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Researcher Information

last modified:2021/04/01

Associate Professor KITAMURA Yoji


Faculty, Affiliation

Research Center for Experimental Modeling of Human Disease

College and School Educational Field

Division of Natural System, Graduate School of Natural Science and Technology


Division of Tracer Kinetics, Advanced Science Research Center TEL:076-265-2474 FAX:076-234-4245

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kyoto University Doctor 200303 Unfinished course
Kyoto University Master 200103 Completed
【Academic background(Bachelor's Degree)】
Kyoto University 199903


Kanazawa University Advanced Science Research Center(2009/10/01-)
Okayama University(2007/04/01-2009/09/30)
Okayama University(2005/04/01-2007/04/01)
Okayama University(2004/06/15-2005/04/01)
Kobe Gakuin University(2003/04/01-2004/06/14)

Year & Month of Birth


Academic Society

The Pharmaceutical Society of Japan
Japanese Society for Molecular Imaging
Japanese Cancer Association
Japanese Society of Radiation Safety Management

The Japan Society for Analytical Chemistry
Japan Society for Biomedical Research on Trace Elements
Japanese Society for Food Hygiene and Safety


Japanese Society for Food Hygiene and Safety


Speciality Keywords

Research Themes



  •  Redesign of negatively charged 111In-DTPA-octreotide derivative to reduce renal radioactivity Oshima N., Akizawa H., Kawashima H., Zhao S., Zhao Y., Nishijima K. I., Kitamura Y., Arano Y., Kuge Y. and Ohkura K. Nuclear medicine and biology 48 16 2017/02/06
  •  Evaluation of Ga-DOTA-(D-Asp)n as bone imaging agents: D-aspartic acid peptides as carriers to bone Ogawa K., Ishizaki A., Takai K., Kitamura Y., Makino A., Kozaka T., Kiyono Y., Shiba K. and Odani A. Scientific Reports 7 1 13971 2017/10/25
  •  Synthesis and evaluation of radioiodinated 1-{2-[5-(2-methoxyethoxy)-1H-benzo[d]imidazol-1-yl]quinolin-8-yl}piperidin-4-amine derivatives for platelet-derived growth factor receptor β (PDGFRβ) imaging. Effendi N., Ogawa K., Mishiro K., Takarada T., Yamada D., Kitamura Y., Shiba K., Maeda T. and Odani A. Bioorganic & Medicinal Chemistry 25 20 5576-5585 2017/10/15
  •  Redesign of negatively charged 111In-DTPA-octreotide derivative to reduce renal radioactivity Nobuhiro Oshima, Hiromichi Akizawa, Hidekazu Kawashima, Songji Zhao, Yan Zhao, Ken-ichi Nishijima, Yoji Kitamura, Yasushi Arano, Yuji Kuge, Kazue Ohkura Nuclear Medicine and Biology 48 16-25 2017/02/06
  •  In Vivo Differences between Two Optical Isomers of Radioiodinated o-iodo-trans-decalinvesamicol for Use as a Radioligand for the Vesicular Acetylcholine Transporter Uno I., Kozaka T., Miwa D., Kitamura Y., Azim M. A.-u., Ogawa K., Taki J., Kinuya S. and Shiba K. PLoS ONE 11 1 e0146719 2016/01/11

