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Researcher Information

last modified:2021/06/16

Associate Professor YAMASHITA Tatsuya

Mail

Faculty, Affiliation

ADVANCED PREVENTIVE MEDICAL SCIENCES RESEARCH CENTER Department of Gastroenterology, Kanazawa University Hospital
Lecturer

College and School Educational Field

Division of Health Sciences,Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Dept. of Gastroenterology, Kanazawa Univ. Hospital TEL:076-265-2232 FAX:076-234-4250

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine 1998 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 1993

Career

Year & Month of Birth

1969/02

Academic Society










European Society for Medical Oncology




Award

Specialities

Gastroenterology、Tumor therapeutics、General internal medicine (including psychosomatic medicine)

Speciality Keywords

Hepatocellular carcinoma Chenotherapy Percutaneous ablation therapy

Research Themes

Research for community medicine in Ishikawa Prefacture

Hemodialysis therapy for HCV infection

INF combined hepatic arterial chemotherapy for advanced HCC

Books

  •  Regorafenib Treatment for Hepatocellular carcinoma 2017

Papers

  •  Delineation of regions important for heteromeric association of hepatitis C virus E1 and E2 VIROLOGY 231 1 119-129 1997/01
  •  Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity J Biol Chem 277 13,11149-11155 2002/03
  •  Human hepatitis B virus X protein is detectable in nuclei of transfected cells, and is active for transactivation Biochim Biophys Acta 1453 3 330-340 1999/03
  •  Mutational analysis of the structure and functions of hepatitis C virus RNA-dependent RNA polymerase HEPATOLOGY 33 3 728-737 2001/03
  •  Oligomeric interaction of hepatitis C virus NS5B is critical for catalytic activity of RNA-dependent RNA polymerase J Biol Chem 277 3 2132-2137 2002/01

