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Researcher Information

last modified:2021/11/29

Professor YAMAMOTO Yasuhiko

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Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Department of Biochemistry and Molecular Vascular Biology
Advisor to the President
Professor

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medical Science, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science TEL:076-265-2181 FAX:076-234-4217

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine 199603 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University School of Medicine 199203

Career

JSPS Research Associate Dept. Biochem, Kanazawa Univ. Sch. Med.(1997/09-1999/03)
Kanazawa University School of Medicine Instructor(1999/04-2001/03)
Kanazawa University Graduate School of Medical Science(2001/04-2006/06)
金沢大学 Graduate School of Medical Science(2006/07-2012/04)
Joslin Diabetes Center & Harvard Medical School Visiting Scientist(2006/10-2009/08)
Kanazawa University Graduate School of Medical Sciences(2012/05-2015/04)
Kanazawa University(2015/05-)

Year & Month of Birth

1968/03

Academic Society



JMARS
International Maillard Reaction Society (IMARS)

Anti-Aging Medicine
Japanese Society of Internal Medicine





Award



○Japan Diabetic Complication Society Young Investigator Award(2008/10/03)
○Sr. Iacocca Visiting Scientist Award(2007/05/08)
○Sumitomo Life Social Welfare Foundation(2006/09/27)
○Japan Diabetes Foundation(2004/11/26)
○Young Investigator Award, Japan Biochemical Society Hokuriku Branch(2003/05/31)
○Young Investigator Award, Japan Biochemical Society Hokuriku Branch(2003/05/31)
○Young Investigator Award, Japan Biochemical Society Hokuriku Branch(2003/05/31)

Specialities

General medical chemistry、Pathological medical chemistry

Speciality Keywords

Cellmetabolism, Diabetic vascular complications, Immunity, Neuroendocine

Research Themes

Inflammation in obesity

Cell metabolism and diseases

Molecular mechanism for development of diabetic vascular complications

Innate immunity

Books

  •  RAGE as a functional receptor for AGE CMC Publishers 2010/12
  •  AGE receptors Asakura
  •  AGE-RAGE system in diabetic vascular complications Nipponrinshosha Co., Ltd. 68 増刊 39-44 2010/11
  •  Identification of mouse ortholog of endogenous secretory receptor for advanced glycation endproducts: structure, function and expression. 396 1  109-115 2006/01
  •  A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in the RAGE/ iNOS transgenic mice. 55  356-366 2006

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  •  Development of an ELISA for esRAGE and its application to type 1 diabetic patients. 73  158-165 2006
  •  Deletion of RAGE causes hyperactivity and increased sensitivity to auditory stimuli in mice. 4 12 e8309 2009
  •  Isoflavones inhibit nicotine C-oxidation catalyzed by human CYP2A6. 46 3  337-344 2006/03
  •  Expression profiling of endogenous secretory receptor for advanced glycation end products in human organs. 18 10  1385-1396 2005/10

Papers

  •  RAGE regulates oxytocin transport into the brain. Yasuhiko Yamamoto,Haruhiro Higashida Communications biology 3 1 70 2020/02/13
  •  Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice Yamamoto Y, Liang M, Munesue S, Deguchi K, Harashima A, Furuhara K, Yuhi T, Zhong J, Akther S, Goto H, Eguchi Y, Kitao Y, Hori O, Shiraishi Y, Ozaki N, Shimizu Y, Kamide T, Yoshikawa A, Hayashi Y, Nakada M, Lopatina O, Gerasimenko M, Komleva Y, Malinovskaya N, Salmina AB, Asano M, Nishimori K, Shoelson SE, Yamamoto H, Higashida H. Commun Biol  2 76 2019
  •  Aquaporin 1 elicits cell motility and coordinates vascular bed formation by downregulating thrombospondin type-1 domain-containing 7A in glioblastoma. Masahiro Oishi,Seiichi Munesue,Ai Harashima,Mitsutoshi Nakada,Yasuhiko Yamamoto,Yasuhiko Hayashi Cancer medicine 9 11 3904 2020/06
  •  Deletion of CD38 and supplementation of NAD+ attenuate axon degeneration in a mouse facial nerve axotomy model. Yuji Takaso,Masao Noda,Tsuyoshi Hattori,Jureepon Roboon,Miyako Hatano,Hisashi Sugimoto,Charles Brenner,Yasuhiko Yamamoto,Hiroshi Okamoto,Haruhiro Higashida,Makoto Ito,Tomokazu Yoshizaki,Osamu Hori Scientific reports 10 1 17795 2020/10/20
  •  RAGE signaling is required for AMPA receptor dysfunction in the hippocampus of hyperglycemic mice. Zeinab Momeni,Maricris Bautista,Joseph Neapetung,Rylan Urban,Yasuhiko Yamamoto,Anand Krishnan,Verónica A Campanucci Physiology & behavior 229 113255 2021/02/01

