lung cancers—a review Minamoto T, Mai M, Ronai Z CANCER DETECTION AND PREVENTION 24 1 1-12 2000/01
  •  Wnt/beta-catenin signaling induces the expression and activity of bTrCP ubiquitin ligase receptor. Spiegelman VS, Slaga TJ, Pagano M, Minamoto T, Ronai Z, Fuchs SY. MOLECULAR CELL 5 5 877-882 2000/05
  •  Altered expression of beta-catenin and c-erbB-2 in early gastric cancer. Ougolkov A, Mai M, Takahashi Y, Bilim V, Shimizu A, Minamoto T. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 19 3 349-355 2000/09
  •  Altered expression of p53 and p27 proteins, alone or combined, as a predictor of metastatic potential in early invasive carcinomas of colon and rectum ? a comparative clinicopathologic and molecular analysis. Hirano K, Minamoto T. CANCER DETECTION AND PREVENTION 24 4 343-355 2000/04
  •  Early detection of gene mutation in cancer diagnosis Ronai Z, Minamoto T Principle and Practice in Oncology 15 1 1-16 2001/01
  •  Endosonographic features of advanced gastric carcinoma invading the colon: is it easy to differentiate from pancreatic invasion? Sabet EA, Okai T, Minamoto T, Sawabu N. ENDOSCOPY 33 2 197 2001/02
  •  Presacral ganglioneuroma arising in an elderly man with constipation. Okai T, Minamoto T, Ohtsubo K, Takahashi Y, Kitagata H, Kadoya M, Oda Y, Sawabu N. ABDOMINAL IMAGING 26 2 215-217 2001/03
  •  Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Buschman T, Ivanov VN, Henderson S, Fried VA, Minamoto T, Alarcon-Vargas D, Pincus MR, Fuchs SY, Ronai Z. MOLECULAR AND CELLULAR BIOLOGY 21 8 2743-54 2001/04
  •  Distinct pattern of p53 phosphorylation in human tumors. Minamoto T, Buschmann T, Habelhah H, Matusevich E, Tahara H, Boerresen-Dale A-L, Harris C, Ronai Z. ONCOGENE 20 26 3341-3347 2001/06
  •  Gene mutation as target for early detection in cancer diagnosis Minamoto T, Ronai Z CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY 40 3 195-213 2001/12
  •  Oncogenic beta-catenin and MMP-7 (matrilysin) cosegregate in the late-stage clinical colon cancer. Ougolkov AV, Yamashita K, Mai M, Minamoto T. GASTROENTEROLOGY 122 1 60-71 2002/01
  •  Non-Hodgkin lymphoma in a patient with probable hereditary nonpolyposis colorectal cancer. Report of a case and review of the literature. Hirano K, Yamashita N, Ohta T, Yamashita K, Nakazumi Y, Esumi H, Kawashima A, Mai M, Minamoto T. DISEASES OF THE COLON & RECTUM 45 2 273-279 2002/02
  •  Three-dimensional endoscopic ultrasonography for the assessment of gastric carcinoma invasion: could it provide diagnostic innovations? Sabet EA, Okai T, Minamoto T, Mai M, Sawabu N Digestive Endoscopy 14 53-60 2002/02
  •  Detection of oncogenes in the diagnosis of cancers with active oncogenic signaling Minamoto T, Ougolkov A Mai M Expert Reviews in Molecular Diagnostics 2 6 565-575 2002/11
  •  Abnormal expression of E-cadherin, beta-catenin and c-erbB-2 in gastric cancer with liver metastasis Ougolkov A, Yamashita K, Bilim V, Takahashi Y, Mai M, Minamoto T INTERNATIONAL JOURNAL OF COLORECTAL DISEASE 18 2 160-166 2003/02
  •  Visualizing the gastric wall with a 30-MHz ultrasonic miniprobe: ex vivo imaging of normal gastric sites and sites of early gastric cancer Sabet EA, Okai T, Minamoto T, Mai M, Sawabu N ABDOMINAL IMAGING 28 2 252-256 2003/02
  •  Collagenofibrotic glomerulopathy with a widespread expression of type V collagen Morita H, Hasegawa T, Minamoto T, Oda Y, Inui K, Tayama H, Nakao N, Nakamoto Y, Ideura T, Yoshimura A VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY 442 2 163-168 2003/02
  •  Endosonographic evaluation of c-kit-positive gastrointestinal stromal tumor Okai T, Minamoto T, Ohtsubo K, Minato H, Oda Y, Mai M, Sawabu N ABDOMINAL IMAGING 28 3 301-307 2003/05
  •  Expression of alpha-v integrin family in gastric carcinomas: increased alpha-v beta-6 is associated with lymph node metastasis Kawashima A, Tsugawa S, Boku A, Kobayashi M, Minamoto T, Nakanishi I, Oda Y PATHOLOGY RESEARCH AND PRACTICE 199 2 57-64 2003/04