show all

  •  RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein Mol Cell Biol 18 12 7546-7555 1998/12
  •  RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region J Biol Chem 273 25 15479-15486 1998/06
  •  Telomerase activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA component J Biol Chem 275 29 22568-22573 2000/07
  •  Adipose tissue-derived stem cells prevent fibrosis in murine steatohepatitis by suppressing IL-17-mediated inflammation. Yamato M, Sakai Y, Mochida H, Kawaguchi K, Takamura M, Usui S, Seki A, Mizukoshi E, Yamashita T, Yamashita T, Ishida K, Nasti A, Tuyen HTB, Komura T, Yoshida K, Wada T, Honda M, Kaneko S. J Gastroenterol Hepatol. 2019/03/03
  •  The transactivation and p53-interacting functions of hepatitis B virus X protein are mutually interfering but distinct Cancer Res 57 22 5137-5142 1997/11
  •  Distinct chemotherapy-associated anti-cancer immunity by myeloid cells inhibition in murine pancreatic cancer models. Sakai Y, Miyazawa M, Komura T, Yamada T, Nasti A, Yoshida K, Takabatake H, Yamato M, Yamashita T, Yamashita T, Mizukoshi E, Okuzono M, Ho TTB, Kawaguchi K, Wada T, Honda M, Kaneko S Cancer Sci. 110 3 903 2019/03/01
  •  Direct interaction between nucleolin and hepatitis C virus NS5B. JOURNAL OF BIOCHEMISTRY 278 7 5105-5115 2003/02
  •  Prediction of Prognosis of Intermediate-Stage HCC Patients: Validation of the Tumor Marker Score in a Nationwide Database in Japan. Hiraoka A1, Michitaka K1, Kumada T2, Izumi N3, Kadoya M4, Kokudo N5, Kubo S6, Matsuyama Y7, Nakashima O8, Sakamoto M9, Takayama T10, Kokudo T11, Kashiwabara K12, Eguchi S13, Yamashita T14, Kudo M15 Liver Cancer. 8 5 403 2019/02/18
  •  Development of novel diagnostic system for pancreas cancer including early stages measuring mRNA of whole blood cells. Sakai Y, Honda M, Matsui S, Komori O, Murayama T, Fujiwara T, Mizuno M, Imai Y, Yoshimura K, Nasti A, Wada T, Iida N, Kitahara M, Horii R, Tamai T, Nishikawa M, Okafuji H, Mizukoshi E, Yamashita T, Yamashita T, Arai K, Kitamura K, Kawaguchi K, Takatori H, Shimakami T, Terashima T, Hayashi T, Nio K, Kaneko S; Hokuriku Liver Study Group. Cancer Sci. 2019/02/11
  •  Three renal failure cases successfully treated with ombitasvir/paritaprevir/ritonavir for genotype 1b hepatitis C virus reinfection after liver transplantation. Orita N, Shimakami T, Sunagozaka H, Horii R, Nio K, Terashima T, Iida N, Kitahara M, Takatori H, Kawaguchi K, Kitamura K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S. Clin J Gastroenterol. 12 1 63-70 2019/02/01
  •  Serum aldo-keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis. Kanno M, Kawaguchi K, Honda M, Horii R, Takatori H, Shimakami T, Kitamura K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.   J Gastroenterol. 2019/02/01
  •  Inactivation of Transcriptional Repressor Capicua Confers Sorafenib Resistance in Human Hepatocellular Carcinoma Hashiba T, Yamashita T, Okada H, Nio K, Hayashi T, Asahina Y, Hayashi T, Terashima T, Iida N, Takatori H, Shimakami T, Kawaguchi K, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Takamura H, Ohta T, Honda M, Kaneko S. Cell Mol Gastroenterol Hepatol.  2020/03/10
  •  IL-28B Variant as a Predictor in Patients With Advanced Hepatocellular Carcinoma Treated With Hepatic Arterial Infusion Chemotherapy Terashima T, Honda M, Toyama T, Shimakami T, Shimizu R, Takatori H, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S. J Gastroenterol Hepatol.  2020/03/16
  •  Regenerative Therapy for Liver Cirrhosis Based on Intrahepatic Arterial Infusion of Autologous Subcutaneous Adipose Tissue-Derived Regenerative (Stem) Cells: Protocol for a Confirmatory Multicenter Uncontrolled Clinical Trial Sakai Y, Fukunishi S, Takamura M, Inoue O, Takashima S, Usui S, Seki A, Nasti A, Ho TTB, Kawaguchi K, Asai A, Tsuchimoto Y, Yamashita T, Yamashita T, Mizukoshi E, Honda M, Imai Y, Yoshimura K, Murayama T, Wada T, Harada K, Higuchi K, Kaneko S. JMIR Res Protoc.  9 3 e17904 2020/03/31
  •  Ramucirumab -the first antibody preparation for hepatocellular carcinoma- Tatsuya Yamashita, Takeshi Terashima,Kuniaki Arai, Shuichi Kaneko 5 2 209-214 2019/10/31
  •  Expectancy of immune checkpoint inhibitors for advanced hepatocellular carcinoma Tatsuya Yamashita, Takeshi Terashima,Kuniaki Arai, Shuichi Kaneko 5 1 67-74 2019/05/15
  •  Adipose tissue-derived stem cells prevent fibrosis in murine steatohepatitis by suppressing IL-17-mediated inflammation. Yamato M1, Sakai Y2, Mochida H3, Kawaguchi K2, Takamura M4, Usui S4, Seki A3, Mizukoshi E3, Yamashita T5, Yamashita T2, Ishida K3, Nasti A3, Tuyen HTB3, Komura T3, Yoshida K3, Wada T6, Honda M2, Kaneko S1,2,3. J Gastroenterol Hepatol.  34 8 1432 2019/05/31
  •  Serum C16:1n7/C16:0 ratio as a diagnostic marker for non-alcoholic steatohepatitis. Yamada K1, Mizukoshi E1, Seike T1, Horii R1, Terashima T1, Iida N1, Kitahara M1, Sunagozaka H1, Arai K1, Yamashita T1, Honda M1, Takamura T2, Harada K3, Kaneko S1. J Gastroenterol Hepatol.  34 10 1829 2019/04/07
  •  Surrogacy of Time to Progression for Overall Survival in Advanced Hepatocellular Carcinoma Treated with Systemic Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Terashima T1, Yamashita T1, Toyama T2, Arai K1, Kawaguchi K1, Kitamura K1, Yamashita T1, Sakai Y1, Mizukoshi E1, Honda M1, Kaneko S1. Liver Cancer.  8 2 130 2019/05/01
  •  Subgroup analysis of efficacy and safety of orantinib in combination with TACE in Japanese HCC patients in a randomized phase III trial (ORIENTAL). Hidaka H1, Izumi N2, Aramaki T3, Ikeda M4, Inaba Y5, Imanaka K6, Okusaka T7, Kanazawa S8, Kaneko S9, Kora S10, Saito H11, Furuse J12, Matsui O13, Yamashita T9, Yokosuka O14, Morita S15, Arioka H16, Kudo M17, Arai Y18. Med Oncol. 36 6 52 2019/05/01
  •  Response Evaluation Criteria in Cancer of the Liver version 5 (RECICL 2019 revised version). Kudo M1, Ikeda M2, Ueshima K1, Sakamoto M3, Shiina S4, Tateishi R2, Hasegawa K5, Furuse J6, Miyayama S7, Murakami T8, Yamashita T9, Kokudo N10. Hepatol Res. 49 9 981 2019/07/25
  •  Combination gemcitabine plus S-1 versus gemcitabine plus cisplatin for advanced/recurrent biliary tract cancer: the FUGA-BT (JCOG1113) randomized phase III clinical trial. Morizane C1, Okusaka T2, Mizusawa J3, Katayama H3, Ueno M4, Ikeda M5, Ozaka M6, Okano N7, Sugimori K8, Fukutomi A9, Hara H10, Mizuno N11, Yanagimoto H12, Wada K13, Tobimatsu K14, Yane K15, Nakamori S16, Yamaguchi H17, Asagi A18, Yukisawa S19, Kojima Y20, Kawabe K21, Kawamoto Y22, Sugimoto R23, Iwai T24, Nakamura K25, Miyakawa H26, Yamashita T27, Hosokawa A28, Ioka T29, Kato N30, Shioji K31, Shimizu K32, Nakagohri T33, Kamata K34, Ishii H35, Furuse J7; members of the Hepatobiliary and Pancreatic Oncology Group of the Japan Clinical Oncology Group (JCOG-HBPOG). Ann Oncol. 30 12 1950 2019/12/01