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  •  Advanced glycation end products-driven angiogenesis in vitro S Yamagishi,H Yonekura,Y Yamamoto,K Katsuno,F Sato,Mita, I,H Ooka,N Satozawa,T Kawakami,M Nomura,H Yamamoto JOURNAL OF BIOLOGICAL CHEMISTRY 272 13 8723 1997/03
  •  Hyperglycemia induces RAGE-dependent hippocampal spatial memory impairments. Zeinab Momeni,Joseph Neapetung,Anthony Pacholko,Tabitha Achan Bol Kiir,Yasuhiko Yamamoto,Lane K Bekar,Verónica A Campanucci Dr Physiology & behavior 229 113287 2021/02/01
  •  Receptor for advanced glycation end products is a promising target of diabetic nephropathy Y Yamamoto,T Doi,Kato, I,H Shinohara,S Sakurai,H Yonekura,T Watanabe,KM Myint,A Harashima,M Takeuchi,S Takasawa,H Okamoto,N Hashimoto,M Asano,H Yamamoto MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE 1043 562 2005
  •  Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia. Kohei Hosokawa,Hiroki Mizumaki,Mahmoud I Elbadry,Chizuru Saito,J Luis Espinoza,An Thi Thanh Dao,Takamasa Katagiri,Ai Harashima,Akihiro Kikuchi,Akinori Kanai,Hirotaka Matsui,Toshiya Inaba,Masafumi Taniwaki,Yasuhiko Yamamoto,Shinji Nakao Leukemia 33 11 2732 2019/11
  •  Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxic to HepG2 cells Y Yamamoto,H Yamazaki,T Ikeda,T Watanabe,H Iwabuchi,M Nakajima,T Yokoi DRUG METABOLISM AND DISPOSITION 30 2 155 2002/02
  •  Roles of the receptor for advanced glycation endproducts in diabetes-induced vascular injury H Yonekura,Y Yamamoto,S Sakurai,T Watanabe,H Yamamoto JOURNAL OF PHARMACOLOGICAL SCIENCES 97 3 305 2005/03
  •  Interaction of receptor for advanced glycation end products with advanced oxidation protein products induces podocyte injury Yasuhiko Yamamoto,Hiroshi Yamamoto KIDNEY INTERNATIONAL 82 7 733 2012/10
  •  Controlling the receptor for advanced glycation end-products to conquer diabetic vascular complications Yasuhiko Yamamoto,Hiroshi Yamamoto Journal of Diabetes Investigation 3 2 107 2012/04
  •  Endogenous Secretory Receptor for Advanced Glycation End-Products Inhibits Amyloid-beta(1-42) Uptake into Mouse Brain Takahiro Sugihara,Seiichi Munesue,Yasuhiko Yamamoto,Shigeru Sakurai,Nasima Akhter,Yoji Kitamura,Kazuhiro Shiba,Takuo Watanabe,Hideto Yonekura,Yasuhiko Hayashi,Jun-ichiro Hamada,Hiroshi Yamamoto JOURNAL OF ALZHEIMERS DISEASE 28 3 709 2012
  •  Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications Myat Thu Thu Win,Yasuhiko Yamamoto,Seiichi Munesue,Hidehito Saito,Dong Han,So Motoyoshi,Tarek Kamal,Takuro Ohara,Takuo Watanabe,Hiroshi Yamamoto EXPERIMENTAL DIABETES RESEARCH 2012 894605 2012
  •  Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells Mei He,Hiroshi Kubo,Konosuke Morimoto,Naoya Fujino,Takaya Suzuki,Toru Takahasi,Mitsuhiro Yamada,Mutsuo Yamaya,Tomoyuki Maekawa,Yasuhiko Yamamoto,Hiroshi Yamamoto EMBO REPORTS 12 4 358 2011/04
  •  The effects of the receptor for advanced glycation end products (RAGE) on bone metabolism under physiological and diabetic conditions Yasuhiro Hamada,Sohei Kitazawa,Riko Kitazawa,Keiji Kono,Shunsuke Goto,Hirotaka Komaba,Hideki Fujii,Yasuhiko Yamamoto,Hiroshi Yamamoto,Makoto Usami,Masafumi Fukagawa ENDOCRINE 38 3 369 2010/12 
  •  RAGE mediates vascular injury and inflammation after global cerebral ischemia Tomoya Kamide,Yasuko Kitao,Toshiaki Takeichi,Akiko Okada,Hiromi Mohri,Ann Marie Schmidt,Takayuki Kawano,Seiichi Munesue,Yasuhiko Yamamoto,Hiroshi Yamamoto,Jun-ichiro Hamada,Osamu Hori NEUROCHEMISTRY INTERNATIONAL 60 3 220 2012/02
  •  Diabetes alters subsets of endothelial progenitor cells that reside in blood, bone marrow, and spleen Hidehito Saito,Yasuhiko Yamamoto,Hiroshi Yamamoto AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 302 6 C892 2012/03
  •  Anti-high mobility group box-1 antibody therapy for traumatic brain injury Yu Okuma,Keyue Liu,Hidenori Wake,Jiyong Zhang,Tomoko Maruo,Isao Date,Tadashi Yoshino,Aiji Ohtsuka,Naoki Otani,Satoshi Tomura,Katsuji Shima,Yasuhiko Yamamoto,Hiroshi Yamamoto,Hideo K. Takahashi,Shuji Mori,Masahiro Nishibori ANNALS OF NEUROLOGY 72 3 373 2012/09
  •  Receptor for advanced glycation end products regulates adipocyte hypertrophy and insulin sensitivity in mice: Involvement of toll-like receptor 2 Masayo Monden,Hidenori Koyama,Yoshiko Otsuka,Tomoaki Morioka,Katsuhito Mori,Takuhito Shoji,Yohei Mima,Koka Motoyama,Shinya Fukumoto,Atsushi Shioi,Masanori Emoto,Yasuhiko Yamamoto,Hiroshi Yamamoto,Yoshiki Nishizawa,Masafumi Kurajoh,Tetsuya Yamamoto,Masaaki Inaba Diabetes 62 2 478 2013/02
  •  Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic beta-cell failure in type 2 diabetes Dong Han,Yasuhiko Yamamoto,Seiichi Munesue,So Motoyoshi,Hidehito Saito,Myat Thu Thu Win,Takuo Watanabe,Koichi Tsuneyama,Hiroshi Yamamoto GENES TO CELLS 18 4 302 2013/04
  •  CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice Shirin Akther,Natalia Korshnova,Jing Zhong,Mingkun Liang,Stanislav M. Cherepanov,Olga Lopatina,Yulia K. Komleva,Alla B. Salmina,Tomoko Nishimura,Azam A. K. M. Fakhrul,Hirokazu Hirai,Ichiro Kato,Yasuhiko Yamamoto,Shin Takasawa,Hiroshi Okamoto,Haruhiro Higashida MOLECULAR BRAIN 6 41 2013/09
  •  Regulation of Diet-Induced Adipose Tissue and Systemic Inflammation by Salicylates and Pioglitazone Myung-Sunny Kim,Yasuhiko Yamamoto,Kyungjin Kim,Nozomu Kamei,Takeshi Shimada,Libin Liu,Kristin Moore,Ju Rang Woo,Steven E. Shoelson,Jongsoon Lee PLOS ONE 8 12 e82847 2013/12
  •  The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism K Abeyama,DM Stern,Y Ito,K Kawahara,Y Yoshimoto,M Tanaka,T Uchimura,N Ida,Y Yamazaki,S Yamada,Y Yamamoto,H Yamamoto,S Iino,N Taniguchi,Maruyama, I JOURNAL OF CLINICAL INVESTIGATION 115 5 1267 2005/05
  •  The effects of the receptor for advanced glycation end products (RAGE) on bone metabolism under physiological and diabetic conditions Yasuhiro Hamada,Sohei Kitazawa,Riko Kitazawa,Keiji Kono,Shunsuke Goto,Hirotaka Komaba,Hideki Fujii,Yasuhiko Yamamoto,Hiroshi Yamamoto,Makoto Usami,Masafumi Fukagawa Endocrine 38 3 369 2010/12
  •  Validated Liquid Culture Monitoring System for Lifespan Extension of Caenorhabditis elegans through Genetic and Dietary Manipulations Myat Thu Thu Win,Yasuhiko Yamamoto,Seiichi Munesue,Dong Han,Shin-ichi Harada,Hiroshi Yamamoto AGING AND DISEASE 4 4 178 2013/08
  •  Molecular mechanism of diabetic angiopathy T Watanabe,H Yonekura,Y Yamamoto,S Sakurai,H Yamamoto SEIKAGAKU 75 10 1361 2003/10
  •  RAGE-mediated inflammation, type 2 diabetes, and diabetic vascular complication Yasuhiko Yamamoto,Hiroshi Yamamoto Frontiers in Endocrinology 4 105 2013
  •  Receptor for advanced glycation end-products-mediated inflammation and diabetic vascular complications Yasuhiko Yamamoto,Hiroshi Yamamoto Journal of Diabetes Investigation 2 3 155 2011/06
  •  AGE-RAGE system in the development of diabetic vascular complications Y Yamamoto SEIKAGAKU 75 9 1230 2003/09
  •  Septic Shock Is Associated with Receptor for Advanced Glycation End Products Ligation of LPS Yasuhiko Yamamoto,Ai Harashima,Hidehito Saito,Koichi Tsuneyama,Seiichi Munesue,So Motoyoshi,Dong Han,Takuo Watanabe,Masahide Asano,Shin Takasawa,Hiroshi Okamoto,Satoshi Shimura,Tadahiro Karasawa,Hideto Yonekura,Hiroshi Yamamoto JOURNAL OF IMMUNOLOGY 186 5 3248 2011/03
  •  Advanced glycation endproducts and RAGE have a central role in the development of diabetic vascular complications. Yamamoto Y,Doi T,Kato I,Sakurai S,Yonekura H,Watanabe T,Myint K. M,Takasawa S,Okamoto H,Asano M,Shinohara H,Yamamoto H Atherosclerosis Supplements 4 2 56 2003/04
  •  Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes R Petrova,Y Yamamoto,K Muraki,H Yonekura,S Sakurai,T Watanabe,H Li,M Takeuchi,Z Makita,Kato, I,S Takasawa,H Okamoto,Y Imaizumi,H Yamamoto JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 34 10 1425 2002/10
  •  CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status Hironori Kitade,Kazuki Sawamoto,Mayumi Nagashimada,Hiroshi Inoue,Yasuhiko Yamamoto,Yoshimichi Sai,Toshinari Takamura,Hiroshi Yamamoto,Ken-ichi Miyamoto,Henry N. Ginsberg,Naofumi Mukaida,Shuichi Kaneko,Tsuguhito Ota DIABETES 61 7 1680 2012/07
