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Researcher Information

last modified:2022/03/30

Associate Professor HASHIMOTO, Noriyoshi


Faculty, Affiliation

Research Center for Experimental Modeling of Human Disease

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medical Science, Graduate School of Medical Science


Division of Transgenic Animal Science (Institute for Experimental Animals) TEL:076-234-4241 FAX:076-234-4240

Academic Background

【Academic background(Doctoral/Master's Degree)】
Hokkaido University Doctor Graduate School, Division of Veterinary Medicine 199203 Accomplished credits for doctoral program
【Academic background(Bachelor's Degree)】
Hokkaido University 198703


Kanazawa University Graduate School of Medical Science(1992/04/01-2003/07/31)
Kanazawa University Advanced Science Research Center Associate Professor(2003/08/01-)

Year & Month of Birth


Academic Society



Laboratory animal science、Pathological Model Knockout mice Glycosyltransferase

Speciality Keywords

Pathological Model,Knockout mice,Glycosyltransferase,

Research Themes

Role of the sialic acid-containing carbohydrates in the marrow homing

Analysis of Hemophagocytic syndrome like disease in legumain deficient mice

Analysis of asparaginyl endopeptidase function in immune system



  •  Galactosyl carbohydrate residues on hematopoietic stem/progenitor cells are essential for homing and engraftment to the bone marrow Soichiro Takagaki, Rieko Yamashita, Noriyoshi Hashimoto, Kazushi Sugihara, Kanako Kanari, Keisuke Tabata, Toshikazu Nishie, Shogo Oka, Masanori Miyanishi, Chie Naruse, and Masahide Asano Sientific Reports 9 7133 2019/05/09
  •  Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME 106 2 468-473 2009/01
  •  Development of immunoglobulin A nephropathy- like disease in beta-1,4-galactosyltransferase-I-deficient mice Nishie T, Miyaishi O, Azuma H, Kameyama A, Naruse C, Hashimoto N, Yokoyama H, Narimatsu H, Wada T, Asano M. AMERICAN JOURNAL OF PATHOLOGY 170 2 447-456 2007/02
  •  Development of IgA nephropathy-like disease with high serum IgA levels and increased proportion of polymeric IgA in Beta-1,4-galactosyltransferase-deficient mice CONTRIBUTIONS TO NEPHROLOGY 157 125-128 2007/06
  •  RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin DIABETES 55 9 2510-2522 2006/09

show all

  •  Receptor for advanced glycation end products is a promising target of diabetic nephropathy Annals of the New York Academy of Sciences 1043 562-566 2005/06
  •  Impaired selectin-ligand biosynthesis and reduced inflammatory responses in beta-1,4-galactosyltransferase-I-deficient mice BLOOD 102 5 1678-1685 2003/09
  •  Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice JOURNAL OF BIOLOGICAL CHEMISTRY 278 35 33194-33199 2003/08
  •  Functional Relevance of Carnitine Transporter OCTN2 to Brain Distribution of L-Carnitine and Acetyl-L-Carnitine across the Blood-Brain Barrier J Neurochem. 79 5 959-969 2001/12
  •  Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2 Mol. Pharmacol. 59 2 358-366 2001
  •  Effect of gamma-butyrobetaine on fatty liver in juvenile visceral steatosis mice J. Pharm. Pharmacol. 53 4 527-533 2001
  •  Gene-dose effect on carnitine transport activity in embryonic fibroblasts of JVS mice as a model of human carnitine transporter deficiency Biochem Pharmacol. 55 10 1729-1732 1998/05
  •  Loss of wild-type carrier-mediated L-carnitine transport activity in hepatocytes of juvenile visceral steatosis mice. HEPATOLOGY 30 4 997-1001 1999/10
  •  Murine plasmacytomas, carrier of the t(12;15) chromosomal translocation, develop from immature/mature B cells not from differentiated plasma cells. CARCINOGENESIS 20 4 529-538 1999/04
  •  Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter NATURE GENETICS 21 1 91-94 1999/01
  •  SCID-bg mice as xenograft recipients Lab Anim. 31 2 163-168 1997/04
  •  TCR beta-independent development of CD4+ CD8+ thymocytes observed in a strain of scid mice Immunol Cell Biol. 75 2 154-160 1997/04
  •  Enhanced human tumor cell transplantability in a new congenic immunodeficient mouse; KSN-BNX Folia Microbiol 43 5 493-494 1998
  •  Decreased tissue distribution of L-carnitine in juvenile visceral steatosis mice. J Pharmacol Exp Ther. 289 1 224-230 1999/04
  •  Characterization of CD4+CD8+ thymocytes observed in SCID-bg mice Immunol Cell Biol 75 5 472-477 1997/10
  •  A comparison of UVB-carcinogenesis between nude mice and nude beige mice J Radiat Res 39 2 119-127 1998/06

Conference Presentations

  • Development of new albino inbred strain mice for embryo-transfer recipient(2018/05/16)


Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Laboratory animal science and stem cell biology(2018)
○Laboratory animal science and stem cell biology(2017)
○Laboratory animal science and stem cell biology(2016)

Classes (Graduate Schools)

○Advanced Transgenic Animal Science(2017)
○Advanced Transgenic Animal Science(2017)
○Seminar on Animal Experimentation(2017)
○Mouse Embryo Manipulation Basic Course(2017)
○Seminar on Advanced Medical Science(2017)
○Seminar on Animal Experimentation(2016)
○Introduction to Basic Medical Science(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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