  •  beta-catenin and ras oncogenes detect most human colorectal cancers Zhang B, Ougolkov A, Yamashita K, Takahashi Y, Mai M, Minamoto T CLINICAL CANCER RESEARCH 9 8 3073-9 2003/08
  •  Pilot study of low-dose, divided maximum tolerated dose of CPT-11 in 21 consecutive patients with metastatic colorectal or gastric cancer Takahashi Y, Kitakata H, Yamashita K, Yasumoto K, Omote K, Minamoto T, Mai M SURGERY TODAY 34 3 246-50 2004/03
  •  Epidermoid cyst of the intrapancreatic accessory spleen producing CA19-9 Watanabe H, Yamaguchi Y, Ohtsubo K, Mouri H, Motoo Y, Yamashita K, Minamoto T, Gabata T, Sawabu N DIGESTIVE ENDOSCOPY 16 3 244-248 2004/07
  •  Associations among beta-TrCP, an E3 ubiquitin ligase receptor, beta-catenin and NF-kappaB in colorectal cancer Ougolkov A, Zhang B, Yamashita K, Bilim V, Mai M, Fuchs SY, Minamoto T. JOURNAL OF THE NATIONAL CANCER INSTITUTE 96 15 1161-1170 2004/08
  •  A full genome scan for gastric cancer. Aoki M, Yamamoto K, Noshiro H, Sakai K, Yokota J, Kohno T, Tokino T, Ishida S, Ohyama S, Ninomiya I, Uesaka K, Kitajima M, Shimada S, Matsuno S, Yano M, Hiratsuka M, Sugimura H, Itoh F, Minamoto T, Maehara Y, Takenoshita S, Aikou T, Katai H, Yoshimura K, Takahashi T, Akagi K, Sairenji M, Yamamura Y, Sasazuki T. JOURNAL OF MEDICAL GENETICS 42 1 83-7 2005/01
  •  Correlation of gamma-catenin expression with good prognosis in medulloblastomas. Misaki K, Marukawa K, Hayashi Y, Fukusato T, Minamoto T, Hasegawa M, Yamashita J, Fujisawa H JOURNAL OF NEUROSURGERY 102 2 suppl 197-206 2005/03
  •  Primary minute invasive de novo colonic adenocarcinoma appearing as submucosal tumor. Zenda T, Masunaga T, Shinozaki K, Hashiba A, Fuwa B, Okada T, Minamoto T, Minato H. INTERNATIONAL JOURNAL OF GASTROINTESTINAL CANCER 40 3 177-81 2005/03
  •  Adhesiveness of beta5 integrin variant lacking FNK767-769 is similar to that of the prototype containing FNKFNK764-769. Kawahara E, Saito A, Kobayashi J, Maenaka S, Minamoto T, Akasofu-Imai M, Oda Y. CELL BIOLOGY INTERNATIONAL 29 7 521-8 2005/07
  •  Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation. Shakoori A, Ougolkov A, Yu ZW, Zhang B, Modarressi MH, Billadeau DD, Mai M, Takahashi Y, Minamoto T BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 334 4 1365-73 2005/09
  •  A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population. Aoki M, Yamamoto K, Ohyama S, Yamamura Y, Takenoshita S, Sugano K, Minamoto T, Kitajima M, Sugimura H, Shimada S, Noshiro H, Hiratsuka M, Sairenji M, Ninomiya I, Yano M, Uesaka K, Matsuno S, Maehara Y, Aikou T, Sasazuki T. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 335 2 566-74 2005/09
  •  Oncogenic β-catenin signaling network in colorectal cancer Fuchs SY, Ougolkov AV, Spiegelman VS, Minamoto T Cell Cycle 4 11 1522-1539 2005/11
  •  c-kit gene mutation is common and widely distributed in intracranial germinomas. Kamakura Y, Hasegawa M, Kida S, Tachibana O, Okamoto Y, Minamoto T, Yamashita J, Fujisawa H. JOURNAL OF NEUROSURGERY 104 3 Suppl) 173-80 2006/03
  •  Effect of gemcitabine on the expression of apoptosis-related genes in human pancreatic cancer cells. Jiang PH, Motoo Y, Sawabu N, Minamoto T. WORLD JOURNAL OF GASTROENTEROLOGY 12 10 1597-602 2006/03
  •  Loss of imprinting in IGF2 in colorectal carcinoma assessed by microdissection. Maenaka S, Hikichi T, Imai-Akasofu M, Minamoto T, Kawahara E ONCOLOGY REPORTS 15 4 791-5 2006/04
  •  CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signaling. Noubissi F, Elcheva I, Bhatia N, Shakoori A, Ougolkov A, Liu J, Minamoto T, Ross J, Fuchs SY, Spiegelman VS. NATURE 441 7095 898-901 2006/06
  •  Apoptosis-related gene expression profile is changed by gemcitabine in pancreatic cancer cell line (PANC-1). Shimasaki T, Ishigaki Y, Minamoto T, Motoo Y Pancreas 22 1 14-20 2007/01