  •  Low molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression of malignant phenotype in human fibrosarcoma cells Akihiko Takeuchi,Yasuhiko Yamamoto,Seiichi Munesue,Ai Harashima,Takuo Watanabe,Hideto Yonekura,Hiroshi Yamamoto,Hiroyuki Tsuchiya CANCER SCIENCE 104 6 740 2013/06
  •  [AGE-RAGE system in diabetic vascular complications]. Yamamoto Y,Yamamoto H Nihon rinsho. Japanese journal of clinical medicine 68 Suppl 9 39 2010/11
  •  Ocular Diseases Caused by Accumulation of Proteins with Post-translational Modifications KAJI Yuichi Journal of Japanese Ophthalmological Society 113 3 424 2009/03
  •  [AGE-RAGE system in diabetic microangiopathy]. Ai Harashima,Yasuhiko Yamamoto,Hiroshi Yamamoto Nihon rinsho. Japanese journal of clinical medicine 63 Suppl 6 62 2005/06
  •  Plasma level of endogenous secretory RAGE is associated with components of the metabolic syndrome and atherosclerosis H Koyama,T Shoji,H Yokoyama,K Motoyama,K Mori,S Fukumoto,M Emoto,T Shoji,H Tamei,H Matsuki,S Sakurai,Y Yamamoto,H Yonekura,T Watanabe,H Yamamoto,Y Nishizawa ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 25 12 2587 2005/12
  •  Role of cell-cell interactions in high mobility group box 1 cytokine activity in human peripheral blood mononuclear cells and mouse splenocytes Hideo Kohka Takahashi,Hiroshi Sadamori,Keyue Liu,Hidenori Wake,Shuji Mori,Tadashi Yoshino,Yasuhiko Yamamoto,Hiroshi Yamamoto,Masahiro Nishibori European Journal of Pharmacology 701 1-3 194 2013/02/15
  •  Emphysema Requires the Receptor for Advanced Glycation End-Products Triggering on Structural Cells Koichi Waseda,Nobuaki Miyahara,Akihiko Taniguchi,Etsuko Kurimoto,Genyo Ikeda,Hikari Koga,Utako Fujii,Yasuhiko Yamamoto,Erwin W. Gelfand,Hiroshi Yamamoto,Mitsune Tanimoto,Arihiko Kanehiro AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 52 4 482 2015/04
  •  [Therapeutic strategies for RAGE-mediated diseases]. Yamamoto Y,Yamamoto H Nihon yakurigaku zasshi. Folia pharmacologica Japonica 143 1 10 2014/01
  •  Longistatin in tick saliva blocks advanced glycation end-product receptor activation Anisuzzaman,Takeshi Hatta,Takeharu Miyoshi,Makoto Matsubayashi,M. Khyrul Islam,M. Abdul Alim,M. Abu Anas,M. Mehedi Hasan,Yasunobu Matsumoto,Yasuhiko Yamamoto,Hiroshi Yamamoto,Kozo Fujisaki,Naotoshi Tsuji JOURNAL OF CLINICAL INVESTIGATION 124 10 4429 2014/10
  •  Enzymatic and non-enzymatic post-translational modifications linking diabetes and heart disease Yasuhiko Yamamoto,Hiroshi Yamamoto JOURNAL OF DIABETES INVESTIGATION 6 1 16 2015/01
  •  Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity Byung-Cheol Lee,Myung-Sunny Kim,Munkyong Pae,Yasuhiko Yamamoto,Delphine Eberle,Takeshi Shimada,Nozomu Kamei,Hee-Sook Park,Souphatta Sasorith,Ju Rang Woo,Jia You,William Mosher,Hugh J. M. Brady,Steven E. Shoelson,Jongsoon Lee CELL METABOLISM 23 4 685 2016/04
  •  Contrasting roles for the receptor for advanced glycation end-products on structural cells in allergic airway inflammation vs. airway hyperresponsiveness Akihiko Taniguchi,Nobuaki Miyahara,Koichi Waseda,Etsuko Kurimoto,Utako Fujii,Yasushi Tanimoto,Mikio Kataoka,Yasuhiko Yamamoto,Erwin W. Gelfand,Hiroshi Yamamoto,Mitsune Tanimoto,Arihiko Kanehiro AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 309 8 L789 2015/10
  •  Growth Arrest and DNA Damage-Inducible 34 Regulates Liver Regeneration in Hepatic Steatosis in Mice Yuka Inaba,Tomoko Furutani,Kumi Kimura,Hitoshi Watanabe,Sanae Haga,Yoshiaki Kido,Michihiro Matsumoto,Yasuhiko Yamamoto,Kenichi Harada,Shuichi Kaneko,Seiichi Oyadomari,Michitaka Ozaki,Masato Kasuga,Hiroshi Inoue HEPATOLOGY 61 4 1343 2015/04
  •  RAGE mediates the inactivation of nAChRs in sympathetic neurons under high glucose conditions Andrew R. Chandna,Manoj Nair,Christine Chang,Paul R. Pennington,Yasuhiko Yamamoto,Darrell D. Mousseau,Veronica A. Campanucci EUROPEAN JOURNAL OF NEUROSCIENCE 41 3 341 2015/02
  •  RAGE Expression in Tumor-Associated Macrophages Promotes Angiogenesis in Glioma Xuebo Chen,Leying Zhang,Ian Y. Zhang,Junling Liang,Huaqing Wang,Mao Ouyang,Shihua Wu,Anna Carolina Carvalho da Fonseca,Lihong Weng,Yasuhiko Yamamoto,Hiroshi Yamamoto,Rama Natarajan,Behnam Badie CANCER RESEARCH 74 24 7285 2014/12
  •  Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation Md Ashik Ullah,Zhixuan Loh,Wan Jun Gan,Vivian Zhang,Huan Yang,Jian Hua Li,Yasuhiko Yamamoto,Ann Marie Schmidt,Carol L. Armour,J. Margaret Hughes,Simon Phipps,Maria B. Sukkar JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 134 2 440 2014/08
  •  Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis Kenichi Harada,Yuko Kakuda,Yasunori Sato,Hiroko Ikeda,Shinji Shimoda,Yasuhiko Yamamoto,Hiroshi Inoue,Hajime Ohta,Satomi Kasashima,Atsuhiro Kawashima,Yasuni Nakanuma JOURNAL OF CLINICAL PATHOLOGY 67 5 396 2014/05
  •  Sivelestat Sodium Hydrate Inhibits Neutrophil Migration to the Vessel Wall and Suppresses Hepatic Ischemia-Reperfusion Injury Seisho Sakai,Hidehiro Tajima,Tomoharu Miyashita,Shin-ichi Nakanuma,Isamu Makino,Hironori Hayashi,Hisatoshi Nakagawara,Hirohisa Kitagawa,Sachio Fushida,Takashi Fujimura,Hidehito Saito,Seiichi Munesue,Yasuhiko Yamamoto,Tetsuo Ohta DIGESTIVE DISEASES AND SCIENCES 59 4 787 2014/04
  •  Low-molecular weight fractions of Japanese soy sauce act as a RAGE antagonist via inhibition of RAGE trafficking to lipid rafts Seiichi Munesue,Yasuhiko Yamamoto,Ryouta Urushihara,Kouhei Inomata,Hidehito Saito,So Motoyoshi,Takuo Watanabe,Hideto Yonekura,Hiroshi Yamamoto FOOD & FUNCTION 4 12 1835 2013/12
  •  Clinical relevance of peroxisome proliferator-activated receptor-gamma expression in myxoid liposarcoma Akihiko Takeuchi,Norio Yamamoto,Toshiharu Shirai,Katsuhiro Hayashi,Shinji Miwa,Seiichi Munesue,Yasuhiko Yamamoto,Hiroyuki Tsuchiya BMC CANCER 16 442 2016/07
  •  Receptor for advanced glycation end products expressed on alveolar epithelial cells is the main target for hyperoxia-induced lung injury Chiharu Ota,Kota Ishizawa,Mitsuhiro Yamada,Yukiko Tando,Mei He,Toru Takahashi,Mutsuo Yamaya,Yasuhiko Yamamoto,Hiroshi Yamamoto,Shigeo Kure,Hiroshi Kubo Respiratory Investigation 54 2 98 2016/03/01
  •  Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction Yu Okuma,Keyue Liu,Hidenori Wake,Rui Liu,Yoshito Nishimura,Zhong Hui,Kiyoshi Teshigawara,Jun Haruma,Yasuhiko Yamamoto,Hiroshi Yamamoto,Isao Date,Hideo K. Takahashi,Shuji Mori,Masahiro Nishibori NEUROPHARMACOLOGY 85 18 2014/10
  •  Thrombomodulin Modulates Dendritic Cells via Both Antagonism of High Mobility Group Protein B1 and an Independent Mechanism Masaaki Toda,Corina N. D'Alessandro-Gabazza,Takehiro Takagi,Ayshwarya-Lakshmi Chelakkot-Govindalayathila,Osamu Taguchi,Ziaurahman Roeen,Seiichi Munesue,Yasuhiko Yamamoto,Hiroshi Yamamoto,Esteban C. Gabazza,John Morser ALLERGOLOGY INTERNATIONAL 63 1 57 2014/03
  •  cAMP ameliorates inflammation by modulation of macrophage receptor for advanced glycation end-products So Motoyoshi,Yasuhiko Yamamoto,Seiichi Munesue,Hirobumi Igawa,Ai Harashima,Hidehito Saito,Dong Han,Takuo Watanabe,Hiroshi Sato,Hiroshi Yamamoto BIOCHEMICAL JOURNAL 463 1 75 2014/10
  •  Receptor for advanced glycation endproducts modulates leukotriene B-4 receptor 1 signaling Takako Ichiki,Tomoaki Koga,Toshiaki Okuno,Kazuko Saeki,Yasuhiko Yamamoto,Masakiyo Sakaguchi,Takehiko Yokomizo FASEB JOURNAL 30 2016/04
  •  Receptor for advanced glycation endproducts modulates leukotriene B-4 receptor 1 signaling Takako Ichiki,Tomoaki Koga,Toshiaki Okuno,Kazuko Saeki,Yasuhiko Yamamoto,Masakiyo Sakaguchi,Takehiko Yokomizo FASEB JOURNAL 30 2016/04
  •  Longistatin in tick saliva blocks advanced glycation end-product receptor activation Anisuzzaman,Takeshi Hatta,Takeharu Miyoshi,Makoto Matsubayashi,M. Khyrul Islam,M. Abdul Alim,M. Abu Anas,M. Mehedi Hasan,Yasunobu Matsumoto,Yasuhiko Yamamoto,Hiroshi Yamamoto,Kozo Fujisaki,Naotoshi Tsuji JOURNAL OF CLINICAL INVESTIGATION 124 10 4429 2014/10