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  •  Evaluation of Chlorella as a Decorporation Agent to Enhance the Elimination of Radioactive Strontium from Body Ogawa K., Fukuda T., Han J., Kitamura Y., Shiba K. and Odani A. Plos One 11 2 2016/02/01
  •  The potential of o-bromo-trans-decalinvesamicol as a new PET ligand for vesicular acetylcholine transporter imaging Azim M. A.-u., Kozaka T., Uno I., Miwa D., Kitamura Y., Ogawa K., Makino A., Kiyono Y. and Shiba K. Synapse 68 10 445-453 2014/08 
  •  Synthesis and evaluation of a new vesamicol analog o-[11C]methyl-trans-decalinvesamicol as a PET ligand for the vesicular acetylcholine transporter Kitamura Y., Kozaka T., Miwa D., Uno I., Azim M. A.-u., Ogawa K., Taki J., Kinuya S. and Shiba K. Annals of Nuclear Medicine 30 2 122-129 2015/11/25
  •  Radiogallium Complex-Conjugated Bifunctional Peptides for Detecting Primary Cancer and Bone Metastases Simultaneously Ogawa K., Yu J., Ishizaki A., Yokokawa M., Kitamura M., Kitamura Y., Shiba K. and Odani A Bioconjugate Chemistry 26 8 1561-1570 2015/08/19
  •  Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease Lopatina O., Yoshihara T., Nishimura T., Zhong J., Akther S., Fakhrul A. A., Liang M., Higashida C., Sumi K., Furuhara K., Inahata Y., Huang J. J., Koizumi K., Yokoyama S., Tsuji T., Petugina Y., Sumarokov A., Salmina A. B., Hashida K., Kitao Y., Hori O., Asano M., Kitamura Y., Kozaka T., Shiba K., Zhong F., Xie M. J., Sato M., Ishihara K. and Higashida H. Front Behav Neurosci 8 133 2014/04/22
  •  Regional brain imaging of vesicular acetylcholine transporter using o-[125I]iodo-trans-decalinvesamicol as a new potential imaging probe Kozaka T., Uno I., Kitamura Y., Miwa D., Anwar-Ul Azim M., Ogawa K. and Shiba K. Synapse 68 3/7 107-113 2014
  •  Design, synthesis and biological evaluation of negatively charged 111In-DTPA-octreotide derivatives Oshima N., Akizawa H., Zhao S., Zhao Y., Nishijima K., Kitamura Y., Arano Y., Kuge Y. and Ohkura K. Bioorg Med Chem 22 4 1377-82 2014/02/15
  •  Development of Novel Radiogallium-Labeled Bone Imaging Agents Using Oligo-Aspartic Acid Peptides as Carriers PLoS ONE 8 12 e84335 2013/12/31
  •  Development and Evaluation of a Novel 99mTc-Labeled Annexin A5 for Early Detection of Response to Chemotherapy Ogawa K., Ohtsuki K., Shibata T., Aoki M., Nakayama M., Kitamura Y., Ono M., Ueda M., Doue T., Onoguchi M., Shiba K. and Odani A. PLoS ONE 8 12 e81191 2013/12/04
  •  Decontamination of radioactivity from contaminated vegetables derived from the Fukushima nuclear accident RADIATION MEASUREMENTS 55 26-29 2013/08
  •  Development of new zinc dithiosemicarbazone complex for use as oral antidiabetic agent. BIOLOGICAL TRACE ELEMENT RESEARCH 154 1 111-119 2013/07
  •  Development and evaluation of a radiobromine-labeled sigma ligand for tumor imaging. NUCLEAR MEDICINE AND BIOLOGY 40 4 445-450 2013/05
  •  Development and evaluation of a novel radioiodinated vesamicol analog as a sigma receptor imaging agent EJNMMI Research 2 1 54 2012/12
  •  Characteristics of radioactive contamination of vegetables derived from the Fukushima nuclear accident. Radiation Safety Management 11 1 23-26 2012/12
  •  Chemical removal of radionuclides in contaminated spinach derived from the Fukushima nuclear accident Radiation Safety Management 11 1 in press 2012/12
  •  Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT) BIOORGANIC & MEDICINAL CHEMISTRY 20 16 4936-4941 2012/07
  •  Endogenous Secretory Receptor for Advanced Glycation End-Products Inhibits Amyloid-beta1-42 Uptake into Mouse Brain. Sugihara T., Munesue S., Yamamoto Y., Sakurai S., Akhter N., Kitamura Y., Shiba K., Watanabe T., Yonekura H., Hayashi Y., Hamada J. and Yamamoto H. J Alzheimers Dis 28 709-720 2012/01
  •  Preparation and evaluation of a radiogallium complex-conjugated bisphosphonate as a bone scintigraphy agent. Ogawa K., Takai K., Kanbara H., Kiwada T., Kitamura Y., Shiba K. and Odani A. NUCLEAR MEDICINE AND BIOLOGY 38 631-636 2011/01
  •  5-Iodo-A-85380, a specific ligand for alpha4beta2 nicotinic acetylcholine receptors, prevents glutamate neurotoxicity in rat cortical cultured neurons. Ueda M., Iida Y., Kitamura Y., Kawashima H., Ogawa M., Magata Y. and Saji H. BRAIN RESEARCH 1199 46-52 2008/01
  •  Peroxidase-like catalytic activity of aqueous- and immobilized-Mn3+-octabromo- porphyrins on ion-exchange resin supplied as mimetic of horseradish peroxidase. Kitamura Y., Mori K., Yamamoto M., Nozaki A., Saito M., Tsukamoto I., Mifune M. and Saito Y. CHEMICAL & PHARMACEUTICAL BULLETIN 56 1364-1366 2008/01
  •  Ion-exchange resins modified with metal-porphyrin as a catalysis for oxidation of epinephrine (adrenaline). Kitamura Y., Mifune M., Takatsuki T., Iwasaki T., Kawamoto M., Iwado A., Chikuma M. and Saito Y. Catalysis Communications 9 224-228 2008/01
  •  Catalytic activity of silica gels bound manganese(III)-porphyrin on oxidative reaction of adrenaline. Kitamura Y., Takatsuki T., Kawamoto M., Saito M., Iwado A., Tsukamoto I., Mifune M. and Saito Y. CHEMICAL & PHARMACEUTICAL BULLETIN 55 500-502 2007/01
  •  Chemical Control of Biological Activity and Biodistribution of Metal Compounds: Drug Design of Metal Complexes with Biological Activity and Target-Specific Biodistribution.  Saji H., Ogawa K., Kitamura Y., Kubota-Akizawa M. and Kawashima H. Biomed Res Trace Elements 18 255-263 2007/01
  •  Effect of Carboxyl-Group of D-Glutamic Acid or gamma-Carboxy-D-glutamic Acid as N-Terminal Amino Acid of (111)In-Diethylenetriaminepentaacetic Acid-Octreotide on Accumulation of Radioactivity in Kidney.  Akizawa H., Saito M., Tsukamoto I., Ohkura T., Shimizu T., Kitamura Y.(Corresponding Authre), Mifune M., Saito Y., Arano Y. and Saji H. BIOLOGICAL & PHARMACEUTICAL BULLETIN 30 2226-2228 2007/01
  •  Peroxidase-like catalytic activity of Mn3+-octabromo-tetrakis(4-sulfophenyl)porphine on linoleate hydroperoxide and its analytical application.  Mifune M., Kamiguchi H., Tai T., Kuremoto S., Yamamoto M., Tsukamoto I., Saito M., Kitamura Y., and Saito Y. TALANTA 71 456-461 2007/01