  •  REFLECT-a phase 3 trial comparing efficacy and safety of lenvatinib to sorafenib for the treatment of unresectable hepatocellular carcinoma: an analysis of Japanese subset. Yamashita T1, Kudo M2, Ikeda K3, Izumi N4, Tateishi R5, Ikeda M6, Aikata H7, Kawaguchi Y8,9, Wada Y10, Numata K11, Inaba Y12, Kuromatsu R13, Kobayashi M3, Okusaka T14, Tamai T15, Kitamura C15, Saito K15, Haruna K15, Okita K16, Kumada H3. J Gastroenterol.  55 1 113 2019/11/12
  •  Gut-derived Enterococcus faecium from ulcerative colitis patients promotes colitis in a genetically susceptible mouse host. Seishima J1, Iida N1, Kitamura K1, Yutani M2, Wang Z1, Seki A1, Yamashita T1, Sakai Y1, Honda M3, Yamashita T1, Kagaya T1, Shirota Y1, Fujinaga Y2, Mizukoshi E4, Kaneko S1. Genome Biol.  20 1 252 2019/11/25
  •  MicroRNA-10a Impairs Liver Metabolism in Hepatitis C Virus-Related Cirrhosis Through Deregulation of the Circadian Clock Gene Brain and Muscle Aryl Hydrocarbon Receptor Nuclear Translocator-Like 1. Horii R1, Honda M1,2, Shirasaki T2, Shimakami T1, Shimizu R2, Yamanaka S2, Murai K2, Kawaguchi K1, Arai K1, Yamashita T1, Sakai Y1, Yamashita T1, Okada H1, Nakamura M1, Mizukoshi E1, Kaneko S1. Hepatol Commun.  3 12 1687 2019/09/26
  •  Danaparoid sodium-based anticoagulation therapy for portal vein thrombosis in cirrhosis patients. Hayashi T1,2, Takatori H3, Horii R1, Nio K1, Terashima T1, Iida N1, Kitahara M1, Shimakami T1, Arai K1, Kitamura K1, Kawaguchi K1, Yamashita T1, Sakai Y1, Yamashita T1, Mizukoshi E1, Honda M1, Toyama T4, Okumura K5, Kozaka K5, Kaneko S1. BMC Gastroenterol.  19 1 217 2019/12/01
  •  Study Protocol for Pleiotropic Effects and Safety of Sodium-Glucose Cotransporter 2 Inhibitor Versus Sulfonylurea in Patients with Type 2 Diabetes and Nonalcoholic Fatty Liver Disease. Takeshita Y1, Kanamori T1, Tanaka T1, Kaikoi Y1, Kita Y1, Takata N2, Iida N2, Arai K2, Yamashita T2, Harada K3, Gabata T4, Nakamura H5, Kaneko S2, Takamura T6. Diabetes Ther.  11 2 549 2020/01/20
  •  Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice. Nishikawa T1, Nagata N2,3, Shimakami T1, Shirakura T4, Matsui C4, Ni Y2, Zhuge F2, Xu L2, Chen G2, Nagashimada M2, Yamashita T1, Sakai Y1, Yamashita T1,2, Mizukoshi E1, Honda M1, Kaneko S1, Ota T5,6. Sci Rep.  2020/01/21
  •  Ramucirumab after prior sorafenib in patients with advanced hepatocellular carcinoma and elevated alpha-fetoprotein: Japanese subgroup analysis of the REACH-2 trial. Kudo M1, Okusaka T2, Motomura K3, Ohno I4, Morimoto M5, Seo S6, Wada Y7, Sato S8, Yamashita T9, Furukawa M10, Aramaki T11, Nadano S12, Ohkawa K13, Fujii H14, Kudo T15, Furuse J16, Takai H17, Homma G17, Yoshikawa R17, Zhu AX18. J Gastroenterol. 2020/02/27
  •  A novel α-fetoprotein-derived helper T-lymphocyte epitope with strong immunogenicity in patients with hepatocellular carcinoma. Tamai T1, Mizukoshi E2, Kumagai M1, Terashima T1, Iida N1, Kitahara M1, Shimakami T1, Kitamura K1, Arai K1, Yamashita T1, Sakai Y1, Yamashita T1, Honda M1, Fushimi K1, Kaneko S1. Sci Rep.  10 1 4021 2020/03/04
  •  Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients. Seike T1, Mizukoshi E2, Yamada K1, Okada H1, Kitahara M1, Yamashita T1, Arai K1, Terashima T1, Iida N1, Fushimi K1, Yamashita T1, Sakai Y1, Honda M1, Harada K3, Kaneko S1. J Gastroenterol. 2020/03/02
  •  Characteristics of Impaired Dendritic Cell Function in Patients With Hepatitis B Virus Infection. Yonejima A1, Mizukoshi E1, Tamai T1, Nakagawa H1, Kitahara M1, Yamashita T1, Arai K1, Terashima T1, Iida N1, Fushimi K1, Okada H1, Yamashita T1, Sakai Y1, Honda M1, Kaneko S1. Hepatology. 70 1 25 2019/07/01
  •  Characteristics of Immune Response to Tumor-Associated Antigens and Immune Cell Profile in Patients With Hepatocellular Carcinoma. Inada Y1, Mizukoshi E1, Seike T1, Tamai T1, Iida N1, Kitahara M1, Yamashita T1, Arai K1, Terashima T1, Fushimi K1, Yamashita T1, Honda M1, Kaneko S1. Hepatology. 69 2 653 2019/02/01
  •  Biological characteristics of gene expression features in pancreatic cancer cells induced by proton and X-ray irradiation.  Fujinaga H, Sakai Y, Yamashita T, Arai K, Terashima T, Komura T, Seki A, Kawaguchi K, Nasti A, Yoshida K, Wada T, Yamamoto K, Kume K, Hasegawa T, Takata T, Honda M, Kaneko S Int J Radiat Biol.  95 5 571 2019/05/01
  •   Liver Cancer Study Group of Japan. Liver Resection for Multiple Hepatocellular Carcinomas: A Japanese Nationwide Survey. Fukami Y, Kaneoka Y, Maeda A, Kumada T, Tanaka J, Akita T, Kubo S, Izumi N, Kadoya M, Sakamoto M, Nakashima O, Matsuyama Y, Kokudo T, Hasegawa K, Yamashita T, Kashiwabara K, Takayama T, Kokudo N, Kudo M; Liver Cancer Study Group of Japan. Ann Surg.  2019/01/16
  •  Outline of HIMALAYA study 77 2 467-471 2018/08/28
  •  Development status of other combination immune-oncology with thymidine kinase inhibitor for patients with advanced hepatocellular carcinoma  77 2 491-498 2018/08/28
  •  Clinical trial design in advanced hepatocellular carcinoma 77 2 413-418 2018/08/28
  •  Subsequent treatment for patients with advanced hepatocellular carcinoma who were intolerant to sorafenib: positioning of hepatic arterial infusion chemotherapy  77 2 254-261 2018/08/28
  •  Biological characteristics of gene expression features in pancreatic cancer cells induced by proton and X-ray irradiation. Fujinaga H, Sakai Y, Yamashita T, Arai K, Terashima T, Komura T, Seki A, Kawaguchi K, Nasti A, Yoshida K, Wada T, Yamamoto K, Kume K, Hasegawa T, Takata T, Honda M, Kaneko S. Int J Radiat Biol.  2018/12/17
  •  Immune response to human telomerase reverse transcriptase-derived helper T cell epitopes in hepatocellular carcinoma patients. Kumagai M, Mizukoshi E, Tamai T, Kitahara M, Yamashita T, Arai K, Terashima T, Iida N, Fushimi K, Kaneko S. Liver Int. 38 9 1635-1345 2018/09/01
  •  Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease. Yamada K, Mizukoshi E, Seike T, Horii R, Kitahara M, Sunagozaka H, Arai K, Yamashita T, Honda M, Kaneko S. PLoS One.  13 1 e0191026 2018/01/01
  •  Gadoxetic acid-enhanced magnetic resonance imaging reflects co-activation of ホイ-catenin and hepatocyte nuclear factor 4ホア in hepatocellular carcinoma. Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Koda W, Minami T, Inoue D, Yoshida K, Yamashita T, Yamashita T, Kaneko S, Takamura H, Ohta T, Ikeda H, Sato Y, Nakanuma Y, Harada K, Kita R, Gabata T. Hepatol Res 48 2 205-216 2018/02/01
  •  Treatment patterns and outcomes of unresectable pancreatic cancer patients in real-life practice: a region-wide analysis. Terashima T, Yamashita T, Sakai A, Ohta H, Hinoue Y, Toya D, Kawai H, Yonejima M, Urabe T, Noda Y, Mizukoshi E, Kaneko S. Jpn J Clin Oncol. 48 11 966-973 2018/11/01