  •  Detection of active fraction of GSK3beta in cancer cells by nonradioisotopic in vitro kinase assay. Mai W, Miyashita K, Shakoori A, Zhang B, Yu ZW, Takahashi Y, Motoo Y, Kawakami K, Minamoto T ONCOLOGY 71 3-4 297-305 2007/07
  •  Adjuvant immunochemotherapy with protein-bound polysaccharide K for colon cancer in relation to oncogenic beta-catenin activation. Yamashita K, Ougolkov A, Nakazato H, Ito K, Ohashi Y, Kitakata H, Yasumoto K, Omote K, Mai M, Takahashi Y, Minamoto T. DISEASES OF THE COLON & RECTUM 50 8 1182-11187 2007/08
  •  Inhibition of GSK-3beta activity attenuates proliferation of human colon cancer cells in rodents. Shakoori A, Mai W, Miyashita K, Yasumoto K, Takahashi Y, Ooi A, Kawakami K, Minamoto T Cancer Science 98 9 1388-93 2007/09
  •  Methylation levels of LINE-1 repeats and CpG island loci are are inversely related in normal colonic mucosa. Iacopetta B, Grieu F, Phillips M, Ruszkiewicz A, Moore J, Minamoto T, Kawakami K Cacer Science 98 9 1454-60 2007/09
  •  Low expression of gamma-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype. Kawakami K, Ooyama A, Ruszkiewicz A, Jin M, Watanabe G, Moore J, Oka T, Iacopetta B, Minamoto T BRITISH JOURNAL OF CANCER 98 9 1555-61 2008/05
  •  Expression of NLRP7 (PYPAF3, NALP7) protein in endometrial cancer tissues. Ohno S, Kinoshita T, Ohno Y, Minamoto T, Suzuki N, Inoue M, Suda T ANTICANCER RESEARCH 28 4C 2493-7 2008/07
  •  Potential therapeutic effect of glycogen synthase kinase 3β inhibition against human glioblastoma Miyashita K, Kawakami K, Mai W, Shakoori A, Fujisawa H, Nakada M, Hayashi Y, Hamada J, Minamoto T CLINICAL CANCER RESEARCH 15 3 887-97 2009/02
  •  The IL-6 family cytokine IL-11 regulates homeostatic epithelial cell turnover and promotes gastric tumor development Howlett M, Giraud AS, Lescesen H, Jackson CB, Kalantzis A, van Driel IR, Robb L, Van der Hoek M, Ernst M, Minamoto T, Boussioutas A, Oshima H, Oshima M, Judd LM GASTROENTEROLOGY 136 3 967-977 2009/03
  •  Induction and downregulation of Sox17and its possible roles during the course of gastrointestinal tumorigenesis Du YC, Oshima H, Oguma K, Kitamura T, Itadani H, Fujimura T, Piao YS, Yoshimoto T, Minamoto T, Kotani H, Taketo MM, Oshima M GASTROENTEROLOGY 134 4 1346-1357 2009/06
  •  Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA Noubissi FK, Sanek NA, Kawakami K, Minamoto T, Moser A, Grinblat Y, Spiegelman VS CANCER RESEARCH 69 22 8572-8578 2009/11
  •  Different histological types of non-small cell lung cancer have distinct folate and DNA methylation levels Jin MJ, Kawakami K, Fukui Y, Tsukioka S, Oda M, Watanabe G, Takechi T, Oka T, Minamoto T CANCER SCIENCE 100 12 2325-2330 2009/08
  •  Deregulated glycogen synthase kinase 3β sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase Mai W, Kawakami K, Shakoori A, Kyo S, Miyashita K, Yokoi K, Jin MJ, Shimasaki T, Motoo Y, Minamoto T CLINICAL CANCER RESEARCH 15 22 6810-6819 2009/11
  •  An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3β Miyashita K, Nakada M, Shakoori A, Ishigaki Y, Shimasaki T, Motoo Y, Kawakami K, Minamoto T Anticancer Agents in Medicinal Chemistry 9 10 1114-1122 2009/11
  •  Long interspersed nuclear element 1 hypomethylation is a marker of poor prognosis in stage IA non–small cell lung cancer Saito K, Kawakami K, Matsumoto I, Oda M, Watanabe G, Minamoto T CLINICAL CANCER RESEARCH 16 8 2418-2426 2010/04
  •  Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation Nakajima H, Ishigaki Y, Xia QS, Ikeda T, Yoshitake Y, Yonekura H, Nojima T, Tanaka T, Umehara H, Tomosugi N, Takata T, Shimasaki T, Nakaya N, Sato I, Kawakami K, Koizumi K, Minamoto T, Motoo Y. INTERNATIONAL JOURNAL OF ONCOLOGY 37 3 583-593 2010/09