  •  中枢神経・認知症 内在性分泌型RAGEは脳虚血から神経細胞を保護する 清水 有,山本 靖彦,原島 愛,棟居 聖一,大石 正博,林 康彦,中田 光俊,北尾 康子,堀 修,山本 博 糖尿病合併症 29 Suppl.1 197 2015/11
  •  Epidermal expression of receptor for advanced glycation end products (RAGE) is related to inflammation and apoptosis in human skin Maeko Iwamura,Yasuhiko Yamamoto,Yoshiaki Kitayama,Kazuhiko Higuchi,Tsutomu Fujimura,Tadashi Hase,Hiroshi Yamamoto EXPERIMENTAL DERMATOLOGY 25 3 235 2016/03
  •  Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy Tarek Kamal Abouzed,Seiichi Munesue,Ai Harashima,Yusuke Masuo,Yukio Kato,Khaled Khailo,Hiroshi Yamamoto,Yasuhiko Yamamoto JOURNAL OF DIABETES RESEARCH 2016 1786789 2016
  •  Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE) Takako Ichiki,Tomoaki Koga,Toshiaki Okuno,Kazuko Saeki,Yasuhiko Yamamoto,Hiroshi Yamamoto,Masakiyo Sakaguchi,Takehiko Yokomizo FASEB JOURNAL 30 5 1811 2016/05
  •  Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice. Jing Zhong,Sarwat Amina,Mingkun Liang,Shirin Akther,Teruko Yuhi,Tomoko Nishimura,Chiharu Tsuji,Takahiro Tsuji,Hong-Xiang Liu,Minako Hashii,Kazumi Furuhara,Shigeru Yokoyama,Yasuhiko Yamamoto,Hiroshi Okamoto,Yong Juan Zhao,Hon Cheung Lee,Makoto Tominaga,Olga Lopatina,Haruhiro Higashida Frontiers in neuroscience 10 304 2016
  •  Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice Jing Zhong,Sarwat Amina,Mingkun Liang,Shirin Akther,Teruko Yuhi,Tomoko Nishimura,Chiharu Tsuji,Takahiro Tsuji,Hong-Xiang Liu,Minako Hashii,Kazumi Furuhara,Shigeru Yokoyama,Yasuhiko Yamamoto,Hiroshi Okamoto,Yong Juan Zhao,Hon Cheung Lee,Makoto Tominaga,Olga Lopatina,Haruhiro Higashida FRONTIERS IN NEUROSCIENCE 10 2016/07
  •  [AGE-RAGE system]. Ai Harashima,Seiichi Munesue,Yasuhiko Yamamoto Nihon rinsho. Japanese journal of clinical medicine 74 Suppl 2 49 2016/04
  •  CD38 in the Nucleus Accumbens is Critical in Paternal Behavior in Mice Akther, Shirin,Zhong, Jing,Liang, Mingkun,Cherepanov,Stanislav M,Lopatina, Olga,Salmina, Alla B,Tsuji, Chiharu,Tsuji, Takahiro,Yamamoto, Yasuhiko,Yokoyama, Shegeru,Higashida, Haruhiro 6 4 81 2018/11
  •  Nitration and Glycation Turn Mature NGF into a Toxic Factor for Motor Neurons: A Role for p75NTR and RAGE Signaling in ALS Mi Jin Kim,Marcelo R. Vargas,Benjamin A. Harlan,Kelby M. Killoy,Lauren E. Ball,Susana Comte-Walters,Monika Gooz,Yasuhiko Yamamoto,Joseph S. Beckman,Luis Barbeito,Mariana Pehar Antioxidants and Redox Signaling 28 18 1587 2018/06/20
  •  Soluble Thrombomodulin Attenuates Endothelial Cell Damage in Hepatic Sinusoidal Obstruction Syndrome. Takada S,Miyashita T,Yamamoto Y,Kanou S,Munesue S,Ohbatake Y,Nakanuma S,Okamoto K,Sakai S,Kinoshita J,Makino I,Nakamura K,Tajima H,Takamura H,Ninomiya I,Fushida S,Ohta T In vivo (Athens, Greece) 32 6 1409 2018/11
  •  Citrullinated Histone H3: Early Biomarker of Neutrophil Extracellular Traps in Septic Liver Damage. Kozo Nomura,Tomoharu Miyashita,Yasuhiko Yamamoto,Seiichi Munesue,Ai Harashima,Hideo Takayama,Sachio Fushida,Tetsuo Ohta The Journal of surgical research 234 132 2019/02
  •  JNK and ATF4 as two important platforms for tumor necrosis factor-α-stimulated shedding of receptor for advanced glycation end products. Miyoshi A,Koyama S,Sasagawa-Monden M,Kadoya M,Konishi K,Shoji T,Inaba M,Yamamoto Y,Koyama H FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33 3 3575 2019/03
  •  Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice. Yasuhiko Yamamoto,Mingkun Liang,Seiichi Munesue,Kisaburo Deguchi,Ai Harashima,Kazumi Furuhara,Teruko Yuhi,Jing Zhong,Shirin Akther,Hisanori Goto,Yuya Eguchi,Yasuko Kitao,Osamu Hori,Yoshitake Shiraishi,Noriyuki Ozaki,Yu Shimizu,Tomoya Kamide,Akifumi Yoshikawa,Yasuhiko Hayashi,Mitsutoshi Nakada,Olga Lopatina,Maria Gerasimenko,Yulia Komleva,Natalia Malinovskaya,Alla B Salmina,Masahide Asano,Katsuhiko Nishimori,Steven E Shoelson,Hiroshi Yamamoto,Haruhiro Higashida Communications biology 2 76 2019
  •  Development of a Highly Potent Analogue and a Long-Acting Analogue of Oxytocin for the Treatment of Social Impairment-Like Behaviors. Wataru Ichinose,Stanislav M Cherepanov,Anna A Shabalova,Shigeru Yokoyama,Teruko Yuhi,Hiroaki Yamaguchi,Ayu Watanabe,Yasuhiko Yamamoto,Hiroshi Okamoto,Shinichi Horike,Junpei Terakawa,Takiko Daikoku,Mizuki Watanabe,Nariyasu Mano,Haruhiro Higashida,Satoshi Shuto Journal of medicinal chemistry 62 7 3297 2019/04/11
  •  Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts. Yosuke Mitsui,Nahoko Tomonobu,Masami Watanabe,Rie Kinoshita,I Wayan Sumardika,Chen Youyi,Hitoshi Murata,Ken-Ichi Yamamoto,Takuya Sadahira,Acosta Gonzalez Herik Rodrigo,Hitoshi Takamatsu,Kota Araki,Akira Yamauchi,Masahiro Yamamura,Hideyo Fujiwara,Yusuke Inoue,Junichiro Futami,Ken Saito,Hidekazu Iioka,Eisaku Kondo,Masahiro Nishibori,Shinichi Toyooka,Yasuhiko Yamamoto,Yasutomo Nasu,Masakiyo Sakaguchi Oncology research 27 8 945 2019/08/08
  •  The regulation of soluble receptor for AGEs contributes to carbonyl stress in schizophrenia. Mitsuhiro Miyashita,Takuo Watanabe,Tomoe Ichikawa,Kazuya Toriumi,Yasue Horiuchi,Akiko Kobori,Itaru Kushima,Ryota Hashimoto,Motoyuki Fukumoto,Shinsuke Koike,Hiroshi Ujike,Tadao Arinami,Yoshitaka Tatebayashi,Kiyoto Kasai,Masatoshi Takeda,Norio Ozaki,Yuji Okazaki,Takeo Yoshikawa,Naoji Amano,Shinsuke Washizuka,Hiroshi Yamamoto,Toshio Miyata,Masanari Itokawa,Yasuhiko Yamamoto,Makoto Arai Biochemical and biophysical research communications 479 3 447 2016/10/21
  •  Contribution of methylglyoxal to delayed healing of bone injury in diabetes Takao Aikawa,Hidenori Matsubara,Shuhei Ugaji,Junichi Shirakawa,Ryoji Nagai,Seiichi Munesue,Ai Harashima,Yasuhiko Yamamoto,Hiroyuki Tsuchiya MOLECULAR MEDICINE REPORTS 16 1 403 2017/07
  •  From insulin synthesis to secretion: Alternative splicing of type 2 ryanodine receptor gene is essential for insulin secretion in pancreatic beta cells Hiroshi Okamoto,Shin Takasawa,Yasuhiko Yamamoto INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 91 Pt B 176 2017/10
  •  In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system. Ali Hafez Ali Mohammed El-Far,Seiichi Munesue,Ai Harashima,Akira Sato,Mika Shindo,Shingo Nakajima,Mana Inada,Mariko Tanaka,Akihiko Takeuchi,Hiroyuki Tsuchiya,Hiroshi Yamamoto,Hazem M E Shaheen,Yasser S El-Sayed,Shuhei Kawano,Sei-Ichi Tanuma,Yasuhiko Yamamoto Oncology letters 15 4 4627 2018/04
  •  Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice Haruhiro Higashida,Kazumi Furuhara,Agnes-Mikiko Yamauchi,Kisaburo Deguchi,Ai Harashima,Seiichi Munesue,Olga Lopatina,Maria Gerasimenko,Alla B. Salmina,Jia-Sheng Zhang,Hikari Kodama,Hironori Kuroda,Chiharu Tsuji,Satoshi Suto,Hiroshi Yamamoto,Yasuhiko Yamamoto SCIENTIFIC REPORTS 7 1 7883 2017/08
  •  Effects of Three Lipidated Oxytocin Analogs on Behavioral Deficits in CD38 Knockout Mice. Stanislav M Cherepanov,Shirin Akther,Tomoko Nishimura,Anna A Shabalova,Akira Mizuno,Wataru Ichinose,Satoshi Shuto,Yasuhiko Yamamoto,Shigeru Yokoyama,Haruhiro Higashida Brain sciences 7 10 2017/10/16
  •  CD38 is Required for Dendritic Organization in Visual Cortex and Hippocampus Thom P. Nelissen,Rosemary A. Bamford,Shiro Tochitani,Kamuran Akkus,Aurimas Kudzinskas,Kenichiro Yokoi,Hiroshi Okamoto,Yasuhiko Yamamoto,J. Peter H. Burbach,Hideo Matsuzaki,Asami Oguro-Ando Neuroscience 372 114 2018/02/21
  •  Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression. Takashi Higuchi,Akihiko Takeuchi,Seiichi Munesue,Norio Yamamoto,Katsuhiro Hayashi,Hiroaki Kimura,Shinji Miwa,Hiroyuki Inatani,Shingo Shimozaki,Takashi Kato,Yu Aoki,Kensaku Abe,Yuta Taniguchi,Hisaki Aiba,Hideki Murakami,Ai Harashima,Yasuhiko Yamamoto,Hiroyuki Tsuchiya Cancer medicine 7 5 1944 2018/05
  •  TRPM2, a New Player, in Cyclic ADP-Ribose/CD38-Dependent Oxytocin Release in the Hypothalamus Tsuji, Takahiro,Liang, Mingkun,Lopatina, Olga,Yuhi, Teruko,Tsuji, Chiharu,Zhong, Jing,Akther, Shirin,Nishimura, Tomoko,Amina, Sarwat,Liu, Hong-Xiang,Hashii, Minako,Furuhara, Kazumi,Yamamoto, Yasuhiko,Yokoyama, Shigeru,Higashida, Haruhiro 6 5 71 2018/11