  •  Immune responses of human T lymphocytes to novel hepatitis B virus-derived peptides. Yamamiya D, Mizukoshi E, Kaji K, Terashima T, Kitahara M, Yamashita T, Arai K, Fushimi K, Honda M, Kaneko S. PLoS One.  13 6 e0198264 2018/06/01
  •  Analysis of the liver functional reserve of patients with advanced hepatocellular carcinoma undergoing sorafenib treatment: Prospects for regorafenib therapy. Terashima T, Yamashita T, Sunagozaka H, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S. Hepatol Res. 48 12 956-966 2018/12/01
  •  Immune responses against tumour-associated antigen-derived cytotoxic T lymphocyte epitopes in cholangiocarcinoma patients. Kida A, Mizukoshi E, Tamai T, Terashima T, Kitahara M, Arai K, Yamashita T, Fushimi K, Honda M, Kaneko S. Liver Int. 38 11 2040-2050 2018/11/01
  •  Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts hepatocellular carcinoma incidence and recurrence in nucleos(t)ide analogue therapy for chronic hepatitis B. Kawaguchi K, Honda M, Ohta H, Terashima T, Shimakami T, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Komura T, Unoura M, Kaneko S.  J Gastroenterol. 53 6 740-751 2018/06/01
  •  Serum cytokine profiles predict survival benefits in patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective cohort study. Hayashi T, Yamashita T, Terashima T, Suda T, Okada H, Asahina Y, Hayashi T, Hara Y, Nio K, Sunagozaka H, Takatori H, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S. BMC Cancer.  17 1 870 2017
  •  Prognosis of type 1 autoimmune pancreatitis after corticosteroid therapy-induced remission in terms of relapse and diabetes mellitus. Miyazawa M, Takatori H, Shimakami T, Kawaguchi K, Kitamura K, Arai K, Matsuda K, Sanada T, Urabe T, Inamura K, Kagaya T, Mizuno H, Fuchizaki U, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S. PLoS One. 12 11 e0188549 2017
  •  Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts hepatocellular carcinoma incidence and recurrence in nucleos(t)ide analogue therapy for chronic hepatitis B. Kawaguchi K, Honda M, Ohta H, Terashima T, Shimakami T, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Komura T, Unoura M, Kaneko S. J Gastroenterol. 2017
  •  Reactivation of hepatitis B virus from an isolated anti-HBc positive patient after eradication of hepatitis C virus with direct-acting antiviral agents. Suda T, Shimakami T, Shirasaki T, Yamashita T, Mizukoshi E, Honda M, Kaneko S. J Hepatol.  67 5 1108-1111 2017
  •  A Novel mTOR Inhibitor; Anthracimycin for the Treatment of Human Hepatocellular Carcinoma. Hayashi T, Yamashita T, Okada H, Oishi N, Sunagozaka H, Nio K, Hayashi T, Hara Y, Asahina Y, Yoshida M, Hashiba T, Suda T, Shirasaki T, Igarashi Y, Miyanouchi K, Yamashita T, Honda M, Kaneko S. Anticancer Res.  37 7 3397-3403 2017
  •  Beneficial Effect of Maintaining Hepatic Reserve during Chemotherapy on the Outcomes of Patients with Hepatocellular Carcinoma. Terashima T, Yamashita T, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S. Liver Cancer 6 3 236-249 2017
  •  Direct-acting antiviral agents improved nephrotic syndrome associated with refractory pleural effusion and ascites caused by hepatitis C virus-related nephropathy: a case report. Yamato M, Arai K, Takatori H, Shimakami T, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S. Nihon Shokakibyo Gakkai Zasshi 114 6 1031-1038 2017
  •  Association Between High-avidity T-cell Receptors, Induced by Alpha Fetoprotein-derived Peptides, and Anti-tumor Effects in Patients with Hepatocellular Carcinom Hidetoshi Nakagawa, Eishiro Mizukoshi, Eiji Kobayashi, Toshikatsu Tamai1, Hiroshi Hamana, Tatsuhiko Ozawa, Hiroyuki Kishi, Masaaki Kitahara, Tatsuya Yamashita, Kuniaki Arai, Takeshi Terashima, Noriho Iida, Kazumi Fushimi, Atsushi Muraguchi, Shuichi Kaneko Gastroenterology 2017
  •  Lidocaine spray alone is similar to spray plus viscous solution for pharyngeal observation during transoral endoscopy: a clinical randomized trial Tomoyuki Hayashi, Yoshiro Asahina, Yohei Waseda, Kazuya Kitamura, Takashi Kagaya, Takuya Seike, Kazuhiro Okada, Yuki Inada, Hisashi Takabatake, Noriaki Orita, Yuko Yanase, Tatsuya Yamashita, Itasu Ninomiya, Kenichi Yoshimura, Shuichi Kaneko Endosc Int Open 5 1 E47 2017
  •  Cellular Immune Responses for Squamous Cell Carcinoma Antigen Recognized by T Cells 3 in Patients with Hepatocellular Carcinoma Kiichiro Kaji, Eishiro Mizukoshi, Tatsuya Yamashita, Kuniaki Arai, Hajime Sunagozaka, Kazumi Fushimi, Hidetoshi Nakagawa, Kazutoshi Yamada, Takeshi Terashima, Masaaki Kitahara, Shuichi Kaneko PLoS One 12 1 e01702 2017
  •  Response to chemotherapy improves hepatic reserve for patients with hepatocellular carcinoma and Child-Pugh B cirrhosis Takeshi Terashima, Tatsuya Yamashita, Kuniaki Arai, Kazunori Kawaguchi, Kazuya Kitamura, Taro Yamashita, Yoshio Sakai, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko Cancer Sci 107 9 1263 2016
  •  Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver Cancer. Kazunori Kawaguchi, Masao Honda, Taro Yamashita, Hikari Okada, Takayoshi Shirasaki, Masashi Nishikawa, Kouki Nio, Kuniaki Arai, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Shuichi Kaneko Am J Pathol 186 8 2055 2016
  •  Potential efficacy of therapies targeting intrahepatic lesions after sorafenib treatment of patients with hepatocellular carcinoma Takeshi Terashima, Tatsuya Yamashita, Rika Horii, Kuniaki Arai, Kazunori Kawaguchi, Kazuya Kitamura, Taro Yamashita, Yoshio Sakai, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko BMC Cancer 16 338 2016
  •  Myeloid-derived suppressor cells correlate with patient outcomes in hepatic arterial infusion chemotherapy for hepatocellular carcinoma. Eishiro MizukoshiTatsuya YamashitaKuniaki AraiTakeshi TerashimaMasaaki KitaharaHidetoshi NakagawaNoriho IidaKazumi FushimiShuichi Kaneko Cancer Immunol Immunother. 65 6 715 2016
  •  Hepatitis B Virus (HBV) Core-Related Antigen During Nucleos(t)ide Analog Therapy Is Related to Intra-hepatic HBV Replication and Development of Hepatocellular Carcinoma Masao Honda Takayoshi Shirasaki Takeshi Terashima Kazunori Kawaguchi Mikiko Nakamura Naoki Oishi Xuyang Wang Tetsuro Shimakami Hikari Okada Kuniaki Arai Taro Yamashita Yoshio Sakai Tatsuya Yamashita Eishiro Mizukoshi Shuichi Kaneko J Infect Dis 213 7 1096 2016
  •  Post-progression survival and progression-free survival in patients with advanced hepatocellular carcinoma treated by sorafenib Takeshi Terashima, Tatsuya Yamashita, Noboru Takata, Hidetoshi Nakagawa, Tadashi Toyama, Kuniaki Arai, Kazuya Kitamura, Taro Yamashita, Yoshio Sakai,Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko Hepatol Res. 46 7 650 2016