  •  Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans Peterson AJ, Menheniott TR, O'Connor L, Walduck AK, Fox JG, Kawakami K, Minamoto T, Ong EK, Wang TC, Judd LM, Giraud AS GASTROENTEROLOGY 139 6 2005-2017 2010/12
  •  Long interspersed nuclear element-1 hypomethylation is a potential biomarker for the prediction of response to oral fluoropyrimidines in microsatellite stable and CpG island methylator phenotype-negative colorectal cancer Kawakami K, Matsunoki A, Kaneko M, Saito K, Watanabe G, Minamoto T Cancer Science 102 1 166-174 2011/01
  •  Metabolic disorder, inflammation, and deregulated molecular pathways converging in pancreatic cancer development: Implications for new therapeutic strategies Motoo Y, Shimasaki T, Ishigaki Y, Nakajima H, Kawakami K, Minamoto T Cancers 3 1 446-460 2011/03
  •  Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing Tomita H, Takaishi S, Menheniott TR, Yang X, Shibata W, Jin G, Betz KS, Kawakami K, Minamoto T, Tomasetto C, Rio MC, Lerkowit N, Varro A, Giraud AS, Wang TC GASTROENTEROLOGY 140 3 879-891 2011/03
  •  AP1B plays an important role in intestinal tumorigenesis with the truncating mutation of an APC gene Mimura M, Masuda A, Nishiumi S, Kawakami K, Fujishima Y, Yoshie T, Mizuno S, Miki I, Ohno H, Hase K, Minamoto T, Azuma T, Yoshida M INTERNATIONAL JOURNAL OF CANCER 130 5 1011-20 2011/03
  •  Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine Shimasaki T, Ishigaki Y, Nakamura Y, Takata T, Nakaya N, Nakajima H, Sato I, Zhao X, Kitano A, Kawakami K, Tanaka T, Takegami T, Tomosugi N, Minamoto T, Motoo Y. JOURNAL OF GASTROENTEROLOGY 47 3 321-333 2012/03
  •  Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells Kong D, Piao YS, Yamashita S, Oshima H, Oguma K, Fushida S, Fujimura T, Minamoto T, Seno H, Yamada Y, Satou K, Ushijima T, Ishikawa TO, Oshima M. ONCOGENE 31 35 3949-3960 2012/08
  •  Can population differences in chemotherapy outcomes be inferred from differences in pharmacogenetic frequencies? Loh M, Chua D, Yao Y, Soo RA, Garrett K, Zeps N, Platell C, Minamoto T, Kawakami K, Iacopetta B, Soong R. in press in press in press 2012/06
  •  Loss of HITS (FAM107B) expression in cancers of multiple organs: tissue microarray analysis Nakajima H, Koizumi K, Tanaka T, Ishigaki Y, Yoshitake Y, Yonekura H, Sakuma T, Fukushima T, Umehara H, Ueno S, Minamoto T, Motoo Y. INTERNATIONAL JOURNAL OF ONCOLOGY 41 4 1347-1357 2012/10
  •  The strategy for enhancing temozolomide against malignant glioma Nakada M, Furuta T, Hayashi Y, Minamoto T, Hamada J 14 2 98 2012/08
  •  LINE-1 methylation shows little intra-patient heterogeneity in primary and synchronous metastatic colorectal cancer Matsunoki A, Kawakami K, Kotake M, Kaneko M, Kitamura H, Ooi A, Watanabe G, Minamoto T 12 574 2012/12
  •  Aberrant glycogen synthase kinase 3β in the development of pancreatic cancer Shimasaki T, Kitano A, Motoo Y, Minamoto T 11 15 2012/09
  •  Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy Kitano A, Shimasaki T, Chikano Y, Nakada M, Hirose M, Higashi T, Ishigaki Y, Endo Y, Takino T, Sato H, Sai Y, Miyamoto K, Motoo Y, Kawakami K, Minamoto T 8 2 e55289 2013/02
  •  Glycogen synthase kinase 3β inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling Pyko IV, Nakada M, Sabit H, Teng L, Furuyama N, Hayashi Y, Kawakami K, Minamoto T, Fedulau AS, Hamada JI CARCINOGENESIS in press in press in press 2013/06
  •  TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells Oshima H, Ishikawa T, Yoshida GJ, Naoi K, Maeda Y, Naka K, Ju X, Yamada Y, Minamoto T, Mukaida N, Saya H, Oshima M ONCOGENE in press in press in press 2013/08
  •  Inhibition of angiopoietin 2 attenuates lumen formation of tumour-associated vessels in vivo Suzuki R, Yamamoto H, Ngan CY, Ohtsuka M, Kitani K, Uemura M, Nishimura J, Takemasa I, Mizushima T, Sekimoto M, Minamoto T, Doki Y, Mori M INTERNATIONAL JOURNAL OF ONCOLOGY in press in press in press 2013/08