  •  Structure-specific effects of lipidated oxytocin analogs on intracellular calcium levels, parental behavior, and oxytocin concentrations in the plasma and cerebrospinal fluid in mice. Stanislav M Cherepanov,Shigeru Yokoyama,Akira Mizuno,Wataru Ichinose,Olga Lopatina,Anna A Shabalova,Alla B Salmina,Yasuhiko Yamamoto,Hiroshi Okamoto,Satoshi Shuto,Haruhiro Higashida Pharmacology research & perspectives 5 1 e00290 2017/02
  •  Monitoring of Heat Shock Response and Phenotypic Changes in Hepatocellular Carcinoma After Heat Treatment. Ryosuke Zaimoku,Tomoharu Miyashita,Hidehiro Tajima,Hiroyuki Takamura,A I Harashima,Seiichi Munesue,Yasuhiko Yamamoto,Itasu Ninomiya,Sachio Fushida,Kenichi Harada Anticancer research 39 10 5393 2019/10
  •  Atf6 alpha deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis Hieu Minh Ta,Thuong Manh Le,Hiroshi Ishii,Mika Takarada-Iemata,Tsuyoshi Hattori,Koji Hashida,Yasuhiko Yamamoto,Kazutoshi Mori,Ryosuke Takahashi,Yasuko Kitao,Osamu Hori JOURNAL OF NEUROCHEMISTRY 139 6 1124 2016/12
  •  Extracellular S100A11 Plays a Critical Role in Spread of the Fibroblast Population in Pancreatic Cancers. Hitoshi Takamatsu,Ken-Ichi Yamamoto,Nahoko Tomonobu,Hitoshi Murata,Yusuke Inoue,Akira Yamauchi,I Wayan Sumardika,Youyi Chen,Rie Kinoshita,Masahiro Yamamura,Hideyo Fujiwara,Yosuke Mitsui,Kota Araki,Junichiro Futami,Ken Saito,Hidekazu Iioka,I Made Winarsa Ruma,Endy Widya Putranto,Masahiro Nishibori,Eisaku Kondo,Yasuhiko Yamamoto,Shinichi Toyooka,Masakiyo Sakaguchi Oncology research 27 6 713 2019/06/21
  •  Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of Demyelination. Jureepon Roboon,Tsuyoshi Hattori,Hiroshi Ishii,Mika Takarada-Iemata,Thuong Manh Le,Yoshitake Shiraishi,Noriyuki Ozaki,Yasuhiko Yamamoto,Akira Sugawara,Hiroshi Okamoto,Haruhiro Higashida,Yasuko Kitao,Osamu Hori Frontiers in cellular neuroscience 13 258 2019
  •  RAGE-dependent potentiation of TRPV1 currents in sensory neurons exposed to high glucose Doris Lam,Zeinab Momeni,Michael Theaker,Santosh Jagadeeshan,Yasuhiko Yamamoto,Juan P. Ianowski,Verónica A. Campanucci PLoS ONE 13 2 e0193312 2018/02/01
  •  CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously Tsuyoshi Hattori,Minoru Kaji,Hiroshi Ishii,Roboon Jureepon,Mika Takarada-Iemata,Hieu Minh Ta,Thuong Manh Le,Ayumu Konno,Hirokazu Hirai,Yoshitake Shiraishi,Noriyuki Ozaki,Yasuhiko Yamamoto,Hiroshi Okamoto,Shigeru Yokoyama,Haruhiro Higashida,Yasuko Kitao,Osamu Hori GLIA 65 6 974 2017/06
  •  Low-dose paclitaxel suppresses the induction of M2 macrophages in gastric cancer Takahisa Yamaguchi,Sachio Fushida,Yasuhiko Yamamoto,Tomoya Tsukada,Jun Kinoshita,Katsunobu Oyama,Tomoharu Miyashita,Hidehiro Tajima,Itasu Ninomiya,Seiichi Munesue,Ai Harashima,Shinichi Harada,Hiroshi Yamamoto,Tetsuo Ohta ONCOLOGY REPORTS 37 6 3341 2017/06
  •  Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination Takahisa Yamaguchi,Sachio Fushida,Yasuhiko Yamamoto,Tomoya Tsukada,Jun Kinoshita,Katsunobu Oyama,Tomoharu Miyashita,Hidehiro Tajima,Itasu Ninomiya,Seiichi Munesue,Ai Harashima,Shinichi Harada,Hiroshi Yamamoto,Tetsuo Ohta GASTRIC CANCER 19 4 1052 2016/10
  •  Effects of RAGE inhibition on the progression of the disease in hSOD1G93A ALS mice. Liping Liu,Kelby M Killoy,Marcelo R Vargas,Yasuhiko Yamamoto,Mariana Pehar Pharmacology research & perspectives 8 4 e00636 2020/08
  •  CD38, CD157, and RAGE as Molecular Determinants for Social Behavior. Haruhiro Higashida,Minako Hashii,Yukie Tanaka,Shigeru Matsukawa,Yoshihiro Higuchi,Ryosuke Gabata,Makoto Tsubomoto,Noriko Seishima,Mitsuyo Teramachi,Taiki Kamijima,Tsuyoshi Hattori,Osamu Hori,Chiharu Tsuji,Stanislav M Cherepanov,Anna A Shabalova,Maria Gerasimenko,Kana Minami,Shigeru Yokoyama,Sei-Ichi Munesue,Ai Harashima,Yasuhiko Yamamoto,Alla B Salmina,Olga Lopatina Cells 9 1 2019/12/25
  •  Oxytocin and CD38 in the paraventricular nucleus play a critical role in paternal aggression in mice. Anna A Shabalova,Mingkun Liang,Jing Zhong,Zhiqi Huang,Chiharu Tsuji,Natalia A Shnayder,Olga Lopatina,Alla B Salmina,Hiroshi Okamoto,Yasuhiko Yamamoto,Zeng-Guo Zhong,Shigeru Yokoyama,Haruhiro Higashida Hormones and behavior 120 104695 2020/04
  •  Intake of ω-6 Polyunsaturated Fatty Acid-Rich Vegetable Oils and Risk of Lifestyle Diseases. Tetsumori Yamashima,Tsuguhito Ota,Eishiro Mizukoshi,Hiroyuki Nakamura,Yasuhiko Yamamoto,Mitsuru Kikuchi,Tatsuya Yamashita,Shuichi Kaneko Advances in nutrition (Bethesda, Md.) 11 6 1489 2020/11/16
  •  Glycation reaction and the role of the receptor for advanced glycation end-products in immunity and social behavior. Nontaphat Leerach,Ai Harashima,Seiichi Munesue,Kumi Kimura,Yu Oshima,Hisanori Goto,Hiroshi Yamamoto,Haruhiro Higashida,Yasuhiko Yamamoto Glycoconjugate journal 2020/10/27
  •  Inhibitory Effects of Beraprost Sodium in Murine Hepatic Sinusoidal Obstruction Syndrome. Makoto Nakura,Tomoharu Miyashita,Yasuhiko Yamamoto,Satoshi Takada,Shunsuke Kanou,Hidehiro Tajima,Hiroyuki Takamura,Tetsuo Ohta Anticancer research 40 9 5171 2020/09
  •  Neuroprotective Effects of Endogenous Secretory Receptor for Advanced Glycation End-products in Brain Ischemia. Yu Shimizu,Ai Harashima,Seiichi Munesue,Masahiro Oishi,Tsuyoshi Hattori,Osamu Hori,Yasuko Kitao,Hiroshi Yamamoto,Nontaphat Leerach,Mitsutoshi Nakada,Yasuhiko Yamamoto,Yasuhiko Hayashi Aging and disease 11 3 547 2020/05
  •  Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging. Maria Gerasimenko,Olga Lopatina,Anna A Shabalova,Stanislav M Cherepanov,Alla B Salmina,Shigeru Yokoyama,Hisanori Goto,Hiroshi Okamoto,Yasuhiko Yamamoto,Katsuhiko Ishihara,Haruhiro Higashida PloS one 15 12 e0244022 2020
  •  Development of a highly potent analogue and a long-acting analogue of oxytocin for the treatment of social impairment-like behaviors. Ichinose W, Cherepanov SM, Shabalova AA, Yokoyama S, Yuhi T, Yamaguchi H, Watanabe A, Yamamoto Y, Okamoto H, Horike S, Terakawa J, Daikoku T, Watanabe M, Mano N, Higashida H, Shuto S. J Med Chem 2019
  •  Extracellular S100A11 plays a critical role in spread of the fibroblast population in pancreatic cancers Takamatsu H, Yamamoto K, Tomonobu N, Murata H, Inoue Y, Yamauchi A, Sumardika W, Youyi C, Kinoshita R, Yamamura M, Fujiwara H, Mitsui Y, Araki K, Futami J, Saito K, Iioka H, Ruma MW, Putranto EW, Nishibori M, Kondo E, Yamamoto Y, Toyooka S, Sakaguchi M. Oncol Res 2019
  •  JNK and ATF4 as two important platforms for tumor necrosis factor-α-stimulated shedding of receptor for advanced glycation endproducts Miyoshi A, Koyama S, Sasagawa-Monden M, Kadoya M, Konishi K, Shoji T, Inaba M, Yamamoto Y, Koyama H.  FASEB J 33 3 3575-3589 2019
  •  Tuning inflammation: inducing ectodomain shedding of receptor for advanced glycation end-products (RAGE) and formation of soluble RAGE Kawano S, Yamamoto Y.  IMARS Highlight 14 1 18-19 2019
  •  Soluble thrombomodulin attenuates endothelial cell damage in hepatic sinusoidal obstruction syndrome Takada S, Miyashita T, Yamamoto Y, Kanou S, Munesue S, Ohbatake Y, Nakanuma S, Okamoto K, Sakai S, Knoshita J, Makino I, Nakamura K, Tajima H, Takamura H, Ninomiya I, Fushida S, Ohta T. In Vivo 32 6 1409-1417 2018
  •  In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system El-Far A, Munesue S, Harashima A, Sato A, Shindo M, Nakajima S, Inada M, Tanaka M, Takeuchi A, Tsuchiya H, Yamamoto H, Shaheen HME, El-Sayed YS, Kawano S, Tanuma S, Yamamoto Y. Oncology Lett 25 4 4627-4634 2018
  •  Nitration and glycation turn mature NGF into a toxic factor for motor neurons: a role for p75NTR and RAGE signaling in ALS Kim MJ, Vargas MR, Harlan BA, Killoy KM, Ball L, Comte-Walters S, Gooz M, Yamamoto Y, Beckman JS, Barbeito L, Pehar M. Antioxid Redox Signal 28 18 1587-1602 2018
  •  Citrullinated histone H3: early biomarker of neutrophil extracellular traps in septic liver damage Nomura K, Miyashita T, Yamamoto Y, Munesue S, Harashima A, Takayama H, Fushida S, Ohta T. J Surg Res 234 132-138 2018