  •  Phase I trial of multidrug resistance-associated protein 3-derived peptide in patients with hepatocellular carcinoma. Eishiro Mizukoshi, Hidetoshi Nakagawa, Masaaki Kitahara, Tatsuya Yamashita, Kuniaki Arai, Hajime Sunagozaka, Noriho Iida, Kazumi Fushimi, Shuichi Kaneko Cancer Lett.  369 1 242 2015
  •  Immunological features of T cells induced by human telomerase reverse transcriptase-derived peptides in patients with hepatocellular carcinoma Eishiro Mizukoshi, Hidetoshi Nakagawa, Masaaki Kitahara, Tatsuya Yamashita, Kuniaki Arai, Hajime Sunagozaka, Kazumi Fushimi, Eiji Kobayashi, Hiroyuki Kishi, Atsushi Muraguchi, Shuichi Kaneko Cancer Lett. 364 2 98 2015
  •  Hepatocellular Carcinoma with β-Catenin Mutation: Imaging and Pathologic Characteristics. Kitao A1, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Sanada J, Koda W, Minami T, Inoue D, Yoshida K, Yamashita T, Yamashita T, Kaneko S, Takamura H, Ohta T, Ikeda H, Nakanuma Y, Kita R, Gabata T. Radiology 275 3 708 2015
  •  Response to Importance of confounding factors in assessing fatty acid compositions in patients with non-alcoholic steatohepatitis Kazutoshi Yamada, Eishiro Mizukoshi, Hajime Sunagozaka, Kuniaki Arai, Tatsuya Yamashita, Yumie Takeshita, Hirofumi Misu, Toshinari Takamura, Seiko Kitamura, Yoh Zen, Yasuni Nakanuma, Masao Honda, Shuichi Kaneko Liver Int.  35 6 2015
  •  Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis. Kazutoshi Yamada, Eishiro Mizukoshi, Hajime Sunagozaka, Kuniaki Arai, Tatsuya Yamashita, Yumie Takeshita, Hirofumi Misu, Toshinari Takamura, Seiko Kitamura, Yoh Zen, Yasuni Nakanuma, Masao Honda, Shuichi Kaneko Liver Int 35 2 582 2014
  •  Efficacy of continuous plasma diafiltration therapy in critical patients with acute liver failure Komura T, Taniguchi T, Sakai Y, Yamashita T, Mizukoshi E, Noda T, Okajima M, Kaneko S. J Gastroenterol Hepatol 29 4 782 2014
  •  Feasibility and efficacy of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma after sorafenib Terashima T, Yamashita T, Arai K, Sunagozaka H, Kitahara M, Nakagawa H, Kagaya T, Mizukoshi E, Honda M, Kaneko S. Hepatol Res 44 12 1179 2014
  •  Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma Yamashita T, Kitao A, Matsui O, Hayashi T, Nio K, Kondo M, Ohno N, Miyati T, Okada H, Yamashita T, Mizukoshi E, Honda M, Nakanuma Y, Takamura H, Ohta T, Nakamoto Y, Yamamoto M, Takayama T, Arii S, Wang X, Kaneko S. Hepatology 60 5 1674 2014
  •  Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes Honda M, Shirasaki T, Shimakami T, Sakai A, Horii R, Arai K, Yamashita T, Sakai Y, Yamashita T, Okada H, Murai K, Nakamura M, Mizukoshi E, Kaneko S. Hepatology 59 3 828 2014
  •  Transarterial chemoembolization failure/refractoriness: JSH-LCSGJ criteria 2014 update Kudo, M. Matsui, O. Izumi, N. Kadoya, M. Okusaka, T. Miyayama, S. Yamakado, K. Tsuchiya, K. Ueshima, K. Hiraoka, A. Ikeda, M. Ogasawara, S. Yamashita, T.Minami, T. Oncology 87 22 2014
  •  JSH Consensus-Based Clinical Practice Guidelines for the Management of Hepatocellular Carcinoma: 2014 Update by the Liver Cancer Study Group of Japan. Kudo M., Matsui O., Izumi N., Iijima H., Kadoya M., Imai Y., Okusaka T., Miyayama S., Tsuchiya K., Ueshima K., Hiraoka A., Ikeda M., Ogasawara S., Yamashita T., Minami T., Yamakado K., on behalf of the Liver Cancer Study Group of Japan  Liver Cancer 3 3-4 458 2014
  •  Severe Veno-occlusive Disease/Sinusoidal Obstruction Syndrome After Deceased-donor and Living-donor Liver Transplantation H. Takamura, , S. Nakanuma, H. Hayashi, H. Tajima, K. Kakinoki, M. Kitahara, S. Sakai, I. Makino, H. Nakagawara, T. Miyashita, K. Okamoto, K. Nakamura, K. Oyama, M. Inokuchi, I. Ninomiya, H. Kitagawa, S. Fushida, T. Fujimura, I. Onishi, M. Kayahara, T. Tani, K. Arai, Taro Yamashita, Tatsuya Yamashita, H. Kitamura, H. Ikeda, d, S. Kaneko, Y. Nakanuma, O. Matsui, T. Ohta Transplant Proc.  46 10 3523 2014
  •  P53, hTERT, WT-1, and VEGFR2 are the most suitable targets for cancer vaccine therapy in HLA-A24 positive pancreatic adenocarcinoma. Takeshi Terashima, Eishiro Mizukoshi, Kuniaki Arai,Tatsuya Yamashita, Mariko Yoshida, Hajime Ota, Ichiro Onishi, Masato Kayahara, Koushiro Ohtsubo, Takashi Kagaya, Masao Honda, Shuichi Kaneko Cancer Immunol Immunother. 63 5 479 2014
  •  The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial Yumie Takeshita, Toshinari Takamura, Masao Honda, Yuki Kita, Yoh Zen, Ken-ichiro KatoHirofumi MisuTsuguhito OtaMikiko NakamuraKazutoshi YamadaHajime Sunagozaka, Kuniaki Arai, Tatsuya Yamashita, Eishiro Mizukoshi, Shuichi Kaneko Diabetologia 57 5 878 2014
  •  The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: Correlation with gadoxetic acid enhanced MR imaging Kitao, Azusa; Matsui, Osamu; Yoneda, Norihide; Kozaka, Kazuto; Shinmura, Rieko; Koda, Wataru; Kobayashi, Satoshi; Gabata, Toshifumi; Zen, Yoh; Yamashita, Tatsuya; Kaneko, Shuichi; Nakanuma, Yasuni European Radiology 21 10 2056-2066 2011/10/01 
  •  Frequency of CD45RO+ subset in CD4+CD25high regulatory T cells associated with progression of hepatocellular carcinoma Takata, Yoshiko; Nakamoto, Yasunari; Nakada, Akiko; Terashima, Takeshi; Arihara, Fumitaka; Kitahara, Masaaki; Kakinoki, Kaheita; Arai, Kuniaki; Yamashita, Taro; Sakai, Yoshio; Yamashita, Tatsuya; Mizukoshi, Eishiro; Kaneko, Shuichi Cancer Letters 307 2 165-173 2011/08/28 
  •  Effect of vitamin K2 on the recurrence of hepatocellular carcinoma Yoshida, Haruhiko; Shiratori, Yasushi; Kudo, Masatoshi; Shiina, Shuichiro; Mizuta, Toshihiko; Kojiro, Masamichi; Yamamoto, Kyosuke; Koike, Yukihiro; Saito, Kenichi; Koyanagi, Nozomu; Kawabe, Takao; Kawazoe, Seiji; Kobashi, Haruhiko; Kasugai, Hiroshi; Osaki, Yukio; Araki, Yasuyuki; Izumi, Namiki; Oka, Hiroko; Tsuji, Kunihiko; Toyota, Joji; Seki, Toshihito; Osawa, Toshiya; Masaki, Naohiko; Ichinose, Masao; Seike, Masataka; Ishikawa, Akihisa; Ueno, Yoshiyuki; Tagawa, Kazumi; Kuromatsu, Ryoko; Sakisaka, Shotaro; Ikeda, Hiroshi; Kuroda, Hidekatsu; Kokuryu, Hiroyuki; Yamashita, Tatsuya; Sakaida, Isao; Katamoto, Tetsuo; Kikuchi, Kentaro; Nomoto, Minoru; Omata, Masao Hepatology 54 2 532-540 2011/08/01 
  •  Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C Honda, Masao; Takehana, Kenji; Sakai, Akito; Tagata, Yusuke; Shirasaki, Takayoshi; Nishitani, Shinobu; Muramatsu, Takahiko; Yamashita, Tatsuya; Nakamoto, Yasunari; Mizukoshi, Eishiro; Sakai, Yoshio; Yamashita, Taro; Nakamura, Mikiko; Shimakami, Tetsuro; Yi, MinKyung; Lemon, Stanley M.; Suzuki, Tetsuo; Wakita, Takaji; Kaneko, Shuichi Gastroenterology 141 1 128-14000 2011/07/01 