Conference Presentations


  •  K-ras oncogene in lung cancer Medical Review Co., Ltd. 11 3 289-297 2003/07
  •  Stool DNA testing for colorectal cancer screening: a review Minamoto T 8 6 463-67 2004/06
  •  Present status and future of surgical treatment of gastric cancer Mai M, Watanabe M, Omote K, Yasumoto K, Takahashi Y, Minamoto T 40 1 84-93 2005/01
  •  Pathologic findings of metastatic liver tumor and their significance in the prognosis of the patients Kosaka K, Sato Y, Sawada S, Kobayashi S, Terayama N, Matsui O, Minamoto T, Nakanuma Y 92 2 133-8 2005/02
  •  Glycogen synthase kinase 3beta (GSK3beta): a novel therapeutic target in gastrointestinal cancer. Minamoto T, Kawakami K, Mai W, Shimasaki T, Takahashi Y, Motoo Y 44 5 468-77 2007/05

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  •  Stool based molecular and cellular assays for early diagnosis and screening of colorectal cancer. Minamoto T, Uotani C, Kawakami K 23 2 183-89 2008/02

Arts and Fieldwork


○Suppression of cancer and method for evaluating anticancer agent based on the effect of inhibiting GSK3beta(country:PCT)(No:PCT/JP2006/300160)
○Suppression of cancer and method for evaluating anticancer agent based on the effect of inhibiting GSK3beta(country:Japan)(No:特願2006-550915)
○Suppression of cancer and method for evaluating anticancer agent based on the effect of inhibiting GSK3beta(country:United States of America)(No:アメリカ合衆国特許出願 No. 11/794,716)
○Suppression of cancer and method for evaluating anticancer agent based on the effect of inhibiting GSK3beta(country:The United Kingdom)(No:ヨーロッパ特許出願 No. 06700524.9)
○Suppression of cancer and method for evaluating anticancer agent based on the effect of inhibiting GSK3beta(country:Germany)(No:ヨーロッパ特許出願 No. 06700524.9)
○Suppression of cancer and method for evaluating anticancer agent based on the effect of inhibiting GSK3beta(country:France)(No:ヨーロッパ特許出願 No. 06700524.9)