  •  TRPM2, a new player, in cyclic ADP-ribose/CD38-dependent oxytocin release in the hypothalamus Tsuji T, Liang M, Lopatina O, Yuhi T, Tsuji C, Zhong J, Akther S, Zhong J, Nishimura T, Amina S, Liu HX, Hashii M, Furuhara K, Yamamoto Y, Yokoyama S, Higashida H. Messenger 6 71-75 2018
  •  CD38 in the nucleus accumbens is critical in paternal behavior in mice Akther S, Zhong J, Liang M, Cherepanov SM, Lopatina O, Salmina AB, Tsuji C, Tsuji T, Yamamoto Y, Yokoyama S, Higashida H. Messenger 6 81-84 2018
  •  CD38 is Required for Dendritic Organization in Visual Cortex and Hippocampus Nelissen TP, Bamford RA, Tochitani S, Akkus K, Kudzinskas A, Yokoi K, Okamoto H, Yamamoto Y, Burbach JPH, Matsuzaki H, Oguro-Ando A. Neuroscience 372 114-125 2018/02/21
  •  RAGE-dependent potentiation of TRPV1 currents in sensory neurons exposed to high glucose Lam D, Momeni Z, Theaker M, Jagadeeshan S, Yamamoto Y, Ianowski JP, Campanucci VA. PLoS One 13 2 e0193312 2018/02/23
  •  Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression metalloproteinase-2 expression. Higuchi T, Takeuchi A, Munesue S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Inatani H, Shimozaki S, Kato T, Aoki Y, Abe K, Taniguchi Y, Aiba H, Murakami H, Harashima A, Yamamoto Y, Tsuchiya H. Cancer Med 2018/03/23
  •  In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system structure-based drug design system. El-Far AHAM, Munesue S, Harashima A, Sato A, Shindo M, Nakajima S, Inada M, Tanaka M, Takeuchi A, Tsuchiya H, Yamamoto H, Shaheen HME, El-Sayed YS, Kawano S, Tanuma SI, Yamamoto Y. Oncol Lett 15 4 4627-4634 2018/04/01
  •  Targeting RAGE: a viable strategy for cancer prevention and treatment? Munesue S, Yamamoto Y. IMARS Highlights 12 6 5-6 2017/12/01
  •  Effects of three lipidated oxytocin analogs on behavioral deficits in CD38 knockout mice Cherepanov SM, Akther S, Nishimura T, Shabalova AA, Mizuno A, Ichinose W, Satoshi Shuto S, Yamamoto Y, Yokoyama S, Higashida H. Brain Sci 7 10 E132 2017/10/01
  •  From insulin synthesis to secretion: alternative splicing of type 2 ryanodine receptor gene is essential for insulin secretion in pancreatic β cells Okamoto H, Takasawa S, Yamamoto Y. Int J Biochem Cell Biol 91 176-183 2017/08/01
  •  Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice Higashida H, Furuhara K, Yamauchi AM, Deguchi K, Harashima A, Munesue S, Lopatina O, Gerasimenko M, Salmina AB, Zhang JS, Kodama H, Kuroda H, Tsuji C, Suto S, Yamamoto H, Yamamoto Y. Sci Rep 7 1 7883 2017/07/01
  •  Perception of pathogenic bacteria by pattern recognition receptor RAGE in the frontline Harashima A, Yamamoto Y. IMARS Highlights 12 2 5-7 2017/02/01
  •  Nitration and glycation turn mature NGF into a toxic factor for motor neurons: a role for p75NTR and RAGE signaling in ALS Kim MJ, Vargas MR, Harlan BA, Killoy KM, Ball L, Comte-Walters S, Gooz M, Yamamoto Y, Beckman JS, Barbeito L, Pehar M. Antioxid Redox Signal 2017 2017/06/26
  •  Low-dose paclitaxel suppresses the induction of M2 macrophages in gastric cancer Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T. Oncology Rep 37 6 3341-3350 2017/06/01
  •  CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously Hattori T, Kaji M, Ishii H, Jureepon R, Takarada-Iemata M, Minh Ta H, Manh Le T, Konno A, Hirai H, Shiraishi Y, Ozaki N, Yamamoto Y, Okamoto H, Yokoyama S, Higashida H, Kitao Y, Hori O. Glia 65 6 974-89 2017/06/01
  •  Targeting of RAGE-ligand signaling impairs breast cancer cell invasion and metastasis Kwak T, Drews-Elger K, Ergonul A, Miller PC, Braley A, Hwang GH, Zhao D, Besser A, Yamamoto Y, Yamamoto H, El-Ashry D, Slingerland JM, Lippman ME, Hudson BI. Oncogene 36 11 1559-72 2017/11/01
  •  Contribution of methylglyoxal to delayed healing of bone injury in diabetes Aikawa T, Matsubara H, Ugaji S, Shirakawa J, Nagai R, Munesue S, Harashima A, Yamamoto Y, Tsuchiya H.  Mol Med Rep 16 1 402-409 2017/08/01
  •  Structure-specific effects of lipidated oxytocin analogs on intracellular calcium levels, parental behavior, plasma and cerebrospinal fluid oxytocin concentrations in mice Cherepanov S, Yokoyama S, Mizuno A, Ichinose W, Lopatina O, Shabalova A, Salmina A, Yamamoto Y, Okamoto H, Shuto S, Higashida H. Pharmacology Research & Perspectives 5 1 e00290 2017/05/01
  •  Deletion of RAGE causes hyperactivity and increased sensitivity to auditory stimuli in mice 4 12 8309 2009/12
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  •  Spontaneous bone loss in RIP-iNOS transgenic mouse: A mouse model for diabetes- mediated osteopenia/osteoporosis. Cell Cycle 8 24 4179-4181 2009
  •  Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: the role of macrophage scavenger receptor class A type I and II. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 125 1 175-183 2010
  •  RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice. CARDIOVASCULAR RESEARCH 82 2  371-381 2009/02
  •  The solution structure of variable-type domain of receptor for advanced glycation endproducts: a new insight into AGE-RAGE interaction. BIOCHEMISTRY 47 47  12299-12311 2008
  •  Neural activity dependent release of S100B from astrocytes enhances kainite-induced gamma oscillations in vivo. JOURNAL OF NEUROSCIENCE 28 43  10928-10936 2008
  •  Reduced expression of endogenous secretory receptor for advanced glycation endproducts in hippocampal neurons of Alzheimer's disease brains. ARCHIVES OF HISTOLOGY AND CYTOLOGY 70 5  279-290 2007/05
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  •  Assaying soluble forms of receptor for advanced glycation endproducts. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 27  33-34 2007
  •  The role of the receptor for advanced glycation end-products in lung fibrosis. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2007/06
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  •  Endogenous secretory receptor for advanced glycation endproducts levels are correlated with serum pentosidine and CML in patients with type 1 diabetes. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 27 1  253-254 2007/01
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  •  Plasma level of endogenous secretory receptor for advanced glycation endproducts (esRAGE) is associated with components of the metabolic syndrome and atherosclerotic arterial wall thickness. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 25 12  2587-2593 2005/12
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  •  The role of AGE-RAGE system in the development of diabetic nephropathy in vivo. Excerpta Medica International Congress Series 45-50 2002/10
  •  Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 34 1425-1431 2002/10
  •  Novel splice variants of the RAGE expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. BIOCHEMICAL JOURNAL 370 3 1097-1109 2003/03
  •  AGE-deriven angiogenesis in vitro: induction of the growth and tube formation of human microvascular endothelial cells through autocrine VEGF. JOURNAL OF BIOLOGICAL CHEMISTRY 272 13 8723-8730 1997/04
  •  The regulation of soluble receptor for AGEs contributes to carbonyl stress in schizophrenia Miyashita M, Watanabe T, Ichikawa T, Toriumi K, Horiuchi Y, Kobori A, Kushima I, Hashimoto R, Fukumoto M, Koike S, Ujike H, Arinami T, Tatebayashi Y, Kasai K, Takeda M, Ozaki N, Okazaki Y, Yoshikawa T, Amano N, Washizuka S, Yamamoto H, Miyata T, Itokawa M, Yamamoto Y, Arai M Biochemical and Biophysical Research Communications 2016
  •  Targeting of RAGE-ligand signaling impairs breast cancer cell invasion and metastasis Hudson B, Kwak TY, Drews-Elger K, Ergonul A, Braley A, Zhao D, Besser A, El-Ashry D, Slingerland J, Lippman M, Miller P, Yamamoto Y, Yamamoto H, Hwang G Oncogene 2016
  •  Clinical relevance of peroxisome proliferator-activated receptor-gamma expression in myxoid liposarcoma Takeuchi A, Yamamoto N, Shirai T, Hayashi K, Miwa S, Munesue S, Yamamoto Y, Tsuchiya H BMC Cancer 16 442 2016/07