  •  Current status of hepatocellular carcinoma treatment in Japan: Case study and discussion-voting system Kudo, Masatoshi; Tateishi, Ryosuke; Yamashita, Tatsuya; Ikeda, Masafumi; Furuse, Junji; Ikeda, Kenji; Kokudo, Norihiro; Izumi, Namiki; Matsui, Osamu Clinical Drug Investigation 32 SUPPL. 2 37-51 2012/08/13 
  •  Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: Implications for type 2 diabetes Takeshita, Yumie; Takamura, Toshinari; Kita, Yuki; Ando, Hitoshi; Ueda, Teruyuki; Kato, Kenichiro; Misu, Hirofumi; Sunagozaka, Hajime; Sakai, Yoshio; Yamashita, Tatsuya; Mizukoshi, Eishiro; Honda, Masao; Kaneko, Shuichi Metabolism: Clinical and Experimental 61 10 1388-1394 2012/10/01 
  •  A phase I/II study of S-1 with sorafenib in patients with advanced hepatocellular carcinoma Ooka, Yoshihiko; Chiba, Tetsuhiro; Ogasawara, Sadahisa; Arai, Kuniaki; Suzuki, Eiichiro; Tawada, Akinobu; Yamashita, Tatsuya; Kanai, Fumihiko; Kaneko, Shuichi; Yokosuka, Osamu Investigational New Drugs 32 4 723-728 2014/01/01 
  •  Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma Sunagozaka, Hajime; Honda, Masao; Yamashita, Taro; Nishino, Ryuhei; Takatori, Hajime; Arai, Kuniaki; Yamashita, Tatsuya; Sakai, Yoshio; Kaneko, Shuichi International Journal of Cancer 129 7 1576-1585 2011/10/01 
  •  Enhancement of tumor-associated antigen-specific T cell responses by radiofrequency ablation of hepatocellular carcinoma Mizukoshi, Eishiro; Yamashita, Tatsuya; Arai, Kuniaki; Sunagozaka, Hajime; Ueda, Teruyuki; Arihara, Fumitaka; Kagaya, Takashi; Yamashita, Taro; Fushimi, Kazumi; Kaneko, Shuichi Hepatology 57 4 1448-1457 2013/04/01 
  •  Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma Yamashita, Taro; Honda, Masao; Nakamoto, Yasunari; Baba, Masayo; Nio, Kouki; Hara, Yasumasa; Zeng, Shasha; Hayashi, Takehiro; Kondo, Mitsumasa; Takatori, Hajime; Yamashita, Tatsuya; Mizukoshi, Eishiro; Ikeda, Hiroko; Zen, Yoh; Takamura, Hiroyuki; Wang, Xin Wei; Kaneko, Shuichi Hepatology 57 4 1484-1497 2013/04/01 
  •  Increase in CD14+HLA-DR-/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis Arihara, Fumitaka; Mizukoshi, Eishiro; Kitahara, Masaaki; Takata, Yoshiko; Arai, Kuniaki; Yamashita, Tatsuya; Nakamoto, Yasunari; Kaneko, Shuichi Cancer Immunology, Immunotherapy 62 8 1421-1430 2013/08/01 
  •  Evaluation of eligibility criteria in living donor liver transplantation for hepatocellular carcinoma by α-SMA-positive cancer-associated fibroblasts Takamura, Hiroyuki; Nakanuma, Shinichi Ichi; Hayashi, Hironori; Tajima, Hidehiro; Kakinoki, Kaheita; Sakai, Seisyo; Makino, Isamu; Nakagawara, Hisatoshi; Miyashita, Tomoharu; Okamoto, Koichi; Nakamura, Keishi; Oyama, Katunobu; Inokuchi, Masashi; Ninomiya, Itasu; Kitagawa, Hirohisa; Fushida, Sachio; Fujimura, Takashi; Ohnishi, Ichiro; Kayahara, Masato Sato; Tani, Takashi; Arai, Kuniaki; Yamashita, Taro; Yamashita, Tatsuya; Kitamura, Hoshiko; Ikeda, Hiroko; Kaneko, Shuichi; Nakanuma, Yasuni; Matsui, Osamu; Ohta, Tetsuo Oncology Reports 30 4 1561-1574 2013/10/01 
  •  Revision process for the Japanese practice guidelines for hepatocellular carcinoma 2013 Kokudo, Norihiro; Takayama, Tadatoshi; Izumi, Namiki; Tateishi, Ryosuke; Yamashita, Tatsuya; Sakamoto, Michiie; Nakayama, Hisashi Acta Hepatologica Japonica 55 10 571-588 2014/01/01 
  •  Diagnostic benefits of adrenocortical scintigraphy in hepatic adrenal rest tumor Ishida, Kosuke; Horii, Rika; Yamashita, Tatsuya; Arai, Kuniaki; Yamashita, Taro; Kagaya, Takashi; Sakai, Yoshio; Mizukoshi, Eishiro; Honda, Masao; Kaneko, Shuichi Journal of Japanese Society of Gastroenterology 111 10 2004-2012 2014/01/01 
  •  Blood neutrophil to lymphocyte ratio as a predictor in patients with advanced hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy Terashima, Takeshi; Yamashita, Tatsuya; Iida, Noriho; Yamashita, Taro; Nakagawa, Hidetoshi; Arai, Kuniaki; Kitamura, Kazuya; Kagaya, Takashi; Sakai, Yoshio; Mizukoshi, Eishiro; Honda, Masao; Kaneko, Shuichi Hepatology Research 2014/01/01 
  •  Expression of chondroitin-glucuronate C5-epimerase and cellular immune responses in patients with hepatocellular carcinoma Mizukoshi, Eishiro; Fushimi, Kazumi; Arai, Kuniaki; Yamashita, Tatsuya; Honda, Masao; Kaneko, Shuichi Liver International 32 10 1516-1526 2012/11/01 
  •  [A case report of S-1 monotherapy for advanced hepatocellular carcinoma]. Yamashita, Tatsuya; Arai, Kuniaki; Terashima, Takeshi; Sunagozaka, Hajime; Shimakami, Tetsuro; Yamashita, Taro; Mizukoshi, Eishiro; Sakai, Akito; Honda, Masao; Kaneko, Shuichi Gan to kagaku ryoho. Cancer & chemotherapy 39 9 1435-1437 2012/09/01 
  •  Current status of hepatocellular carcinoma treatment in Japan: Hepatic arterial infusion chemotherapy Yamashita, Tatsuya Clinical Drug Investigation 32 SUPPL. 2 15-23 2012/08/13 
  •  Hypervascular hepatocellular carcinoma: Correlation between biologic features and signal intensity on gadoxetic acid - Enhanced MR images Kitao, Azusa; Matsui, Osamu; Yoneda, Norihide; Kozaka, Kazuto; Kobayashi, Satoshi; Koda, Wataru; Gabata, Toshifumi; Yamashita, Tatsuya; Kaneko, Shuichi; Nakanuma, Yasuni; Kita, Ryuichi; Arii, Shigeki Radiology 265 3 780-789 2012/11/30 
  •  Direct-Acting Antiviral Agents Reduce the Risk of Malignant Transformation of Hepatobiliary Phase-Hypointense Nodule without Arterial Phase Hyperenhancement to Hepatocellular Carcinoma on Gd-EOB-DPTA-Enhanced Imaging in the Hepatitis C Virus-Infected Liver. Yoshiaki Shimizu,Kuniaki Arai,Taro Yamashita,Tatsuya Yamashita,Tetsuro Shimakami,Kazunori Kawaguchi,Kazuya Kitamura,Yoshio Sakai,Eishiro Mizukoshi,Masao Honda,Azusa Kitao,Kazuto Kozaka,Satoshi Kobayashi,Shuichi Kaneko Liver cancer 9 3 261 2020/06
  •  Inactivation of Transcriptional Repressor Capicua Confers Sorafenib Resistance in Human Hepatocellular Carcinoma. Tomomi Hashiba,Taro Yamashita,Hikari Okada,Kouki Nio,Takehiro Hayashi,Yoshiro Asahina,Tomoyuki Hayashi,Takeshi Terashima,Noriho Iida,Hajime Takatori,Tetsuro Shimakami,Kazunori Kawaguchi,Kuniaki Arai,Yoshio Sakai,Tatsuya Yamashita,Eishiro Mizukoshi,Hiroyuki Takamura,Tetsuo Ohta,Masao Honda,Shuichi Kaneko Cellular and molecular gastroenterology and hepatology 10 2 269 2020
  •  Management of biliary stricture in patients with IgG4-related sclerosing cholangitis. Masaki Miyazawa,Hajime Takatori,Kazunori Kawaguchi,Kazuya Kitamura,Kuniaki Arai,Koichiro Matsuda,Takeshi Urabe,Katsuhisa Inamura,Takuya Komura,Hideki Mizuno,Uichiro Fuchizaki,Taro Yamashita,Yoshio Sakai,Tatsuya Yamashita,Eishiro Mizukoshi,Masao Honda,Shuichi Kaneko PloS one 15 4 e0232089 2020
  •  Intake of ω-6 Polyunsaturated Fatty Acid-Rich Vegetable Oils and Risk of Lifestyle Diseases. Tetsumori Yamashima,Tsuguhito Ota,Eishiro Mizukoshi,Hiroyuki Nakamura,Yasuhiko Yamamoto,Mitsuru Kikuchi,Tatsuya Yamashita,Shuichi Kaneko Advances in nutrition (Bethesda, Md.) 11 6 1489 2020/11/16