Theme to the desired joint research

○Molecular Diagnosis of Colorectal Cancer
○Development of molecular target-directed cancer treatment

Grant-in-Aid for Scientific Research

○「消化器癌(胃癌・大腸癌)の転移の予知とその対策−分子腫瘍マーカーよりの検討 (1995-1997)」(1995-) 
○「罹患同胞対法を用いた胃がん関連遺伝子の解明 (1999-2000)」(1998-) 
○「ヒト胃癌における遺伝子発現異常の連鎖解析(SAGE)を用いた包括的解明 (1999-2000)」(1999-) 
○「胃がん発症に関与する遺伝子の解明 (2000-2001)」(2000-) 
○「消化器癌における転移分子機構の解明とその制御-特に,マトリックスメタロプロテイナーゼと血管新生ならびにその阻害物質による微小転移の抑制− (2000-2002)」(2000-) 
○「ヒト大腸癌におけるbeta-カテニンシグナル伝達系活性化と制御機構の解析 (2001-2002)」(2001-) 
○「胃がん発症に関与する遺伝子の解明 (2002-2004)」(2002-) 
○「消化器癌におけるbeta-カテニンがん遺伝子シグナル伝達活性化と制御機構の解明:がん分子診断と検診への応用 (2002-2004)」(2002-) 
○「大腸癌におけるがん化シグナルの特異的活性化・制御機構の個別的ならびに網羅的解析-beta-カテニンシグナル伝達関連遺伝子群を中心に- (2003-2005)」(2003-) 
○「大腸癌の発生進展に関わる新世代がん遺伝子の活性化機構:遺伝子診断と分子標的治療の開発を目指して(Activation of the new generation oncogenes in colorectal cancer as targets for diagnosis and therapy)(2003-2005)」(2003-) 
○「糖代謝調節キナーゼのWntシグナル非依存的がん化作用の解明と大腸癌制御 (2004-2005)」(2004-) 
○「alpha-V beta8インテグリンによるTGF-beta1の活性化が大腸癌の浸潤・転移に及ぼす影響 (2004-2005)」(2004-) 
○「がん生物学に基づく新しい治療法に関する研究:細胞調節システム破綻の解析と大腸がん制御への応用 (2004-2008)」(2004-2008) 
○「Tailored dose化学療法の確立とその基礎的研究 (2005-2006)」(2005-) 
○「Wntを中心とする基幹的細胞シグナル破綻機構の解明と大腸がん制御への応用 (2006-2008)」(2006-) 
○「beta-catenin/Tcf複合体の新規転写標的分子の同定と大腸癌における機能解析 (2006-2007)」(2006-) 
○「樹状細胞による自己癌標的免疫療法を増強させる,各種抗癌剤の適量に関する検討 (207-2008)」(2007-) 
○「GSK3betaのがん細胞生存・増殖維持機能の解明と分子標的がん治療法の開発 (2007-2008)」(2007-) 
○「塩酸ゲムシタビンによる膵がん細胞のEMT誘導の検証と分子細胞機構の解明 (2007-2008)」(2007-2008) 
○「GSK3beta阻害に基づく新しいがん治療法と抗がん剤,放射線感受性の修飾効果 (2008-2009)」(2008-) 
○「GSK3betaのがん促進機能の分子機構解明とその阻害に基づく消化器がん制御法の開発 (2008-2009)」(2008-2009) 
○「大腸癌におけるDNAメチル化の調節機構解明と遺伝子診断・治療への応用 (2008-2010)」(2008-2010) 

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

○Clinical and Molecular Oncology(2017)
○Clinical and Molecular Oncology(2017)
○Clinical and Molecular Oncology(2017)
○Molecular Oncology(2017)
○Clinical and Molecular Oncology(2016)
○Clinical and Molecular Oncology(2016)
○Clinical and Molecular Oncology(2016)
○Molecular Oncology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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