  •  Atf6α deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis Ta H, Le T, Ishii H, Takarada-Iemata M, Hattori, T, Hashida K, Yamamoto Y, Mori K, Takahashi R, Kitao Y, Hori O J Neurochem 2016/10
  •  Cyclic ADP-ribose and heat regulate oxytocin release via CD38 and TRPM2 in the hypothalamus during social or psychological stress in mice Zhong J, Amina S, Liang M, Akther S, Yuhi T, Nishimura T, Higashida C, Tsuji T, Liu HX, Hashii M, Furuhara K, Yokoyama S, Yamamoto Y, Okamoto H, Zhao YJ, Lee HC, Tominaga M, OLopatina O, Higashida H Front Neurosci 10 304 2016/10
  •  Adipose natural killer cells regulate adipose tissue macrophages to promote insulin resistance in obesity Lee BC, Kim MS, Pae M, Yamamoto Y, Eberlé D, Shimada T, Kamei N, Park HS, Sasorith S, Woo JR, You J, Mosher W, Brady HJM, Shoelson SE, Lee J Cell Metab 23 4 685-698 2016/04
  •  Modulation of leukotriene B4 receptor 1 signaling by RAGE Ichiki T, Koga T, Okuno T, Saeki K, Yamamoto Y, Yamamoto H, Sakaguchi M, Yokomizo T FASEB J 30 5 1811-1822 2016/05
  •  Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T Gastric Cancer 2015/11
  •  The receptor for advanced glycation end-products is associated with apoptosis of alveolar epithelial cells in hyperoxia exposure in vitro and in vivo Ota C, Ishizawa K, Yamada M, Tando Y, Mei H, Takahashi T, Yamamoto Y, Yamamoto H, Kubo H Respiratory Invest 54 2 98-108 2016/02
  •  Epidermal expression of receptor for advanced glycation end-products (RAGE) is related to inflammation and apoptosis in human skin Iwamura M, Yamamoto Y, Kitayama Y, Higuchi K, Fujimura T, Hase T, Yamamoto H Exp Dermatology 25 3 235-237 2016/03
  •  RAGE mediates the interactivation of nAChRs in sympathetic neurons during high glucose conditions Chandna AR, Baskaran MN, Chang C, Pennington PR, Mousseau DD, Yamamoto Y, Campanucci VA Eur J Neurosci 41 3 341-351 2015/03
  •  Gadd34 regulates liver regeneration in hepatic steatosis Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Yamamoto Y, Harada K, Kaneko S, Oyadomari S, Ozaki M, Kasuga M, Inoue H Hepatology 61 4 1343-1356 2015/04
  •  Emphysema requires the receptor for advanced glycation end products triggering on structural cells Waseda K, Miyahara N, Taniguchi A, Kurimoto E, Ikeda G, Koga H, Fujii U, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M, Kanehiro A Am J Respir Cell Mol Biol 52 4 482-491 2015/04
  •  Contrasting Roles for the Receptor for Advanced Glycation End-Products on Structural Cells in Allergic Airway Inflammation versus Airway Hyperresponsiveness Taniguchi A, Miyahara N, Waseda K, Kurimoto E, Fuji U, Tanimoto Y, Kataoka M, Yamamoto, Y, Gelfand E, Tanimoto M, Yamamoto H, Kanehiro A Am J Physiol Lung Cell Mol Physiol 309 8 L789-800 2015/08
  •  Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 and an independent mechanism Toda M, D'Alessandro-Gabazza CN, Takagi T, Chelakkot-Govindalayathila AL, Taguchi O, Roeen Z, Munesue S, Yamamoto Y, Yamamoto H, Gabazza EC, Morser J Allergology Int 63 1 57-66 2014/01
  •  Maltitol endows foods with lower 3-deoxyglucosone content and less RAGE agonism as a sweetener against sucrose Kuretani A, Kawamura R, Munesue S, Yamamoto Y, Honda J, Yamamoto H Glycative Stress Res 1 2 25-31 2014/02
  •  Glycyrrhizin inhibits traumatic brain injury in rats by reducing HMGB1-RAGE interaction Okuma Y, Liu K, Wake H, Liu R, Nishimura Y, Hui Z, Teshigawara K, Haruma J, Yamamoto Y, Yamamoto H, Date I, Takahashi HK, Mori S, Nishibori M Neuropharmacology 85 18-26 2014/07
  •  cAMP ameliorates inflammation in macrophages by modulation of receptor for advanced glycation end-products Motoyoshi S, Yamamoto Y, Munesue S, Igawa H, Harashima A, Saito H, Han H, Watanabe T, Sato H, Yamamoto H Biochem J 463 1 72-82 2014/01
  •  Longistatin secreted with tick saliva blocks RAGE Anisuzzaman, Hatta T, Miyoshi T, Mtsubayashi M, Islam MK, Alim MA, Anas MA, Hasan MM, Matsumoto Y, Yamamoto Y, Yamamoto H, Fujisaki K, Tsuji N J Clin Invest 124 10 4429-4444 2014/10
  •  Expression of RAGE by tumor macrophages promotes angiogenesis in gliomas Chen X, Zhang L, Zhang IY, Liang J, Wang H, Ouyang M, Wu S, da Fonseca ACC, Weng L, Yamamoto Y, Yamamoto H, Natarajan R, Badie B Cancer Res 74 24 7285-7297 2014/08
  •  Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury Sakai S, Tajima H, Miyashita T, Nakanuma SI, Makino I, Hayashi H, Nakagawara H, Kitagawa H, Fushida S, Fujimura T, Saito H, Munesue S, Yamamoto Y, Ohta T Dig Dis Sci 59 4 787-794 2014/04
  •  Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis Harada K, Kakuda Y, Sato Y, Ikeda H, Shimoda S, Yamamoto Y, Inoue H, Ohta H, Kasashima S, Kawashima A, Nakanuma Y J Clin Pathol  67 5 396-402 2014/05
  •  CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice Akther S, Korshnova N, Zhong J, Liang M, Cherepanov SM, Lopatina O, Komleva YK, Salmina AB, Nishimura T, Fakhrul AAKM, Hirai H, Kato I, Yamamoto Y, Takasawa S, Okamoto H, Higashida H Mol Brain 6 41 2013/06
  •  Regulation of diet-induced adipose tissue and systemic inflammation by salicylates and pioglitazone Kim MS, Yamamoto Y, Kim K, Kamei N, Shimada T, Liu L, Moore K, Woo JR, Shoelson SE, Lee J PLoS ONE 8 12 e82847 2013/08
  •  The first case of IDDM with prominent spurious hyperglucagonemia due to interference of IgG in glucagon RIA (OAL-123). HORMONE RESEARCH 45 295-299 1996/03
  •  CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca2+]i,and insulin secretion. J. Biol. Chem. 274 4 1869-1872 1999/01
  •  Relationship between interindividual differences of nicotine metabolism and CYP2A6 genetic polymorphism in humans. Clin. Pharmacol. Ther. 69 1 72-78 2001/01
  •  Placenta growth factor and vascular endothelial growth factor B and C expressions in microvascular endothelial cells and pericytes: implication in autocrine and paracrine regulation of angiogenesis. J. Biol. Chem. 274 49 35172-35178 1999/12
  •  Molecular heterogeneity of the receptor for advanced glycation endproducts. J. Biochem. Mol. Biol. Biophys. 4 373-381 2000
  •  Insulin stimulates the growth and tube formation of human microvascular endothelial cells through autocrine vascular endothelial growth factor. Microvasc. Res. 57 3 329-339 1999/05
  •  Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice. J. Clin. Invest. 108 2 261-268 2001/07
  •  Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human microvascular endothelial cells. DIABETOLOGIA 41 12 1435-1441 1998/12
  •  Inhibitory effect of cyclosporin A on prolactin synthesis in GH3 cells. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 180 337-346 1996/02
  •  Antisense display - A new method for functional gene screen and its application to angiogenesis-related gene isolation. Ann. N. Y. Acad. Sci. 947 382-386 2001/12
  •  Advanced glycosylation end products could not only stimulate the growth , but also inhibit the prostacyclin-producing ability of endothelial cells. FEBS LETTERS 384 103-106 1996/02
  •  Receptor-mediated toxicity to pericytes of advanced glycosylation end products: a possible mechanism of pericyte loss in diabetic microangiopathy. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 213 2 681-687 1995/02
  •  Spinal cord compression by heterotopic ossification associated with Pseudohypoparathyroidism. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 25 364-368 1997/03
  •  Advanced glycation endproducts-receptor interactions stimulate the growth of human pancreatic cancer cells through the induction of PDGF-B. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 222 3 700-703 1996/07
  •  Roles of the AGE-RAGE system in vascular injury in diabetes. Ann. N. Y. Acad. Sci. 902 163-172 2000/05
  •  Vascular endothelial growth factor acts as a pericyte mitogen under hypoxic conditions. Lab. Invest. 79 4 501-509 1999/04
  •  The receptor for advanced glycation endproducts is induced by the glycation products themselves and TNF-a through NF-kB, and by 17b-estradiol through Sp-1 in human vascular endothelial cells. J. Biol. Chem. 275 33 25781-25790 2000/08