  •  Investigation of Thrombosis Volume, Anticoagulants, and Recurrence Factors in Portal Vein Thrombosis with Cirrhosis. Tsuyoshi Suda,Hajime Takatori,Takehiro Hayashi,Rika Horii,Kouki Nio,Takeshi Terashima,Noriho Iida,Masaaki Kitahara,Tetsuro Shimakami,Kuniaki Arai,Taro Yamashita,Tatsuya Yamashita,Eishiro Mizukoshi,Masao Honda,Kenichiro Okumura,Kazuto Kozaka,Shuichi Kaneko Life (Basel, Switzerland) 10 9 2020/09/04 
  •  IL-28B variant as a predictor in patients with advanced hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy. Takeshi Terashima,Masao Honda,Tadashi Toyama,Tetsuro Shimakami,Ryogo Shimizu,Hajime Takatori,Kuniaki Arai,Kazunori Kawaguchi,Kazuya Kitamura,Taro Yamashita,Yoshio Sakai,Tatsuya Yamashita,Eishiro Mizukoshi,Shuichi Kaneko Journal of gastroenterology and hepatology 35 10 1813 2020/10
  •  Safety and Long-Term Outcome of Intratumoral Injection of OK432-Stimulated Dendritic Cells for Hepatocellular Carcinomas After Radiofrequency Ablation. Masaaki Kitahara,Eishiro Mizukoshi,Takeshi Terashima,Hidetoshi Nakagawa,Rika Horii,Noriho Iida,Kuniaki Arai,Taro Yamashita,Yoshio Sakai,Tatsuya Yamashita,Masao Honda,Yasunari Nakamoto,Shuichi Kaneko Translational oncology 13 7 100777 2020/07
  •  Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients. Takuya Seike,Eishiro Mizukoshi,Kazutoshi Yamada,Hikari Okada,Masaaki Kitahara,Tatsuya Yamashita,Kuniaki Arai,Takeshi Terashima,Noriho Iida,Kazumi Fushimi,Taro Yamashita,Yoshio Sakai,Masao Honda,Kenichi Harada,Shuichi Kaneko Journal of gastroenterology 55 7 701 2020/07
  •  Upregulation of the Long Non-Coding RNA HULC by Hepatitis C Virus and its Regulation of Viral Replication. Juria Kitabayashi,Takayoshi Shirasaki,Tetsuro Shimakami,Tomoaki Nishiyama,Christoph Welsch,Masaya Funaki,Kazuhisa Murai,Ariunaa Sumiyadorj,Hajime Takatori,Kazuya Kitamura,Kazunori Kawaguchi,Kuniaki Arai,Taro Yamashita,Yoshio Sakai,Tatsuya Yamashita,Eishiro Mizukoshi,Masao Honda,Shuichi Kaneko The Journal of infectious diseases 2020/06/09
  •  Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis. Tuyen Thuy Bich Ho,Alessandro Nasti,Akihiro Seki,Takuya Komura,Hiiro Inui,Takashi Kozaka,Yoji Kitamura,Kazuhiro Shiba,Taro Yamashita,Tatsuya Yamashita,Eishiro Mizukoshi,Kazunori Kawaguchi,Takashi Wada,Masao Honda,Shuichi Kaneko,Yoshio Sakai Journal for immunotherapy of cancer 8 2 2020/11
  •  Comparative analysis of liver functional reserve during lenvatinib and sorafenib for advanced hepatocellular carcinoma. Takeshi Terashima,Tatsuya Yamashita,Noboru Takata,Tadashi Toyama,Tetsuro Shimakami,Hajime Takatori,Kuniaki Arai,Kazunori Kawaguchi,Kazuya Kitamura,Taro Yamashita,Yoshio Sakai,Eishiro Mizukoshi,Masao Honda,Shuichi Kaneko Hepatology research : the official journal of the Japan Society of Hepatology 50 7 871 2020/07
  •  Liver Resection for Multiple Hepatocellular Carcinomas: A Japanese Nationwide Survey. Yasuyuki Fukami,Yuji Kaneoka,Atsuyuki Maeda,Takashi Kumada,Junko Tanaka,Tomoyuki Akita,Shoji Kubo,Namiki Izumi,Masumi Kadoya,Michiie Sakamoto,Osamu Nakashima,Yutaka Matsuyama,Takashi Kokudo,Kiyoshi Hasegawa,Tatsuya Yamashita,Kosuke Kashiwabara,Tadatoshi Takayama,Norihiro Kokudo,Masatoshi Kudo Annals of surgery 272 1 145 2020/07
  •  Treatment Selection for Early to Intermediate Hepatocellular Carcinoma Kazuhiro Nouso,Takamasa Ohki,Tatsuya Yamashita,Haruyuki Takaki,Chien-Au Liu,Tae Wook Kang,Dong Ho Lee,So Jung Lee,Suyash Kulkarni,Deepa Shree,Masatoshi Tanaka Applied Sciences 2020/07 
  •  Effect of adoptive T-cell immunotherapy on immunological parameters and prognosis in patients with advanced pancreatic cancer. Tatsuo Kumai,Eishiro Mizukoshi,Tomomi Hashiba,Hidetoshi Nakagawa,Masaaki Kitahara,Tomoharu Miyashita,Takafumi Mochizuki,Shigenori Goto,Takashi Kamigaki,Rishu Takimoto,Taro Yamashita,Yoshio Sakai,Tatsuya Yamashita,Masao Honda,Katsuro Tomita,Shuichi Kaneko Cytotherapy 23 2 137 2021/02
  •  Ramucirumab after prior sorafenib in patients with advanced hepatocellular carcinoma and elevated alpha-fetoprotein: Japanese subgroup analysis of the REACH-2 trial. Masatoshi Kudo,Takuji Okusaka,Kenta Motomura,Izumi Ohno,Manabu Morimoto,Satoru Seo,Yoshiyuki Wada,Shinpei Sato,Tatsuya Yamashita,Masayuki Furukawa,Takeshi Aramaki,Seijin Nadano,Kazuyoshi Ohkawa,Hirofumi Fujii,Toshihiro Kudo,Junji Furuse,Hiroki Takai,Gosuke Homma,Reigetsu Yoshikawa,Andrew X Zhu Journal of gastroenterology 55 6 627 2020/06
  •  Tumor lysis syndrome in a patient with metastatic melanoma treated with nivolumab. Saiho Sugimoto,Takeshi Terashima,Tatsuya Yamashita,Noriho Iida,Masaaki Kitahara,Yuji Hodo,Tetsuro Shimakami,Hajime Takatori,Kuniaki Arai,Kazunori Kawaguchi,Kazuya Kitamura,Taro Yamashita,Yoshio Sakai,Yukihiro Shirota,Katsuaki Sato,Eishiro Mizukoshi,Masao Honda,Kenichi Harada,Shuichi Kaneko Clinical journal of gastroenterology 13 5 935 2020/10
  •  Safety and efficacy of sorafenib followed by regorafenib or lenvatinib in patients with hepatocellular carcinoma. Takeshi Terashima,Tatsuya Yamashita,Noboru Takata,Yasuhito Takeda,Hidenori Kido,Noriho Iida,Masaaki Kitahara,Tetsuro Shimakami,Hajime Takatori,Kuniaki Arai,Kazunori Kawaguchi,Kazuya Kitamura,Taro Yamashita,Yoshio Sakai,Eishiro Mizukoshi,Masao Honda,Shuichi Kaneko Hepatology research : the official journal of the Japan Society of Hepatology 51 2 190 2021/02
  •  Hepatic Arterial Infusion Chemotherapy versus Sorafenib in Patients with Advanced Hepatocellular Carcinoma. Kazuomi Ueshima,Sadahisa Ogasawara,Masafumi Ikeda,Yutaka Yasui,Takeshi Terashima,Tatsuya Yamashita,Shuntaro Obi,Shinpei Sato,Hiroshi Aikata,Takumi Ohmura,Hidekatsu Kuroda,Takamasa Ohki,Kengo Nagashima,Yoshihiko Ooka,Masahiro Takita,Masayuki Kurosaki,Kazuaki Chayama,Shuichi Kaneko,Namiki Izumi,Naoya Kato,Masatoshi Kudo,Masao Omata Liver cancer 9 5 583 2020/09
  •  Serum alpha-fetoprotein and clinical outcomes in patients with advanced hepatocellular carcinoma treated with ramucirumab Zhu AX, Finn RS, Kang YK, Yen CJ, Galle PR, Llovet JM, Assenat E, Brandi G, Motomura K, Ohno I, Daniele B, Vogel A, Yamashita T, Hsu CH, Gerken G, Bilbruck J, Hsu Y, Liang K, Widau RC, Wang C, Abada P, Kudo M Br J Cancer. 2021/02/03
  •   Intake of ω-6 Polyunsaturated Fatty Acid-Rich Vegetable Oils and Risk of Lifestyle Diseases. Yamashima T, Ota T, Mizukoshi E, Nakamura H, Yamamoto Y, Kikuchi M, Yamashita T, Kaneko S. Adv Nutr .  2020/07/04
  •  Effects of Adaptive Immune Cell Therapy on the Immune Cell Profile in Patients With Advanced Gastric Cancer Miura M, Mizukoshi E, Hashiba T, Kitahara M, Miyashita T, Mochizuki T, Goto S, Kamigaki T, Takimoto R, Yamashita T, Sakai Y, Yamashita T, Honda M, Kaneko S. 2020/06/11