Conference Presentations

  • Study on the Application of ATR for the Measurement of Infrared Absorption Spectrum of Food Adductives Identification Tests(2017/03/26)
  • The development of a novel σ-1 receptor imaging agent for SPECT(2017/05/25)
  • The structure-activity relationship between structure of vesamicol analogs and affinity of VAChT and sigma receptors(2017/03/26)
  • The possibility of vesamicol analog with 5-membered ring structure as the sigma-1 receptor imaging agents(2017/03/26)
  • Changes of the dopamine nerve system by stress in the model mouse for 15q duplication.(2017/03/25)

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  • Development of a radiobromine-labeled compound as a sigma receptor ligand for tumor imaging.(conference:2016SNMMI 63th annual meeting)(2016/06/12)
  • In vitro evaluation meta-bromo benzovesamicol as PET VAChT imaging Probe.(conference:The 2nd Asian Nuclear Medicine Academic Forum 2016,(ANMAF 2016))(2016/05/06)
  • Bioactive Radionuclear Coordination Compounds(2014/03/28)
  • n vivo evaluation of radiobromine-labeled o-bromo-trans-decalinvesamicol (OBDV) as a potential VAChT imaging probe(2013/12/14)
  • Introduction of radiobromine labeled decalinvesamicol analogue as a new and promising PET vesicular acetylcholine transporter (VAChT) imaging probe(conference:2014 SNMMI 61th annual meeting)(2014/06/08)
  • Evaluation of Radiolabeled o-Bromo-decalinvesamicol (OBDV) as a PET Ligand for the Vesicular Acetylcholine Transporter (VAChT)(conference:International Workshop for Molecular Functional Imaging -Brain and Gynecologic Oncology-(Fukui2014: The Fifth International Workshop on Biomedical Imaging))(2014/03/03)
  • Usefulness of radioiodinated 2-[4-(2-iodophenyl)piperidino] cyclopentanol (OI5V) for early diagnosing neurodegenerative disorder caused by stress. (conference:12th World Congress of the World Federation of Nuclear Medicine and Biology.)(2018/04/22)
  • Characteristics of 2-[4-(2-iodophenyl)piperidino]cyclopenntanon (OI5V) as a new sigma-1 receptor imaging agent.(conference:SNMMI 2017 Annual Meeting)(2017/06/12)


Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「種々のγ線放出核を用いた早期疾患診断プローブ開発とコンプトンカメラによる複数核種同時イメージング 」(2009-2009) 

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Radiation Protection and Safety Experiment(2017)
○Radioisotope in In-Vitro and In-Vivo Techniques(2017)
○Radioisotope in In-Vitro and In-Vivo Techniques(2016)
○Radiation Protection and Safety Experiment(2016)

Classes (Graduate Schools)

○Introduction to Basic Medical Science(2016)
○Seminar on Advanced Medical Science(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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