Conference Presentations

  • RAGE: a pattern-recognition receptor(conference:12th International congress on amino acids, peptides and proteins)(2011/08/01)
  • RAGE: a pattern-recognition receptor(conference:International Guest Lecture for the Scientific Community of the University of Barcelona)(2012/02/23)
  • AGE, diabetes and its vascular complications(conference:International Conference on Diabetes and Metabolism 2012)(2012/11/09)

Others

  •  AGE and endothelial cells. 4 4 141-143 1998
  •  Roles of AGE-RAGE system in vascular injury in diabetes. 902 163-172 2000/03
  •  The AGE-RAGE System and Diabetic Nephropathy. 14 Suppl3 S259-263 2003/08
  •  Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice. 1 1 32-33 2002/05
  •  Nurture vs. nature in diabetic vasculopathy: role of advanced glycation endproducts and the receptor for them. Elsevier 1262 164-167 2004/04

show all

  •  Roles of the receptor for advanced glycation endproducts in diabetes-induced vascular injury. 97 305-311 2005/03
  •  Blockage of diabetic vascular injury by controlling of AGE-RAGE system. 6 4  447-452 2005//6
  •  RAGE in diabetic nephropathy. 7 8  752-757 2007//8
  •  Significance of advanced glycation endproducts (AGEs) in aging-related disease. 2010

Arts and Fieldwork

Patent

Theme to the desired joint research

○Prevention of development of diabetic complications
○animal models of diabetic nephropathy
○Role of endogenous secretory RAGE (esRAGE) in human diseases
○Transporter of hormones
○Molecular mechanisms in the development of cancer stem-like cells
○Drugs targeting RAGE

Grant-in-Aid for Scientific Research

○「愛情ホルモン・オキシトシンによる炎症免疫抑制作用の分子基盤の解明」(2021-2023) 
○2023「リンパ管のin vitroモデル構築とリンパ浮腫治療法開発の基礎研究」(2020-2023) 
○「糖尿病による骨癒合遅延を解消する挑戦的治療の開発」(2019-2021) 
○「胚シグナルに対する免疫応答異常を共通の病因とする新しい疾患群の同定と解析」(2019-2020) 
○「リンパ浮腫に対する培養リンパ管移植の効果と瘢痕組織のリンパ管再生阻害の基礎研究」(2018-2020) 
○「オキシトシンの血液脳関門移行に関わる分子装置の解明と愛情の構築研究」(2018-2020) 
○「骨肉腫幹細胞モデルにおけるmiR-35aの役割と治療ターゲットの可能性の解析」(2018-2020) 
○「頭脳循環を加速する戦略的国際研究ネットワーク推進プログラム 「慢性炎症と線維化をきたす生体ネットワークの解明とその制御の国際研究拠点形成」 」(2017-2019) 
○「RAGEにより誘導される骨肉腫幹細胞モデルの確立とその分子機構の解明」(2015-2017) 
○「RAGE欠損によりマウス養育行動異常が生じるメカニズムの解明」 
○「関節リウマチ滑膜の上皮間葉移行の分子機構の解析と新規治療法への応用」(2015-2017) 
○「糖化ストレス消去系酵素の転写発現調節機構の解明」
○「食品に含まれるRAGEシグナル阻害成分の同定と阻害機構の解明」(2014-2016)
○「2型糖尿病の膵β細胞不全におけるRAGE・糖脂肪毒性・レプチンの役割の解明 」(2013-2016) 
○「スンクスにおける脂肪幹細胞の分布と分化能の解析」(2013-2016) 
○「パターン認識受容体の切断により糖尿病血管合併症を制御する」(2012-2014) 
○「新規血管保護因子-分泌型RAGEの発現機構と病態生理の解明」(2007-2010) 
○「マルチリガンド受容体RAGEによる細胞内シグナル生成機構の解明」(2006-) 
○「血管新生・糖尿病血管症罹患感受性を制御する選択的mRNAスプライシングの新機構」(2005-) 
○「内在性分泌型RAGEタンパクの病原微生物に対する防御作用」(2004-) 
○「多機能受容体RAGEのシグナリングネットワークの解明」(2004-) 
○「新規糖化蛋白質分子種による血管障害機序の解明」(2002-) 
○「グライコミクスによる糖尿病合併症発症の新機序の解明」(2005-) 
○「グライコミクスによる糖尿病合併症発症の新機序の解明」(2004-) 
○「遺伝子ターゲティングによる糖尿病血管合併症の原因・治療の解明」(2003-) 
○「遺伝子ターゲティングによる糖尿病血管合併症の原因・治療の解明」(2002-) 
○「発生工学的手法を用いた糖尿病性血管合併症発症機構の解明」(2001-) 
○「糖化蛋白レセプター(RAGE)情報伝達系の解明―糖尿病性血管病変発生の新機構」(2001-) 
○「新しい機能性遺伝子同定技術の創出と成人病性血管障害関連遺伝子探索への応用」(2000-) 
○「発生工学的手法を用いた糖尿病性血管合併症発症機構の解明」(2000-) 

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Basic Health Science(2017)
○Biochemistry2(2017)
○Presentation and Debate (Freshman Seminar II)(2017)
○Practical Medical Research(2017)
○Introduction to Region-studies(2017)
○Presentation and Debate (Freshman Seminar II)(2017)
○Molecular Basis of the Cell Functions(2016)
○Basic Health Science(2016)
○Presentation and Debate (Freshman Seminar II)(2016)
○Introduction to Region-studies(2016)

Classes (Graduate Schools)

○Molecular Biology of the Cardiovascular System(2017)
○Molecular Biology of the Cardiovascular System(2017)
○Fostering the Independence of Researchers(2017)
○Molecular Biology of the Cardiovascular System(2017)
○BIOETHICS(2017)
○Introduction to Basic Medical Science(2016)
○Molecular Biology of the Cardiovascular System(2016)
○Molecular Biology of the Cardiovascular System(2016)
○Molecular Biology of the Cardiovascular System(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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