Conference Presentations

  • Optimizing clinical application of Lenvatinib as first line therapy in unresectable HCC(conference:KSMO 2019 Satellite Symposium 7)(2019/11/08)
  • Treatment strategies in advanced HCC – Focus on Lenvatinib –(conference:JSH International Liver Conference 2019 Luncheon Seminar 2)(2019/10/01)
  • Prognostic and Predictive Value of Baseline Alpha-fetoprotein in Patients with Advanced Hepatocellular Carcinoma Treated with Ramucirumab from Two Phase 3 Studies (REACH, REACH-2)(conference:ESMO2019)(2019/09/27)
  • Ramucirumab as Second-Line Treatment in Patients With Advanced Hepatocellular Carcinoma and Elevated Alpha-Fetoprotein Following First-Line Sorafenib: Pooled Efficacy and Safety in Japanese Patients Across Two Global Randomized Phase 3 Studies (REACH-2 and REACH)(conference:ASCO-GI)(2019/01/17)
  • Diagnosis and treatment of hepatitis and liver cancer (conference:SIXTH LEADERSHIP WORKSHOP FOR CANCER CONTROL (CanLEAD))(2019/09/19)

show all

  • Data supporting updated treatment strategies in advanced HCC(conference:Lilly Satellite at APPLE 2019)(2019/08/30)
  • Review of current strategies for HBV and HCV testing and treatment(conference:WONCA Hepatitis seminar )(2019/05/16)
  • REFLECT Study –Data Interpretation and comparison with real-world experience(conference:Lenvima HCC Launch Symposium)(2019/01/12)
  • Recent advance of molecular targeted therapies for hepatocellular carcinoma(conference:56th JSCO )(2018/10/18)
  • Current treatment strategies for persons with chronic hepatitis B infection in Japan(conference:The 4th International Symposium on Viral Hepatitis)(2018/11/16)
  • Current positioning of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma in Japan(conference:JSMO2018)(2018/07/19)
  • Discussion: Subanalysis of Japanese patients in a phase 3 study of lenvatinib vs sorafenib for unresectable hepatocellular carcinoma (conference:JSMO2017)(2017/07/28)
  • Module 3B Assessing liver fibrosis -Non-invasive biomarkers and other methods (conference:Training workshop on hepatitis B and hepatitis C screening, diagnosis and treatment and HIV coinfection.)(2017/12/06)
  • Longitudinal cohort monitoring for hepatitis B and liver cancer(conference:Expert Consultation on Advancing Implementation Research on Syphilis, HIV and Hepatitis in Asia)(2017/09/23)
  • Clinical Practice Guidelines for Hepatocellular Carcinoma “ The algorithm for treatment of hepatocellular carcinoma ”(2017/10/13)
  • Up to date of cancer medical treatment against hepatocellular carcinoma(2017/10/12)
  • Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy in patients with intermediate-stage Hepatocellular carcinoma(conference:APDW(アジア太平洋消化器病週間))(2016/11/05)

Others

  •  Chemotherapy for advanced hepatocellular carcinoma: systemic chemotherapy or hepatic arterial infusion chemotherapy? 39 4 404-406 2004/04

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「食用油に由来するヒドロキシノネナールが生活習慣病を惹起する機序」(2019-2023) 
○「「肝硬変における炎症細胞社会の解明」」(2017-2021) 
○「肝がんのがんエコシステム解析に基づく新規治療標的分子探索」(2018-2020) 

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

○Disease Control and Homeotasis(2017)
○Disease Control and Homeotasis(2017)
○Disease Control and Homeotasis(2016)
○Disease Control and Homeotasis(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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